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Axel Loewe

Dr.-Ing. Axel Loewe

Assistant Professor (Akademischer Rat)
Head of Computational Cardiac Modeling, KIT Junior Research Group leader, Young Investigator Network (YIN) member
group: 

KIT-Nachwuchsgruppenleiter, Mitglied im Young Investigator Network (YIN)


room: 509
phone: +49 721 608 - 42790
fax: +49 721 608 - 42789
Axel LoeweSeb3∂kit edu

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Lectures
title type place time start lecturer
Seminar 16.10.2018
Lecture 23.Apr.2019


Vacant thesis
title type tutor
Bachelor or master thesis


Current theses
Titel Typ Bearbeiter Betreuer


Completed theses
title type person in charge tutor
Research project

Dr. Tiago Paggi de Almeida

Student research project

Maximilian Stabel

Student research project

Robin Andlauer

Bachelor thesis

Maria Hernandez Mesa

Master thesis

Laura Unger

Bachelor thesis

Sebastian Debatin

Master thesis

Willi Kahlmann

Master thesis

Nicolas Pilia

Master thesis

Yannick Lutz

Student research project

Eura Shin

Bachelor thesis

Huy Nguyen Cong

Student research project

Yannick Lutz

Bachelor thesis

Robin Andlauer

Bachelor thesis

Amine Khalef

Diploma thesis

Andreas Wachter

Bachelor thesis

Yan Xu

Bachelor thesis

Emanuel Poremba 

Bachelor thesis

Yannick Lutz

Masterarbeit

Axel Loewe 

Bachelorarbeit

Axel Loewe



Publications


  All Publications, sorted by years

          2019 2018 2017 2016 2015 2014 2013 2011 2010 [All]


Selected Publications

Journal Articles (19)

A. Loewe, E. Poremba, T. Oesterlein, A. Luik, C. Schmitt, G. Seemann, and O. Dössel.
Patient-Specific Identification of Atrial Flutter Vulnerability–A Computational Approach to Reveal Latent Reentry Pathways.
In Frontiers in Physiology, vol. 9(Article 1910) , 2019
  PDF    
  
A. Loewe, E. M. Wülfers, and G. Seemann.
Cardiac ischemia-insights from computational models..
In Herzschrittmachertherapie & Elektrophysiologie, vol. 29(1) , pp. 48-56, 2018
  PDF    
  
  
A. Loewe, and O. Dössel.
Commentary: Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study.
In Frontiers in Physiology, vol. 8, pp. 1113, 2017
  PDF    
  
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dossel, G. Seemann, and P. G. Platonov.
Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
In Europace, vol. 18(suppl 4) , pp. iv35-iv43, 2016
  PDF    
  
  
A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, D. Thomas, E. P. Scholz, O. Dössel, and G. Seemann.
Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016
  PDF    
  
  
A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology..
In Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 16(S4) , pp. iv30-iv38, 2014
  PDF    
  
  
A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, A. Luik, O. Dössel, and G. Seemann.
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
In BioMed Research International Article, vol. 2015, pp. 530352, 2014
  PDF    
  
  
A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
In Europace, vol. 16(3) , pp. 435-443, 2014
  PDF    
  
  
R. Andlauer, G. Seemann, L. Baron, O. Dössel, P. Kohl, P. Platonov, and A. Loewe.
Influence of left atrial size on P-wave morphology: differential effects of dilation and hypertrophy.
In Europace, vol. 20(S3) , pp. iii36-iii44, 2018
  PDF    
  
S. Pollnow, N. Pilia, G. Schwaderlapp, A. Loewe, O. Dössel, and G. Lenis.
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, vol. 102, pp. 267-277, 2018
  PDF    
  
  
T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, vol. 65(10) , pp. 2334-2344, 2018
  PDF    
  
  
M. Alessandrini, M. Valinoti, L. Unger, T. Oesterlein, O. Dössel, C. Corsi, A. Loewe, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation in Atrial Fibrillation.
In Frontiers in Physiology, vol. 9, pp. 1251, 2018
  PDF    
  
H. Lehrmann, A. S. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel Electrocardiographic Criteria for Real-Time Assessment of Anterior Mitral Line Block.
In JACC: Clinical Electrophysiology, vol. 4(7) , pp. 920-932, 2018
  PDF    
  
B. Verma, T. Oesterlein, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional conduction velocity calculation from clinical multichannel electrograms in human atria.
In Computers in Biology and Medicine, vol. 92, pp. 188-196, 2018
  PDF    
  
O. Dössel, and A. Loewe.
Computerized modeling of the human heart.
In Zeitschrift für Medizinische Physik, vol. 27(3) , pp. 167-169, 2017
  PDF    
  
G. Lenis, N. Pilia, A. Loewe, W. H. W. Schulze, and O. Dössel.
Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017
  PDF    
  
  
S. Pollnow, J. Greiner, T. Oesterlein, E. M. Wülfers, A. Loewe, and O. Dössel.
Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information? Insights from a Computational Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017
  PDF    
  
  
O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
  PDF    
T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
  PDF    
  
  

Conference Contributions (65)

A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients.
In Biophysical Journal, vol. 116(3 suppl1) , pp. 231A, 2019
  PDF    
A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Severe sinus bradycardia due to electrolyte changes as a pathomechanism of sudden cardiac death in chronic kidney disease patients undergoing hemodialysis.
In Heart Rhythm, vol. 15(5S) , pp. S354-S355, 2018
  PDF    
  
A. Loewe, M. Hernandez Mesa, N. Pilia, S. Severi, and O. Dössel.
A Heterogeneous Formulation of the Himeno et al. Human Ventricular Myocyte Model for Simulation of Body Surface ECGs .
In Computing in Cardiology, vol. 45, 2018
  PDF    
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
  PDF    
  
  
A. Loewe, R. Andlauer, S. Pollnow, J. Greiner, T. G. Oesterlein, G. Seemann, and O. Dössel.
Validation upside down - In-silico models to sound the potential and limitations of diagnostic tools.
In TRM Forum, 2017
A. Loewe, Y. Lutz, A. Fabbri, S. Severi, G. Seemann, and D. Dössel.
Influence of Electrolyte Concentration Changes on Sinus Node Function - A new Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?.
In Gordon Research Conference on Cardiac Arrhythmia Mechanisms, 2017
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
A. Loewe, E. Poremba, T. G. Oesterlein, N. Pilia, M. Pfeiffer, O. Dössel, and S. Speidel.
An interactive virtual reality environment for analysis of clinical atrial arrhythmias and ablation planning.
In Computing in Cardiology, vol. 44, 2017
  PDF    
A. Loewe, R. Andlauer, P. G. Platonov, O. Dössel, and G. Seemann.
Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration.
In Computing in Cardiology, vol. 43, pp. 1-4, 2016
  PDF    
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size.
In Biomedizinische Technik, vol. 61, pp. S223, 2016
  
  
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by site of earliest right atrial activation.
In Cardiac Physiome Project, 2016
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by the site of earliest right atrial activation independent from atrial size in silico.
In International Conference on Electrocardiology, 2016
  PDF    
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
P-wave morphology is affected by site of earliest right atrial activation: a simulation study.
In TRM Forum, 2015
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
Left and Right Atrial Contribution to the P-wave in Realistic Computational Models.
In Lecture Notes in Computer Science, vol. 9126, pp. 439–447, 2015
  PDF    
  
A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Cardiac Physiome Workshop, 2015
  PDF    
A. Loewe, Y. Xu, E. P. Scholz, O. Dössel, and G. Seemann.
Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 418–-422, 2015
  PDF    
  
  
A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seeman.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Atrial Signals, 2015
A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Emerging Mathematical Topics in Biology and Life Sciences, 2015
A. Loewe, Y. Lutz, M. Wilhelms, E. P. Scholz, O. Dössel, and G. Seemann.
Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Computing in Cardiology, vol. 41, pp. 745-748, 2014
  PDF    
A. Loewe, M. Wilhelms, O. Dössel, and G. Seemann.
Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(S1) , pp. S929-S932, 2014
  PDF    
  
A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents.
In Simula Cardiac Modeling Workshop, 2014
A. Loewe, E. Poremba, M. W. Krueger, O. Dössel, and G. Seemann.
Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning.
In TRM Forum, 2013
A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Impact of hERG Mutations on Simulated Human Atrial Action Potentials.
In Biomedizinische Technik/Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data.
In Cardiac Physiome Workshop, 2013
A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, and O. Dössel.
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study.
In Computing in Cardiology, vol. 38, pp. 741-744, 2011
  PDF    
  
T. Fritz, E. Kovacheva, G. Seemann, O. Dössel, and A. Loewe.
The inverse problem of cardiac mechanics - estimation of cardiac active stress from endocardial motion tracking.
In Computational & Mathematical Biomedical Engineering Proceedings, vol. 1, pp. 91-95, 2019
  PDF    
D. Nairn, X. Ye, D. H. Fuertinger, P. Kotanko, A. Loewe, and J. Raimann.
Low Serum Calcium is Correlated with Lower Heart Rate in Elderly Dialysis Patients.
In Nephrology Dialysis Transplantation, vol. 34(S1) , 2019
  PDF    
S. Schuler, A. Loewe, and O. Dössel.
Forcing Transmembrane Voltages to Decrease Slowly: A Temporal Regularization for ECG Imaging.
In Computing in Cardiology, vol. 45, 2018
  PDF    
  
O. Dössel, T. Oesterlein, L. Unger, A. Loewe, C. Schmitt, and A. Luik.
Spatio-temporal Analysis of Multichannel Atrial Electrograms Based on a Concept of Active Areas.
In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2018, pp. 490-493, 2018
  PDF    
  
  
M. Hernández Mesa, N. Pilia, O. Dössel, S. Severi, and A. Loewe.
Effects of Serum Calcium Changes on the Cardiac Action Potential and the ECG in a Computational Model.
In Current Directions in Biomedical Engineering, vol. 4(1) , pp. 251-254, 2018
  PDF    
  
E. Kovacheva, L. Baron, O. Dössel, and A. Loewe.
Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry.
In Computing in Cardiology Conference (CinC), vol. 45, 2018
  PDF    
  
H. Lehrmann, A. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel ECG-criteria For Real-time Assessment Of Anterior Mitral Line Block - “V1-jump” And “V1-delay”.
In Heart Rhythm, vol. 15(5S) , pp. S229, 2018
  PDF    
  
A. Daub, A. Loewe, and B. Frohnapfel.
Haemodynamics in an elasto-mechanic model of the human heart.
In Annual Scientific Conference of the International Association of Applied Mathematics and Mechanics, 2018
  PDF    
S. Severi, A. Fabbri, M. Paci, R. Wilders, Y. Lutz, and A. Loewe.
Computational Modeling of the Cardiac Pacemaking in Humans.
In INdAM Workshop on Mathematical and Numerical Modeling of the Cardiovascular System, 2018
  PDF    
L. A. Unger, T. G. Oesterlein, P. Spector, A. Luik, C. Schmitt, A. Loewe, and O. Dössel.
Cycle Length Statistics During Atrial Fibrillation Reflect Refractory Properties of the Underlying Substrate.
In Annual Congress of the European Cardiac Arrhythmia Society, pp. 16-27 A15-61, 2018
L. Baron, A. Loewe, and O. Dössel.
From clinics to the virtual beating heart a general modeling workflow for patient-specific electromechanical heart simulations.
In BMTMedPhys 2017, vol. 62(S1) , pp. S70, 2017
  PDF    
  
  
O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
  PDF    
  
  
W. Kahlmann, E. Poremba, D. Potyagaylo, O. Dössel, and A. Loewe.
Modelling of patient-specific Purkinje activation based on measured ECGs.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 171-174, 2017
  PDF    
  
  
Y. Lutz, . Fabbri A., S. Severi, O. Dössel, and A. Loewe.
Plasma electrolyte concentrations in patients with chronic kidney disease influence cardiac pacemaking in a computational model.
In BMTMedPhys 2017, vol. 62(s1 - V71) , pp. 67, 2017
  PDF    
  
  
T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
  PDF    
  
  
S. Schuler, L. Baron, A. Loewe, and O. Dössel.
Developing and coupling a lumped element model of the closed loop human vascular system to a model of cardiac mechanics.
In BMTMedPhys 2017, vol. 62(S1) , pp. S69, 2017
  PDF    
L. Unger, T. Oesterlein, G. Seemann, O. Dössel, P. Spector, and A. Loewe.
Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 317-320, 2017
  PDF    
  
  
M. Alessandrini, M. Valinoti, A. Loewe, T. Oesterlein, O. Dössel, C. Corsi, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
O. Dössel, and A. Loewe.
V 10 Computer Modelling pharmakologischer Effekte.
In Frühjahrstagung der Deutschen Gesellschaft für Kardiologie, 2017
A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Propagation of the primary pacemaker activity in the human heart: a computational approach.
In European Medical and Biological Engineering Conference (EMBEC), vol. 65, pp. 201, 2017
  PDF  
A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Pace-and-Drive of the Human Sinoatrial Node – A Preliminary Computational Investigation.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
N. Nagy, A. Loewe, Z. Kohaida, K. Halász, N. Tóth, J. Levijoki, P. Pollesello, T. Koskelainen, L. Otsomaa, A. Tóth, J. Gy, and A. Varró.
Selective Inhibition of the Cardiac Na+/Ca2+ Exchanger by a Novel Compound ORM-10962 Modulates Spontaneous Automaticity.
In European Working Group on Cardiac Cellular Electrophysiology, 2017
  PDF  
N. Pilia, O. Dössel, G. Lenis, and A. Loewe.
ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
G. Seemann, A. Loewe, and E. M. Wülfers.
Effects of Fibroblasts Coupling on the Electrophysiology of Cardiomyocytes from Different Regions of the Human Atrium: A Simulation Study.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
G. Seemann, A. Loewe, and E. M. Wülfers.
Computational Study on Regional Differences in Pro-Arrhythmic Effects of Fibroblasts Coupling to Human Atrial Myocytes.
In TRM Forum, 2017
M. Valinoti, F. Bertoni, M. Alessandrini, R. Mantovan, A. Loewe, O. Dössel, S. Severi, and C. Corsi.
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation.
In Computing in Cardiology Conference, vol. 44, 2017
  PDF    
  
E. M. Wülfers, A. Loewe, and G. Seemann.
A Computational Study on the Electrophysiological Effects of Fibroblasts Coupling to Human Atrial Myocytes from Different Regions.
In Cardiac Physiome Project, 2017
R. Andlauer, A. Loewe, O. Dössel, and G. Seemann.
Effect of left atrial hypertrophy on P-wave morphology in a computational model.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 603-606, 2016
  PDF    
B. Verma, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries.
In Computing in Cardiology, vol. 43, pp. 985-988, 2016
  PDF    
D. Potyagaylo, A. Loewe, P. van Dam, and O. Dössel.
ECG imaging of focal atrial excitation: Evaluation in a realistic simulation setup.
In Computing in Cardiology, vol. 43, pp. 113-116, 2016
  PDF    
  
E. Shin, E. Poremba, O. Dössel, and A. Loewe.
Automated Initiation of Fibrillatory Excitation in Monodomain Simulations.
In Kentucky Academy of Science , 2016
N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and . O. Dössel.
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
  PDF    
  
  
M. Rottmann, L. A. Unger, W. Kaltenbacher, . Seemann G., A. Loewe, M. W. Krueger, A. S. Jadidi, T. Arentz, and O. Dössel.
Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
In Computing in Cardiology, vol. 42, pp. 485-488, 2015
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J. Trächtler, . Oesterlein T., A. Loewe, E. Poremba, A. Luik, C. Schmitt, and O. Dössel.
Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 405-408, 2015
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A. Wachter, A. Loewe, M. W. Krueger, O. Dössel, and G. Seemann.
Mesh structure-independent modeling of patient-specific atrial fiber orientation.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 409-412, 2015
  PDF    
  
  
M. Rottmann, L. A. Unger, W. Kaltenbacher, A. Loewe, M. W. Krueger, G. Seemann, T. Arentz, A. Jadidi, and O. Dössel.
Methods for Analyzing Signal Characteristics of Stable and Unstable Rotors in a Realistic Heart Model.
In Atrial Signals, 2015
Y. Lutz, A. Loewe, O. Dössel, and G. Seemann.
Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s933-s936, 2014
  PDF    
J. Liu, A. Loewe, M. Zenge, A. Lefebvre, E. Mueller, and M. S. Nadar.
Elora: Enforcing Low Rank for Parallel MR Reconstruction.
In International Society for Magnetic Resonance in Medicine, pp. 2652, 2013
  PDF  
W. H. W. Schulze, F. Elies Henar, D. Potyagaylo, A. Loewe, M. Stenroos, and O. Dössel.
Kalman Filter with Augmented Measurement Model: an ECG Imaging Simulation Study.
In FIMH, LNCS 7945, pp. 200-207, 2013
  PDF    
G. Seemann, A. Loewe, Y. Lutz, M. Wilhelms, and O. Dössel.
Simulating the Effects of Drugs and Genetic Defects on Atrial Electrophysiology.
In TRM Forum, 2013

Patents (3)



Patents

  • Alban Lefebvre, Axel Loewe, Mariappan S Nadar, Jun Liu, Zero Communication Block Partitioning, US Patent App. 2014/0037228 A1 (2012P18991 US01, 13/950,535, 2012P18991 US, 61/679,132)
  • Jun Liu, Zhili Yang, Mariappan S Nadar, Nirmal Janardhanan, Qiu Wang, Axel Loewe, Multi-stage Magnetic Resonance Reconstruction for Parallel Imaging Applications, US Patent App. 2014/0133724 A1 (2012P26350 US01, 14/054,003, 2012P26350 US, 61/724,470)

 

Awards

Biophysical Society Travel Award for the 63rd Annual Meeting 2019 in Baltimore, MD (USA).

Bill and Gary Sanders Poster Award, Conference "Computing in Cardiology" 2018 in Maastricht (The Netherlands)
Ekaterina Kovacheva, Lukas Baron, Olaf Dössel, Axel Loewe: "Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry"

Patient Safety Award 2018
Axel Loewe and Olaf Dössel won the Patient Safety Award (2nd place) together with clinical collaborators from University Heart Center Freiburg-Bad Krozingen.
The honored study introduces two novel ECG-based approaches for real-time assessment of success of catheter ablation to terminate perimitral flutter.

3rd place at Gips-Schüle junior scientist award 2018
Axel Loewe for his dissertation Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Semi-Finalist Rosanna Degani Young Investigator Award​, Conference „Computing in Cardiology“ 2017 in Rennes (France)
Nicolas Pilia, Olaf Doessel, Gustavo Lenis, Axel Loewe, ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space

Bill and Gary Sanders Poster Award, Conference „Computing in Cardiology“ 2017 in Rennes (France)
Axel Loewe, Emanuel Poremba, Tobias G. Oesterlein, Nicolas Pilia, Micha Pfeiffer, Olaf Doessel, Stefanie Speidel:
An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning

KIT Doctoral Award, Karlsruhe, July/12/2017
KIT acknowledges outstanding doctoral researchers with the KIT Doctoral Award. One of the three prizes for the academic year 2015/16 was awarded to Axel Loewe  who is with the Institute of Biomedical Engineering for his PhD thesis  „Modeling human atrial patho-electrophysiology from ion channels to ECG: substrates, pharmacology, vulnerability, and P-waves“.  [See Video]

Best Poster Presentation: Kentucky Academy of Science 2016, Student Research Competition, Computer and Information Sciences,
Eura Shin, Emanuel Poremba, Olaf Dössel, Axel Loewe: "Automated Initiation of Fibrillatory Excitation in Monodomain Simulations“

1st place in student competition at the "DGBMT Anniversary (DACH) 2016 in Basel: Axel Loewe, Robin Andlauer, Olaf Dössel, Gunnar Seemann: "Effect of Left Atrial Hypertrophy on P-Wave Morphology in a Computational Model“

Awards at the Conference „Computing in Cardiology“ 2016 at Vancouver (Kanada)
Rosanna Degani Young Investigator Award: Axel Loewe, Robin Andlauer, Olaf Dössel, Gunnar Seemann, Pyotr Platonov: „Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration“
Bill and Gary Sanders Poster Award: Axel Loewe, Bhawna Verma,  Armin Luik, Claus Schmitt, Olaf Dössel: „Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries“
Mortara Fellowship: Gustavo Lenis, Axel Loewe

1st place in student competition, DGBMT annual conference 2014, Hannover,
Y. T. LutzA. LoeweM. Wilhelms, O. Dössel, G. Seemann.
Submitted paper: Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.

Preis für das beste Doktorandenposter im Rahmen des Cardiac Physiome Workshop in Bar Harbor, USA, 2013
Axel Loewe, Mathias Wilhelms, Jochen Schmid, Mathias J. Krause, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
"A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations"

2nd place in student competition, BMT, 2013 Graz, Axel Loewe, Mathias Wilhelms, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann,
submitted paper: "Impact of hERG Mutations on Simulated Human Atrial Action Potentials"

Best poster award on the conference Computers in Cardiology at Hangzhou: A. LoeweW. H. W. SchulzeYuan JiangM. WilhelmsO. Dössel
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study; Computing in Cardiology, vol. 38, pp. 741 - 744, 2011

Please find details about my group's research at the Computational Cardiac Modeling page.

Reviewer Activity

Publons Profile

 

Conferences

BMT: Annual Meeting of the German Society for Biomedical Engineering (DGBMT)

  • 2018 (Aachen, Germany) - Presentation “Sudden cardiac death in hemodialysis patients: severe sinus bradycardia due to hypocalcaemia as a potential pathomechanism”
  • 2017 (Dresden, Germany) - Presentation "Optimal ECG Lead Systems to Maximimze Left Atrial Information Content"
  • 2016 (Basel, Switzerland) - Poster "P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activa-tion and its Proximity to Inter-Atrial Connections Independent from Atrial Size"
  • 2015 (Lübeck, Germany) - Presentation "Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions"
  • 2014 (Hanover, Germany) - Presentation "Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model"
  • 2013 (Graz, Austria) - Presentation "Impact of hERG Mutations on Simulated Human Atrial Action Potentials" (2nd Prize Student Competition)

BPS: Biophysical Society

  • 2019 (Baltimore, USA) 63rd Annual Meeting - Poster "Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients" (Early Career Travel Award Winner)
  • 2018 (Berlin, Germany) Thematic Meeting "The heart by Numbers" - Poster "The Challenge of Transferring in vitro Calcium Concentrations to Models Reflecting in vivo Conditions"

CARP: CARP User Workshop

  • 2018 (Bordeaux, France) Talk "Open Source CARP"

CinC: Computing in Cardiology

  • 2018 (Maastricht, The Netherlands) - Talk “A Heterogeneous Formulation of the Himeno et al. Human Ventricular Myocyte Model for Simulation of Body Surface ECGs"
  • 2017 (Rennes, France) - Poster "An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning" & Poster "Left Atrial Information Through the Optimization of ECG Lead Systems"
  • 2016 (Vancouver, Canada) - Presentation "Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration" (Winner Young Investigator Award)
  • 2014 (Boston, USA) - Presentation "Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology"

CMBE: Computational & Mathematical Biomedical Engineering

  • 2019 (Sendai City, Japan) - inivited presentation "The Inverse Problem of Cardiac Mechanics - Estimation of Cardiac Active Stress from
Endocardial Motion Tracking"

CPP: Cardiac Physiome Workshop

  • 2016 (Seoul, Korea) - Presentation "P-wave terminal force is affected by site of earliest right atrial activation"
  • 2015 (Auckland, New Zealand) - Presentation "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology"
  • 2013 (Bar Harbor, USA) - Poster "A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data" (Best Graduate Student Poster)

deRSE: German Conference for Research Software Engineering

  • 2019 (Potsdam, Germany) - Workshop "Herausforderungen für die nachhaltige Entwicklung, Bereitstellung und Pflege von Forschungssoftware in Deutschland" & Poster "The SuLMaSS Project: Development of a Sustainable Open Source Software Package for Cardiac Electrophysiology"

EMBC: IEEE Engineering in Medicine and Biology Conference 

  • 2019 (Berlin, Germany) - Presentation "Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium" & Special Session Organizer "Computational Cardiac Modeling at the Interface of Engineering and Clinics"

FIMH: Functional Imaging and Modelling of the Heart

  • 2015 (Maastricht, The Netherlands) - Presentation "Left and Right Atrial Contribution to the P-wave in Realistic Computational Models"

GRC/GRS: Gordon Research Conference / Gordon Research Seminar on Cardiac Arrhythmia Mechanisms

  • 2019 (Lucca, Italy) - Chair of the Gordon Research Seminar on Cardiac Arrhythmia Mechanisms
  • 2019 (Lucca, Italy) - Poster "The Challenge of Transferring in vitro Extracellular Calcium Concen-trations to Models Reflecting in vivo Conditions"
  • 2017 (Ventura Beach, USA) - Presentation (GRS) / Poster (GRC) "Influence of Electrolyte Concentration Changes on Sinus Node Function - A New Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?"

GYSS: Global Young Scientists Summit

  • 2019 (Singapur) inivited participant, Poster "Severe Sinus Bradycardia Due To Electrolyte Changes As A Pathomechanism Of Sudden Cardiac Death In Chronic Kidney Disease Patients Undergoing Hemodialysis"

HRS: Heart Rhythm Society Scientific Sessions

  • 2018 (Boston, USA) - Poster "Severe Sinus Bradycardia Due To Electrolyte Changes As A Pathomechanism Of Sudden Cardiac Death In Chronic Kidney Disease Patients Undergoing Hemodialysis"

ICIAM: International Congress of Industrial and Applied Mathematics

  • 2019 (Valencia, Spain) - Invited Presentation "The inverse problem of cardiac biomechanics: estimating active stress distribution through imaging-driven computational modeling"

MEC: Cardiac Mechano-Electric Coupling and Arrhythmias

  • 2016 (Freiburg, Germany)

TRM: Theo-Rossi-di-Montelera Forum on Computer Simulation and Experimental Assessment of Cardiac Function

  • 2017 (Lugano, Switzerland) - Talk "Validation upside down - in-silico models to sound the potential and limitations of diagnostic tools"
  • 2015 (Lugano, Switzerland) - Poster "P-wave morphology is affected by site of earliest right atrial activation: a simulation study"
  • 2013 (Lugano, Switzerland) - Poster "Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning"

Chairing:

  • Session chair "Cardiac Mechanics and Heart Failure" for Computing in Cardiology conference 2017

  • Session chair "Atrial Fibrillation Drivers & Targets" for Computing in Cardiology conference 2018

  • Co-chair for the Gordon Research Seminar on Cardiac Arrhythmia Mechanisms 2019

  • Chair of Invited Session "Computational Cardiac Modeling at the Interface of Engineering and Clinics", IEEE Engineering in Medicine and Biology Conference 2019

 

 

Invited Talks

  • "Validation upside down - in-silico models to sound the potential and limitations of diagnostic tools", TRM Forum, Lugano, Switzerland, 04 December 2017
  • „Multiscale modeling of cardiac electrophysiology”, School of Science and Engineering, Reykjavik University (RU) / Háskólann í Reykjavík (HR), Iceland, 30 August 2017
  • "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology", Workshop "Emerging mathematical topic in biology and life sciences", Research Core Area "Modeling and Simulation", Karl-Franzens-Universität Graz, Austria, 07 May 2015
  • "Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents", Simula Cardiac Modeling Workshop, Oslo, Norway, 06 November 2014

 

Other Talks

  • "Multiscale in silico modeling of human atrial electrophysiology", Computational Cardiology Lab (Prof. Natalia Trayanova), Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA, 03 Sep 2014 via Contact scholarship of Karlsruhe House of Young Scientists (KHYS)
  • "Multiscale computational cardiology", Computational Physiopathology Unit (Prof. Stefano Severi), Laboratory of Cellular and Molecular Engineering “Silvio Cavalcanti“, University of Bologna, Italy, 29 Jun 2016 via DAAD-MIUR joint mobility program