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Modeling and Coupling of a Haemodynamics- and Temperature Model for the Human Brain

Modeling and Coupling of a Haemodynamics- and Temperature Model for the Human Brain
type:Bachelor- or master thesis

M.Sc. Yannick Lutz

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In industrialized countries, stroke is the third-most widespread cause of death. The mortality rate of an ischemic stroke is about 25% while 35–55% of the patients experience of permanent disability.
Hypothermia is a promising treatment of brain tissue after it has gone through reduced blood supply as observed in ischemic stroke patients. The treatment aims to ensure reduced metabolism and an anti-inflammatory effect to avoid possible severe brain damage. A new approach involves developing a procedure to cool the blood selectively in the proximity of the vascular obstruction combined with the reperfusion. However, controlling the brain temperature and adjusting the cooling parameters are essential. Unfortunately, a selective, closeup measurement of the affected brain areas with intracranial probes is invasive and poses an additional risk of injury.

At the Institute of Biomedical Engineering in Karlsruhe, the main objective of this research project is the development of a brain model containing the most important blood vessels and blood-perfused brain tissue. On this purpose, there are several possibilities for student tasks. The first task is the adaption and extension of an existing haemodynamics model. This includes the design of a simplified user interface for an appropriate visualisation of the model results. A second task is the integration of physiological tissue response to the induced hypothermia in the model. Here, the emphasis is on literature research and the realisation and analysis of different modelling approaches.

To be noticed

  • Prior knowledge in MATLAB is essential
  • Programming skills in C++ and Simulink are desirable
  • The work includes practical challenges and should make a substantial
  • contribution to the development of a new medical device