Atrial fibrillation (AF) is a common cardiac arrhythmia characterised by an irregular heart rhythm, which can cause various complications such as heart failure and stroke. Catheter ablation of the pulmonary veins is an effective therapy for patients suffering from paroxysmal atrial fibrillation (AF). However, medicine is lacking a reliable curative therapy for patients with persistent AF. Recently, catheter ablation targeting areas of low voltage identified by intracardiac mapping has gained attention as a promising approach for persistent AF patients. However, there is a lack of understanding and consideration of confounding variables that influence voltage but are not indicative of an arrhythmic substrate.
The aim of this work is to investigate how the effects of one or more of the confounding factors (like electrode size, distance, catheter angle,...) effect the voltage being calculated and if these factors can be accounted for.
By using our computational modeling framework we will be able to dissect the effect of these confounding factors (individually and in combination) under perfectly controlled conditions.
Prior knowledge of MATLAB is required Communication and work will be done in English.