Overview and Motivation
In western countries, stroke is the third-most widespread cause of death. 80% of all strokes are ischemic and caused by a cerebral thrombosis or an embolism. The mortality rate of ischemic strokes is about 25%, while 35–55% of affected patients experience permanent disability. Therapeutic hypothermia (TH) showed neuroprotective effect and can possibly decrease the stroke induced cerebral damage. Recently, an intracarotid cooling sheath was developed to induce local TH in the penumbra using the cooling effect of cranial blood flow via collaterals. Unfortunately, so far, the control and regulation of the temporal and spatial cerebral temperature course is connected to invasive temperature measurements. Computational modelling provides unique opportunities to predict the resulting temperature decrease of the brain tissue and could replace the invasive procedure.
The aim of the work is to realize a comparison between results of a model of spatial brain temperature and images of a thermal imaging camera. For the implementation, the head geometry used must be adapted in the simulation. For the important observance of realistic conditions, literature research is necessary. The actual temperature calculation is performed with a model that uses the "bioheat module" in COMSOL®. This model must also be adapted for the comparison and the images from the thermal imaging camera evaluated accordingly. After the successful simulation, the cause for possible model deviations is to be found and possible parameters for further model improvement and validation are to be identified.
To be noticed
- Previous knowledge of MATLAB and Simulink is required.
- Knowledge of mesh machining is advantageous
- The work contains practical challenges and should make a relevant contribution to the validation of the project.