Institute of Biomedical Engineering

Comparison of intra-cardiac mapping modalities by analysing the amplitude of electrogram signals

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Atrial fibrillation (AF) is a common cardiac arrhythmia characterised by an irregular heart rhythm, which can cause various complications such as heart failure and stroke. Recently, catheter ablation targeting areas of low voltage identified by intra-cardiac mapping has gained attention as a promising approach for treating AF patients. However, it is still uncertain in which modality the voltage maps should be obtained. Typically, clinicians do the mapping procedure when patients are in sinus rhythm (SR) using bipolar signals. However, it has been studied that areas which sustain the arrhythmia may be better identified when mapping in AF and that the bipolar voltage can be effected by various aspects of the catheter, for example the angle in relation to the wavefront.

This work will therefore consist of creating a robust automatic method for calculating the voltage in SR and AF for either bipolar or unipolar signals.
The information can then be used to assess the correlation between SR and AF maps or between using bipolar and unipolar signals.

Prior knowledge of MATLAB and signal processing would be beneficial.
Communication and work will be done in English.

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