Quantitative Optical Coherence Flowmetry

In patients undergoing vascular surgeries (e.g., bypass grafting), the use of intraoperative blood flow measurements has proven to be effective in reducing recurrence rate. This is made possible by Optical Coherence Tomography Angiography (OCTA).
 OCTA is a contact-free technique to visualize vascular flow based on the motion and scattering of erythrocytes. Therefore, repeated Optical Coherence Tomography (OCT) scans are performed to detect motion contrast and to visualize vasculature. Although OCTA is already used in clinical settings, it is primarily a qualitative tool. Up to now, there is no quantitative blood flow assessment available based on OCT hardware and OCTA algorithms.
 In this project, the application areas of OCTA will be expanded and its limitations will be explored. The goal is to quantitatively correlate the OCTA signal with blood flow in large vessels by measuring this signal at a single location of the vessel.