Model-informed machine learning for the prediction of postoperative atrial fibrillation

  • type:Master thesis
  • tutor:

    PD Dr.-Ing. Axel Loewe

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    Motivation and Background
    Postoperative atrial fibrillation (POAF) complicates around 20% of surgical procedures and can lead to haemodynamic instability, increased risk of stroke, lengthened hospital and intensive care unit stays and greater costs (Dobrev et al. 2023, https://doi.org/10.1038/s41569-019-0166-5). The onset is typically 2-4 days after the surgery, which implicates a promising time window for preventive inter-ventions if patients at high risk could be identified during the surgery or shortly after. 
    Heidelberg University Hospital has collected a rich dataset of biosignals and clinical readouts before, during, and after surgery. While this dataset comprises a sizable number of patients, it is likely un-derpowered for classic deep learning approaches. This is why we want to combine this real-world dataset with synthetic data obtained through validated multi-scale simulations of cardiac electrophys-iology (Luongo et al. https://doi.org/10.1016/j.cvdhj.2021.03.002, Pilia et al. https://doi.org/10.1016/j.artmed.2023.102619).

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    Student Project
    This thesis project shall first explore the potential of the clinical dataset with feature-based machine learning approaches. In the second phase of the project, the focus will be modeling of relevant risk factors and simulation of big synthetic data and/or deep learning approaches based on the prelimi-nary results and your interest. For this, the student will be integrated in the Cardiac Modeling Group at IBT/KIT (simulation and machine learning) and the IMI/UniHD (medical domain expertise and machine learning).
    If you are interested or have questions, send an email!