The objective of this work is to find a way to see the influence of drugs on the QT interval in human ECG signals. As the measured QT interval in ECG signals is dependent from the heart rate (RR), a model of QT-RR relation should be developed to get a heart rate independent QTc. Changes caused by drugs should be seen in the QTc.
The data for the models are taken from heart cell measurements and simulations which show the action potential duration at different stimulation frequencies.
This project is in collaboration with Kent Institute of Medicine and Health Science (KIMHS) at the University of Kent and Pfizer Global Research and Development (PGRD) Sandwich, UK.