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Axel Loewe

Dr.-Ing. Axel Loewe

Akademischer Rat
Gruppenleiter Computatonal Cardiac Modeling
Raum: 509
Tel.: +49 721 608 - 42790
Fax: +49 721 608 - 42789
Axel LoeweWcp5∂kit edu

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Zu vergebende Arbeiten
Titel Typ Betreuer
Bachelor- oder Masterarbeit


Laufende Arbeiten
Titel Typ Bearbeiter Betreuer
Masterarbeit

Laura Unger

Studentische Forschungsarbeit

Robin Andlauer



Abgeschlossene Arbeiten
Titel Typ Bearbeiter Betreuer
Bachelorarbeit

Sebastian Debatin

Masterarbeit

Willi Kahlmann

Masterarbeit

Nicolas Pilia

Masterarbeit

Yannick Lutz

Studentische Forschungsarbeit

Eura Shin

Bachelorarbeit

Huy Nguyen Cong

Studentische Forschungsarbeit

Yannick Lutz

Bachelorarbeit

Robin Andlauer

Bachelorarbeit

Amine Khalef

Diplomarbeit

Andreas Wachter

Bachelorarbeit

Yan Xu

Bachelorarbeit

Emanuel Poremba 

Bachelorarbeit

Yannick Lutz

Masterarbeit

Axel Loewe 

Bachelorarbeit

Axel Loewe



Veröffentlichungen

  Alle Veröffentlichungen, sortiert nach Jahren

          2016 2015 2014 2013 2011 2010 [Alle]



Ausgewählte Veröffentlichungen

Journal Articles (9)

  • A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, D. Thomas, E. P. Scholz, O. Dössel, and G. Seemann.
    Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
  • In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016

        [request PDF]  [doi]  


  • A. Loewe, M. W. Krueger, F. Holmqvist, O. Dossel, G. Seemann, and P. G. Platonov.
    Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
  • In Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 18(suppl 4) , pp. iv35-iv43, 2016

        [request PDF]  [doi]  


  • A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
    Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
  • In Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 16(3) , pp. 435-443, 2014

        [request PDF]  [doi]  


  • A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dossel, G. Schmidt, and G. Seemann.
    In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology.
  • In Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 16(suppl 4) , pp. iv30-iv38, 2014

        [request PDF]  [doi]  


  • A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, A. Luik, O. Dössel, and G. Seemann.
    ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
  • In BioMed Research International Article, vol. 2015, pp. 530352, 2014

        [request PDF]  [doi]  


  • G. Lenis, N. Pilia, A. Loewe, Walther H. W. Schulze, and O. Dössel.
    Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
  • In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017

        [request PDF]  [doi]  [url]  


  • S. Pollnow, J. Greiner, T. Oesterlein, Eike M. Wülfers, A. Loewe, and O. Dössel.
    Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information?—Insights from a Computational Study.
  • In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017

        [request PDF]  [doi]  [url]  


  • O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
    Model Assisted Biosignal Analysis of Atrial Electrograms.
  • In Technisches Messen, vol. 83(2) , pp. 102-111, 2016

        [request PDF]  


  • T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
    Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
  • In BioMed Research International(Article ID 5340574) , pp. 1-13, 2016

        [request PDF]  [doi]  [url]  


Conference Contributions (15)

  • A. Loewe, R. Andlauer, P. G. Platonov, O. Dössel, and G. Seemann.
    Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration.
  • In Computing in Cardiology, vol. 43, pp. 1-4, 2016

        [request PDF]


  • A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
    Left and Right Atrial Contribution to the P-wave in Realistic Computational Models.
  • In Functional Imaging and Modeling of the Heart 2015, Lecture Notes in Computer Science(9126) , pp. 439-447, 2015

        [request PDF]


  • A. Loewe, Y. Xu, E. P. Scholz, O. Dössel, and G. Seemann.
    Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions.
  • In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 418–422, 2015

        [request PDF]  [doi]  


  • A. Loewe, M. Wilhelms, O. Dössel, and G. Seemann.
    Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model.
  • In Biomedizinische Technik / Biomedical Engineering, vol. 59(S1) , pp. S929-S932, 2014

        [request PDF]  


  • A. Loewe, Y. Lutz, M. Wilhelms, E. P. Scholz, O. Dössel, and G. Seemann.
    Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
  • In Computing in Cardiology, vol. 41, pp. 745-748, 2014

        [request PDF]  


  • A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and Seemann G..
    Impact of hERG Mutations on Simulated Human Atrial Action Potentials.
  • In Biomedizinische Technik/Biomedical Engineering, vol. 58(s1) , 2013

        [request PDF]  [doi]  


  • A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, and O. Dössel.
    Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study.
  • In Computing in Cardiology, vol. 38, pp. 741 - 744, 2011

        [request PDF]  [url]  


  • R. Andlauer, A. Loewe, O. Dössel, and G. Seemann.
    Effect of left atrial hypertrophy on P-wave morphology in a computational model.
  • In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 603-606, 2016

        [request PDF]  


  • B. Verma, A Loewe, A. Luik, C. Schmitt, and O. Dössel.
    Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries.
  • In Computing in Cardiology, vol. 43, pp. 985- 988, 2016

        [request PDF]


  • M. Rottmann, L. A. Unger, W. Kaltenbacher, Seemann G., A. Loewe, M. W. Krueger, A. S. Jadidi, T. Arentz, and O. Dössel.
    Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
  • In Computing in Cardiology, vol. 42, pp. 485-488, 2015

        [request PDF]  


  • N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and O. Dössel.
    The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
  • In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015

        [request PDF]  [doi]  


  • J. Trächtler, Oesterlein T., A. Loewe, E. Poremba, A. Luik, C. Schmitt, and O. Dössel.
    Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars.
  • In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 405-408, 2015

        [request PDF]  [doi]  


  • Y. Lutz, A. Loewe, O. Dössel, and G. Seemann.
    Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
  • In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s933-s936, 2014

        [request PDF]  


  • W. H. W. Schulze, F. Elies Henar, D. Potyagaylo, A. Loewe, M. Stenroos, and O. Dössel.
    Kalman Filter with Augmented Measurement Model: an ECG Imaging Simulation Study.
  • In FIMH, LNCS 7945, pp. 200-207, 2013

        [request PDF]  


  • J. Liu, A. Loewe, M. Zenge, A. Lefebvre, E. Mueller, and M. S. Nadar.
    Enforcing Low Rank for Parallel MR Reconstruction.
  • In International Society for Magnetic Resonance in Medicine, pp. 2652, 2013





Patente

  • Alban Lefebvre, Axel Loewe, Mariappan S Nadar, Jun Liu, Zero Communication Block Partitioning, US Patent App. 2014/0037228 A1 (2012P18991 US01, 13/950,535, 2012P18991 US, 61/679,132)
  • Jun Liu, Zhili Yang, Mariappan S Nadar, Nirmal Janardhanan, Qiu Wang, Axel Loewe, Multi-stage Magnetic Resonance Reconstruction for Parallel Imaging Applications, US Patent App. 2014/0133724 A1 (2012P26350 US01, 14/054,003, 2012P26350 US, 61/724,470)

 

Preise

Beste Poster Präsentation: Kentucky Academy of Science 2016, Student Research Competition, Computer and Information Sciences,
Eura Shin, Emanuel Poremba, Olaf Dössel, Axel Loewe: "Automated Initiation of Fibrillatory Excitation in Monodomain Simulations“

1. Preis im Studentenwettbewerb bei der DGBMT Jahrestagung (DACH) 2016 in Basel: Robin Andlauer, Axel Loewe, Olaf Dössel, Gunnar Seemann: "Effect of Left Atrial Hypertrophy on P-Wave Morphology in a Computational Model“

Preise bei der Konferenz „Computing in Cardiology“ 2016 in Vancouver (Kanada)
Rosanna Degani Young Investigator Award: Axel Loewe, Robin Andlauer, Olaf Dössel, Gunnar Seemann, Pyotr Platonov: „Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration“
Bill and Gary Sanders Poster Award: Axel Loewe, Bhawna Verma, Armin Luik, Claus Schmitt, Olaf Dössel: „Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries“
Mortara Fellowship: Gustavo Lenis, Axel Loewe

1. Preis im Studentenwettbewerb, DGBMT Jahrestagung 2014, Hannover,
Y. T. LutzA. LoeweM. Wilhelms, O. Dössel, G. Seemann.
Eingereichte Arbeit: Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.

Preis für das beste Doktorandenposter im Rahmen des Cardiac Physiome Workshop in Bar Harbor, USA, 2013
Axel Loewe, Mathias Wilhelms, Jochen Schmid, Mathias J. Krause, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
"A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations"

2. Preis im Studentenwettbewerb, BMT, 2013 Graz, Axel Loewe, Mathias Wilhelms, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
Eingereichte Arbeit: "Impact of hERG Mutations on Simulated Human Atrial Action Potentials"

Preis für bestes Poster im Rahmen der Tagung Computers in Cardiology in Hangzhou: A. LoeweW. H. W. SchulzeYuan JiangM. WilhelmsO. Dössel
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study; Computing in Cardiology, vol. 38, pp. 741 - 744, 2011

Gutachtertätigkeit

 

Konferenzen

CinC: Computing in Cardiology

  • 2016 (Vancouver, Kanada) - Vortrag "Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration" (1. Preis im Young Investigator Award)
  • 2014 (Boston, USA) - Vortrag "Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology"

CPP: Cardiac Physiome Workshop

  • 2016 (Seoul, Korea) - Vortrag "P-wave terminal force is affected by site of earliest right atrial activation"
  • 2015 (Auckland, Neuseeland) - Vortrag "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology"
  • 2013 (Bar Harbor, USA) - Poster "A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data" (Bestes Doktorandenposter)

FIMH: Functional Imaging and Modelling of the Heart

  • 2015 (Maastricht, Niederlande) - Vortrag "Left and Right Atrial Contribution to the P-wave in Realistic Computational Models"

BMT: Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT)

  • 2016 (Basel, Schweiz) - Poster "P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size"
  • 2015 (Lübeck, Deutschland) - Vortrag "Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions"
  • 2014 (Hannover, Deutschland) - Vortrag "Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model"
  • 2013 (Graz, Österreich) - Vortrag "Impact of hERG Mutations on Simulated Human Atrial Action Potentials" (2. Preis im Studentenwettbewerb)

MEC: Cardiac Mechano-Electric Coupling and Arrhythmias

  • 2016 (Freiburg, Deutschland)

TRM: Theo-Rossi-di-Montelera Forum on Computer Simulation and Experimental Assessment of Cardiac Function

  • 2015 (Lugano, Schweiz) - Poster "P-wave morphology is affected by site of earliest right atrial activation: a simulation study"
  • 2013 (Lugano, Schweiz) - Poster "Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning"

GRC/GRS: Gordon Research Conference / Gordon Research Seminar on Cardiac Arrhythmia Mechanisms

  • 2017 (Ventura Beach, USA) - Vortrag (GRS) / Poster (GRC) "Influence of Electrolyte Concentration Changes on Sinus Node Function - A New Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?"
  • 2019 - Chair of the Gordon Research Seminar on Cardiac Arrhythmia Mechanisms

 

Eingeladene Vorträge:

  • "Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents", Simula Cardiac Modeling Workshop, Oslo, Norwegen, 06. November 2014
  • "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology", Workshop "Emerging mathematical topic in biology and life sciences", Research Core Area "Modeling and Simulation", Karl-Franzens-Universität Graz, Österreich, 07. Mai 2015

 

Andere Vorträge

  • "Multiscale in silico modeling of human atrial electrophysiology", Computational Cardiology Lab (Prof. Natalia Trayanova), Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA, 02. September 2014 über Kontaktstipendium des Karlsruhe House of Young Scientists (KHYS)
  • "Multiscale computational cardiology", Computational Physiopathology Unit (Prof. Stefano Severi), Laboratory of Cellular and Molecular Engineering “Silvio Cavalcanti“, Universität Bologna, Italien, 29. Juni 2016 via DAAD-MIUR joint mobility program