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Tobias Oesterlein

Dr.-Ing. Tobias Oesterlein

Alumnus


Forschungsprojekte
Titel Ansprechpartner


Intracardial ECG Signal Processing / Mapping of endocardial activation patterns

Intracardial ECG Signal Processing / Mapping of endocardial activation patterns
Ansprechpartner:

Tobias Oesterlein, Olaf Dössel 

Projektgruppe:Medizinische Messtechnik &. digitale Signalverarbeitung

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Atrial Fibrillation (AFib) is the most common cardiac arrhythmia, showing an increasing prevalence with age. Hemodynamic impairment and thromboembolic events related to AFib result in significant morbidity and mortality.

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Catheter ablation, notably the electric isolation of the pulmonary veins, has become a well-established curative therapeutic approach in drug-resistant atrial fibrillation. Despite the considerable clinical experience and accumulated evidence from experimental data, the exact mechanisms behind AFib are still not completely understood. Different concepts like rotational drivers, ectopic foci or dissociation of layers are discussed controversially - together with their respective curative ablation approaches.

PRJ_2011-02-16_C_Schilling_csc_Bild_02.jpg

Together with Städtisches Klinikum Karlsruhe, we are trying to understand endocardial activity during AFib. Electrograms measured intracardially during an electrophysiological examination are analyzed with methods of signal processing and multivariate statistics. A large set of descriptors can be computed for each signal and used to classify several different types of fractionated electrograms. The spatio-temporal pattern of excitation is evaluated using simultaneous multichannel data from catheters recording in local high-density or in panoramic mode with up to 64 electrodes. Quantitative analysis helps to identify dominant mechanisms and their degree of stability. All information can be visualized on patient specific geometries and related to the atrial anatomy. This will support the physician in finding the best ablation strategy in treatment of AFib.

Recent Publications

  • T. G. Oesterlein et al. Removing ventricular far-field signals in intracardiac electrograms during stable atrial tachycardia using the periodic component analysis, Journal of Electrocardiology, 48(2), pp. 171-180, 2015
  • C. Schilling et al. Fuzzy decision tree to classify complex fractionated atrial electrograms, BMT, 2015
  • F. M. Weber et al. Wave Direction and Conduction Velocity Analysis from Intracardiac Electrograms - A Single-Shot Technique. IEEE TBME (57), 2394-2401, 2010
Abgeschlossene Arbeiten
Titel Typ Bearbeiter Betreuer
Masterarbeit

Daniel Frisch

Masterarbeit

Laura Unger

Bachelorarbeit

Michael Stritt

Studentische Forschungsarbeit

Salina Huck

Studentische Forschungsarbeit

Felix Plappert

Bachelorarbeit

Benedikt Ebener

Bachelorarbeit

Felix Plappert

Studentische Forschungsarbeit

Sophie An

Studentische Forschungsarbeit

Daniel Frisch

Masterarbeit

Franziska Schäuble

Bachelorarbeit

Salina Huck

Studentische Forschungsarbeit

Illya Grygoryev

Masterarbeit

Christian Reich

Masterarbeit

Alexander Kramlich

Bachelorarbeit

Johann Jazewitsch

Masterarbeit

Daniela Zöller

Masterarbeit

Niko Konrad

Bachelorarbeit

Julia Trächtler

Masterarbeit

Dan-Timon Rudolph

Bachelorarbeit

Daniel Frisch 

Bachelorarbeit

Fabian Schenkel

Masterarbeit

Markus Rottmann 

Studienarbeit

Tobias Oesterlein 



Veröffentlichungen


  Alle Veröffentlichungen, sortiert nach Jahren

          2017 2016 2015 2014 2013 2012 2011 [Alle]

Journal Articles (13)

T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity.
In IEEE Transactions on Biomedical Engineering, pp. 1-1, 2018
  PDF    
  
T. G. Oesterlein, J. Schmid, S. Bauer, A. Jadidi, C. Schmitt, O. Dössel, and A. Luik.
Analysis and visualization of intracardiac electrograms in diagnosis and research: Concept and application of KaPAVIE.
In Computer Methods and Programs in Biomedicine, vol. 127, pp. 165-173, 2016
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T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
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T. G. Oesterlein, G. Lenis, D.-T. Rudolph, A. Luik, B. Verma, C. Schmitt, and O. Dössel.
Removing ventricular far-field signals in intracardiac electrograms during stable atrial tachycardia using the periodic component analysis.
In Journal of Electrocardiology, vol. 48(2) , pp. 171-180, 2015
  PDF    
  
  
G. A. Begg, R. Karim, T. Oesterlein, L. N. Graham, A. J. Hogarth, S. P. Page, C. B. Pepper, K. Rhode, G. Y. H. Lip, A. V. Holden, S. Plein, and M. H. Tayebjee.
Left atrial voltage, circulating biomarkers of fibrosis, and atrial fibrillation ablation. A prospective cohort study..
In PloS one, vol. 13(1) , pp. e0189936, 2018
  PDF    
  
  
B. Verma, T. Oesterlein, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional conduction velocity calculation from clinical multichannel electrograms in human atria.
In Computers in Biology and Medicine, vol. 92, pp. 188-196, 2018
  PDF    
G. A. Begg, R. Karim, T. Oesterlein, L. N. Graham, A. J. Hogarth, S. P. Page, C. B. Pepper, K. Rhode, G. Y. H. Lip, . Holden, . A. V., S. Plein, and M. H. Tayebjee.
Intra-cardiac and peripheral levels of biochemical markers of fibrosis in patients undergoing catheter ablation for atrial fibrillation.
In Europace, 2017
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S. Pollnow, J. Greiner, T. Oesterlein, E. M. Wülfers, A. Loewe, and O. Dössel.
Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information? Insights from a Computational Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017
  PDF    
  
  
O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
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G. Lenis, N. Pilia, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
P wave detection and delineation in the ECG based on the phase free stationary wavelet transform and using intracardiac atrial electrograms as reference.
In Biomedizinische Technik. Biomedical Engineering, vol. 61(1) , pp. 37-56, 2016
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C. Schilling, M. Keller, D. Scherr, T. Oesterlein, M. Haissaguerre, C. Schmitt, O. Dössel, and A. Luik.
Fuzzy decision tree to classify complex fractionated atrial electrograms.
In Biomedizinische Technik. Biomedical Engineering, vol. 60(3) , pp. 245-255, 2015
  PDF    
  
  
J. P. Ugarte, A. Orozco-Duque, C. Tobon, V. Kremen, D. Novak, J. Saiz, T. Oesterlein, C. Schmitt, A. Luik, and J. Bustamante.
Dynamic approximate entropy electroanatomic maps detect rotors in a simulated atrial fibrillation model.
In PloS one, vol. 9(12) , pp. e114577, 2014
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J. E. Quijano, R. L. J. Campbell, T. G. Oesterlein, and L. M. Zurk.
Experimental observations of active invariance striations in a tank environment.
In The Journal of the Acoustical Society of America, vol. 128(2) , pp. 611-618, 2010
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Conference Contributions (46)

T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
  PDF    
  
  
T. Oesterlein, A. Luik, P. Hörmann, C. Schmitt, and O. Dössel.
Visitation of the dynamic 2D rhythmview gray-scale excitation pattern in 3D.
In Journal of Interventional Cardiac Electrophysiology, vol. 48(Suppl 1) , pp. S44, 2017
  PDF  
T. Oesterlein, A. Luik, P. Hörmann, C. Schmitt, and O. Dössel.
Computation of panoramic electrogram phase to identify excitation patterns during atrial fibrillation.
In Journal of Interventional Cardiac Electrophysiology, vol. 48(Suppl 1) , pp. S42-S43, 2017
  PDF  
T. Oesterlein, A. Kramlich, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Automatic detection and mapping of double potentials in intracardiac electrograms.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 179-183, 2016
  PDF    
T. Oesterlein, D. Frisch, A. Luik, C. Schmitt, and O. Dössel.
An approach to model the catheter deformation in virtual cardiac anatomies for simulation of intraatrial electrogram recordings.
2015
T. Oesterlein, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Optimized Approach for the Detection of Active Segments in Intracardiac Electrograms Measured during Atrial Flutter.
In 42nd International Congress on Electrocardiology Conference Book of Abstracts, 2015
  PDF  
T. Oesterlein, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Periodic component analysis to eliminate ventricular far field artifacts in unipolar atrial electrograms of patients suffering from atrial flutter.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 14, 2014
  PDF  
T. Oesterlein, G. Lenis, A. Luik, B. Verma, C. Schmitt, and O. Dössel.
Removing ventricular far field artifacts in intracardiac electrograms during stable atrial flutter using the periodic component analysis proof of concept study.
In Proceedings 41th International Congress on Electrocardiology, pp. 49--52, 2014
  PDF    
T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Neue Möglichkeiten zur Diagnose von Arrhythmien durch Visualisierung der zeitlichen Dynamik von Elektrogrammen.
In Deutsche Gesellschaft für Kardiologie 80. Jahrestagung Mannheim, vol. 103(Suppl 1) , pp. V167, 2014
  PDF    
  
T. G. Oesterlein, M. W. Keller, S. Schuler, A. Luik, G. Seemann, C. Schmitt, and O. Dössel.
Determination of local activation time in bipolar endocardial electrograms: a comparison of clinical criteria and a new method based on the non-linear energy operator.
In Journal of Electrocardiology, vol. 46(4) , pp. e18, 2013
  PDF    
  
  
T. G. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Generating biatrial local activation time maps using the non-linear energy operator reveals arrhythmia.
In Biomedizinische Technik. Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
T. Oesterlein, T. Baas, H. Malberg, and O. Dössel.
Multivariate AR model parameter estimation on time series extracted from the ECG of myocarditis patients.
In Biomedizinische Technik / Biomedical Engineering (Proceedings BMT2011), vol. 56(1) , 2011
  PDF    
T. G. Oesterlein, C. He, J. E. Quijano, R. L. Campbell, L. M. Zurk, and M. Siderius.
Extraction of time-frequency target features.
In 2010 Conference Record of the Forty Fourth Asilomar Conference on Signals, Systems and Computers, pp. 2156-2163, 2010
  PDF    
  
L. A. Unger, T. G. Oesterlein, P. Spector, A. Luik, C. Schmitt, A. Loewe, and O. Dössel.
Cycle Length Statistics During Atrial Fibrillation Reflect Refractory Properties of the Underlying Substrate.
In Annual Congress of the European Cardiac Arrhythmia Society, pp. 16-27 A15-61, 2018
C. Butcher, T. Oesterlein, N. Hillier, K. Viswanathan, P. Kohl, T. Wong, and C. Johnston.
Comparison of ventricular electrogram characteristics obtained using a novel mini-electrode basket catheter and a conventional 4mm tip ablation catheter.
In Deutsche Gesellschaft für Kardiologie 83. Jahrestagung Mannheim, vol. 106(Suppl 1) , pp. P1813, 2017
  PDF    
  
O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
  PDF    
  
  
M. Kottmaier, T. Oesterlein, T. Reents, F. Bourier, A. Reiter, V. Semmler, M. Telishevska, M. Deiß, K. Koch-Büttner, S. Lengauer, M. Kornmayer, E. Rousseva, S. Brooks, C. Grebmer, C. Lennerz, A. Brkic, C. Kolb, G. Heßling, and I. Deisenhofer.
How reliable are left atrial voltage maps assessed during atrial fibrillation?.
In Deutsche Gesellschaft für Kardiologie 83. Jahrestagung Mannheim, vol. 106(Suppl 1) , pp. P1783, 2017
  PDF    
  
A. Luik, T. Oesterlein, M. Merkel, P. Hörmann, K. Schmidt, T. Schenk, M. Brinkmeier-Theofanopoulou, A. Radzewitz, G. Schymik, and C. Schmitt.
Individualized ablation approach for left atrial tachycardia after previous catheter ablation of atrial fibrillation.
In Journal of Interventional Cardiac Electrophysiology, vol. 48(Suppl 1) , pp. S35, 2017
  PDF  
A. Luik, T. Oesterlein, M. Merkel, P. Hörmann, K. Schmidt, T. Schenk, A. Radzewitz, G. Schymik, and C. Schmitt.
Individualized ablation approach for left atrial tachycardia after previous catheter ablation of atrial fibrillation.
In Deutsche Gesellschaft für Kardiologie 83. Jahrestagung Mannheim, vol. 106(Suppl 1) , pp. P1851, 2017
  PDF    
  
G. Schwaderlapp, T. Oesterlein, O. Dössel, A. Luik, C. Schmitt, and G. Lenis.
Definition, estimation and limitations of the dominant frequency in intracardiac electrograms.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 95-98, 2017
  PDF    
  
  
M. Stritt, T. Oesterlein, S. Pollnow, A. Luik, and C. Schmitt.
Assessment of local high-density mapping for the analysis of radiofrequency ablation lesions in the left atrium.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 109-112, 2017
  PDF    
  
  
L. Unger, T. Oesterlein, G. Seemann, O. Dössel, P. Spector, and A. Loewe.
Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 317-320, 2017
  PDF    
  
  
M. Alessandrini, M. Valinoti, A. Loewe, T. Oesterlein, O. Dössel, C. Corsi, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
A. Loewe, R. Andlauer, S. Pollnow, J. Greiner, T. G. Oesterlein, G. Seemann, and O. Dössel.
Validation upside down - In-silico models to sound the potential and limitations of diagnostic tools.
In TRM Forum, 2017
A. Loewe, E. Poremba, T. G. Oesterlein, N. Pilia, M. Pfeiffer, O. Dössel, and S. Speidel.
An interactive virtual reality environment for analysis of clinical atrial arrhythmias and ablation planning.
In Computing in Cardiology, vol. 44, 2017
  PDF    
J. Greiner, T. Oesterlein, G. Lenis, and O. Dössel.
Virtual-Reality Based Visualization of Cardiac Arrhythmias on Mobile Devices.
In Computing in Cardiology, 2016
  PDF    
S. Huck, T. Oesterlein, A. Luik, C. Schmitt, R. Wakili, and O. Dössel.
Preprocessing of unipolar signals acquired by a novel intracardiac mapping system.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 259–262, 2016
  PDF    
G. Lenis, A. Kramlich, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Development and Benchmarking of Activity Detection Algorithms for Intracardiac Electrograms Measured During Atrial Flutter.
In Workshop Biosignal 2016. Innovation bei der Erfassung und Analyse bioelektrischer und bimagnetischer Signale, pp. 5-8, 2016
  PDF  
C. Reich, T. Oesterlein, M. Rottmann, G. Seemann, and O. Dössel.
Classification of cardiac excitation patterns during atrial fibrillation.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 161-166, 2016
  PDF    
M. Rottmann, T. Oesterlein, C. Reich, A. Luik, C. Schmitt, and O. Dössel.
Characteristic features of electrograms of depolarization waves during atrial fibrillation.
In 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2016
  
B. Verma, T. G. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Combined analysis of unipolar and bipolar electrograms for local activation time annotation near the stimulus site of paced rhythms..
In Dreilandertagung Swiss, Austrian, and German society of Biomedical Engineering, 2016
  PDF  
B. Verma, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Combined analysis of unipolar and bipolar electrograms for local activation time annotation near the stimulus site of paced rhythms.
In Current Directions in Biomedical Engineering, vol. 2, 2016
  PDF  
S. Bauer, T. Oesterlein, J. Schmid, and O. Dössel.
Interactive visualization of cardiac anatomy and atrial excitation for medical diagnosis and research.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 400-404, 2015
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O. Dössel, A. Luik, T. Oesterlein, M. Rottmann, B. Verma, and . Schmitt C..
Computer modeling of the atria and clinical electrograms.
In 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. Poster Session, 2015
  
G. Lenis, T. Oesterlein, and O. Dössel.
Orthogonal component analysis to remove ventricular far field in non periodic sustained atrial flutter.
In Computing in Cardiology, vol. 42, pp. 669-672, 2015
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B. Verma, T. G. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Analyzing the Atrial Depolarization Wavefront Triggered from Sinus Node and Coronary Sinus for Identification of the Arrhythmogenic Substrate.
In Computing in Cardiology, vol. 42, pp. 897-900, 2015
  PDF    
B. Verma, T. G. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Locating regions of arrhythmogenic substrate by analyzing the duration of triggered atrial activities.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 50-53, 2015
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B. Verma, T. G. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Determination of region with arrhythmogenic substrate based on local activation time and activity duration.
In Gordon Research Conference, 2015
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A. Luik, T. Oesterlein, R. Wakili, K. Schmidt, H. Estner, A. Radzewitz, N. Horn, P. Hoermann, M. Merkel, G. Schymik, O. Dössel, and C. Schmitt.
Coverage of the left atrial surface in patients with basket mapping for atrial fibrillation.
In Heart Rhythm On Demand 2014 - Poster Session II, vol. Lecture ID 5941, 2014
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M. Rottmann, M. W. Keller, T. Oesterlein, G. Seemann, and O. Dössel.
Comparison of different methods and catheter designs to estimate the rotor tip position a simulation study.
In Computing in Cardiology, vol. 41, pp. 133-136, 2014
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M. Rottmann, T. Oesterlein, and O. Dössel.
Local activation time based estimation of the direction of propagation of plane wave and the corresponding conduction velocity in simulated electrograms.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 152-155, 2014
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F. Schenkel, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Detection and classification of atrial excitation patterns in intracardiac electrograms with application on biatrial basket catheter measurements.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 166-169, 2014
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K. Schmidt, T. Oesterlein, R. Wakili, H. L. Estner, A. Radzewitz, N. Horn, P. Hörmann, M. Merkel, G. Schymik, O. Dössel, C. Schmitt, and A. Luik.
Abdeckungsrate der atrialen Oberfläche bei Patienten mit biatrialem Basket Mapping.
In Deutsche Gesellschaft für Kardiologie 80. Jahrestagung Mannheim, vol. 103(Suppl 1) , pp. P1857, 2014
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B. Verma, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Analysis of local activation times and complexity in the intracardiac electrograms.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s14, 2014
  PDF  
S. Schuler, M. W. Keller, T. Oesterlein, G. Seemann, and O. Dössel.
Influence of Catheter Orientation, Tissue Thickness and Conduction Velocity on the Intracardiac Electrogram.
In Biomedical Engineering/Biomedizinische Technik, vol. 58(s1) , 2013
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Preise

2017

2. Preis Klee-Preis der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT)
Tobias Oesterlein, Multichannel Analysis of Intracardiac Electrograms

Bill and Gary Sanders Poster Award, Konferenz „Computing in Cardiology“ 2017 in Rennes (Frankreich)
Axel Loewe, Emanuel Poremba, Tobias G. Oesterlein, Nicolas Pilia, Micha Pfeiffer, Olaf Doessel, Stefanie Speidel:
An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning

2. Preis im Studentenwettbewerb, DGBMT und DGMP Jahrestagung 2017, Dresden;
M. Stritt, T. Oesterlein, S. Pollnow, A. Luik, and C. Schmitt.
Eingereichte Arbeit: Assessment of local high-density mapping for the analysis of radiofrequency ablation lesions in the left atrium.

 

2016

Auszeichnung bei der Konferenz „Computing in Cardiology“ 2016 in Vancouver (Kanada)
Bill and Gary Sanders Poster Award: Joachim Greiner, Tobias Oesterlein, Gustavo Lenis, Olaf Dössel: „Virtual Reality Visualization of Arrhythmias on a Smartphone“

2. Platz im Nachwuchswettbewerb im Rahmen des Workshop "Innovationen bei der Erfassung und Analyse bioelektrischer und biomagnetischer Signale - BBS 2016" durch Gustavo Lenis, Alexander Kramlich, Tobias Oesterlein and Olaf Dössel mit dem Beitrag: "Development and Benchmarking of Activity Detection Algorithms for Intracardiac Electrograms Measured During Atrial Flutter"

 

2014
Young Investigator Award im Rahmen der 41. Tagung International Congress on Electrocardiology in Bratislava, 2014.
T. G. Oesterlein, G. Lenis; A. Luik, B. Verma, C. Schmitt, O. Dössel
Eingereichte Arbeit: "Removing Ventricular Far Field Artifacts in Intracardiac Electrograms during Stable Atrial Flutter using the Periodic Component Analysis – Proof of Concept Study"

3. Preis im Studentenwettbewerb, DGBMT Jahrestagung 2014, Hannover,
T. G. Oesterlein, G. Lenis; A. Luik, C. Schmitt, O. Dössel
Eingereichte Arbeit: "Periodic component analysis to eliminate ventricular far field artifacts in unipolar atrial electrograms of patients suffering from atrial flutter"