|First MY-ATRIA newsletter|
The first newsletter of MY-ATRIA consortium, “Introducing MY-ATRIA”, has been issued. This is a presentation of the project, the beneficiaries, partners, and the PhDs involved in it. It also describes the introductory event held in Milan in October 2018, and some interesting facts about Marie Curie.
|Annual DGK congress in Mannheim|
The PhD students Laura Unger and Mark Nothstein from the IBT participated in the annual congress of the German Society for Cardiology (DGK) in Mannheim together with Prof. Olaf Dössel. The pronounced clinical focus of the congress presented a perfect opportunity to gain insight into the open questions and problems of clinicians. While Laura Unger attended several project meetings as part of the congress Mark Nothstein represented the association project (KIT, Universitäts-Herzzentrum Freiburg / Bad Krozingen, Städtisches Klinikum Karlsruhe) with a poster presentation giving him the chance to discuss his approach towards quantifying pathological substrate with the clinical experts in the field. His contribution was selected to be published as an interview on the online platform “esanum”.Link_more
|Workshop on cardiac modeling|
Coupling relevant physiological aspects of cardiac modeling in the right way – that was the subject of a three-day workshop. About 50 scientists from various teams from different European countries met from April 15th to April 17th in Bad Herrenalb. The workshop was partly organized by the IBT. Among others, invited speakers gave insight to the current state and the developments of their research. Besides, there of course was enough room for discussions and exchange.More
|Gordon Research Conference 2019|
Three members of the IBT (Luca Azzolin, Axel Loewe, Giorgio Luongo) participated in the Gordon Research Seminar and Conference on Cardiac Arrhythmia Mechanisms in Lucca (Barga), Italy. They contributed with poster each and discussed their research with other leading experts in various fields connected with heart rhythm disorders: from computational modellers to electrophysiologists and experimentalists. It was a unique opportunity to listen to cutting-edge talks given by outstanding scientists reporting unpublished discoveries. Our member Luca Azzolin had the honour of winning one of the Deutsche Herzstiftung travel grants for his abstract and Axel Loewe co-chaired the Gordon Research Seminar together with Mathilde Rivaud from the Amsterdam Medical Center.More
|Girls’ Day 2019 at the IBT|
On the 27th of April 2019, the Girls’ Day took place and the IBT was pleased to introduce the world of Medical Technologie to the visiting girls. 20 girls signed up for our workshop on „Technology in the Hospital - visualizing heart and lung activities“. Content was the Electrical Impedance Tomography, Photoplethysmography and the Electrocardiography. The short introduction into the methods and the following experiments created a diverse and exciting time for the girls and the presenters. The active participation and the experiments made it a great and funny event. We’d like to thank the organizers, supporters, participants and we are looking forward to the next Girls’ Day 2020!More
|IBT presents at SPIE Photonic West 2019|
At the international conference SPIE Photonic West in San Francisco, CA, USA Andreas Wachter presents his currents results. The paper "Development of a real-time virtual reality environment for visualization of fully digital microscope datasets” was presented during the poster session.
|IBT presents at Biophysical Society Meeting|
Recent IBT research was presented at the 63rd Annual Meeting of the Biophysical Society in Baltimore, MD, USA. Die work "Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients“ was featured with an Early Career Scientist Travel Award and well received in the poster session.More
|IBT represented at Honorable Reception of the President|
Axel Loewe was credited during the Honorable Reception of the KIT president for his success in the Gips-Schüle junior scientist award. Around 80 invited guests experienced a 3 hour program together with a gala dinner in the casino of KIT campus north. Besides the presentation of the KIT doctoral prizes, those KIT members who won important prizes and grants were honored.More
|Estimating the personal risk for atrial flutter|
Researchers at IBT in collaboration with clinicians from Städtisches Klinikum Karlsruhe have developed a method to estimate an individual’s risk to suffer from atrial flutter using computational models. The novel method has lately been published in the journal „Frontiers in Physiology“ and allows to identify all pathways along which atrial flutter can be sustained in a personalized model of the patient. In this way, the effect of therapeutic interventions like catheter ablation or drugs can be assessed in advance.More
|PhD graduation Stefan Pollnow|
Stefan Pollnow defended his PhD thesis „Characterizing Cardiac Electrophysiology during Radiofrequency Ablation - An Integrative Ex vivo, In silico, and In vivo Approach“ on December 13 and passed the exam with distinction. We congratulate warmly!
|Influence of left atrial size on the ECG|
How does left atrial size affect the electrocardiogram (ECG)? If a robust recognition of left atrial enlargement would be possible using only the ECG, physicians would be provided with a cheap means to identify an important predictor for atrial fibrillation. In an effort to answer this question, scientists of the IBT have designed and performed a study to virtually enlarge the left atrium and simulate the corresponding ECG. Results of this study show how different types and degrees of left atrial enlargement influence the ECG and how they could potentially be detected in clinical practice. A particularly interesting results is that the frequently used clinical marker „PTF-V1“ is rather an indicator for a thicker atrial wall than for an enlarged atrium.Mehr
|IBT presents at r2b-student techpitch|
Convincing the audience in 180 seconds – scientists and founders presented their ideas and concepts during the r2b-student techpitch on Nov, 15. Afterwards, interested students could get in touch with the researchers to discuss about potential thesis projects.More
|IBT strongly represented at the Conference of the Society of Biomedical Engineering 2018 in Aachen|
The annual conference of the Society of Biomedical Engineering (DGBMT) 2018 took place in Aachen.
|Campus Report podcast features IBT|
A step towards personalized medicine and more effective treatments that’s what computer simulation of atrial fibrillation promise. The Computational Cardiac Modeling group at the Institute of Biomedical Engineering of KIT works towards a mathematical formulation of the heart’s function and its realistic representation in computational models. The head of the group, Dr. Axel Loewe, reports about the work in this week’s Campus Report podcast.More
|Patient Safety Award|
IBT scientists Axel Loewe and Olaf Dössel won the Patient Safety Award (2nd place) together with clinical collaborators from University Heart Center Freiburg-Bad Krozingen. The honored study introduces two novel ECG-based approaches for real-time assessment of success of catheter ablation to terminate perimitral flutter. Perimitral flutter is an atrial arrhythmia, which occurs frequently subsequent to ablation for atrial fibrillation. The methods were thoroughly evaluated using medical engineering simulations and put to test in a clinical study comprising a validation cohort. In the future, the methods can be implemented in clinical mapping devices. The suggested measures to assess success of ablation have great potential to significantly increase patient safety through shorter invasive procedures as well as higher success rates and therefore a smaller number of redo procedures.More
|New research assistant at IBT|
We welcome Miss Deborah Nairn as a research assistant starting October 2018. Her research will focus on identifying low voltage areas to guide atrial fibrillation therapy. This consists of identifying the relationship between bipolar voltage during sinus rhythm and ongoing AF. She aims to develop a robust method to pinpoint diseased tissue based on bipolar voltage taking into consideration different confounding factors.
|Successful participation in Computing in Cardiology (CinC) conference|
Members of IBT presented 3 scientific contributions at the CinC conference in Maastricht, Netherlands. The contribution "Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry" was honored with a price for the poster presentation. Furthermore, members of IBT were involved in the organisation of the conference being session chairs and organizers of the hackathon for inverse problem at this conference.
|Holistic evaluation of atrial fibrillation ablation using computational models|
Therapy of atrial fibrillation often entails catheter ablation, which however does not show satisfactory success in many patients. IBT researchers in collaboration with the University of Bologna developed a method, which allows to assess novel ablation strategies thoroughly using computational models. In particular the holistic consideration of the entire cycle from simulation of atrial fibrillation episodes, the resulting extracellular potentials, the mechanical deformation of the catheter, signal acquisition, clinical signal processing, and eventually ablation in the model is unique. In a first application, it could be shown that ablation of so-called rotors is not always constructive.More
|New spatio-temporal method for ECG imaging|
Every spread of electrical excitation in the heart creates a characteristic spatio-temporal pattern of potentials on the surface of the body.
|Axel Loewe awarded third place of the Gips-Schüle young talent award 2018|
Atrial fibrillation is one of the most common cardiac arrhythmias in humans and responsible for 25 percent of all strokes. Drug therapy or surgery on the heart are often ineffective in the long term.
|New research assistant at IBT|
We would like to welcome Mr. Luca Azzolin as a research assistant at the Institute of Biomedical Engineering, started at July 1st, 2018. Within the framework of the MY-ATRIA Innovative Training Network (ITN), funded by the European Commission’s Horizon 2020 Marie Sklodowska-Curie programme, Mr. Azzolin is working in the cardiac modeling group at IBT at the development of an integrated and personalized computational model of the atria for an efficient ablation therapy for atrial fibrillation. The final expected result will be a tool helping the cardiologist to predict the ablation outcome.
Mr. Azzolin completed his Bachelor’s and Master’s degree in Computational Science and Engineering (Mathematical Engineering) at Politecnico di Milano. His research topics were focused on the electromechanical modelling and computer simulation of the human ventricles.
|New research assistant at IBT|
We would like to welcome Mr. Jorge Sánchez as a research assistant starting July 2018. As a member of the computational cardiac modeling group, Jorge Sánchez‘s research will focus on the development of an open source modeling framework for the electrophysiology of the heart. We aim to provide a sustainable research software of high quality and a focus on user-friendliness. This will provide an optimal solution for a large proportion of those who can potentially benefit from cardiac computer modeling methods.
|New research assistant at IBT|
We would like to welcome Mr. Giorgio Luongo as a research assistant at the Institute of Biomedical Engineering as of July 1st, 2018. Inside the framework of the MY-ATRIA Innovative Training Network (ITN), funded by the European Commission’s Horizon 2020 Marie Sklodowska-Curie programme, Mr. Luongo is working with the biosignals group at IBT to understand the relationship between various patterns of depolarization in the atria during Sinus Rhythm, Atrial Flutter, Atrial Fibrillation, and the corresponding 12-lead ECG as well as BSPM. Additionally, to understand which of the atrial depolarization patterns can be reliably detected, identified, or localized.
Mr. Luongo completed his Bachelor’s and Master’s degree in Clinical Engineering and Biomedical Engineering at the University of Rome “La Sapienza”. His research topics were focused on the implementation of a regularized classifier based on evoked potentials EEG signals and on the implementation of an asynchronous control for Brain Computer Interface systems.
|IBT at the Interdisciplinary Cerebrovascular Symposium (ICS)|
In 2018, the international conference celebrated its 15th birthday in Magdeburg, Germany. Following the conference series motto “Bringing together international PhD and MD experts”, Yannick Lutz presented his work concerning the development of a numerical model of brain and systemic temperature during local hypothermia for ischemic stroke treatment. The usage of a novel cooling catheter enables the possibility for fast local inducement of therapeutic hypothermia while reducing systemic side effects.
|Interactive presentation within the workshop on medical technologies of the university group EESTEC|
Within the international workshop on medical technologies of the EESTEC university group, the IBT gave an interactive presentation on “Technology in hospitals”. Many interested students from various European countries could gain insights into multiple medical measurement principles of vital signs as well as test them themselves. The measurements comprised clinically essential measurements such as the electrocardiogram and newer technologies such as lung monitoring using Electrical Impedance tomography (EIT).
|Best student paper award for Michael Kircher|
Michael Kircher was awarded the “Best student paper award” of the 19th International Conference on Biomedical Applications of Electrical Impedance Tomography sponsored by the Institute of Physics (IOP) society. The Conference took place in Edinburgh from June 11th to June 13th.
|Novel filtering method for processing optical mapping data|
IBT researchers published a novel method for the analysis of cardiac optical mapping data in the journal of “Computers in Biology and Medicine”. An adaptive spatio-temporal Gaussian filter is presented to process fluorescence-optical mapping data according to the signal characteristics of recorded optical action potentials. The developed filter approach outperformed standard filtering methods from literature at low SNRs. Therefore, experimenters are able to effectively analyze optical mapping data with the help of this new filter approach.More
|Novel Method for Real Time Assessment of Treatment Efficacy|
IBT researchers published a novel method for the immediate assessment of successful treatment together with physicians from the University Heart Centre Freiburg · Bad Krozingen in the journal "JACC Clinical Electrophysiology". The ECG-based method is used to evaluate the completeness of an anterior mitral line during ablation for atrial flutter in the left atrium. Thanks to this new method, the duration of the invasive procedure might shorten markedly and the success rate might increase in future. The clinical study was complemented and fortified by computer simulations performed at IBT.More
|Excursion to the cardiac catheterization lab|
Last Thursday, research assistants of IBT and IANM visited the cardiac catheterization lab at the Städtische Klinikum Karlsruhe. Dr. Armin Luik and Prof. Dr. Claus Schmitt provided some useful insight into the electrophysiological unit and drew our attention to current scientific questions, which are of major importance to our joint projects.
|ZEISS and KIT Robotics Innovation Competition|
Health care technology and application are focus areas of the Zeiss-KIT joint Robotics Innovation Competition.
Technologies (Health Care)
|Interview with Werner Nahm|
Interview with Werner Nahm on optical technologies in medicine (medizin&technik 2/2018)medizin&technik
|Olaf Dössel appointed Fellow of the EAMBES|
Prof. Dr. Olaf Dössel was appointed Fellow of the European Alliance for Medical and Biological Engineering and Science.
|KIT Doctoral Award for Gustavo Lenis|
Gustavo Lenis is one of the recipients of the 10th KIT Doctoral Award. With this award, KIT honors outstanding doctoral candidates and emphasizes the high status of junior scientists. His doctorate reflects the wide range of research opportunities at KIT and should be a role model for others.
|Automatic identification of atrial tachycardia mechanisms|
Atrial tachycardia still poses a major challenge in catheter ablation. Researchers at IBT have developed a method to automatically analyze intracardiac signals leveraging spatio-temporal relationships. Using this method, reentry mechanisms and critical sites in the atria can be automatically identified. Such automatic interpretation of intracardiac mapping data could help to improve the treatment strategy in complex cases of atrial tachycardia. The study was published in the scientific journal "IEEE Transactions on Biomedical Engineering".Mehr
|New research assistant at IBT|
We would like to welcome Mr. Mark Nothstein as a research assistant starting January 1st, 2018. Mr. Mark Nothstein‘s research focuses on the characterization of the electrophysiological substrate in patients with atrial fibrillation. The existing classification system used in clinics today is based solely on a patient’s symptoms. Recent studies suggest, however, the symptoms do not correlate with the patient’s actual burden of atrial fibrillation. Since the success rates of interventional or medical therapy are dependent on the individual disease progression stage, a classification is required which better correlates with the severity of electrophysiological changes to improve the currently unsatisfactory success rates of atrial fibrillation treatment.More
|Review article about modeling ischemia|
In the special issue "Advances in cardiac cellular electrophysiology – relevance for clinical translation" of the journal "Herzschrittmachertherapie und Elektrophysiologie", a review article about "Cardiac ischemia—insights from computational models" by authors from IBT and the University Heart Center Freiburg/Bad Krozingen will be published. In this article the basics of multiscale computational modeling of cardiac electrophysiology from the molecular ion channel to the whole body scale are described. By modeling cardiac ischemia, it is illustrated how in silico experiments can contribute to our understanding of how the pathophysiolo- gical mechanisms translate into changes observed in diagnostic tools such as the electrocardiogram (ECG).More
|Commentary in Frontiers in Physiology|
IBT researchers have published a commentary on an article recently published in the journal "Frontiers in Physiology". Axel Loewe and Olaf Dössel highlight the achievement of Shim et al., who used computational models to guide cateheter ablation for atrial fibrillation. On the other hand, the commentary points out potential for further optimization of computer-guided personalized therapy. Exploitation of computational models for a better treatment of atrial fibrillation is one of the research focusses at IBT.More
|New research assistant at IBT|
We would like to welcome Ms. Ekaterina Kovacheva as a research assistant at the Institute of Biomedical Engineering as of November 1st, 2017. As a member of the Computatonal Cardiac Modelling group, Ekaterina Kovacheva is working on the further development and merging of available cardiac models. So far the models for the electrophysiological excitation propagation, elastomechanical contraction, fluid dynamics and the circulatory system are developed separataly. The aim of this project is to implement the mutual interaction - as it is in the real-life heart.More
|Novel method for determination of cardiac conduction velocity|
Researcher from IBT together with electrophysiologists at Klinikum Karlsruhe have published an paper introducing a novel method to determine the conduction velocity within the heart. The approach is based on triangulation and provides a means to compute the conduction velocity of cardiac depolarization waves based in intracardiac catheter measurements. Both computer simulations and clinical measurements werd used to validate the novel method.More
|IBT present at TRM Forum|
Axel Loewe from IBT was invited to present at the 9th "TRM Forum on the Computer Simulation of Cardiac Function“. The meeting brings together leading experts on computational modeling, experimental assessment, and clinical research in the field of cardiac arrhythmias. We contributed to this year’s theme „From Model to Clinical Outcome“ by presenting work using computational models to validate diagnostic and therapeutic concepts, in particular novel mapping catheters with integrated mini electrodes and ECG features to estimate anatomical properties of the left atrium.More
|IBT on TV|
Together with our collaborators Prof. Schmitt and Dr. Luik from Städtisches Klinikum Karlsruhe, Prof. Dössel discusses cardiac arrhythmias in the show "Klinik Talk". The show is broadcasted on the channel BadenTV and is available online (in German).More
|New research assistant at IBT|
We would like to welcome Ms. Laura Anna Unger as a research assistant at the Institute of Biomedical Engineering as of October 1st, 2017. As a member of the biosignals group, Laura Unger is working on the analysis of intraatrial signals in close cooperation with electrophysiologists in clinical practice. The projects focus on novel methods in the diagnosis and therapy of atrial tachycardia such as atrial fibrillation and atrial flutter.
Laura Unger completed her Bachelor’s and Master’s degree in Electrical Engineering and Information Technology at KIT. She has already built up a background in modeling and processing of intraatrial signals during her final theses and her work as a student research assistant at IBT.More
|Atrial Signals 2017 in Valencia|
Three members of IBT, Olaf Dössel, Tobias Oesterlein, and Laura Unger, attended this year’s workshop Atrial Signals in Valencia from October 5th through 7th. We were happy to witness the successful continuation of the workshop after IBT and the Städtisches Klinikum had created and hosted the first Atrial Signals conference in Karlsruhe in 2015. The philosophy of bringing together engineers and physicians once again triggered fruitful panel discussions after each series of talks. As co-founders of the event, both Olaf Dössel and Tobias Oesterlein had the honor of being invited speakers amongst other well-known personalities.
|Successful participation in Computing in Cardiology (CinC) conference|
Members of IBT presented 8 scientific contributions at the CinC conference in Rennes, France. Two contributions were awarded prizes: The work "ECG as a tool to estimate potassium and calcium concentrations in the extracellular space“ entered the semi-final of the Young Investigators Award. The work "An Interactive Virtual Reality Environment for the Analysis of Clinical Atrial Arrhythmias and Ablation Planning" was honoured with a poster award. Furthermore, members of IBT were involved in the organisation of the conference being session chairs and organisators of the hackathon for inverse problem at this conference.
|Klee-Award 2017 of DGBMT goes to Dr.-Ing. Danila Potyagaylo|
Danila Potyagaylo introduces new algorithms for the localization of ventricular extrasystoles in his dissertation "Non-invasive Electrocardiographical Imaging of Ventricular Activities", which he has developed at the Institute for Biomedical Technology at the Karlsruhe Institute of Technology (KIT).More
|We welcome Mr. Tobias Gerach|
We welcome Mr. Tobias Gerach as a new member at the Institute of Biomedical Engineering. Inside the framework of the Collaborative Research Centre 1173: Wave phenomena, Mr. Gerach is working with the cardiac modeling group at IBT on the dynamics of electro-cardiac depolarization waves.
Mr. Gerach received his bachelor and master degrees in geophysics from the Karlsruher Institute of Technology. His research topics at the Geophysical Institute were focused on the simulation of seismic wave fields and the full waveform inversion of seismic waves in maritime environments.
|IBT strongly represented at the joint annual conference of the Society of Biomedical Engineering and of the Society of Medical Physics|
The annual conference of the Society of Biomedical Engineering (DGBMT) 2017 took place in Dresden together with the Society of Medical Physics (DGMP).
|Presentation of an in-vitro study at EMBC 2017 in Jeju Island|
Hyperthermia during radiofrequency ablation causes reversible and irreversible changes of the electrophysiological properties of cardiac tissue. In a recent published study, we investigated changes of conduction velocity in rat myocardium under hyperthermic conditions from macroscopic to microscopic scale by using simultaneous optical mapping and a miniaturized electrode array. The findings of this study may be used to develop further computational models of acute ablation lesions.More
|KIT Doctoral Award|
|Review article "Computerized modeling of the human heart“ published|
The next issue of the journal "Zeitschrift für Medizinische Physik“ features a review article on „Computerized modeling of the human heart“ by Olaf Dössel and Axel Loewe from IBT. The „Forum“ paper summarizes the state-of-the-art regarding modeling of cardiac electrophysiology, elasto-mechanics, fluid dynamics, and the circulatory system. Both the potential and challenges of this complementary research approach are discussed.More
|A computational study about the additional benefit of an ablation catheter with integrated mini electrodes|
Radiofrequency ablation has become a first-line approach for curative therapy of many cardiac arrhythmias. In a recent published study, the additional diagnostic benefit of an ablation catheter with integrated mini electrodes was investigated. The computational study showed that catheters with mini electrodes bring about additional benefit to differentiate ablated tissue from nonablated tissue in parallel position with high spatial resolution.More
|Girls’ Day 2017 at the IBT|
27th of April 2017. The Girls’ Day took place and the IBT is pleased to introduce the world of Medical Technologie to the visiting girls. 19 girls signed in for our workshop on „Technology in the Hospital - visualizing heart and lung activities“. Content was the electric-impedancetomography, photoplethysmography and the electrocardiography. The short introduction into the methods and the fellowing experiments resulted in a phenomenal feedback. The active participation in our build-in questions and experiments made it a great and funny event. We’d like to thank the organizers, supporters, participants and we are looking forward to the next Girls’ Day 2018!
|IBT presents at ECAS in Rome|
Phase mapping may provide important information about cardiac excitation dynamics during atrial fibrillation. Both computation and realistic visualisation of this novel parameter were addressed in two presentations by Tobias Oesterlein on the ECAS conference in Rome. By combined assessment of electrogram data and its spatial position, the presented methods allow an improved visualisation of cardiac excitation. This was a valuable addition to talks by the groups of Sanjiv Narayan and Vadim Fedorov, who established the link between electrogram information, optical mapping and resulting depolarisation patterns.More
|Influence of filtering on the ST segment in the ECG|
The so-called ST segment in the ECG plays an important role with the diagnosis of myocardial infarction. In a recent published study, the influence of different filtering methods on the ST segment in the ECG was analyzed. Realistic, simulated ECGs with a region of infarction und known noise were used for evaluation. It became apparent, that methods can influence the ST segment in such a manner that the diagnostic information can be falsified.More
|Valuable Information Regarding the Interpretation of the Atrial ECG Published|
|Paper about the Mapping using Basket Catheters published|
Basket-type catheters allow to acquired simultaneous electrograms from many distributed atrial positions. Correct interpretation of the mapping data, however, is complicated by the deformation of the catheter. We quantitatively analyzed both in-silico and clinical data from panoramic basket catheter mapping in our open-access publication „Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage“. Results emphasize that knowledge about the electrode positions during mapping is required for correct interpretation of panoramic mapping data.More ...
|IBT strongly represented at the annual meeting of the German Society for Biomedical Engineering|
|Prof. Dössel gives keynote lecture at IHU-LIRYC|
|IBT contributions win prizes in Vancouver|
|IBT presents at Cardiac Physiome Workshop in Seoul, Korea|
|IBT awarded teaching prize|