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Computermodelle des Herzens

Die Arbeitsgruppe Herzmodellierung hat sich zum Ziel gesetzt die Herzfunktion mathematisch zu formulieren und realitätsgetreu in Computermodellen abzubilden. Im Fokus unserer Forschung stehen die Elektrophysiologie sowie die Mechanik des Herzens, die wir mit Multiskalenmodellen repräsentieren. Diese umfassen mehrere biologische Integrationsebenen vom Ionenkanal über Zellen hin zu Geweben und Organen wobei sich die relevanten Phänomene auf unterschiedlichsten zeitlichen und räumlichen Skalen (Mikrosekunden bis Minuten; Mikrometer bis Zentimeter) abspielen. 

Die Arbeitsgruppe Herzmodellierung hat sich sowohl der Methodenentwicklung als auch der Anwendung von Computersimulationen zur Beantwortung klinisch relevanter Fragen verschrieben. Hierbei verfolgen wir zwei Wege: Zum einen untersuchen wir grundlegende physiologische und pathologische Mechanismen im Computermodell komplementär zu klassischen Ansätzen wie Zell- und Tierexperimenten. Die dabei identifizierten Mechanismen und Zusammenhänge im Bereich Krankheitsentstehung, Diagnose und Therapie können Ärzte dann auf die Situation des individuellen Patienten übertragen. Zum anderen verwenden wir personalisierte Modelle, die den individuellen Patienten repräsentieren, um die klinische Entscheidungsfindung zu unterstützen. Zur Personalisierung der Modelle basierend auf Messdaten des individuellen Patienten arbeiten wir eng mit der Arbeitsgruppe Bioelektrische Signale zusammen.

Die Forschung in unserer KIT Nachwuchsgruppe findet im Grenzbereich der Ingenieurswissenschaften, Informatik, Naturwissenschaften und der Medizin statt. Zur Methodenentwicklung und Durchführung von Simulationsstudien bedienen wir uns Methoden des Software Engineerings, der Algorithmik und Numerik, der Signalverarbeitung, Datenanalyse und Statistik.

 

 

 

Veröffentlichungen

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Ausgewählte Veröffentlichungen

Journal Articles (26)

S. Pollnow, G. Schwaderlapp, A. Loewe, and O. Dössel.
Monitoring the dynamics of acute radiofrequency ablation lesion formation in thin-walled atria - a simultaneous optical and electrical mapping study.
In Biomedizinische Technik. Biomedical Engineering, 2019
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Y. Lutz, R. Daschner, L. Krames, A. Loewe, G. Cattaneo, S. Meckel, and O. Dössel.
Modeling selective therapeutic hypothermia in case of acute ischemic stroke using a 1D hemodynamics model and a simplified brain geometry.
In Mathematical Biosciences and Engineering, vol. 17(2) , pp. 1147-1167, 2019
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Y. Lutz, A. Loewe, S. Meckel, O. Dössel, and G. Cattaneo.
Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model..
In Journal of Thermal Biology, vol. 84, pp. 316-322, 2019
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A. Loewe, Y. Lutz, D. Nairn, A. Fabbri, N. Nagy, N. Toth, X. Ye, D. H. Fuertinger, S. Genovesi, P. Kotanko, J. G. Raimann, and S. Severi.
Hypocalcemia-Induced Slowing of Human Sinus Node Pacemaking.
In Biophysical journal, 2019
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A. Loewe, Y. Lutz, N. Nagy, A. Fabbri, C. Schweda, A. Varró, and S. Severi.
Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium.
In bioRxiv - the preprint server for biology, 2019
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A. Loewe, E. Poremba, T. Oesterlein, A. Luik, C. Schmitt, G. Seemann, and O. Dössel.
Patient-Specific Identification of Atrial Flutter Vulnerability–A Computational Approach to Reveal Latent Reentry Pathways.
In Frontiers in Physiology, vol. 9(Article 1910) , 2019
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S. Hallensleben, and A. Loewe.
Wie wirken Arzt und digitale Technik im Jahr 2035 zusammen?.
In VDE DGBMT, 2019
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Y. Wang, Z. Xiong, A. Nalar, B. J. Hansen, S. Kharche, G. Seemann, A. Loewe, V. V. Fedorov, and J. Zhao.
A robust computational framework for estimating 3D Bi-Atrial chamber wall thickness.
In Computers in Biology and Medicine, vol. 114, pp. 103444, 2019
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R. Andlauer, G. Seemann, L. Baron, O. Dössel, P. Kohl, P. Platonov, and A. Loewe.
Influence of left atrial size on P-wave morphology: differential effects of dilation and hypertrophy.
In Europace, vol. 20(S3) , pp. iii36-iii44, 2018
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S. Pollnow, N. Pilia, G. Schwaderlapp, A. Loewe, O. Dössel, and G. Lenis.
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, vol. 102, pp. 267-277, 2018
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A. Loewe, E. M. Wülfers, and G. Seemann.
Cardiac ischemia-insights from computational models..
In Herzschrittmachertherapie & Elektrophysiologie, vol. 29(1) , pp. 48-56, 2018
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T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, vol. 65(10) , pp. 2334-2344, 2018
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M. Alessandrini, M. Valinoti, L. Unger, T. Oesterlein, O. Dössel, C. Corsi, A. Loewe, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation in Atrial Fibrillation.
In Frontiers in Physiology, vol. 9, pp. 1251, 2018
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H. Lehrmann, A. S. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel Electrocardiographic Criteria for Real-Time Assessment of Anterior Mitral Line Block.
In JACC: Clinical Electrophysiology, vol. 4(7) , pp. 920-932, 2018
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B. Verma, T. Oesterlein, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional conduction velocity calculation from clinical multichannel electrograms in human atria.
In Computers in Biology and Medicine, vol. 92, pp. 188-196, 2018
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O. Dössel, and A. Loewe.
Computerized modeling of the human heart.
In Zeitschrift für Medizinische Physik, vol. 27(3) , pp. 167-169, 2017
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G. Lenis, N. Pilia, A. Loewe, W. H. W. Schulze, and O. Dössel.
Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017
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A. Loewe, and O. Dössel.
Commentary: Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study.
In Frontiers in Physiology, vol. 8, pp. 1113, 2017
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S. Pollnow, J. Greiner, T. Oesterlein, E. M. Wülfers, A. Loewe, and O. Dössel.
Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information? Insights from a Computational Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017
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O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
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A. Loewe, M. W. Krueger, F. Holmqvist, O. Dossel, G. Seemann, and P. G. Platonov.
Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
In Europace, vol. 18(suppl 4) , pp. iv35-iv43, 2016
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A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, D. Thomas, E. P. Scholz, O. Dössel, and G. Seemann.
Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016
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T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology..
In Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 16(S4) , pp. iv30-iv38, 2014
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A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, A. Luik, O. Dössel, and G. Seemann.
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
In BioMed Research International Article, vol. 2015, pp. 530352, 2014
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A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
In Europace, vol. 16(3) , pp. 435-443, 2014
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Books (1)

C. Wieners, O. Dössel, A. Loewe, B. Frohnapfel, and V. Heuveline.
Book of Abstracts - Workshop on Cardiac Modeling. - Towards an integrated numerical heart model, Coupling the relevant physics the right way.
April 15-17 2019, Bad Herrenalb, Germany. 2019.
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Conference Contributions (78)

A. Loewe, G. Seemann, E. M. Wülfers, Y.-L. Huang, J. Sanchez, F. Bach, R. Ulrich, and M. Selber.
SuLMaSS - Sustainable Lifecycle Management for Scientific Software.
In E-Science-Tage 2019: Data to Knowledge, 2019
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T. Fritz, E. Kovacheva, G. Seemann, O. Dössel, and A. Loewe.
The inverse problem of cardiac mechanics - estimation of cardiac active stress from endocardial motion tracking.
In Computational & Mathematical Biomedical Engineering Proceedings, vol. 1, pp. 91-95, 2019
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R. Daschner, L. Krames, Y. Lutz, A. Loewe, O. Dössel, and G. Cattaneo.
Generation of a Simplified Brain Geometry for the Calculation of Local Cerebral Temperature using a 1D Hemodynamic Model.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 529-532, 2019
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M. Hernández Mesa, N. Pilia, O. Dössel, and A. Loewe.
Influence of ECG Lead Reduction Techniques for Extracellular Potassium and Calcium Concentration Estimation.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 69-72, 2019
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L. Krames, R. Daschner, Y. Lutz, A. Loewe, O. Dössel, and G. Cattaneo.
Modeling of the Human Cerebral Collateral Circulation: Evaluation of the Impact on the Cerebral Perfusion in Case of Ischemic Stroke.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 533-536, 2019
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A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients.
In Biophysical Journal, vol. 116(3 suppl1) , pp. 231A, 2019
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D. Nairn, X. Ye, D. H. Fuertinger, P. Kotanko, A. Loewe, and J. Raimann.
FP616 Low Serum Calcium is Correlated with Lower Heart Rate in Elderly Dialysis Patients.
In Nephrology Dialysis Transplantation, vol. 34(S1) , 2019
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T. P. Almeida, L. A. Unger, D. C. Soriano, X. Li, O. Dössel, T. Yoneyama, and A. Loewe.
Recurrence Quantification Analysis for Investigating Atrial Fibrillation Dynamics in a Heterogeneous Simulation Setup*.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 2277-2280, 2019
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J. Elliott, O. Dössel, A. Loewe, L. Mainardi, V. Corino, and J. F. Rodriquez Matas.
An In-Silico Study of the Effects of Conductance Variation on the Regionally Based Action Potential Morphology.
In Computing in Cardiology (CinC), vol. 46, 2019
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T. Gerach, D. Weiß, O. Dössel, and A. Loewe.
Observation guided systematic reduction of a detailed human ventricular cell model.
In Computing in Cardiology (CinC), vol. 46, 2019
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E. Kovacheva, S. Schuler, T. Gerach, O. Dössel, and A. Loewe.
A Method for Pressure-Volume-Based Parameter Identification for a Passive Constitutive Model of Myocardium.
In RISM Congress: iHEART - Modelling the Cardiac Function, 2019
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A. Loewe, Y. Lutz, N. Nagy, A. Fabbri, C. Schweda, A. Varro, and S. Severi.
Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 1875-1878, 2019
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Y. Lutz, R. Daschner, L. Krames, A. Loewe, O. Dössel, and G. Cattaneo.
Estimating Local Therapeutic Hypothermia in Case of Ischemic Stroke Using a 1D Hemodynamics Model and an Energetic Temperature Model.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 3983-3986, 2019
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D. Nairn, H. Lehrmann, A. Jadidi, O. Dössel, and A. Loewe.
Comparison of Voltage Map Calculation Methods using Non-Fractionated EGM Signals in a Persistent AF Patient.
In Computing in Cardiology (CinC), vol. 46, 2019
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D. Nairn, X. Ye, D. H. Fuertinger, P. Kotanko, A. Loewe, and J. G. Raimann.
Hypocalcemia-Induced Bradycardia Is More Pronounced in Male Hemodialysis Patients.
In Kidney Week 2019, vol. 30(AS) , pp. 542-543, 2019
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N. Pilia, M. H. Mesa, O. Dössel, and A. Loewe.
ECG-based Estimation of Potassium and Calcium Concentrations: Proof of Concept with Simulated Data.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 2610-2613, 2019
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L. Unger, T. G. Oesterlein, A. Loewe, and O. Dössel.
Noise quantification and noise reduction for unipolar and bipolar electrograms.
In Computing in Cardiology (CinC), vol. 46, 2019
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S. Schuler, A. Loewe, and O. Dössel.
Forcing Transmembrane Voltages to Decrease Slowly: A Temporal Regularization for ECG Imaging.
In Computing in Cardiology, vol. 45, 2018
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O. Dössel, T. Oesterlein, L. Unger, A. Loewe, C. Schmitt, and A. Luik.
Spatio-temporal Analysis of Multichannel Atrial Electrograms Based on a Concept of Active Areas.
In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2018, pp. 490-493, 2018
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M. Hernández Mesa, N. Pilia, O. Dössel, S. Severi, and A. Loewe.
Effects of Serum Calcium Changes on the Cardiac Action Potential and the ECG in a Computational Model.
In Current Directions in Biomedical Engineering, vol. 4(1) , pp. 251-254, 2018
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E. Kovacheva, L. Baron, O. Dössel, and A. Loewe.
Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry.
In Computing in Cardiology Conference (CinC), vol. 45, 2018
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H. Lehrmann, A. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel ECG-criteria For Real-time Assessment Of Anterior Mitral Line Block - “V1-jump” And “V1-delay”.
In Heart Rhythm, vol. 15(5S) , pp. S229, 2018
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A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Severe sinus bradycardia due to electrolyte changes as a pathomechanism of sudden cardiac death in chronic kidney disease patients undergoing hemodialysis.
In Heart Rhythm, vol. 15(5S) , pp. S354-S355, 2018
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A. Daub, A. Loewe, and B. Frohnapfel.
Haemodynamics in an elasto-mechanic model of the human heart.
In Annual Scientific Conference of the International Association of Applied Mathematics and Mechanics, 2018
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A. Loewe, M. Hernandez Mesa, N. Pilia, S. Severi, and O. Dössel.
A Heterogeneous Formulation of the Himeno et al. Human Ventricular Myocyte Model for Simulation of Body Surface ECGs .
In Computing in Cardiology, vol. 45, 2018
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S. Severi, A. Fabbri, M. Paci, R. Wilders, Y. Lutz, and A. Loewe.
Computational Modeling of the Cardiac Pacemaking in Humans.
In INdAM Workshop on Mathematical and Numerical Modeling of the Cardiovascular System, 2018
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L. A. Unger, T. G. Oesterlein, P. Spector, A. Luik, C. Schmitt, A. Loewe, and O. Dössel.
Cycle Length Statistics During Atrial Fibrillation Reflect Refractory Properties of the Underlying Substrate.
In Annual Congress of the European Cardiac Arrhythmia Society, pp. 16-27 A15-61, 2018
L. Baron, A. Loewe, and O. Dössel.
From clinics to the virtual beating heart a general modeling workflow for patient-specific electromechanical heart simulations.
In BMTMedPhys 2017, vol. 62(S1) , pp. S70, 2017
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O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
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W. Kahlmann, E. Poremba, D. Potyagaylo, O. Dössel, and A. Loewe.
Modelling of patient-specific Purkinje activation based on measured ECGs.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 171-174, 2017
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A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
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Y. Lutz, . Fabbri A., S. Severi, O. Dössel, and A. Loewe.
Plasma electrolyte concentrations in patients with chronic kidney disease influence cardiac pacemaking in a computational model.
In BMTMedPhys 2017, vol. 62(s1 - V71) , pp. 67, 2017
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T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
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S. Schuler, L. Baron, A. Loewe, and O. Dössel.
Developing and coupling a lumped element model of the closed loop human vascular system to a model of cardiac mechanics.
In BMTMedPhys 2017, vol. 62(S1) , pp. S69, 2017
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L. Unger, T. Oesterlein, G. Seemann, O. Dössel, P. Spector, and A. Loewe.
Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 317-320, 2017
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M. Alessandrini, M. Valinoti, A. Loewe, T. Oesterlein, O. Dössel, C. Corsi, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation.
In Computing in Cardiology, vol. 44, 2017
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O. Dössel, and A. Loewe.
V 10 Computer Modelling pharmakologischer Effekte.
In Frühjahrstagung der Deutschen Gesellschaft für Kardiologie, 2017
A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Propagation of the primary pacemaker activity in the human heart: a computational approach.
In European Medical and Biological Engineering Conference (EMBEC), vol. 65, pp. 201, 2017
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A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Pace-and-Drive of the Human Sinoatrial Node – A Preliminary Computational Investigation.
In Computing in Cardiology, vol. 44, 2017
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A. Loewe, R. Andlauer, S. Pollnow, J. Greiner, T. G. Oesterlein, G. Seemann, and O. Dössel.
Validation upside down - In-silico models to sound the potential and limitations of diagnostic tools.
In TRM Forum, 2017
A. Loewe, Y. Lutz, A. Fabbri, S. Severi, G. Seemann, and D. Dössel.
Influence of Electrolyte Concentration Changes on Sinus Node Function - A new Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?.
In Gordon Research Conference on Cardiac Arrhythmia Mechanisms, 2017
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
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A. Loewe, E. Poremba, T. G. Oesterlein, N. Pilia, M. Pfeiffer, O. Dössel, and S. Speidel.
An interactive virtual reality environment for analysis of clinical atrial arrhythmias and ablation planning.
In Computing in Cardiology, vol. 44, 2017
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N. Nagy, A. Loewe, Z. Kohaida, K. Halász, N. Tóth, J. Levijoki, P. Pollesello, T. Koskelainen, L. Otsomaa, A. Tóth, J. Gy, and A. Varró.
Selective Inhibition of the Cardiac Na+/Ca2+ Exchanger by a Novel Compound ORM-10962 Modulates Spontaneous Automaticity.
In European Working Group on Cardiac Cellular Electrophysiology, 2017
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N. Pilia, O. Dössel, G. Lenis, and A. Loewe.
ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space.
In Computing in Cardiology, vol. 44, 2017
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G. Seemann, A. Loewe, and E. M. Wülfers.
Effects of Fibroblasts Coupling on the Electrophysiology of Cardiomyocytes from Different Regions of the Human Atrium: A Simulation Study.
In Computing in Cardiology, vol. 44, 2017
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G. Seemann, A. Loewe, and E. M. Wülfers.
Computational Study on Regional Differences in Pro-Arrhythmic Effects of Fibroblasts Coupling to Human Atrial Myocytes.
In TRM Forum, 2017
M. Valinoti, F. Bertoni, M. Alessandrini, R. Mantovan, A. Loewe, O. Dössel, S. Severi, and C. Corsi.
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation.
In Computing in Cardiology Conference, vol. 44, 2017
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E. M. Wülfers, A. Loewe, and G. Seemann.
A Computational Study on the Electrophysiological Effects of Fibroblasts Coupling to Human Atrial Myocytes from Different Regions.
In Cardiac Physiome Project, 2017
R. Andlauer, A. Loewe, O. Dössel, and G. Seemann.
Effect of left atrial hypertrophy on P-wave morphology in a computational model.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 603-606, 2016
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A. Loewe, R. Andlauer, P. G. Platonov, O. Dössel, and G. Seemann.
Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration.
In Computing in Cardiology, vol. 43, pp. 1-4, 2016
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A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size.
In Biomedizinische Technik, vol. 61, pp. S223, 2016
  
  
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by site of earliest right atrial activation.
In Cardiac Physiome Project, 2016
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by the site of earliest right atrial activation independent from atrial size in silico.
In International Conference on Electrocardiology, 2016
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B. Verma, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries.
In Computing in Cardiology, vol. 43, pp. 985-988, 2016
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D. Potyagaylo, A. Loewe, P. van Dam, and O. Dössel.
ECG imaging of focal atrial excitation: Evaluation in a realistic simulation setup.
In Computing in Cardiology, vol. 43, pp. 113-116, 2016
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E. Shin, E. Poremba, O. Dössel, and A. Loewe.
Automated Initiation of Fibrillatory Excitation in Monodomain Simulations.
In Kentucky Academy of Science , 2016
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
P-wave morphology is affected by site of earliest right atrial activation: a simulation study.
In TRM Forum, 2015
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
Left and Right Atrial Contribution to the P-wave in Realistic Computational Models.
In Lecture Notes in Computer Science, vol. 9126, pp. 439–447, 2015
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Cardiac Physiome Workshop, 2015
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A. Loewe, Y. Xu, E. P. Scholz, O. Dössel, and G. Seemann.
Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 418–-422, 2015
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N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and . O. Dössel.
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
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M. Rottmann, L. Unger, W. Kaltenbacher, G. Seemann, A. Loewe, M. W. Krueger, A. S. Jadidi, T. Arentz, and O. Doessel.
Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
In 2015 Computing in Cardiology Conference (CinC), pp. 485-488, 2015
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J. Trächtler, . Oesterlein T., A. Loewe, E. Poremba, A. Luik, C. Schmitt, and O. Dössel.
Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 405-408, 2015
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A. Wachter, A. Loewe, M. W. Krueger, O. Dössel, and G. Seemann.
Mesh structure-independent modeling of patient-specific atrial fiber orientation.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 409-412, 2015
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seeman.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Atrial Signals, 2015
A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Emerging Mathematical Topics in Biology and Life Sciences, 2015
A. Loewe, Y. Lutz, M. Wilhelms, E. P. Scholz, O. Dössel, and G. Seemann.
Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Computing in Cardiology, vol. 41, pp. 745-748, 2014
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A. Loewe, M. Wilhelms, O. Dössel, and G. Seemann.
Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(S1) , pp. S929-S932, 2014
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Y. Lutz, A. Loewe, O. Dössel, and G. Seemann.
Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s933-s936, 2014
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A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents.
In Simula Cardiac Modeling Workshop, 2014
J. Liu, A. Loewe, M. Zenge, A. Lefebvre, E. Mueller, and M. S. Nadar.
Elora: Enforcing Low Rank for Parallel MR Reconstruction.
In International Society for Magnetic Resonance in Medicine, pp. 2652, 2013
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A. Loewe, E. Poremba, M. W. Krueger, O. Dössel, and G. Seemann.
Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning.
In TRM Forum, 2013
A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Impact of hERG Mutations on Simulated Human Atrial Action Potentials.
In Biomedizinische Technik/Biomedical Engineering, vol. 58(s1) , 2013
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A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data.
In Cardiac Physiome Workshop, 2013
W. H. W. Schulze, F. Elies Henar, D. Potyagaylo, A. Loewe, M. Stenroos, and O. Dössel.
Kalman Filter with Augmented Measurement Model: an ECG Imaging Simulation Study.
In FIMH, LNCS 7945, pp. 200-207, 2013
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G. Seemann, A. Loewe, Y. Lutz, M. Wilhelms, and O. Dössel.
Simulating the Effects of Drugs and Genetic Defects on Atrial Electrophysiology.
In TRM Forum, 2013
A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, and O. Dössel.
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study.
In Computing in Cardiology, vol. 38, pp. 741-744, 2011
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Patents (3)



Herzmodellierung
Titel Ansprechpartner


Modelle vom Körper
Titel Ansprechpartner


Herzmodellierung
Titel Ansprechpartner


Modelle vom Körper
Titel Ansprechpartner


Förderung

183027722, 391128822258734477 (SFB 1173)

Research Seed Capital Program

   

MY-ATRIA, MEDALCARE

ZF4363901AK6

   

05M2016

MTH16