Home | english  | Impressum | Datenschutz | Sitemap | KIT
Gustavo Lenis 2014

Dr.-Ing. Gustavo Lenis

Alumnus


Forschungsprojekte
Titel Ansprechpartner


Analysis of rhythmical and morphological properties of the ECG to detect cardiac abnormalities

Analysis of rhythmical and morphological properties of the ECG to detect cardiac abnormalities
Ansprechpartner:

Gustavo Lenis, Olaf Dössel 

Projektgruppe:

Medizinische Messtechnik, Digitale Signalverarbeitung 

Download als PDF

Ectopic beats are together with atrial fibrillation the most common cause of cardiac arrhythmias. These arrhythmias can occur on healthy subjects but normally are related to heart diseases.PRJ Lenis 2014-11-17 The 12 standard ECG leads are the usual way of diagnosing these cardiac abnormalities. In addition, there are other methods like the analysis of the RR and QT time series, the morphological variations of the ECG waves and the heart rate turbulence, that are highly relevant research topics.

The goal of this research project is the analysis of the surface ECG using innovative methods of signal processing, system theory, estimation theory, statistics machine learning in order to investigate the effects of external factors (diseases, medicine and physical stress) on the heart. These factors modify the normal rhythmical and morphological properties of the heart and can be used to diagnose a patient. Specially interesting for this research project are the ventricular ectopic beats. Such ectopic beats have their origin in the ventricles and can trigger tachycardia. They also generate short time fluctuations in the normal sinus rhythm of the heart (heart rate turbulence). This information can be used to estimate the risk of sudden cardiac death in a patient with a history of cardiac infarction. Modeling and simulation of those ectopic beats should help understand what physiological processes occur during such an event.

This project profits from its partners at other universities and hospitals that provide the medical studies for investigation. Furthermore, it is possible to run electrocardiographic studies with our cooperation partners.

Publications:

  • Ectopic beats and their influence on the morphology of subsequent waves in the electrocardiogram. In Biomedical Engineering / Biomedizinische Technik, 2013.
  • Removing ventricular far-field signals in intracardiac electrograms during stable atrial tachycardia using periodic component analysis. In Journal of Electrocardiology 2015

Abgeschlossene Bachelor- oder Masterarbeit
Titel Typ Bearbeiter Betreuer
Bachelorarbeit

Carl Gross

Bachelorarbeit

Gerald Schwaderlapp

Masterarbeit

Nicolas Pilia

Studentische Forschungsarbeit

Robert Menges

Masterarbeit

Christian Ritter

Studentisches Forschungsprojekt

Nicolas Pilia

Studentische Forschungsarbeit

Christian Ritter

Masterarbeit

Michael Kircher

Masterarbeit

Alexander Kramlich

Studentisches Forschungsprojekt

Robert Menges

Studentisches Forschungsprojekt

Yannick Lutz

Studentisches Forschungsprojekt

Nicolas Pilia

Masterarbeit

Dan-Timon Rudolph

Masterarbeit

Felix Conz

Masterarbeit

Patrick Reichensperger

Masterarbeit

Patrick Reichensperger

Studentisches Forschungsprojekt

Martin Pfeifer 

Bachelorarbeit

Ina Morath

Bachelorarbeit

Robert Menges

Bachelorarbeit

Nicolas Pilia

Bachelorarbeit

Eulàlia Mascareñas 

Diplomarbeit

Gustavo Lenis 

Studienarbeit

Gustavo Lenis



Veröffentlichungen


  Alle Veröffentlichungen, sortiert nach Jahren

          2017 2016 2015 2014 2013 2012 2011 2010 [Alle]


Ausgewählte Veröffentlichungen

Journal Articles (11)

G. Lenis, T. Heine, P. Reichensperger, T. Beran, O. Dössel, and B. Deml.
Electrocardiographic features for the measurement of drivers' mental workload.
In Applied Ergonomics, vol. 61(May) , pp. 31-43, 2017
  PDF    
  
  
G. Lenis, M. Kircher, J. Lazaro, R. Bailon, E. Gil, and O. Dössel.
Separating the effect of respiration on the heart rate variability using Granger's causality and linear filtering.
In Biomedical Signal Processing and Control, vol. 31, pp. 272-278, 2017
  PDF    
  
  
G. Lenis, N. Pilia, A. Loewe, W. H. W. Schulze, and O. Dössel.
Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017
  PDF    
  
  
G. Lenis, N. Pilia, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
P wave detection and delineation in the ECG based on the phase free stationary wavelet transform and using intracardiac atrial electrograms as reference.
In Biomedizinische Technik. Biomedical Engineering, vol. 61(1) , pp. 37-56, 2016
  PDF    
  
  
G. Lenis, T. Baas, and O. Dössel.
Ectopic beats and their influence on the morphology of subsequent waves in the electrocardiogram.
In Biomedical Engineering / Biomedizinische Technik, vol. 58(2) , pp. 109-119, 2013
  PDF    
S. Pollnow, N. Pilia, G. Schwaderlapp, A. Loewe, O. Dössel, and G. Lenis.
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, 2018
  PDF    
  
  
T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, 2018
  PDF    
  
  
O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
  PDF    
T. G. Oesterlein, G. Lenis, D.-T. Rudolph, A. Luik, B. Verma, C. Schmitt, and O. Dössel.
Removing ventricular far-field signals in intracardiac electrograms during stable atrial tachycardia using the periodic component analysis.
In Journal of Electrocardiology, vol. 48(2) , pp. 171-180, 2015
  PDF    
  
  
J. Ramirez, V. Monasterio, A. Minchole, M. Llamedo, G. Lenis, I. Cygankiewicz, A. Bayes de Luna, M. Malik, J. P. Martinez, P. Laguna, and E. Pueyo.
Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers.
In Journal of Electrocardiology, vol. 48(4) , pp. 551-557, 2015
  PDF    
  
  
M. Keller, S. Schuler, M. Wilhelms, G. Lenis, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Characterization of radiofrequency ablation lesion development based on simulated and measured intracardiac electrograms.
In IEEE Transactions on Biomedical Engineering, vol. 61(9) , pp. 2467-2478, 2014
  PDF    
  
  

Conference Contributions (35)

G. Lenis, A. Kramlich, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Development and Benchmarking of Activity Detection Algorithms for Intracardiac Electrograms Measured During Atrial Flutter.
In Workshop Biosignal 2016. Innovation bei der Erfassung und Analyse bioelektrischer und bimagnetischer Signale, pp. 5-8, 2016
  PDF  
G. Lenis, R. Menges, J. Ramirez, I. Cygankiewicz, A. Bayes de Luna, P. Laguna, and O. Dössel.
Post Extrasystolic T Wave Change to Stratify Risk of Pump Failure Death in Patients with Chronic Heart Failure.
In Computing in Cardiology, 2016
  PDF    
G. Lenis, P. Reichensperger, D. Sommer, C. Heinze, M. Golz, and O. Dössel.
Detection of microsleep events in a car driving simulation study using electrocardiographic features.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 283-287, 2016
  PDF    
G. Lenis, F. Conz, and O. Dössel.
Combining different ECG derived respiration tracking methods to create an optimal reconstruction of the breathing pattern.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 54-57, 2015
  PDF    
  
  
G. Lenis, T. Oesterlein, and O. Dössel.
Orthogonal component analysis to remove ventricular far field in non periodic sustained atrial flutter.
In Computing in Cardiology, vol. 42, pp. 669-672, 2015
  PDF    
G. Lenis, H. G. Jahnke, and O. Dössel.
An algorithm to analyze extracellular field potentials measured from cardiac myocytes.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin, 2014
  PDF    
G. Lenis, Y. Lutz, G. Seeman, A. García-Alberola, J. L. Rojo-Álvarez, O. Barquero-Peréz, E. Gil, and O. Dössel.
Post Extrasystolic T Wave Change in Subjects With Structural Healthy Ventricles Measurement and Simulation.
In Computing in Cardiology, vol. 41, pp. 1069-1072, 2014
  PDF    
G. Lenis, and O. Dössel.
T wave morphology during heart rate turbulence in patients with chronic heart failure.
In Biomedizinische Technik. Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
G. Lenis, T. Baas, and O. Dössel.
Rhythmical and morphological features of the ECG following a premature ventricular contraction.
In 46. Jahrestagung der DGBMT im VDE. Proceedings BMT 2012(s1) , 2012
  PDF    
G. Lenis, T. Baas, and O. Dössel.
Artefaktdetektion im Elektrokardiogramm, um eine robustere Extrasystolenerkennung und Klassifizierung zu ermöglichen.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin. Proceedings BBS 2012, 2012
  PDF    
G. Lenis, T. Baas, and O. Dössel.
Automatic detection and classification of ectopic beats in the ECG using a Support Vector Machine.
In 45. Jahrestagung der DGBMT im VDE. Proceedings BMT 2011, 2011
  PDF    
O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
  PDF    
  
  
C. Gross, S. Pollnow, O. Dössel, and G. Lenis.
Automatic feature extraction algorithms for the assessment of in-vitro electrical recordings of rat myocardium with ablation lesions.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 249-252, 2017
  PDF    
  
  
C. Heinze, C. Hütterer, T. Schnupp, G. Lenis, and M. Golz.
Drowsiness discrimination in an overnight driving simulation on the basis of RR and QT intervals.
2017
  PDF    
  
  
M. Kircher, R. Menges, G. Lenis, and O. Dössel.
Respiratory influence on HRV parameters analyzed during controlled respiration, spontaneous respiration and apnoe.
In Current Directions in Biomedical Engineering, vol. 3(2) , 2017
  
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
  PDF    
  
  
T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
  PDF    
  
  
N. Pilia, C. Ritter, D. Potyagaylo, W. H. W. Schulze, O. Dössel, and G. Lenis.
Determination of the excitation origin in the ventricles from the ECG using support vector regression.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 257-260, 2017
  PDF    
  
  
G. Schwaderlapp, T. Oesterlein, O. Dössel, A. Luik, C. Schmitt, and G. Lenis.
Definition, estimation and limitations of the dominant frequency in intracardiac electrograms.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 95-98, 2017
  PDF    
  
  
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
N. Pilia, O. Dössel, G. Lenis, and A. Loewe.
ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
A. A. Ahmad, J. Johnson, G. Lenis, C. Hunter, and F. B. Sachse.
Deconvolution of multispectral confocal microscopic images using measured point spread functions.
In BMES 2016 Annual Meeting, vol. Poster Session(Fri-400) , pp. 186, 2016
  PDF  
J. Greiner, T. Oesterlein, G. Lenis, and O. Dössel.
Virtual-Reality Based Visualization of Cardiac Arrhythmias on Mobile Devices.
In Computing in Cardiology, 2016
  PDF    
J. Greiner, S. Pollnow, S. Schuler, G. Lenis, G. Seemann, and O. Dössel.
Simulation of intracardiac electrograms around acute ablation lesions.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 607-610, 2016
  PDF    
T. Oesterlein, A. Kramlich, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Automatic detection and mapping of double potentials in intracardiac electrograms.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 179-183, 2016
  PDF    
C. Ritter, G. Lenis, W. H. W. Schulze, D. Potyagaylo, and O. Dössel.
Offset removal methods for the body surface potential map to improve the ECG imaging of ventricular ectopic beats.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin. Proceedings BBS 2016, pp. 1-4, 2016
  PDF    
M. Kircher, G. Lenis, and O. Dössel.
Separating the effect of respiration from the Heart Rate Variability for cases of constant harmonic breathing.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 46-49, 2015
  PDF    
  
  
T. Oesterlein, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Optimized Approach for the Detection of Active Segments in Intracardiac Electrograms Measured during Atrial Flutter.
In 42nd International Congress on Electrocardiology Conference Book of Abstracts, 2015
  PDF  
N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and . O. Dössel.
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
  PDF    
  
  
R. Menges, G. Lenis, and O. Dössel.
Choosing the best rhythmical and morphological features for a QRS complex classification algorithm.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 185, 2014
  PDF    
T. Oesterlein, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Periodic component analysis to eliminate ventricular far field artifacts in unipolar atrial electrograms of patients suffering from atrial flutter.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 14, 2014
  PDF  
T. Oesterlein, G. Lenis, A. Luik, B. Verma, C. Schmitt, and O. Dössel.
Removing ventricular far field artifacts in intracardiac electrograms during stable atrial flutter using the periodic component analysis proof of concept study.
In Proceedings 41th International Congress on Electrocardiology, pp. 49--52, 2014
  PDF    
M. Pfeifer, G. Lenis, and O. Dössel.
A general approach for dynamic modeling of physiological time series.
In Biomedizinische Technik. Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
N. Pilia, G. Lenis, and O. Dössel.
Developing a robust method to delineate the P wave using information from intracardiac electrograms.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin. Proceedings BBS 2014, pp. 2, 2013
  PDF    
E. M. Wülfers, N. S. Torres, G. Lenis, H. Li, G. Seemann, O. Dössel, J. H. B. Bridge, and F. B. Sachse.
An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts.
In Biomedizinische Technik / Biomedical Engineering, vol. 57(s1) , pp. 46, 2012
  PDF    
  
  


Preise

2018
Doktorandenpreis des KIT, Karlsruhe, 21.02.2018
Mit dem KIT-Doktorandenpreis würdigt das KIT herausragende Promovierte. Eine der drei Auszeichnungen für das akademische Jahr 2016/17 geht an Gustavo Lenis, dessen Dissertation „Signal Processing Methods for the Analysis of the Electrocardiogram“ prämiert wurde.

2017
Semi-Finalist Rosanna Degani Young Investigator Award, Konferenz „Computing in Cardiology“ 2017 in Rennes (Frankreich)
Nicolas Pilia, Olaf Doessel, Gustavo Lenis, Axel Loewe, ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space

2016
2. Preis im Studentenwettbewerb bei der DGBMT Jahrestagung (DACH) 2016 in Basel:
Joachim Greiner, Stefan Pollnow, Steffen Schuler, Gustavo Lenis, Gunnar Seemann, Olaf Dössel: "Simulation of Intracardiac Electrograms around Acute Ablation Lesions“

Preise bei der Konferenz „Computing in Cardiology“ 2016 in Vancouver (Kanada)
Bill and Gary Sanders Poster Award: Joachim Greiner, Tobias Oesterlein, Gustavo Lenis, Olaf Dössel: „Virtual Reality Visualization of Arrhythmias on a Smartphone“
Mortara Fellowship: Gustavo Lenis, Axel Loewe

2. Platz im Nachwuchswettbewerb im Rahmen des Workshop "Innovationen bei der Erfassung und Analyse bioelektrischer und biomagnetischer Signale - BBS 2016" durch Gustavo Lenis, Alexander Kramlich, Tobias Oesterlein and Olaf Dössel mit dem Beitrag: "Development and Benchmarking of Activity Detection Algorithms for Intracardiac Electrograms Measured During Atrial Flutter"

Fakultätslehrpreis 2016:
Lehrpreis der Fakultät für Elektro- und Informationstechnik für exzellente Lehre und die Kozeption Video-Übung zur Bachelor-Pflichtvorlesung “Lineare Elektrische Netze”. Der Preis wurde am 14.04.2016 im Rahmen der Jahresfeier des KIT überreicht.
http://www.kit.edu/foerdern/19689.php

2014
3. Vortragspreis im Nachwuchs-Wettbewerb im Ramen des Workshop "Innovative Verarbeitung bioelektrischer und biomagnetischer Signale - BBS 2014" durch Nicolas Pilia, Gustavo Lenis, Olaf Dössel mit dem Beitrag: "Developing a new method to delineate the P wave using information from intracardiac electrograms"

Beste Poster Präsentation, Jahreskonferenz Computing in Cardiology, Boston, Gustavo Lenis
Eingereichte Arbeit: “Post Extrasystolic T Wave Change in Subjects With Structural Healthy Ventricles – Measurement and Simulation"

CC-Studienpreis, Coburger Convent, in Anerkennung seiner wissenschaftlichen Leistungen und seines Einsatzes für den Coburger Convent, Gustavo Lenis

Young Investigator Award im Rahmen der 41. Tagung International Congress on Electrocardiology in Bratislava, 2014.
T. G. Oesterlein, G. Lenis; A. Luik, B. Verma, C. Schmitt, O. Dössel
Eingereichte Arbeit: "Removing Ventricular Far Field Artifacts in Intracardiac Electrograms during Stable Atrial Flutter using the Periodic Component Analysis – Proof of Concept Study"

3. Preis im Studentenwettbewerb, DGBMT Jahrestagung 2014, Hannover,
T. G. Oesterlein, G. Lenis; A. Luik, C. Schmitt, O. Dössel
Eingereichte Arbeit: "Periodic component analysis to eliminate ventricular far field artifacts in unipolar atrial electrograms of patients suffering from atrial flutter"