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Gustavo Lenis 2014

Dr.-Ing. Gustavo Lenis

Alumnus


Research Project
title contact


Analysis of rhythmical and morphological properties of the ECG to detect cardiac abnormalities

Analysis of rhythmical and morphological properties of the ECG to detect cardiac abnormalities
contact:

Gustavo Lenis, Olaf Dössel 

project group:

Medical measurement technology, digital signal processing

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Ectopic beats are together with atrial fibrillation the most common cause of cardiac arrhythmias. These arrhythmias can occur on healthy subjects but normally are related to heart diseases.PRJ Lenis 2014-11-17 The 12 standard ECG leads are the usual way of diagnosing these cardiac abnormalities. In addition, there are other methods like the analysis of the RR and QT time series, the morphological variations of the ECG waves and the heart rate turbulence, that are highly relevant research topics.

The goal of this research project is the analysis of the surface ECG using innovative methods of signal processing, system theory, estimation theory, statistics machine learning in order to investigate the effects of external factors (diseases, medicine and physical stress) on the heart. These factors modify the normal rhythmical and morphological properties of the heart and can be used to diagnose a patient. Specially interesting for this research project are the ventricular ectopic beats. Such ectopic beats have their origin in the ventricles and can trigger tachycardia. They also generate short time fluctuations in the normal sinus rhythm of the heart (heart rate turbulence). This information can be used to estimate the risk of sudden cardiac death in a patient with a history of cardiac infarction. Modeling and simulation of those ectopic beats should help understand what physiological processes occur during such an event.

This project profits from its partners at other universities and hospitals that provide the medical studies for investigation. Furthermore, it is possible to run electrocardiographic studies with our cooperation partners.

Publications:

  • Ectopic beats and their influence on the morphology of subsequent waves in the electrocardiogram. In Biomedical Engineering / Biomedizinische Technik, 2013.
  • Removing ventricular far-field signals in intracardiac electrograms during stable atrial tachycardia using periodic component analysis. In Journal of Electrocardiology 2015
Completed bachelor or master theses
title type person in charge tutor

Gerald Schwaderlapp

Bachelor thesis

Carl Gross

Bachelor thesis

Gerald Schwaderlapp

Master thesis

Nicolas Pilia

Student research project

Robert Menges

Master thesis

Christian Ritter

Student research project

Nicolas Pilia

Student research project

Christian Ritter

Master thesis

Michael Kircher

Master thesis

Alexander Kramlich

Student research project

Robert Menges

Student research project

Yannick Lutz

Student research project

Nicolas Pilia

Master tesis

Dan-Timon Rudolph

Master tesis

Felix Conz

Master thesis

Patrick Reichensperger

Master thesis

Patrick Reichensperger

Student Research Project

Martin Pfeifer 

Bachelor thesis

Ina Morath

Bachelor thesis

Robert Menges

Bachelor thesis

Nicolas Pilia

Bachelor thesis

Eulàlia Mascareñas 

Diplomarbeit

Gustavo Lenis 

Studienarbeit

Gustavo Lenis



Publications


  All Publications, sorted by years

          2017 2016 2015 2014 2013 2012 2011 2010 [All]


Selected Publications

Journal Articles (11)

G. Lenis, T. Heine, P. Reichensperger, T. Beran, O. Dössel, and B. Deml.
Electrocardiographic features for the measurement of drivers' mental workload.
In Applied Ergonomics, vol. 61(May) , pp. 31-43, 2017
  PDF    
  
  
G. Lenis, M. Kircher, J. Lazaro, R. Bailon, E. Gil, and O. Dössel.
Separating the effect of respiration on the heart rate variability using Granger's causality and linear filtering.
In Biomedical Signal Processing and Control, vol. 31, pp. 272-278, 2017
  PDF    
  
  
G. Lenis, N. Pilia, A. Loewe, W. H. W. Schulze, and O. Dössel.
Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017
  PDF    
  
  
G. Lenis, N. Pilia, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
P wave detection and delineation in the ECG based on the phase free stationary wavelet transform and using intracardiac atrial electrograms as reference.
In Biomedizinische Technik. Biomedical Engineering, vol. 61(1) , pp. 37-56, 2016
  PDF    
  
  
G. Lenis, T. Baas, and O. Dössel.
Ectopic beats and their influence on the morphology of subsequent waves in the electrocardiogram.
In Biomedical Engineering / Biomedizinische Technik, vol. 58(2) , pp. 109-119, 2013
  PDF    
S. Pollnow, N. Pilia, G. Schwaderlapp, A. Loewe, O. Dössel, and G. Lenis.
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, vol. 102, pp. 267-277, 2018
  PDF    
  
  
T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, vol. 65(10) , pp. 2334-2344, 2018
  PDF    
  
  
O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
  PDF    
T. G. Oesterlein, G. Lenis, D.-T. Rudolph, A. Luik, B. Verma, C. Schmitt, and O. Dössel.
Removing ventricular far-field signals in intracardiac electrograms during stable atrial tachycardia using the periodic component analysis.
In Journal of Electrocardiology, vol. 48(2) , pp. 171-180, 2015
  PDF    
  
  
J. Ramirez, V. Monasterio, A. Minchole, M. Llamedo, G. Lenis, I. Cygankiewicz, A. Bayes de Luna, M. Malik, J. P. Martinez, P. Laguna, and E. Pueyo.
Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers.
In Journal of Electrocardiology, vol. 48(4) , pp. 551-557, 2015
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M. Keller, S. Schuler, M. Wilhelms, G. Lenis, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Characterization of radiofrequency ablation lesion development based on simulated and measured intracardiac electrograms.
In IEEE Transactions on Biomedical Engineering, vol. 61(9) , pp. 2467-2478, 2014
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Conference Contributions (35)

G. Lenis, A. Kramlich, T. Oesterlein, A. Luik, C. Schmitt, and O. Dössel.
Development and Benchmarking of Activity Detection Algorithms for Intracardiac Electrograms Measured During Atrial Flutter.
In Workshop Biosignal 2016. Innovation bei der Erfassung und Analyse bioelektrischer und bimagnetischer Signale, pp. 5-8, 2016
  PDF  
G. Lenis, R. Menges, J. Ramirez, I. Cygankiewicz, A. Bayes de Luna, P. Laguna, and O. Dössel.
Post Extrasystolic T Wave Change to Stratify Risk of Pump Failure Death in Patients with Chronic Heart Failure.
In Computing in Cardiology, 2016
  PDF    
G. Lenis, P. Reichensperger, D. Sommer, C. Heinze, M. Golz, and O. Dössel.
Detection of microsleep events in a car driving simulation study using electrocardiographic features.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 283-287, 2016
  PDF    
G. Lenis, F. Conz, and O. Dössel.
Combining different ECG derived respiration tracking methods to create an optimal reconstruction of the breathing pattern.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 54-57, 2015
  PDF    
  
  
G. Lenis, T. Oesterlein, and O. Dössel.
Orthogonal component analysis to remove ventricular far field in non periodic sustained atrial flutter.
In Computing in Cardiology, vol. 42, pp. 669-672, 2015
  PDF    
G. Lenis, H. G. Jahnke, and O. Dössel.
An algorithm to analyze extracellular field potentials measured from cardiac myocytes.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin, 2014
  PDF    
G. Lenis, Y. Lutz, G. Seeman, A. García-Alberola, J. L. Rojo-Álvarez, O. Barquero-Peréz, E. Gil, and O. Dössel.
Post Extrasystolic T Wave Change in Subjects With Structural Healthy Ventricles Measurement and Simulation.
In Computing in Cardiology, vol. 41, pp. 1069-1072, 2014
  PDF    
G. Lenis, and O. Dössel.
T wave morphology during heart rate turbulence in patients with chronic heart failure.
In Biomedizinische Technik. Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
G. Lenis, T. Baas, and O. Dössel.
Rhythmical and morphological features of the ECG following a premature ventricular contraction.
In 46. Jahrestagung der DGBMT im VDE. Proceedings BMT 2012(s1) , 2012
  PDF    
G. Lenis, T. Baas, and O. Dössel.
Artefaktdetektion im Elektrokardiogramm, um eine robustere Extrasystolenerkennung und Klassifizierung zu ermöglichen.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin. Proceedings BBS 2012, 2012
  PDF    
G. Lenis, T. Baas, and O. Dössel.
Automatic detection and classification of ectopic beats in the ECG using a Support Vector Machine.
In 45. Jahrestagung der DGBMT im VDE. Proceedings BMT 2011, 2011
  PDF    
O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
  PDF    
  
  
C. Gross, S. Pollnow, O. Dössel, and G. Lenis.
Automatic feature extraction algorithms for the assessment of in-vitro electrical recordings of rat myocardium with ablation lesions.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 249-252, 2017
  PDF    
  
  
C. Heinze, C. Hütterer, T. Schnupp, G. Lenis, and M. Golz.
Drowsiness discrimination in an overnight driving simulation on the basis of RR and QT intervals.
2017
  PDF    
  
  
M. Kircher, R. Menges, G. Lenis, and O. Dössel.
Respiratory influence on HRV parameters analyzed during controlled respiration, spontaneous respiration and apnoe.
In Current Directions in Biomedical Engineering, vol. 3(2) , 2017
  
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
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T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
  PDF    
  
  
N. Pilia, C. Ritter, D. Potyagaylo, W. H. W. Schulze, O. Dössel, and G. Lenis.
Determination of the excitation origin in the ventricles from the ECG using support vector regression.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 257-260, 2017
  PDF    
  
  
G. Schwaderlapp, T. Oesterlein, O. Dössel, A. Luik, C. Schmitt, and G. Lenis.
Definition, estimation and limitations of the dominant frequency in intracardiac electrograms.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 95-98, 2017
  PDF    
  
  
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
N. Pilia, O. Dössel, G. Lenis, and A. Loewe.
ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
A. A. Ahmad, J. Johnson, G. Lenis, C. Hunter, and F. B. Sachse.
Deconvolution of multispectral confocal microscopic images using measured point spread functions.
In BMES 2016 Annual Meeting, vol. Poster Session(Fri-400) , pp. 186, 2016
  PDF  
J. Greiner, T. Oesterlein, G. Lenis, and O. Dössel.
Virtual-Reality Based Visualization of Cardiac Arrhythmias on Mobile Devices.
In Computing in Cardiology, 2016
  PDF    
J. Greiner, S. Pollnow, S. Schuler, G. Lenis, G. Seemann, and O. Dössel.
Simulation of intracardiac electrograms around acute ablation lesions.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 607-610, 2016
  PDF    
T. Oesterlein, A. Kramlich, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Automatic detection and mapping of double potentials in intracardiac electrograms.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 179-183, 2016
  PDF    
C. Ritter, G. Lenis, W. H. W. Schulze, D. Potyagaylo, and O. Dössel.
Offset removal methods for the body surface potential map to improve the ECG imaging of ventricular ectopic beats.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin. Proceedings BBS 2016, pp. 1-4, 2016
  PDF    
M. Kircher, G. Lenis, and O. Dössel.
Separating the effect of respiration from the Heart Rate Variability for cases of constant harmonic breathing.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 46-49, 2015
  PDF    
  
  
T. Oesterlein, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Optimized Approach for the Detection of Active Segments in Intracardiac Electrograms Measured during Atrial Flutter.
In 42nd International Congress on Electrocardiology Conference Book of Abstracts, 2015
  PDF  
N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and . O. Dössel.
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
  PDF    
  
  
R. Menges, G. Lenis, and O. Dössel.
Choosing the best rhythmical and morphological features for a QRS complex classification algorithm.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 185, 2014
  PDF    
T. Oesterlein, G. Lenis, A. Luik, C. Schmitt, and O. Dössel.
Periodic component analysis to eliminate ventricular far field artifacts in unipolar atrial electrograms of patients suffering from atrial flutter.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. 14, 2014
  PDF  
T. Oesterlein, G. Lenis, A. Luik, B. Verma, C. Schmitt, and O. Dössel.
Removing ventricular far field artifacts in intracardiac electrograms during stable atrial flutter using the periodic component analysis proof of concept study.
In Proceedings 41th International Congress on Electrocardiology, pp. 49--52, 2014
  PDF    
M. Pfeifer, G. Lenis, and O. Dössel.
A general approach for dynamic modeling of physiological time series.
In Biomedizinische Technik. Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
N. Pilia, G. Lenis, and O. Dössel.
Developing a robust method to delineate the P wave using information from intracardiac electrograms.
In Biosignalverarbeitung und Magnetische Methoden in der Medizin. Proceedings BBS 2014, pp. 2, 2013
  PDF    
E. M. Wülfers, N. S. Torres, G. Lenis, H. Li, G. Seemann, O. Dössel, J. H. B. Bridge, and F. B. Sachse.
An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts.
In Biomedizinische Technik / Biomedical Engineering, vol. 57(s1) , pp. 46, 2012
  PDF    
  
  


Awards

2018
KIT Doctoral Award, Karlsruhe, Feb/21/2018
KIT acknowledges outstanding doctoral researchers with the KIT Doctoral Award. One of the three prizes for the academic year 2016/17 was awarded to Gustavo Lenis for his PhD thesis  „Signal Processing Methods for the Analysis of the Electrocardiogram“.

2017
Semi-Finalist Rosanna Degani Young Investigator Award​, Conference „Computing in Cardiology“ 2017 in Rennes (France)
Nicolas Pilia, Olaf Doessel, Gustavo Lenis, Axel Loewe, ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space

2016
2nd place in student competition at the "DGBMT Anniversary (DACH) 2016 in Basel:
Joachim Greiner, Stefan Pollnow, Steffen Schuler, Gustavo Lenis, Gunnar Seemann, Olaf Dössel: "Simulation of Intracardiac Electrograms around Acute Ablation Lesions“

Awards at the Conference „Computing in Cardiology“ 2016 at Vancouver (Kanada)
Bill and Gary Sanders Poster Award: Joachim Greiner, Tobias Oesterlein, Gustavo Lenis, Olaf Dössel: „Virtual Reality Visualization of Arrhythmias on a Smartphone“
Mortara Fellowship: Gustavo Lenis, Axel Loewe

2nd place in the young investigator competition at the workshop "Innovative Verarbeitung bioelektrischer und biomagnetischer Signale - BBS 2016" by Gustavo Lenis, Alexander Kramlich, Tobias Oesterlein and Olaf Dössel with the submitted paper: "Development and Benchmarking of Activity Detection Algorithms for Intracardiac Electrograms Measured During Atrial Flutter”

Faculty teaching award 2016:
Faculty teaching award of the faculty of electrical engineering and information technologies for excelent teaching and the creation of the video excercises for the mandatory undergraduate class “Lineare Elektrische Netze”. The preis was given on the 14 of April 2016 during the annual ceremony of KIT.
http://www.kit.edu/foerdern/19689.php

2014
3rd place in the student presentation competition at the workshop "Innovative Verarbeitung bioelektrischer und biomagnetischer Signale - BBS 2014" by Nicolas Pilia, Gustavo Lenis, Olaf Dössel with the submitted paper: "Developing a new method to delineate the P wave using information from intracardiac electrograms"

Best Poster Presentation, Annual Conference of Computing in Cardiology, Boston, Gustavo Lenis
Submitted Paper: “Post Extrasystolic T Wave Change in Subjects With Structural Healthy Ventricles – Measurement and Simulation"

CC Studies Award, Coburger Convent, in recognition to his scientific achievements and for his contribution to the Coburger Convent, Gustavo Lenis

Young Investigator Award at the 41. International Congress on Electrocardiology at Bratislava, 2014.
T. G. Oesterlein, G. Lenis; A. Luik, B. Verma, C. Schmitt, O. Dössel
Submitted paper: "Removing Ventricular Far Field Artifacts in Intracardiac Electrograms during Stable Atrial Flutter using the Periodic Component Analysis – Proof of Concept Study"

3rd place in student competition, DGBMT annual conference 2014, Hannover,
T. G. Oesterlein, G. Lenis; A. Luik, C. Schmitt, O. Dössel
Submitted paper: "Periodic component analysis to eliminate ventricular far field artifacts in unipolar atrial electrograms of patients suffering from atrial flutter"