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News 2025
ImageAdvances and Challenges in Computational Modelling

Since the turn of the millennium, computational modelling of biological systems has evolved remarkably. The article highlights recent achievements and new challenges, particularly in the cardiovascular system. It emphasizes the importance of mechanistic and data-driven models and their synergies to foster future progress in medical research and artificial intelligence.

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ImageEHRA 2025 in Vienna

From March 30 to April 1, the annual meeting of the European Heart Rhythm Association (EHRA) took place, bringing together scientists, healthcare professionals, and key stakeholders from around the world involved in arrhythmia management. Axel Loewe and Silvia Becker represented the IBT at the event. Additionally, Silvia gave a presentation on why it matters how the P-wave is measured in the ECG.

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ImageAdvancing PVC Localization: A New Approach with ECGI and Digital Twins

Accurately identifying the origin of premature ventricular contractions (PVCs) is crucial for improving diagnosis and treatment. Read more about this innovative approach led by a collaborative research team, including contributions from CaMo IBT.

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Eine Präsentation über digitale Zwillinge und Herzmodellierung.E-Science Days in Heidelberg

From March 12 to 14, the E-Science Days took place in Heidelberg with the theme “Research Data Management: Challenges in a Changing World.” Axel Loewe and Silvia Becker represented the IBT in the workshop “Information Infrastructures in the Era of Artificial Intelligence: Opportunities and Challenges,” organized by the Leibniz ScienceCampus DiTraRe. Additionally, Silvia Becker, together with Lea Singson from FIZ Karlsruhe, gave a presentation on the legal aspects of digital twins and synthetic ECGs.

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c'tSupercomputers simulate patients' hearts with highly scalable algorithms

Numerical simulation makes it possible to model very different processes, from the weather to nuclear fusion to individual body organs. This requires highly scalable algorithms that can be put together from a mathematical library like a construction kit.
An article in the current issue of c't Magazine für Computertechnik reports on the research at KIT's Institute of Biomedical Engineering and collaborators.

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<Text wird generiert, bitte warten...>New Insights on Sinoatrial Node Pacemaking Mechanisms

A new paper investigating the interactions between reduced extracellular calcium levels and sympathetic stimulation as a compensatory mechanism, potentially contributing to sudden cardiac death in chronic kidney disease patients, has been published in the Journal of Physiology.

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Cardiac Arrhythmia Mechanisms GRCGRS/GRC 2025 in Barga

The Gordon Research Seminar and on Cardiac Arrhythmia Mechanisms was held in Barga from February 22 to 27. It covered a wide range of topics, from atrial and ventricular mechanisms to micro- and ultrastructures of individual cardiac muscle cells. Christian, Moritz, and Axel (on behalf of Tobias) presented their work.

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ImageCredibility Assessment of Machine Learning Predictors

Our recent publication "Consensus Statement on the Credibility Assessment of Machine Learning Predictors" in the journal Briefings in Bioinformatics aims to ensure the reliability and credibility of machine learning models used in clinical and biomedical contexts. Together with other leading experts, we outline a structured framework based on 12 foundational statements and propose rigorous guidelines for evaluating and enhancing the credibility of ML predictors, particularly when used in high-stakes healthcare decisions.

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ImageSuccessful Doctoral Defense: Dr.-Ing. Cristian Barrios Espinosa at KIT

Dr.-Ing. Cristian Barrios Espinosa successfully defended his doctoral thesis at KIT, advancing Eikonal-based models to improve the accuracy and efficiency of cardiac electrophysiology simulations.

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ImageNews of DREAM

A new paper introduces the latest version of the DREAM for simulating cardiac arrhythmias. Published in Engineering with Computers, it provides an efficient approach to reentry simulations in cardiac electrophysiology.
Read the full paper here.

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News 2024
ImageExploring Innovation in Surgical Technologies

Students from the Medical Image Processing for Guidance and Navigation course visited Getinge, a global leader in Hybrid Operating Room development. The visit offered valuable insights into advanced surgical technologies and their practical applications in modern healthcare.

ImageFirst Nacht der Biosignale

On November 15th, the very first Nacht der Biosignale took place. Simultaneous talks on the fascinating topic of biosignals were held at twelve locations across Germany, including Aachen, Augsburg, Bremen, Dresden, Göttingen, Ilmenau, Jena, Karlsruhe, Kiel, Cologne, Krefeld, and Münster.
Thanks to a live stream on YouTube, the talks were also accessible to an online audience. The event was met with great enthusiasm, with the Triangel venue filling up with curious citizens eager to dive into the captivating world of biosignals.

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LogoHelmholtz Software Award for openCARP

The openCARP cardiac electrophysiology simulator openCARP developed by IBT and collaborators won the Helmholtz Software Award in the Newcomer category. The award aims to promote the development of professional and high-quality research software and to recognize the commitment to software as the basis of modern science.
[more@Helmholtz]

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ImageHonorary Recognition for Axel Loewe

The head of the Computational Cardiac Modeling research group has been elected as a Fellow of the  European Heart Rhythm Association (FEHRA). This recognizes outstanding contributions to research into cardiac arrhythmias.

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ImageA new task for Olaf Dössel and an honor

Prof. Dr. Olaf Dössel was elected spokesperson for the health technologies thematic network at acatech. acatech is the German Academy of Engineering Sciences.
Olaf Dössel also received the KIT Verdienstnadel (KIT Medal of Merit). With this, KIT honors his diverse activities as an ambassador for KIT and as honorary chairman of the Studierendenwohnheim e.V. des KIT (KIT Student Residence Association).

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ImageWhat does it take to build a digital twin of your heart?

Together with researchers from Städtisches Klinikum Karlsruhe and Oxford University, Patricia Martínez and team showed that for atrial arrhythmia prediction, functional measurements make a difference. Incorporating functional personalization into personalize models could improve the ability to stratify patients based on their individual characteristics, leading to more tailored and effective treatment strategies for atrial fibrillation.

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ImageMaster Course “Medical Image Processing for guidance and navigation”

A new course for Master Students will be offered since WS 24/25 from IBT lectures. The course, titled “Medical Image Processing for guidance and navigation”, will be worth 9 ECTs for a total of 6 hours per week of lectures/practical exercises plus the accomplishment of a group project.
Link to Campus Management für Studierende

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ImageNew Research Associate at the IBT

Pascal Maierhofer is working on the validation and improvement of digital twins of the heart for the localization of atrial fibrillation triggers. His focus areas are the application of computer science to medical topics.

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ImageDGK Herztage 2024 in Hamburg

From September 26 to 28, the DGK Herztage took place in Hamburg – a platform for exchanging the latest insights, innovative solutions, and valuable experiences in the field of cardiology. Christian and Silvia represented the IBT with a poster and two presentations.

ImageIBT at BMT2024

From September 18 to September 20 the IBT took part at the BMT2024 (“58th Annual Conference of the German Society for Biomedical Engineering) in Stuttgart. Sara Schwab won the second place in the student’s competition.

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Cardiac Physiome 2024 in FreiburgCardiac Physiome 2024 in Freiburg

This years Cardiac Physiome Workshop 2024 took place from September 12 to 14, where around 140 researchers engaged on integrating experimental and mathematical approaches to advance cardiac physiology research. In addition to three posters from our group, the contribution of our PhD student Stephanie Appel was selected for a presentation. Our PhD student Jonathan Krauß won the poster award.

Computing in Cardiology Poster SessionComputing in Cardiology Conference

KIT hosted the 51st International Computing in Cardiology Conference in Karlsruhe from September 8-11, welcoming over 500 researchers from all over the world. The experts discussed the latest advances in cardiology research and technology in fields including modeling & simulation, ECG signal processing and artificial intelligence in over 220 presentations and 200 posters.

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ImageForty years service anniversary

The state of Baden-Württemberg would like to thank Irenen Günter for her forty years of service in the public service. The certificate of thanks was presented to her by Professor Werner Nahm in the presence of her colleagues. We wish her all the best for her future endeavors.

CinC LogoWorkshop: Artificial Intelligence for Processing of Biomedical Signals with MATLAB

On Sunday September 8, 8:30-11:30am, Mathworks offers a workshop on "Leveraging Artificial Intelligence for Enhanced Processing of Biomedical Signals with MATLAB" on KIT Campus South.

Interested participants can find more information and register here.

ImageNew Research Associate at the IBT

Julian Mierisch is working on model-informed machine learning for the prediction of postoperative atrial fibrillation and its targeted prevention. His focus areas were Data Science and Software Engineering.

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ImageEWGCCE 2024 in Graz

The 48th conference of the ESC Working Group on Cardiac Cellular Electrophysiology took place in Graz from July 1 to 3. The focus was on the influence of the autonomic nervous system on heart rate and arrhythmias, compartmentalisation within cardiac myocytes and the latest experimental findings on iPSC cardiac myocytes. Moritz took the opportunity to present his work on the influence of the autonomic nervous system in sinoatrial node cell models.

ImageSummer School Bordeaux - Cardiac electrophysiology

From June 17th to June 21st, Stephanie and Silvia attended the Summer School in Bordeaux to deepen their knowledge of cardiac electrophysiology. Engaging lectures and an interactive lab tour at Liryc made this week a remarkable experience.

ImageIBT at 8th CMBE

From June 24 to June 26, the 8th International Conference on Computational and Mathematical Biomedical Engineering (CMBE) took place at the George Mason University in Arlington, Virginia. Our PhD student Stephanie was there to present our work on exploring the potential role of stretch-activated channels in the pathogenesis of atrial fibrillation in a mini-symposium on innovative computational models and methods for the cardiac function.

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Imagei-STRATIFICATION study examines 800 virtual patients

In this study by Oxford University and KIT, various therapies were systematically investigated in 800 virtual patients with atrial fibrillation. The study aims to assign patients in whom pulmonary vein isolation was not successful as an initial therapy to optimal pharmacological and ablation therapies on the basis of in-silico tests. Treatment strategies vary depending on atrial size and the presence of low-voltage areas. In-silico models are a promising tool for individual therapy optimization in atrial fibrillation.

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ImageIBT at the International Congress on Electrocardiology

The 49th edition of the International Congress on Electrocardiology, jointly organized by ISE and ISHNE, was held in Lund, Sweden in June. Axel Loewe presented research at the intersection of mechanistic modeling and machine learning to the mixed clinical/technical audience. As this year marks the centennial of Einthoven's Nobel Prize for the electrocardiogram (ECG), the conference was a perfect occasion to celebrate this invention that remains of utmost relevance for clinical practice and is poised to be propelled to new heights with the advent of artificial intelligence.

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ImageFickle Heart Workshop 2024

From June 2 to June 4, the Fickle Heart Workshop took place at the Isaac Newton Institute of Mathematical Science in Cambridge, focusing on digital twins, artificial intelligence and uncertainty quantification tools for calibration and forecasting. Axel, Patricia and Stephanie took the opportunity of this workshop to present their work in this field.

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ImageIBT at the Atrial Signals conference in Maastricht

From June 6th to 8th, IBT attended the Atrial Signals Conference in Maastricht. In addition to 4 poster presentations by our PhD students, Axel Loewe presented his visions for the future of computational models of the heart in atrial fibrillation research.

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ImageIBT at ECCOMAS conference 2024

In this year’s European Community on Computational Methods in Applied Sciences (ECCOMAS) conference in Lisbon, our PhD student Joshua Steyer presented his results on electrograms in a cell-to-cell cardiac model within the "Computational Cardiology: Modeling and Simulating the Heart" mini-symposium.

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ImageCarmen Martínez Antón, PhD

Carmen Martínez Antón successfully defended her PhD thesis „Local Impedance Characterization for Scar and Fibrosis Detection – Towards a New Substrate Assessment for Atrial Mapping” on April 25th 2024. Our heartfelt congratulations!

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ImageIBT present at DGK and EHRA 2024 Conferences

During April the conference of the German society of cardiology (DGK) and the European Heart Rhythm Association (EHRA) took place bringing together cardiologists from Germany and around the world. On the 7th-9th The European Heart Rhythm Association (EHRA) conference took place in Berlin. Our PhD student Patricia Martínez was nominated for the Young Investigator Award in the Basic and Translational Science category and presented her work on the effects of right atrial arrhythmia susceptibility in patient-specific computer models.

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GAMM LogoIBT at the GAMM annual meeting 2024

From March 18 to March 22, 2024 the 94th annual meeting of the GAMM (Association of Applied Mathematics and Mechanics) took place in Magdeburg at the Otto von Guericke university. Our PhD student Jonathan Krauß presented a comparison of different pericardium modeling approaches.

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ImageIBT at Biosignals Workshop Göttingen

In this year’s Biosignals Workshop in Göttingen, we presented our work on electrograms in a cell-by-cell model. We have shown that healthy excitation propagation, as opposed to what we would expect in homogenised models, yields asymmetric electrograms exhibiting several small deflections. These deflections, in turn, can be explained by the multimodality of cell activation as well as the deceleration of the excitation wave when transitioning between two cardiac cells.

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ImageThe right atrium affects in silico arrhythmia vulnerability in both atria

What influence does the inclusion of the right atrium have on the assessment of arrhythmia susceptibility in patient-specific computer models? In this study, we investigated differences in arrhythmia susceptibility between monoatrial and biatrial models. Our results suggest that inclusion of the right atrium increases inducibility in the model and also shows a state-dependent influence on arrhythmia dynamics.

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ImageNew Master Course “Medical Image Processing for guidance and navigation”

A new course for Master Students will be offered since SS24 from IBT lectures. The course, titled “Medical Image Processing for guidance and navigation”, will be worth 6 ECTs for a total of 4 hours per week of lectures/practical exercises plus the accomplishment of a group project.
The language of the lecture is English.

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BildSoftware Carpentry Workshop at KIT

On March 19th and 20th 2024, the Institute of Biomedical Engineering is hosting an in person Software Carpentry workshop, primarily open to graduate students and research staff at KIT.

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ImageToward Good Simulation Practice

This open access book has brought together 138 experts in In Silico Trials working in academia, the medical industry, regulatory bodies, hospitals, and consulting firms. Through a consensus process, these experts produced the first attempt to define some Good Simulation Practices on how to develop, evaluate, and use In Silico Trials.  Good Simulation Practice constitutes an indispensable guide for anyone who is planning to engage at any title with In Silico Trials. IBT researcher Axel Loewe has co-edited the chapters Model Development and The Investigator: Modellers and Analysts.

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ImageKIT HealthTech at City Hall

On January 29, the KIT Center for Health Technologies presented itself to the Karlsruhe city society in the city hall. KIT Distinguished Senior Fellow Prof. Dössel gave a lecture on "Artificial Intelligence and Machine Learning in Medicine".

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ImageNumerical evaluation of (electro-)mechanic cardiac models

Together with our collaborators at the Institute for Applied and Numerical Mathematics, we investigated the impact of modeling choices such as mesh size, incompressibility constraint, active strain or active stress as well as the choice of the damping scheme. Click here to learn about our findings: https://onlinelibrary.wiley.com/doi/10.1002/gamm.202370010

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ImageNew Research Associate at the IBT

The Institute of Biomedical Engineering welcomes Silvia Becker as a new research associate. Since January 2024, she has been working on the analysis of ECG data using machine learning within the “Computational Cardiac Modeling” research group.
Silvia Becker completed a master’s degree in electrical and information technology at the KIT. Her research topics focused on machine learning and heart simulations.

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ImageDifferential effects of mechano-electric feedback mechanisms on whole-heart activation, repolarization, and tension

Which effects does the mechanical activation of the heart cause on the electrical control of cardiac rhythm and excitation? Using the fully coupled electro-mechanical computer model of the heart developed at IBT, we showed that mechano-electric feedback changes activation and repolarization patterns throughout the heart during sinus rhythm and leads to a markedly more heterogeneous electrophysiological substrate. Read the full study published open access in The Journal of Physiology.

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News 2023
ImageRICAM Workshop Mathematical Methods in Medicine

From November 28th until December 1st took place in Linz the Workshop in modeling and simulation of ablation therapies in medicine at the Johann Radon Institute for Computational and Applied Mathematics (RICAM) of the Austrian Academy of Sciences. During the week, our scientist Axel Loewe and Carmen Martinez had the opportunity to present their work and meet other successful researchers in the field.

ImageVisiting Professor at IBT

Prof. Elena De Momi, from Politecnico di Milano University (Italy), hasVisiting Professor at IBT
joined the IBT for 2 months, sponsored by the International Excellence Grants of KIT. Prof. De Momi is renown in the field of Medical Robotics, Computer Vision and Artificial Intelligence. She will work with the group of Prof. Francesca Spadea to develop an explainable artificial intelligence-based framework to predict the surgical outcome of patients affected from late-stage ovarian cancer.

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ImageKIT Podcast: Localization through AI

A research project at the Karlsruhe Institute of Technology relies on artificial intelligence to localize the origin of heart palpitations based solely on a standard ECGS.

 

To KIT Campus Report Podcast (German)

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ImageIBT at BMT2023

From September 26 to September 28 the IBT took part at the BMT2023 (“57th Annual Conference of the German Society for Biomedical Engineering) in Duisburg. Christian Götz won the first place in the student’s competition and Laura Unger was honored with the first prize in the Klee Award for her PhD thesis.

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ImageCinC 2023

With five members and three former members of our Cardiac Modeling Group, we participated in this year’s 50thedition of the Computing in Cardiology conference in Atlanta, USA which took place from October 1st to 4th. After the Sunday symposium of the conference, which put special attention on the impact of racism and sexism on health, we presented some of our most recent results. We are proud of Carmen Martínez who was awarded as a semi-finalist of the Young Investigator Award and our former visitor Albert Dasí who made it to the finalists. Congrats, Carmen and Albert! We are looking forward to hosting the 51st edition of the CinC next year in Karlsruhe.

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ImageMulti-modal substrate characterization to guide atrial-fibrillation treatment

Together with clinicians in Freiburg and industrial partners in Barcelona, we analyzed differences in atrial substrate localization using late gadolinium enhancement-magnetic resonance imaging (LGE-MRI), electrogram voltage, and conduction velocity. A newly proposed LGE-MRI analysis method increases coherence but discordances exist.

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LogoPresentation at the 10th International Conference on Computational Bioengineering

From September 20-22, 2023, the 10th edition of this international conference was held in Vienna, Austria. The IBT was represented with a presentation on Electro-mechanical modeling and simulation of the human heart in the mini-symposium Continuum biomechanics of active biological systems.

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ImageSimulated Cardiac Excitation Patterns and Their Electrograms

As a contribution to the FIMH conference, using simulations, we investigated abnormal excitation patterns in the atrium and their electrograms. In contrast to existing studies, we here considered the curvature, different wall thicknesses, as well as electric heterogeneity in a realistic right-atrial geometry.

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ImageLarge synthetic ECG dataset for machine learning

Together with researchers from the Medical University of Graz, PTB Berlin and King's College London, we have published a dataset of 16,900 synthetic ECGs. The ECGs have been generated by detailed computer simulations that allow each ECG signal to be traced back to unique model parameters with biological meaning.

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ImageMachine learning: Artificial neural networks localize heart palpitations

Extra heartbeats from the main chambers of the heart, so-called ventricular extrasystoles, can be related to serious diseases. Researchers at the Karlsruhe Institute of Technology (KIT) use machine learning to determine the origin of the extrasystoles non-invasively.

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BildIBT-Prototera agreement for PhD fellowships

The IBT and Prototera Association (Portugal) established an agreement for 4-year PhD fellowships funded by the Portuguese Government. Students who are interested in doctoral research projects in the field of Image Guidance in Proton Therapy can contact Prof. Francesca Spadea mf.spadea@kit.edu. The 4 year project will be conducted in joint collaboration with the University “Instituto Superior Técnico” of Lisbon.

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ImafgePipeline for creating digital twins of the heart

Our latest paper describes a methodology to generate anatomical and functional atrial digital twins personalized models from imaging data and/or electroanatomical maps.

The reproducible and automated framework processes geometries derived from clinical data.

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ImageAblation also possible during atrial fibrillation?

Together with physicians from the University Heart Center Freiburg Bad Krozingen, we compared whether substrate underlying atrial fibrillation can be localized not only in sinus rhythm but also during atrial fibrillation. The moderate agreement suggests to perform the investigation in sinus rhythm.

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ImageKIT Open Day

The IBT was represented in the tent of the new KIT Center Health Technologies at the Open Day and was happy to welcome many of the about 25,000 visitors about personalized and digital medicine, optical methods in medicine as well as the study course medical engineering.

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ImageIBT at the 2023 SIAM Conference on Dynamical Systems

At the SIAM Conference in Portland, Cristian Barrios Espinosa presented research on advancing machine learning methods in cardiology. Discover more about the diverse applications of dynamical systems in medicine.

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ImageCNN-based classification approach for craniosynostosis published

In cooperation with researchers from the Institute for Medical Informatics and Oral and Maxillofacial Surgery at Heidelberg University Hospital, IBT employees have developed a method to display the 3D geometry of the head as 2D images, which enables a CNN-based classification of head deformities.

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Logo5th international openCARP user meeting in Karlsruhe

From May 24-26, we could welcome around 60 international guests in Karlsruhe for the 5th openCARP user meeting. The fully booked workshop offered training and discussion formats for both new users and experts.

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ImageKlee Award 2023 presented to Dr.-Ing. Laura Anna Unger

The foundation Familie Klee and the German Society for Biomedical Engineering (DGBMT) within the Association for Electrical, Electronic & Information Technologies (VDE) annually give out an award for practically oriented research and development in medical technology. This year’s jury chose Dr.-Ing. Laura Anna Unger and her dissertation on multimodal characterization of the atrial substrate as the winner. Completed with honors at IBT in 2022, the particularly intense collaboration with cardiologists contributed significantly to the success of the project.

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ImageNew Research Associate at the IBT

The Institute of Biomedical Engineering welcomes Mr. Moritz Linder as a new research associate. Moritz Linder completed a master's degree in mechatronics and information technology at the KIT.

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Logo4 more years of research on wave phenomena

The German Research Foundation (DFG) funds the Collaborative Research Center "Wave Phenomena" for 4 more years after intensive review. We are happy to contribute with the use case propagation waves in the heart!

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ImageECG dataset for machine learning published

Classic machine learning methods require the pre-processing of ECG signals. Together with researchers from the University of Oldenburg, PTB Berlin, Aalborg University and Charité Berlin, among others, IBT researchers have recently published annotations of more than 20,000 ECGs. For this, also signal processing algorithms developed at the IBT were used.

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ImageAtrial fibrillation: Technology for diagnosis, monitoring and therapy

The recently published 2nd edition of the special issue of the journal Frontiers in Physiology highlights the latest developments for technology to diagnose, monitor and treat atrial fibrillation. The collection of 16 articles is co-edited by IBT researcher Axel Loewe.

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LogoPersonalizeAF Consortium Meeting at KIT

At the beginning of May, we had the pleasure to welcome about 30 researchers from all over Europe at KIT, who are working on the improvement of diagnosis and therapy of atrial fibrillation in the European PersonalizeAF project. After two days of "Career Opportunities Workshop" for the 15 PhD students, the focus of the last two days was on the exchange of latest research results.

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ImageTopological Analysis of 2D Cell Networks

Assessing the radiosensitivity of tumoral cells is of paramount importance for understanding the efficacy of radiotherapy treatments and design the proper dose delivery scheme. In this work we showed that the topology of 2D cancer-cell graphs is influenced by ionizing radiation and can be capture by microscopy mage analysis.

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ImageEHRA Conference 2023

The European Heart Rhythm Association (EHRA) conference took place in Barcelona on April 16-18, 2023 at its 20th anniversary. Our PhD student Patricia Martínez was nominated for a Young Investigator Award in Clinical and Translational Science.

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ImageDeep learning PCNSL

Following our previous Radiomics based study, we tailored a Deep Learning (3D ResNet) to predict the Overall Survival of patients with PCNSL. The aim was to overcome the limitation of feature selection and engineering by self-learning relevant image features. Gradient-weighted class activation mapping was applied to interpret the results.

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To the published article
ImageRadiomics and Machine Learning for prognosis in rare tumors

In collaboration with University Magna Graecia (Italy), Politecnico di Milano (Italy) and our Clinical Partner at San Raffaele Hospital of Milan (Italy), we proved that the prognostic value of radiomics features extracted from MR images of PCNSL patients overcomes the current prediction model based on clinical features. These results pave the way for further investigations on the potential role of image features to drive treatment choice.

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ImageWhat’s the role of pulse timing in cardiac defibrillation?

In collaboration with the Biomedical Physics group at the MPI for Dynamics and Self-Organization, we investigated time series of the success rates for cardiac defibrillation. Using a simplified 2D model for chaotic excitation dynamics, we got some interesting insights, especially for the success of low-energy pulses.

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ImageGordon Research Conference 2023: memories from the space city

Last week the Gordon Research Conference (GRC) on Cardiac Arrhythmia Mechanisms was held in Galveston (Texas, USA). Patricia Martínez and Albert Dasí won first prize in the student poster competition.

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Logo signals for lifePodcast on atrial fibrillation research in Karlsruhe

In the latest episode of the Signals for Life podcast of the German Society for Biomedical Engineering (DGBMT) in the VDE, Laura Unger from IBT and Armin Luik from the Karlsruhe Municipal Hospital present their joint research on atrial fibrillation. Another episode will follow soon!

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Logo The carpentries Software Carpentry Workshop at KIT

On March 29th and 30th 2023, the Institute of Biomedical Engineering is hosting a workshop which aims to teach foundational coding to researchers, open to registration for all KIT members.

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ImageRecommender system for ablation lines of atrial tachycardia

Together with researchers from the Università degli Studi di Milano and the Municipal Hospital Karlsruhe, we present a recommendation system for the ablation treatment of atrial flutter. Based on graph theoretic methods, the optimal configuration of the ablation scars to be applied is automatically determined with the help of optimization algorithms.

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Professor SpadeaNew Professor at IBT

On January 1, 2023, Prof. Maria Francesca Spadea took over the professorship for modeling and simulation in medical technology at the Institute of Biomedical Engineering.

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LOGO Atrial SignalsSpecial Issue Atrial Signals

With the title "Together we are strong! Collaboration between clinicians and engineers as an enabler for better diagnosis and therapy of atrial arrhythmias", a special issue of the journal "Medical & Biological Engineering & Computing" was published that contains works presented at the Atrial Signals conference in Karlsruhe. The editorial furthermore highlights the lifework of Olaf Dössel and Claus Schmitt.

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ImageWhat distinguishes different types of atrial fibrillation?

While good treatment options exist for paroxysmal atrial fibrillation, persistent atrial fibrillation still cannot be treated satisfactorily. Together with researchers from the University Heart Center Freiburg Bad Krozingen, anatomical and functional differences between these two types have now been identified, which may form the basis for future tailored therapeutic approaches.

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LogoCommentary in the Journal of Cardiovascular Electrophysiology

In an invited editorial, Axel Loewe (IBT) and Amir Jadidi (University Heart Center Freiburg Bad Krozingen) discuss the recent article by Boyle et al. in the Journal of Cardiovascular Electrophysiology on predicting the success of pulmonary vein isolation using magnetic resonance imaging.

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ImageFunctional characterization of genetic mutations

Together with researchers from Marburg, Munich, Frankfurt, the effect of a new group of genetic mutations on cardiac electrophysiology was investigated. The study was published open access in the special isse "Molecular Effects of Mutations in Human Genetic Diseases" of the "International Journal of Molecular Sciences".

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ImageComparison of numerical methods to simulate the heart

How do different numerical splitting schemes for solving the monodomain equation of cardiac electrophysiology compare in terms of convergence, accuracy and efficiency? We answer this question collaboratively with mathematicians (CRC 1173 - Wave phenomena) in a study published in the "International Journal of Numerical Methods in Biomedical Engineering".

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ImageUncertainty quantification for ECG simulations

Together with researchers from the PTB in Berlin, we systematically studied the influence of uncertainty in the input parameters of multiscale heart simulations on the resulting ECG. The work is published open access in the journal "Metrology".

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News 2022
ImageHow important is the reverse mode of the sodium-calcium exchanger?

Together with a team from the University of Szeged, IBT researchers have studied the reverse mode of the sodium-calcium exchanger for the function of the sinus node, the natural pacemaker of the heart. By combining biological experiments and computer simulations, evidence for a crucial role could be demonstrated.

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ImageBook "Innovative Treatment Strategies for Clinical Electrophysiology"

With contributions of IBT as coeditor and authors of two chapters on machine learning in cardiac electrophysiology and cardiac digital twin modeling, the book was published in the series Lecture Notes in Bioengineering of the Springer publishing house.

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LogoOxford Symposium on the Future of Therapy Discovery and Development

Together with the National Centre for the Replacement, Refinement and Reduction of Animals in Research, the University of Oxford held a symposium on Dec 5 and 6. IBT and its clinical collaborators from Freiburg University presented their work and views on the synergy between computational modeling and machine learning and its clinical translation.

ImageClaudia Nagel, PhD

Claudia Nagel successfully defended her PhD thesis „Multiscale Cohort Modeling of Atrial Electrophysiology - Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms“ on November 17th, 2022. Our heartfelt congratulations!

PhD thesis
ImageWhat makes our heart beat?

IBT researchers present the first functional 3D computer model of the human sinus node in the renowned Biophysical Journal. 
The structure of this natural pacemaker is crucial for successfully exciting the surrounding heart tissue.

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ImageIBT at BMT2022

From September 28 to September 30 the IBT took part at BMT2022 ("Joint Annual Conference of the Austrian, German and Swiss Societies for Biomedical Engineering") in Innsbruck. 3 students and 4 PhDs were responsible for 5 presentations and 2 posters in total. Jule Bender won second place in the student's competition for her paper "A Large-Scale Virtual Patient Cohort to Study ECG Features of Interatrial Conduction Block". Congratulations!
Additionally, two former PhDs were awarded retrospectively for their PhD theses. Congratulations to Giorgio Luongo for getting third place in the Klee Award as well as to Ady Naber for winning the first place award for patient security.

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Image„Modeling the Cardiac Function“ Conferece

The „Modeling the Cardiac Function“ conference hosted by the iHeart project took place in Cetraro from 30.9 to 2.10. An IBT member was there and presented our studies on the influence of boundary conditions on fluid dynamics simulations.

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ImageCinC 2022

The 49th edition of Computing in Cardiology (CinC) took place in Tampere, Finland from 04-07 Sep, 2022. 5 current PhD students from the IBT as well as Albert Dasí who is visiting our lab presented their recent work. Carmen Martínez was recognized as a semi-finalist for the Young Investigators Award and former postdoc Jorge Sánchez took home the Poster Award for the work he did while still at the IBT. Congratulations, Carmen and Jorge!

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BildComparison of propagation models and forward calculation methods in atrial electrophysiology

IBT members and collaborators from the Medical University of Graz investigated if and to what extent simplified methods and models can yield physiologically accurate results in electrophysiological atrial simulations regarding activation times and electrocardiograms (ECG) while reducing computational cost markedly at the same time. These analyses form the basis for extensive ECG-based simulation studies to e.g., generate large-scale datasets for machine learning approaches.

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BildWhich strategy for ablating atrial fibrillation works best?

IBT researchers, together with the University Hospital of Freiburg, have systematically compared different therapeutic approaches in a cohort of 29 digital twins of atrial fibrillation patients. They were able to show that precise identification of tissue changes is crucial. Personalized computer models can help to achieve the optimal therapeutic success with the smallest possible intervention.

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BildEMBC 22

44th International Engineering in Medicine and Biology Conference (EMBC) was held in Glasgow, Scotland,  from 11-15 July 2022.
Four representatives from the Institute of Biomedical Engineering (IBT) participated in EMBC 22, with 3 full paper and one absract presentations.

BildComputational and Mathematical Biomedical Engineering Conference

This year’s Computational and Mathematical Biomedical Engineering Conference (CMBE22) was hosted by the Politecnico di Milano (Italy) from June 27th to 29th. Jochen Brenneisen presented the latest studies on the Immersed Boundary Method to simulate fluid dynamics in the heart.

It was a great conference with highly interesting presentations and fruitful discussions. Conference proceedings will follow soon on https://www.compbiomed.net/2021/

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BildIBT research featured in "AI in Healthcare Highlights & Milestones" report 3/22

The machine learning method to predict atrial fibrillation therapy success noninvasively from the ECG is one of the first approaches trained exclusively on data from computational models and benchmarked on real world clinical data.
[report] [paper]

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BildKlee Prize for Giorgio Luongo

The German Society for Biomedical Engineering (DGBMT) annually awards the Klee Prize to scientists for practical developments in the field of medical technology. Giorgio Luongo was awarded 3rd place for his dissertation "Non-Invasive Atrial Arrhythmia Diagnosis Using the 12-Lead ECG: Machine Learning Leveraging in-silico and Clinical Signals" at IBT.
[DGMBT news] [thesis]

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BildProf. Olaf Dössel was honored for his outstanding scientific achievements in the faculty council

The wish and application of the division and faculty management to appoint the recently retired Prof. Dössel as a Distinguished Senior Fellow was positively approved by the KIT. Prof. Dössel is involved, among other things, in 3 academies of science and in international professional societies as well as an expert in his field of medical technology.
Prof. Dössel and Prof. Ivers-Tiffée are highly regarded in science nationally and internationally and contribute significantly to the visibility of KIT.
Congratulations on these two special awards!

Portrait Joshua SteyerNew research assistant at IBT

As of June 2022, the IBT welcomes Joshua Steyer as a new research assistant within the „Computational Cardiac Modelling“ group. In the scope of the MICROCARD research project, he will investigate the effect of microscopic tissue structure on clinical electrograms using HPC simulations for an improved assessment of the vulnerability to arrhythmias and tailored ablation strategies. He studied physics and numerically analyzed spatiotemporally chaotic excitation dynamics of the heart during his Master’s thesis at the MPI for Dynamics and Self-Organization.

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BildIs electromechanical tissue coupling a determinant for altered left ventricular rotation patterns?

In cooperation with physicians from the St. Anne’s University Hospital, Brno, researchers at IBT showed that a dyssynchronous activation of the left ventricle is insufficient to result in a breakdown of the typical torsional contraction pattern in patients diagnosed with heart failure.

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BildGraduation Tobias Gerach

Tobias Gerach successfully defended his dissertation „ Personalized Electromechanical Modeling of the Human Heart - Challenges and Opportunities in Pathophysiological Scenarios “ on May 19th 2022 and passed the doctoral exam with distinction. Sincere congratulations to our new PhD from the team’s whole heart!

LogoTribute for Prof. Em. Olaf Dössel

Olaf Dössel was appointed Fellow of the International Union for Physical and Engineering Sciences in Medicine (IUPESM) in recognition of his outstanding contribution to the international development of physical and engineering sciences in medicine.
The IUPESM is the worldwide umbrella organization of all scientific societies for biomedical engineering and medical physics.

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Logo DGKDGK Annual Meeting

The 88th Annual Meeting of the German Society of Cardiology, which was held for the first time since 2019 in the presence of the Congress Center Rosengarten in Mannheim, was very well attended. 
More than 7,100 audience members watched the sessions of the 88th Annual Meeting, the majority of them - more than 5,300 people - on site in Mannheim. The IBT was represented with several posters and an invited talk on "Computational Cardiac Modeling - Synergies with Machine Learning" (Axel Loewe).

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BildDeborah Nairn, PhD

Deborah Nairn successfully defended her PhD thesis „Multi-Modality Correspondence to Enhance Arrhythmogenic Atrial Substrate Identification - Guiding Persistent Atrial Fibrillation Ablation Therapy“ on April 14th, 2022.
Our heartfelt congratulations!

BildSymposium and farewell party for Prof. Dr. Olaf Dössel

After more than 25 years at the Faculty of Electrical Engineering and Information Technology, Prof. Dr. Olaf Dössel with a symposium on medical technology and with various subsequent celebrations in retirement. Specialist presentations by current and former representatives of the Institute for Biomedical Engineering (IBT) and the Städtisches Klinikum were followed by greetings from the KIT, Division III, professional associations, companions as well as the faculty and student council. At the celebration that followed, the IBT said goodbye to its head of institute with various musical personal contributions and with the traditional, self-made "doctoral hat".
Many thanks to Olaf Dössel and all the best for your retirement!

Logo EHRAEHRA Congress 2022

Carmen Martinez, scientist in the IBT, presented her research results in the EHRA Congress 2022 poster sessions under the title: “Impact of contact force on local impedance measurements in different atrial locations“. The conference took place in Copenhage between the 3rd and the 5th of April. The scientific program of this year was focused on “Getting back to the rhythm!”, referring also to the recovering of on-site conferences after the pandemic.

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BildDevelopment environment for sustainable research software

How can the maintenance effort for research software be reduced by clever concepts and automation? The article published in the journal "Bausteine Forschungsdatenmanagement" presents ideas and solutions using the example of openCARP.

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BildPhD Laura Unger

Laura Unger successfully defended her PhD thesis „Multimodal Characterization of the Atrial Substrate – Risks and Rewards of Electrogram and Impedance Mapping“ on February 22nd, 2022 and passed the doctoral examination with distinction. Our heartfelt congratulations!

PhD thesis
BildAtrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment

A recent research topic published in the renowned Frontiers in Physiology journal highlights the latest progress in technology for atrial fibrillation diagnosis, monitoring and treatment.
The collection of 38 articles was co-edited by IBT researcher Axel Loewe and features 3 studies in which IBT was involved.

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BildWhich atrial fibrillation patients are at increased risk for heart failure?

Together with physicians at Freiburg University Hospital, IBT researchers present a method to non-invasively identify those atrial fibrillation patients at increased risk of heart failure. The method is based on machine learning on the electrocardiogram.

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BildWhat ECG can tell us about the events on a molecular scale

Our research is featured in the latest episode of Renal Research Institute's "Frontiers in Kidney Medicine and Biology" in an interview with Axel Loewe. Watch the video, listen to the podcast, or read the transcript.

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BildSoftware Carpentry Workshop at KIT

On April 11th and 12th 2022, the Institute of Biomedical Engineering is hosting a workshop which aims at teaching foundational coding to researchers, open to registration for all KIT members.

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BildNew research assistant at IBT

The Institute of Biomedical Engineering welcomes Mr. Jonathan Krauß as a new research assistant. Since January 2022, he has been working in the "Computational Cardiac Modeling“ research group on electro-mechanically coupled human heart simulations. For this purpose, efficient and robust coupling schemes will be developed and evaluated. 
Jonathan Krauß completed his studies in mechanical engineering at KIT. His research topics were focused on continuum mechanics and medical robotics.

BildLet's to talk about research software

In the days of Otto Hahn and Lise Meitner, scientific life was characterized solely by laboratory experiments, observations of nature and theoretical considerations, scientific essays and discourses. What has changed in the last 100 years? Nowadays, there is hardly a field in which research can be carried out without software.

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BildHybrid machine learning to localize atrial flutter substrates using the surface 12-lead ECG

IBT former researcher Giorgio Luongo, PhD presented a hybrid machine learning-based classification of 12-lead ECG to discriminate between patients with three different kind of atrial flutter (cavotricuspidal-isthmus-dependent vs. peri-mitral vs. other left atrium atrial flutters). This novel algorithm may aid to identify non-invasively the best ablation procedure to terminate the arrhythmia prior to the invasive procedure in the EP labs. This work is the result of a successful collaboration between 5 engineering and clinical groups (Università degli Studi di Milano, University of Leicester, ABC Federal University, Städtisches Klinikum Karlsruhe and IBT). The paper is published in EP Europace journal and is freely available.

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BildBlood flow shows minor effects on the deformation of the healthy heart

Researchers of the IBT and the ISTM (Institute of Fluid Mechanics, KIT) have implemented a sequential coupling approach and found that the influence of the blood flow only slightly changes the deformation of the heart wall.

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Atrial Signals LogoProgress - first technical, then clinical

The international "Atrial Signals" congress took place for the fourth time in September 2021 under the patronage of the Karlsruhe Municipal Hospital (Prof. Dr. med. Claus Schmitt) and the Karlsruhe Institute of Technology (Prof. Dr. rer. nat. Olaf Dössel ) including synergy effects.

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BildECG Imaging improved

The solution of the inverse problem for ECG imaging (ECGI) is prone to detection of artifacts. A team around IBT researcher Steffen Schuler presented a method to avoid line-of-block artifacts to improve ECGI as a noninvasive diagnostic tool.

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BildInfluence of cardiac motion on the ECG

Using an electromechanical computational model, researchers at IEKM in Freiburg and IBT could quantify the effect that cardiac motion has on the ECG. This work is an important basis for faster ECG simulations in the future.

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BildEP Europace cover story

A joint study of the University Heart Center Freiburg-Bad Krozingen and the IBT is featured on the cover page of the December issue of the renowned scientific journal "EP Europace". The study uses the ECG and ECGI to diagnose pathological changes in the atria.

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BildAxel Loewe completes habilitation

With the colloquium "Machine Learning for Medicine and the Role of Simulated Data", Dr.-Ing. Axel Loewe qualified as a university lecturer for the field "Modeling and Simulation for Medicine".

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BildPhD Mark Nothstein

The graduations season continues at IBT. We are very proud to announce that Mark Nothstein has successfully defended his PhD thesis: "Characterizing Atrial Fibrillation Substrate by Electrogram and Restitution Analysis”. Look what a nice hat his colleagues have made for him!

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BildPhD Steffen Schuler

Last week, Steffen Schuler from our group successfully defended his thesis “Novel Methods to Incorporate Physiological Prior Knowledge into the Inverse Problem of Electrocardiography” Congratulations to our newest PhD! #phdlife #CardioTwitter.

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BildDirected Graph Mapping for Atrial Flutter

IBT researchers in the MY-ATRIA consortium have published a new method to better characterize atrial flutter. The approach makes use of graph-theoretical methods.

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ImageAmerican Heart Association Meeting

Claudia Nagel participated at the Cardiac Physiome Workshop and at the annual meeting of the American heart association. She presented her latest results regarding the influence of the ventricular shape on simulated QRS complexes in the ECG and showed that an estimation of the left atrial fibrotic volume fraction based on simulated P waves was possible with an average error of 8.7%.

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BildIBT at BMT

20 employees and students of IBT attended this year's annual meeting of the German society of biomedical engineering. 9 presentations and 3 posters from the three research groups were held and presented. Congratulations to Giorgio Luongo for winning the 2nd price for patient safety and to Hannes Welle for the 2nd place in the student competition.

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BildVirtual Metrology Meeting (VirtMet)

Olaf Dössel and Claudia Nagel participated in the first international workshop on metrology for virtual measuring instruments. Olaf Dössel held a keynote lecture about digital twins in medicine and Claudia Nagel talked about how fidelity of simulated ECGs can be assessed for a successful and meaningful application of simulated signals to clinical use cases.

BildWorkshop on Statistical Atlases and Computational Modeling of the Heart (STACOM)

Claudia Nagel presented her work at the workshop for Statistical Atlases and Computational Modeling of the Heart (STACOM). In her presentation, she talked about an application of the bi-atrial statistical shape model developed at IBT for identifying left atrial enlargement with the 12-lead ECG.

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BildAtrial Signals conference

The biannual Atrial Signals conference convened at KIT in September. More than 200 experts from both engineering and clinical communities joined discussions and presented the latest research.

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BildAward for Patient Safety in Biomedical Engineering 2021

Let's congratulate our colleague Giorgio Luongo and the whole team for winning the second prize for the patient safety in biomedical engineering 2021 with the publication “Machine learning enables noninvasive prediction of atrial fibrillation driver location and acute pulmonary vein ablation success using the 12-lead ECG”. The award was handed in occasion of the BMT 21 conference in Hannover, and offered by the German Society of Biomedical Engineering (DGBMT).

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BildNew research scholarship holder at IBT

We welcome Miriam Weiß as a new research scholarship holder in the group "Optical Technologies in Medicine".

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Image Konsistente biventrikuläre KoordinatenCobiveco: Consistent biventricular coordinates

IBT researchers have published an improved ventricular coordinate system for localization, data mapping and regression on cardiac geometries. An open MATLAB implementation of the method for precise and intuitive description of position in the heart is available for the community.
To the article

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Logo The CarpentriesSoftware Carpentry Workshop at KIT

On October 28th and 29th 2021, the Institute of Biomedical Engineering is hosting a workshop which aims at teaching foundational coding to researchers, open to registration for all KIT members.

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BildStatistical Shape Model of the Atria

Claudia Nagel, Steffen Schuler, Olaf Dössel and Axel Loewe published a paper on a bi-atrial statisical shape model. The model includes the anatomical shape variations of the atria in the study population and was analyzed with standard evaluation criteria. The shape model and 100 exemplary atrial geometries suitable for electrophysiological simulations are openly available online.

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Logo de-RSE e.V.Research Software - Sustainable Development and Support

IAMO Policy Brief 42 focuses on the needs and strategies for sustainable research software practices based on a position paper.

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hearts-logoReview article on the calculation of the ECG with the help of computer models of the heart published

Olaf Dössel, Giorgio Luongo, Claudia Nagel and Axel Loewe have written a review article that deals with the calculation of the ECG from computer models of the heart. Both the healthy heart and simulations of various heart diseases are considered. It becomes clear how computer modeling can contribute to a better interpretation of the EKG.

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BildMechanisms of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy impairs cardiac mechanics but the differential effects of a thicker wall, reduced active force, fiber disarray and increased tissue stiffness are not clear. IBT researchers could elucidate their contribution to deformation, strain, strain rate and wall thickening using a computational model of the heart.

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iHeart 2021iHeart conference 2021

During the iHeart conference from July 1-3, about 200 participants virtually presented and discussed their research. The IBT was successfully involved with two presentations.

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BildPromotion Ekaterina Kovacheva

On the 8th of July Ekaterina Kovacheva completed her PhD with the title “Model Based Estimation of the Elastomechanical Properties of the Human Heart.” Congratulations from everyone at IBT.

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BildDoctorate Jorge Sanchez

Congratulations to Jorge Patricio Sanchez Arciniegas on the completion of his PhD and the beginning of his work at IBT as a postdoc.

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Image personalized heartComputer Model of a personalized heart

In cooperation with the IANM (KIT) and the IEKM (University Heart Center Freiburg), researchers at IBT proposed an electro-mechanically coupled computer model of a personalized human heart. The manuscript was published in the Journal Mathematics.

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BildTransit Time Measurement in Indicator Dilution Curves

Researchers at IBT investigated how accurate a transit time measurement of an indicator bolus can be and proposed methods to enhance the accuracy. The work was published in the  Frontiers in Physiology .

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Image graphical abstractNumber of cameras for the 3D reconstruction

Researchers at IBT investigated how many cameras are needed so that a microsurgical operating channel can be reconstructed as completely as possible in 3D.
The work was published in the Journal of Imaging (MDPI): https://doi.org/10.3390/jimaging7050087

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EHRA Congress 2021

A scientist of the IBT presented and discussed their research titled: “Spatial and Quantitative Assessment of the Correlation between Sinus Rhythm and Atrial Fibrillation Voltage Mapping to Identify Low Voltage Substrate in Persistent Atrial Fibrillation“ at this years EHRA congress. The congress was held online from the 23-25th of April, with this years' scientific program emphasising “Making connections to overcome arrhythmia”.

CombinationsEstimation of Atrial Fibrosis with the ECG

Researchers at IBT investigated whether the amount of diseased fibrotic tissue in the atria can be estimated non-invasively and quantitatively with features extracted from P waves of the 12-lead ECG.
The work was published in the Journal of Clinical Medicine (MDPI).

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Girlsday_MedizintechnikGirls’ Day 2021

Der Workshop des IBT im Rahmen des Girls‘ Day 2021 traf auf großes Interesse des weiblichen Nachwuchses in den Bereichen Medizin und Technik.

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Portrait von Simon HoffmannSimon Hoffmann will be research assistant at IBT

We welcome Mr. Simon Hoffmann as a research assistant. His work will focus on data processing in ophthalmology.

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Portrait von Marie HouillonNew research assistant at IBT

Since April 1st, 2021 Dr. Marie Houillon is new research assistant in the computational cardiac modeling group at IBT.

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BildNon invasive prediction of atrial fibrillation driver location

IBT researcher Giorgio Luongo and colleagues presented a machine learning-based classification of 12-lead ECG to discriminate between patients with pulmonary vein drivers vs. those with extra-pulmonary vein drivers of atrial fibrillation.
The paper is published in the Cardiovascular Digital Health Journal.

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Transmembrane potentialProtocol to Assess Arrhythmia Vulnerability

Researchers at IBT showed the influence of the chosen protocol to induce arrhythmia on the assessment of atrial fibrillation vulnerability.

The paper was published in Frontiers of Physiology and is freely available.

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Bild Herzmodellierung 2021Computational hearts for success of therapy

KIT's Institute of Biomedical Engineering develops, based on mathematical equations, a computational heart model to enable targeted therapy of cardiac arrhythmias. The model supports medical research and development in the fields of diagnostic and therapeutic approaches.

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Bild zur Kraft RekonstruktionEstimating Cardiac Active Tension from Wall Motion - An Inverse Problem of Cardiac Biomechanics

IBT researches have published a paper, which presents a model-based method for solving an inverse problem of the heart biomechanics.

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Bild RefraktärzeitCycle Length Statistics during ongoing Atrial Fibrillation Yield Refractory Measure

Researchers at IBT showed that the statistical analysis of cycle lengths during atrial fibrillation allows to estimate refractory periods of the underlying substrate. The study combines a broad set of simulations with clinical acquisitions and was published in Europace EP.

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Bild Nicolas PiliaGraduation Nicolas Pilia

Nicolas Pilia defended his dissertation „Electrocardiogram Signal Analysis and Simulations for Non-Invasive Diagnosis - Model-Based and Data-Driven Approaches for the Estimation of Ionic Concentrations and Localization of Excitation Origins“ on February 18th 2021 and graduated with distinction. Congratulations!

BildWhitepaper on sustainable development of research software in Germany

The Paper describes the environment for the development of sustainable research software in Germany, identifies challenges and calls for action.

To the article

F1000Research
2020
BildComparison of Unipolar and Bipolar Voltage Mapping

IBT researches in collaboration with the University Heart Centre Freiburg have published a paper comparing unipolar and bipolar voltage mapping for localisation of atrial substrate.

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Frontiers in Physiologie
Logo BMT 2020BMT 2020

Das IBT nimmt an der jährlichen VDE DGBMT Kongressveranstaltung teil.

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Logo NBC 2020North Baltic Conference 2020

A scientist of the IBT presented and discussed his results on the simulation of the propagation of photons in a blood vessel.

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GruppenbildComputing in Cardiology 2020

Eight delegates represented IBT at this year’s Computing in Cardiology conference in Rimini which brought together both onsite and remote participants during the COVID-19 pandemic.

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FIG. 1. Each section of this work can be attributed to at least one of the topics in the green boxes. Although they are separated in this diagram, they are closely connected and depend on each other. That is why collaboration between the fields is of paraReview article on the ECG-based potassium and calcium concentration estimation

Researches of IBT, together with researchers from Bologna, Milan, and New York, published a review article on the current state of ECG-based potassium and calcium blood concentration measurements.

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Spektrum der Wissenschaft 2020.10A digital heart

The current issue of the popular scientific journal „Spektrum der Wissenschaft“, the German branch of the Scientific American, features an article of the head of the Computational Cardiac Modeling group at IBT. Under the headline „A digital heart“, Axel Loewe describes the motivation for and the basics of computational heart models and illustrates first successful examples of translation to clinical practice and clinical research.

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Geodätische Längenmessung in medizinischen Aufnahmen.Geodesic Length Measurement in Medical Images

Publication of the investigation of the discretization error and its reduction in the geodesic length measurement.

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AI in medicineArtificial intelligence in medicine

That is the topic of the Herrenhausen Forum on July 14, 2020. The discussion with experts from IT, medicine and law was about responsibility and trust.

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News 2020-06-23Identification of intraatrial arrhythmogenic sources

Contributions by the university medical center Freiburg and IBT resulted in a paper on the identification of intraatrial arrhythmogenic sources using intracardiac electrogram characteristics.

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FasernEffect of fibers and bulk modulus on the electromechanics of the ventricle

In collaboration with the Politecnico of Milan, IBT presented an electromechanical model of bi-ventricular human geometries to study influences on the pressure-volume relation.

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IMG_2020-06-02_atrial flutter in ECGNew spatio-temporal methods to characterize atrial flutter mechanisms using the ECG

IBT researchers published two novel methods for a non-invasive atrial flutter characterization together with physicians from the University of Leicester, the ABC Federal University, and the clinicians form the Städtisches Klinikum Karlsruhe in the journal “IEEE Transactions on Biomedical Engineering”. Spatio-temporal recurrence quantification analysis methods were used to characterize and discriminate several atrial flutter mechanisms from the 12-lead ECG in a computational framework. Thanks to these methods, the duration of the invasive atrial mapping and ablation procedure might shorten significantly. The computational study was complemented and fortified by a clinical case used as a proof of concept.

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Hemmstoff A293Potassium channel inhibitor A293 indicates therapeutic potential for the treatment of atrial fibrillation

In collaboration with the Institute of Biomedical Engineering at KIT and the University Heart Center Freiburg – Bad Krozingen, researchers from the Medical University Hospital Heidelberg published an article on the antiarrhythmic effects of A293 on cardioversion of atrial fibrillation. As a high-affinity potassium channel inhibitor, A293 mitigates the pathological shortening of the atrial action potential duration.  The study indicated the therapeutic potential of A293 for the treatment of atrial fibrillation with single cell experiments, a porcine model, as well as computer simulations in a three-dimensional atrium. The open access article was published in the Journal of the American Heart Association (JAHA).

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Natrium-Calcium-AustauschersWhat's the role of the sodium calcium exchanger for the spontaneous beating of the heart?

Together with researchers from the University of Szeged, IBT researchers have published a review article on the role of the sodium calcium exchanger for the activity of natural pacemaker cells. These cells are located in the so-called sinus node of the heart and make for the rhythmic beating of our hearts. The review article integrates findings from experimental studies with computational modeling. It was published in the Frontiers in Pharmacology journal and is freely available (open access).

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F1000ResearchPolicy paper on Research Software Engineering in Germany

The collaborative opinion article "An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action" was recently published as a preprint for open peer review in F1000Research. This paper is the outcome of a workshop at the first German conference on Research Engineering and a dedicated DFG-funded follow up workshop hosted by the Robert Koch Institute. KIT and IBT researchers played a leading role in bringing together the group and coordinating the writing process. With more than 40 authors and wide community review, this grass-roots initiative calls for action to make software a first class citizen in research.

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openCARPopenCARP released

openCARP is an open cardiac electrophysiology simulator for in-silico experiments. Its source code is public and the software is freely available for academic purposes. openCARP is easy to use and offers single cell as well as multiscale simulations from ion channel to organ level. Additionally, openCARP includes a wide variety of functions for pre- and post-processing of data as well as visualization. The python-based CARPutils framework enables the user to develop and share simulation pipelines, i.e. automating in-silico experiments including all modeling/simulation steps.
openCARP is a joint effort of the Medical University of Graz (Gernot Plank), LIRYC Bordeaux (Ed Vigmond), U Freiburg (Gunnar Seemann) and KIT (Axel Loewe).

openCARP
Konferenz 2020-02-04SPIE Photonics West

Two members of the IBT attended, presented two talks and shared their results on novel segmentation methods and a 3D microscale test target at the SPIE Photonics West Conference in San Francisco on the 01st February to 06th February. The useful feedback will be incorporated in further research and contact to possible new collaborates was set.

News 2020-01-30What makes the heart beat?

The sinus node is the natural pacemaker of the heart initiating each heart beat. Its pacemaking function results from the interplay of to cooperating systems: the so-called membrane clock and the calcium clock. The precise role of these two mechanisms is incompletely understood. Together with a group of experimental researchers from Szeged (Hungrary), the Cardiac Modeling group could now further elucidate the role of the calcium clock. A novel pharmacological agent allows to specifically block the sodim-calcium exchanger. IBT researcher could reproduce and further investigate this effect mechanistically in a computational model. By combining experiment and computer simulation, the crucial role of the sodium-calcium exchanger and the interplay with the membrane clock could be consolidated. The study explains how the natural pacemaker of the heart becomes robust and reliable through the interplay of the two systems calcium clock and membrane clock.

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dotnetpro 2020Heart Simulator 1.0

The issue 1/2020 of the "dotnetpro“ journal features an article about the research of the cardiac modeling group. dotnetpro delivers expert knowledge for software developers, who use Microsoft technologies to write programs for Microsoft and non-Microsoft platforms. The idea behind the article is to provide a broader view for the dotnetpro readers, who mostly are software developers. The article introduces and describes the implementation of the multiscale simulation approach (from ion channels via cells and tissue up to the organ) for electrophysiology, which is developed and used at IBT. 

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TRM_2020Towards the Digital Twin

Axel Loewe from IBT was invited to present at the 10th "TRM Forum on the Computer Simulation of Cardiac Function“. The meeting brings together leading experts on computational modeling, experimental assessment, and clinical research in the field of cardiac arrhythmias. We contributed to this year’s theme „Towards the Digital Twin“ by presenting work that allows to build a biomechanical twin of an individual patient. In addition, the session "Atrial modeling & experimental data" was chaired by the IBT researcher.

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2019
IMG_2019-11-08 DFG_News.jpgDFG roundtable discussion on „Sustainability of Research Software in Germany“

On November 7 and 8, 40 members of the German research software community met at the Robert Koch institute in Berlin to work on a position paper on „Sustainability of Research Software in Germany“. On invitation of the DFG, the topics motivation for and selection of research software, funding, best practices, policies, and infrastructure were discussed. The respective demands, challenges, ideas for solutions were formulated and phrases as central recommendations for decision makers. After internal revision, the document will be made available to the public for discussion as part of the process for position papers of the German Society for Research Software Engineering (deRSE).

Atrial Signals 2019Atrial Signals 2019 in Bordeaux

Six delegates of IBT attended the workshop Atrial Signals in Bordeaux on 14th and 15th October accompanied by their local clinical partners from Städtisches Klinikum Karlsruhe. Four years ago, the format of the workshop was called into being by Olaf Dössel and Claus Schmitt in Karlsruhe. It brings together physicians and engineers and creates a platform for the vivid exchange of needs, possibilities, and novelties in the context of working with signals from the human atria. Olaf Dössel contributed to the scientific program with two invited talks. Furthermore, IBT was represented with five posters. Laura Unger presented her work as one out of three finalists of the poster competition to the plenum.

The next workshop Atrial Signals will take place in Karlsruhe in 2021.

Labtour O-Phase 2019Labtour O-Phase 2019

On October 8th, approximately 15 freshmen seized the opportunity of getting to know IBT during the institute tour in their orientation week. Presentations on three topics of current interest in biomedical research gave them an outlook to possible fields of application of their studies in electrical engineering and information technology starting this October. The event concluded with live demonstrations of different medical devices.

CinC_2019Steffen Schuler wins the YIA at CinC 2019

The Computing in Cardiology conference 2019 was hosted in Singapore from 8th to 11th September. Five doctoral students and Olaf Dössel as a member of the board of directors represented IBT. Amongst others, cardiac modelling and signal processing as well as the inverse problem of electrocardiography were discussed.
Steffen Schuler convinced the committee of the Rosanna Degani Young Investigator Award with his paper and oral presentation on the delay-based regularization for ECG imaging of transmembrane voltages and won the renowned competition.

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VDE_DGBMT 2019How do physicians and digital technology collaborate in 2035?

The VDE "Praxisnetz Digitale Technologien“ and the "Deutsche Gesellschaft für Biomedizinische Technik" (DGBMT) published a future scenario under participation of IBT experts:

„In the year 2035, digital technology and in particular artificial intelligence have overcome most regulatory obstacles. They expanded into virtually all areas of the public health sector and markedly changed the working environment of physicians. Similar to earlier developments in other professions like pilots, physicians experience a symbiotic collaboration with technology in their daily routine...“

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BMT 2019IBT successful at BMT 2019 in Frankfurt

Twelve members of IBT were attending BMT 2019, the joint annual conference of the German, Austrian and Swiss Society for Biomedical Engineering, and presented results of their research work to the community. Claudia Nagel was awarded the 1st prize in the student competition for presenting results of her Master's thesis. Rosa Daschner was awarded the 5th prize for presenting the results of her Bachelor's thesis.

Rätsel HerzMystery of sudden cardiac death of dialysis patients solved?

Dialysis patients have an unexplained high risk to suffer sudden cardiac death: up to 100x higher than patients with normal kidney function. A simulation study of IBT suggests a potential reason: the natural pacemaker of the heart, the sinus node, reacts very sensitive to changes of the calcium concentration in the blood. In collaboration with researchers in Bologna (Italy), Szeged (Hungary), Monza (Italy), and New York City (USA), we could show that the heart beat slows down upon a decrease of the calcium concentration. In extreme cases, the heart beat stops. As calcium and other ion concentrations (such as potassium) undergo massive fluctuations in dialysis patients, this could be a relevant reason for the extreme risk of sudden cardiac death in these patients.

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WanddickeRobust method to determine atrial wall thickness

In collaboration with researchers from Auckland (New Zealand), Ohio (USA), London (Canada), and Freiburg (Germany), IBT researchers have published a novel algorithm to reliably determine the wall thickness of the two atria of the heart. Based on medical imaging data, two coupled partial differential equations are solved. From the solution, the atrial wall thickness can be extracted for every point on the surface of the atria. The efficient new method is more accurate and robust than previous approaches and can in future be used to guide ablation therapy for atrial fibrillation and flutter.

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Press Release 2019/123Heart from the computer supports physicians
KIT Press Release 123/2019
iHeart 2019RISM Congress 2019

The RISM Congress, iHeart - Modeling the Cardiac Function, in Varese Italy, 22-24 Juli 2019, was visited by a member of the IBT Computational Cardiac Modeling group. There the work "A Method for Pressure-Volume-Based Parameter Identification for a Passive Constitutive Model of Myocardium“ was presented in a posterblitz-session.

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gacm8th GACM Colloquium on Computational Mechanics

Ende August fand in Kassel ein dreitägiges Kolloquium der GACM zum Thema „Mechanik“ statt. Auch die Arbeitsgruppe Herzmodellierung war im Rahmen des Minisymposiums „Numerical methods in biomechanics“ vertreten. Der Vortrag mit dem Titel „Estimating Cardiac Active Tension from Wall Motion – The Inverse Problem of Cardiac Mechanics“ vermittelte einen Einblick in den aktuellen Stand der Forschung hinsichtlich der Entwicklung eines Verfahrens zur nichtinvasiven Bestimmung der Kraftentwicklung im menschlichen Herzen.

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News BJAMeasurement of relative lung perfusion with electrical impedance and positron emission tomography

Electrical impedance tomography (EIT) with indicator dilution may be clinically useful to measure relative lung perfusion at bedside in ICUs. To investigate the performance of this technique, researchers from the IBT, Dräger and from the University Hospital in Dresden compared the EIT measure to PET. The satisfactory agreement of PET and EIT may potentially allow the usage of EIT perfusion measurements at bedside. The study was published in the „British Journal of Anaesthesia“.

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New research assistant at IBT

We welcome Mr. Anees Qumar Abbasi as a research assistant at the Institute of Biomedical Engineering, started at August 1st, 2019.
  As member of the Optics group, his research will focus on developing a marker-free video-based human gait analysis system, under real-world conditions. The idea is to provide a system, which can automatically assess human gait parameters based on self-made smartphone videos. The system should be capable of detecting the relevant gait phases and calculating the crucial gait parameters out of it.  Advanced Machine Learning/Deep Learning methods will be used in order to extract the relevant gait features from the video. These features will be used for better classification of diseased and normal subjects as well as for early diagnosis of any gait related problem and monitoring of patient’s progress.
  Mr. Abbasi has completed his Bachelor’s and Master’s degree in Computer Science at University of Azad Jammu and Kashmir Muzaffarabad, Pakistan.  His research topics were focused on the human gait analysis and time series processing. He has been awarded scholarship for his PhD from DAAD and Higher Education Commission of Pakistan.

 

Guo_LNew research assistant at IBT

We would like to welcome Miss Lu Guo as a research assistant at the Institute of Biomedical Engineeing starting from August 2019. Her research will focus on the artificial depth perception in surgical visualization. For real-time 3D modelling of the surgical situs, instant and precise acquisition of spatially dense depth information is required. The aim is to develop new methods for depth estimation based on depth cues known from human depth perception.
  Miss Guo completed her bachelor’s degree in Mechanical Engineering at Tongji University and Master’s degree in Mechanical Engineering at Karlsruhe Institute of Technology.Her research topics were focused on the computer vision in the field of autonomous driving. 

Aton_ANew research assistant at IBT

The Institute of Biomedical Engineering welcomes Mr. Alexander Anton as a new researcher. He joined the team in September 2019 and his research focus will be on the intraoperative visualization of nerve fibers of the human brain. Due to its birefringent properties, the orientation of nerve fibers can be detected optically using polarized light. The goal of this research is to develop an appropriate polarization-sensitive image capturing and processing system for intraoperative optical fiber tracking. Such a system would be a great advance for neurosurgery and could bring further benefits in the field of intraoperative diagnostics.
  Mr. Anton completed his master studies in medical technology at the University of Stuttgart. His research interests were in the field of optical methods and systems for medical technology as well as in biomechanics and bionics.

2019-08-22An energetic model for the prediction of cerebral temperature decrease in the therapy of stroke patients using therapeutic hypothermia

Hypothermia is often used as an additional therapy to reduce the neurological damage caused by an ischemic stroke. Acandis in Pforzheim, Germany, has developed a new blood cooling catheter for targeted and rapid temperature reduction in the ischemic brain regions while simultaneously avoiding systemic side effects. In order to estimate the achievable temperature range, the cooling time required and the associated decrease in body core temperature when using this new catheter, researchers from the Institute of Biomedical Engineering have developed an energetic numerical temperature model. With this model, the researchers were able to show that under ischemic conditions, the catheter enables a decrease in cerebral brain tissue temperature of approx. 2°C after 30 minutes of cooling. In addition, the simulated effects of blood cooling on the rest of the systemic body were very small.

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EMBC 2019International Engineering in Medicine and Biology Conference

Fifteen participants represented the Institute of Biomedical Engineering from July 23rd to 27th 2019 at the 41st International Engineering in Medicine and Biology Conference in Berlin. Eight posters, five oral presentations and numerous session chairmanships showed Karlsruhe to be a strong competence in the field at the conference edition in Germany. Program chair Olaf Dössel gave the meeting a special character. The broad spectrum of discussed topics amongst scientists from all around the world impressed and motivated the delegation of IBT.

ICIAM 2019International Conference on Industrial and Applied Mathematics

This conference on applied mathematics with more than 4000 participants takes place every four years, most recently in July in Valencia, Spain. The Computational Cardiac Modeling group was invited to present their work during the minisymposium "Mathematical and Numerical Modeling of the Human Heart“. 
The contribution "The Inverse Problem of Cardiac Mechanics Estimation of Cardiac Active Stress from Endocardial Motion Tracking“ describes first steps towards a novel method to estimate active force generation in the human heart non-invasively.

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International Conference on Computational and Mathematical Biomedical EngineeringInternational Conference on Computational and Mathematical Biomedical Engineering

The conference took place in June in Sendai City, Japan. The Cardiac Modeling Group of IBT presented their work "The Inverse Problem of Cardiac Mechanics Estimation of Cardiac Active Stress from Endocardial Motion Tracking“ as an invited talk in the minisymposium „Mathematical and Numerical Modeling of the Heart Function“.

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RSE_2019First German Conference on Research Software Engineering

From June 4-6, the first German Conference on Research Software Engineering took place on Telegraphenberg in Potsdam. The IBT-coordinated SuLMaSS project presented a poster and was signifanctly involved in the organization of the workshop "Challenges for the sustainable development, provision, and maintenance of research software in Germany". Many of the projects that were funded in the scope of the DFG call "Sustainable Research Software" were present and discussed lively during three hours in a "World Café". The results of the workshop will serve as the basis for a whitepaper that will be developed during a DFG round table in autumn. If you are interested in contributing, please get in touch with Axel Loewe.

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WellenphänomeneCollaborative Research Centre „Wave phenomena“ extended

The grant committee of the Deutsche Forschungsgemeinschaft (DFG) decided to extend the funding for the collaborative research centre 1173 „wave phenomena: analysis and numerics“ for 4 more years. Together with our mathematics partners, we work on project B7 "Dynamics of electro-cardiac depolarization waves“. An new aspect to be tackled during the second funding period starting in July will be the coupling of the heart’s natural pacemaker, the sinus node, with the surrounding cardiac tissue.

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MY-ATRIAFirst MY-ATRIA newsletter

The first newsletter of MY-ATRIA consortium, “Introducing MY-ATRIA”, has been issued. This is a presentation of the project, the beneficiaries, partners, and the PhDs involved in it.  It also describes the introductory event held in Milan in October 2018, and some interesting facts about Marie Curie.
Soon there will be the second newsletter about the winter school held in Lund in January 2019. For the moment, it is possible to enjoy a video about it.

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DGK 2019 MannheimAnnual DGK congress in Mannheim

The PhD students Laura Unger and Mark Nothstein from the IBT participated in the annual congress of the German Society for Cardiology (DGK) in Mannheim together with Prof. Olaf Dössel. The pronounced clinical focus of the congress presented a perfect opportunity to gain insight into the open questions and problems of clinicians. While Laura Unger attended several project meetings as part of the congress Mark Nothstein represented the association project (KIT, Universitäts-Herzzentrum Freiburg / Bad Krozingen, Städtisches Klinikum Karlsruhe) with a poster presentation giving him the chance to discuss his approach towards quantifying pathological substrate with the clinical experts in the field. His contribution was selected to be published as an interview on the online platform “esanum”.

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Workshop Herzmodellierung 2019Workshop on cardiac modeling

Coupling relevant physiological aspects of cardiac modeling in the right way – that was the subject of a three-day workshop. About 50 scientists from various teams from different European countries met from April 15th to April 17th in Bad Herrenalb. The workshop was partly organized by the IBT. Among others, invited speakers gave insight to the current state and the developments of their research. Besides, there of course was enough room for discussions and exchange.

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Gordon Research Seminar 2019Gordon Research Conference 2019

Three members of the IBT (Luca Azzolin, Axel Loewe, Giorgio Luongo) participated in the Gordon Research Seminar and Conference on Cardiac Arrhythmia Mechanisms in Lucca (Barga), Italy. They contributed with poster each and discussed their research with other leading experts in various fields connected with heart rhythm disorders: from computational modellers to electrophysiologists and experimentalists. It was a unique opportunity to listen to cutting-edge talks given by outstanding scientists reporting unpublished discoveries. Our member Luca Azzolin had the honour of winning one of the Deutsche Herzstiftung travel grants for his abstract and Axel Loewe co-chaired the Gordon Research Seminar together with Mathilde Rivaud from the Amsterdam Medical Center.

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Girls’ Day 2019 am IBTGirls’ Day 2019 at the IBT

On the 27th of April 2019, the Girls’ Day took place and the IBT was pleased to introduce the world of Medical Technologie to the visiting girls. 20 girls signed up for our workshop on „Technology in the Hospital - visualizing heart and lung activities“. Content was the Electrical Impedance Tomography, Photoplethysmography and the Electrocardiography. The short introduction into the methods and the following experiments created a diverse and exciting time for the girls and the presenters. The active participation and the experiments made it a great and funny event. We’d like to thank the organizers, supporters, participants and we are looking forward to the next Girls’ Day 2020!

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SPIEIBT presents at SPIE Photonic West 2019

At the international conference SPIE Photonic West in San Francisco, CA, USA Andreas Wachter presents his currents results. The paper "Development of a real-time virtual reality environment for visualization of fully digital microscope datasets” was presented during the poster session.

Biophysical Society MeetingIBT presents at Biophysical Society Meeting

Recent IBT research was presented at the 63rd Annual Meeting of the Biophysical Society in Baltimore, MD, USA. Die work "Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients“ was featured with an Early Career Scientist Travel Award and well received in the poster session.

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IBT represented at Honorable Reception of the President

Axel Loewe was credited during the Honorable Reception of the KIT president for his success in the Gips-Schüle junior scientist award. Around 80 invited guests experienced a 3 hour program together with a gala dinner in the casino of KIT campus north. Besides the presentation of the KIT doctoral prizes, those KIT members who won important prizes and grants were honored.

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News 2018
IMG_IBT_News 2019-01-14.pngEstimating the personal risk for atrial flutter

Researchers at IBT in collaboration with clinicians from Städtisches Klinikum Karlsruhe have developed a method to estimate an individual’s risk to suffer from atrial flutter using computational models. The novel method has lately been published in the journal „Frontiers in Physiology“ and allows to identify all pathways along which atrial flutter can be sustained in a personalized model of the patient. In this way, the effect of therapeutic interventions like catheter ablation or drugs can be assessed in advance.

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Pollnow PromotionPhD graduation Stefan Pollnow

Stefan Pollnow defended his PhD thesis „Characterizing Cardiac Electrophysiology during Radiofrequency Ablation - An Integrative Ex vivo, In silico, and In vivo Approach“ on December 13 and passed the exam with distinction. We congratulate warmly!

EKG 2018-11-28Influence of left atrial size on the ECG

How does left atrial size affect the electrocardiogram (ECG)? If a robust recognition of left atrial enlargement would be possible using only the ECG, physicians would be provided with a cheap means to identify an important predictor for atrial fibrillation. In an effort to answer this question, scientists of the IBT have designed and performed a study to virtually enlarge the left atrium and simulate the corresponding ECG. Results of this study show how different types and degrees of left atrial enlargement influence the ECG and how they could potentially be detected in clinical practice. A particularly interesting results is that the frequently used clinical marker „PTF-V1“ is rather an indicator for a thicker atrial wall than for an enlarged atrium.

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karlsruhe.r2b-studentIBT presents at r2b-student techpitch

Convincing the audience in 180 seconds – scientists and founders presented their ideas and concepts during the r2b-student techpitch on Nov, 15. Afterwards, interested students could get in touch with the researchers to discuss about potential thesis projects.

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DGBMT 2018IBT strongly represented at the Conference of the Society of Biomedical Engineering 2018 in Aachen

The annual conference of the Society of Biomedical Engineering (DGBMT) 2018 took place in Aachen.
Among a lot of scientific contributions, the IBT was represented with 16 contributions and was one of the strongest groups at the annual conference. Furthermore, Armin Müller and Tamara Wirth won the 7th and 8th prize in the student competition of the DGBMT.

IBT News 2018-10-08Campus Report podcast features IBT

A step towards personalized medicine and more effective treatments that’s what computer simulation of atrial fibrillation promise. The Computational Cardiac Modeling group at the Institute of Biomedical Engineering of KIT works towards a mathematical formulation of the heart’s function and its realistic representation in computational models. The head of the group, Dr. Axel Loewe, reports about the work in this week’s Campus Report podcast.

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Preis PatientensicherheitPatient Safety Award

IBT scientists Axel Loewe and Olaf Dössel won the Patient Safety Award (2nd place) together with clinical collaborators from University Heart Center Freiburg-Bad Krozingen. The honored study introduces two novel ECG-based approaches for real-time assessment of success of catheter ablation to terminate perimitral flutter. Perimitral flutter is an atrial arrhythmia, which occurs frequently subsequent to ablation for atrial fibrillation. The methods were thoroughly evaluated using medical engineering simulations and put to test in a clinical study comprising a validation cohort. In the future, the methods can be implemented in clinical mapping devices. The suggested measures to assess success of ablation have great potential to significantly increase patient safety through shorter invasive procedures as well as higher success rates and therefore a smaller number of redo procedures.

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New research assistant at IBT

We welcome Miss Deborah Nairn as a research assistant starting October 2018. Her research will focus on identifying low voltage areas to guide atrial fibrillation therapy. This consists of identifying the relationship between bipolar voltage during sinus rhythm and ongoing AF. She aims to develop a robust method to pinpoint diseased tissue based on bipolar voltage taking into consideration different confounding factors.  
Miss Nairn completed her bachelor’s degree in Mathematics at the University of Aberdeen and Master’s degree in Data Science for Decision Making at Maastricht University. Her research topics focused on comparing state of the art ECG T-wave detection algorithms and building a signal-based dynamic model to detect ischemia and describe the progression over time.

CinC_PosterSuccessful participation in Computing in Cardiology (CinC) conference

Members of IBT presented 3 scientific contributions at the CinC conference in Maastricht, Netherlands. The contribution "Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry" was honored with a price for the poster presentation. Furthermore, members of IBT were involved in the organisation of the conference being session chairs and organizers of the hackathon for inverse problem at this conference.

Vorhofflimmerablation im ComputermodellHolistic evaluation of atrial fibrillation ablation using computational models

Therapy of atrial fibrillation often entails catheter ablation, which however does not show satisfactory success in many patients. IBT researchers in collaboration with the University of Bologna developed a method, which allows to assess novel ablation strategies thoroughly using computational models. In particular the holistic consideration of the entire cycle from simulation of atrial fibrillation episodes, the resulting extracellular potentials, the mechanical deformation of the catheter, signal acquisition, clinical signal processing, and eventually ablation in the model is unique. In a first application, it could be shown that ablation of so-called rotors is not always constructive.

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IMG_news_2018-08-30_SchulerNew spatio-temporal method for ECG imaging

Every spread of electrical excitation in the heart creates a characteristic spatio-temporal pattern of potentials on the surface of the body.
At IBT, a new method for ECG imaging has now been developed, which utilizes this spatio-temporal relationship by representing measured body surface potentials as superposition of basic potential patterns, for which the corresponding excitation pattern is known. The novel method has been published in the journal „Frontiers in Physiology“.
It could be shown that the origin of simulated atrial extrasystoles can be reconstructed more robustly and more accurately from noisy measurement data than with a commonly used reference method.

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Axel LoeweAxel Loewe awarded third place of the Gips-Schüle young talent award 2018

Atrial fibrillation is one of the most common cardiac arrhythmias in humans and responsible for 25 percent of all strokes. Drug therapy or surgery on the heart are often ineffective in the long term.
In his dissertation, Axel Loewe from the Institute of Biomedical Engineering of KIT examines atrial fibrillation using computer models. He has succeeded in integrating individual measurement data from patients, for example the genome of the cardiovascular system, into mathematical models. The model-based approaches contribute to a broader understanding of the disease. This will allow more efficient, personalized therapies to be developed.
With his research Loewe now took third place in the Gips Schüle Foundation's Gips-Schüle Award 2018.

KIT News
New research assistant at IBT

We would like to welcome Mr. Luca Azzolin as a research assistant at the Institute of Biomedical Engineering, started at July 1st, 2018. Within the framework of the MY-ATRIA Innovative Training Network (ITN), funded by the European Commission’s Horizon 2020 Marie Sklodowska-Curie programme, Mr. Azzolin is working in the cardiac modeling group at IBT at the development of an integrated and personalized computational model of the atria for an efficient ablation therapy for atrial fibrillation. The final expected result will be a tool helping the cardiologist to predict the ablation outcome.

Mr. Azzolin completed his Bachelor’s and Master’s degree in Computational Science and Engineering (Mathematical Engineering) at Politecnico di Milano. His research topics were focused on the electromechanical modelling and computer simulation of the human ventricles.

New research assistant at IBT

We would like to welcome Mr. Giorgio Luongo as a research assistant at the Institute of Biomedical Engineering as of July 1st, 2018. Inside the framework of the MY-ATRIA Innovative Training Network (ITN), funded by the European Commission’s Horizon 2020 Marie Sklodowska-Curie programme, Mr. Luongo is working with the biosignals group at IBT to understand the relationship between various patterns of depolarization in the atria during Sinus Rhythm, Atrial Flutter, Atrial Fibrillation, and the corresponding 12-lead ECG as well as BSPM. Additionally, to understand which of the atrial depolarization patterns can be reliably detected, identified, or localized.

Mr. Luongo completed his Bachelor’s and Master’s degree in Clinical Engineering and Biomedical Engineering at the University of Rome “La Sapienza”. His research topics were focused on the implementation of a regularized classifier based on evoked potentials EEG signals and on the implementation of an asynchronous control for Brain Computer Interface systems.

ICSIBT at the Interdisciplinary Cerebrovascular Symposium (ICS)

In 2018, the international conference celebrated its 15th birthday in Magdeburg, Germany. Following the conference series motto “Bringing together international PhD and MD experts”, Yannick Lutz presented his work concerning the development of a numerical model of brain and systemic temperature during local hypothermia for ischemic stroke treatment. The usage of a novel cooling catheter enables the possibility for fast local inducement of therapeutic hypothermia while reducing systemic side effects.

Workshops zum Thema MedizintechnikInteractive presentation within the workshop on medical technologies of the university group EESTEC

Within the international workshop on medical technologies of the EESTEC university group, the IBT gave an interactive presentation on “Technology in hospitals”. Many interested students from various European countries could gain insights into multiple medical measurement principles of vital signs as well as test them themselves. The measurements comprised clinically essential measurements such as the electrocardiogram and newer technologies such as lung monitoring using Electrical Impedance tomography (EIT).

Best student paper award für Michael KircherBest student paper award for Michael Kircher

Michael Kircher was awarded the “Best student paper award” of the 19th International Conference on Biomedical Applications of Electrical Impedance Tomography sponsored by the Institute of Physics (IOP) society. The Conference took place in Edinburgh from June 11th to June 13th.

Neue FiltermethodeNovel filtering method for processing optical mapping data

IBT researchers published a novel method for the analysis of cardiac optical mapping data in the journal of “Computers in Biology and Medicine”. An adaptive spatio-temporal Gaussian filter is presented to process fluorescence-optical mapping data according to the signal characteristics of recorded optical action potentials. The developed filter approach outperformed standard filtering methods from literature at low SNRs. Therefore, experimenters are able to effectively analyze optical mapping data with the help of this new filter approach.

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News 2018-05-09Novel Method for Real Time Assessment of Treatment Efficacy

IBT researchers published a novel method for the immediate assessment of successful treatment together with physicians from the University Heart Centre Freiburg · Bad Krozingen in the journal "JACC Clinical Electrophysiology". The ECG-based method is used to evaluate the completeness of an anterior mitral line during ablation for atrial flutter in the left atrium. Thanks to this new method, the duration of the invasive procedure might shorten markedly and the success rate might increase in future. The clinical study was complemented and fortified by computer simulations performed at IBT.

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2018-05-03Excursion to the cardiac catheterization lab

Last Thursday, research assistants of IBT and IANM visited the cardiac catheterization lab at the Städtische Klinikum Karlsruhe. Dr. Armin Luik and Prof. Dr. Claus Schmitt provided some useful insight into the electrophysiological unit and drew our attention to current scientific questions, which are of major importance to our joint projects.

Zeiss & KITZEISS and KIT Robotics Innovation Competition

Health care technology and application are focus areas of the Zeiss-KIT joint Robotics Innovation Competition.

Technologies (Health Care)
• Tracking and referencing
• Smart instruments as control module
• Real-time control with sensor feedback
• Reinforcement Learning
 
Application (Health Care)
• Microsurgery, e.g. Resection of tumorous tissue
• Ophtalmology, e.g. Interventions on the retina
• Surgery process, e.g. Recognition of persons, role and situations

ZEISS and KIT Robotics Innovation Competition
Werner Nahm im InterviewInterview with Werner Nahm

Interview with Werner Nahm on optical technologies in medicine (medizin&technik 2/2018)

medizin&technik
EAMBES FellowOlaf Dössel appointed Fellow of the EAMBES

Prof. Dr. Olaf Dössel was appointed Fellow of the European Alliance for Medical and Biological Engineering and Science.
In the document it says: „In recognition of distinguished leadership and important contributions to research and advocacy of Medical and Biological Engineering and Science“.
The document was given on the occation of a meeting on 13rd of March 2017 in London.

EAMBES Fellows
IMG KIT-Ehrenabend_2018-02-21KIT Doctoral Award for Gustavo Lenis

Gustavo Lenis is one of the recipients of the 10th KIT Doctoral Award. With this award, KIT honors outstanding doctoral candidates and emphasizes the high status of junior scientists. His doctorate reflects the wide range of research opportunities at KIT and should be a role model for others.

Reentry MapAutomatic identification of atrial tachycardia mechanisms

Atrial tachycardia still poses a major challenge in catheter ablation. Researchers at IBT have developed a method to automatically analyze intracardiac signals leveraging spatio-temporal relationships. Using this method, reentry mechanisms and critical sites in the atria can be automatically identified. Such automatic interpretation of intracardiac mapping data could help to improve the treatment strategy in complex cases of atrial tachycardia. The study was published in the scientific journal "IEEE Transactions on Biomedical Engineering".

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H+EReview article about modeling ischemia

In the special issue "Advances in cardiac cellular electrophysiology – relevance for clinical translation" of the journal "Herzschrittmachertherapie und Elektrophysiologie", a review article about "Cardiac ischemia—insights from computational models" by authors from IBT and the University Heart Center Freiburg/Bad Krozingen will be published. In this article the basics of multiscale computational modeling of cardiac electrophysiology from the molecular ion channel to the whole body scale are described. By modeling cardiac ischemia, it is illustrated how in silico experiments can contribute to our understanding of how the pathophysiolo- gical mechanisms translate into changes observed in diagnostic tools such as the electrocardiogram (ECG). 

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IBT news
FrontiersCommentary in Frontiers in Physiology

IBT researchers have published a commentary on an article recently published in the journal "Frontiers in Physiology". Axel Loewe and Olaf Dössel highlight the achievement of Shim et al., who used computational models to guide cateheter ablation for atrial fibrillation. On the other hand, the commentary points out potential for further optimization of computer-guided personalized therapy. Exploitation of computational models for a better treatment of atrial fibrillation is one of the research focusses at IBT.

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New research assistant at IBT

We would like to welcome Ms. Ekaterina Kovacheva as a research assistant at the Institute of Biomedical Engineering as of November 1st, 2017. As a member of the Computatonal Cardiac Modelling group, Ekaterina Kovacheva is working on the further development and merging of available cardiac models. So far the models for the electrophysiological excitation propagation, elastomechanical contraction, fluid dynamics and the circulatory system are developed separataly. The aim of this project is to implement the mutual interaction - as it is in the real-life heart.

News 2017-12-07Novel method for determination of cardiac conduction velocity

Researcher from IBT together with electrophysiologists at Klinikum Karlsruhe have published an paper introducing a novel method to determine the conduction velocity within the heart. The approach is based on triangulation and provides a means to compute the conduction velocity of  cardiac depolarization waves based in intracardiac catheter measurements. Both computer simulations and clinical measurements werd used to validate the novel method.

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TRMIBT present at TRM Forum

Axel Loewe from IBT was invited to present at the 9th "TRM Forum on the Computer Simulation of Cardiac Function“. The meeting brings together leading experts on computational modeling, experimental assessment, and clinical research in the field of cardiac arrhythmias. We contributed to this year’s theme „From Model to Clinical Outcome“ by presenting work using computational models to validate diagnostic and therapeutic concepts, in particular novel mapping catheters with integrated mini electrodes and ECG features to estimate anatomical properties of the left atrium.

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Baden TV Nov 2017IBT on TV

Together with our collaborators Prof. Schmitt and Dr. Luik from Städtisches Klinikum Karlsruhe, Prof. Dössel discusses cardiac arrhythmias in the show "Klinik Talk". The show is broadcasted on the channel BadenTV and is available online (in German).

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Atrial_Signals_2017Atrial Signals 2017 in Valencia

Three members of IBT, Olaf Dössel, Tobias Oesterlein, and Laura Unger, attended this year’s workshop Atrial Signals in Valencia from October 5th through 7th. We were happy to witness the successful continuation of the workshop after IBT and the Städtisches Klinikum had created and hosted the first Atrial Signals conference in Karlsruhe in 2015. The philosophy of bringing together engineers and physicians once again triggered fruitful panel discussions after each series of talks. As co-founders of the event, both Olaf Dössel and Tobias Oesterlein had the honor of being invited speakers amongst other well-known personalities.

CinC 2017Successful participation in Computing in Cardiology (CinC) conference

Members of IBT presented 8 scientific contributions at the CinC conference in Rennes, France. Two contributions were awarded prizes: The work "ECG as a tool to estimate potassium and calcium concentrations in the extracellular space“ entered the semi-final of the Young Investigators Award. The work "An Interactive Virtual Reality Environment for the Analysis of Clinical Atrial Arrhythmias and Ablation Planning" was honoured with a poster award. Furthermore, members of IBT were involved in the organisation of the conference being session chairs and organisators of the hackathon for inverse problem at this conference.

Potyagaylo newsKlee-Award 2017 of DGBMT goes to Dr.-Ing. Danila Potyagaylo

Danila Potyagaylo introduces new algorithms for the localization of ventricular extrasystoles in his dissertation "Non-invasive Electrocardiographical Imaging of Ventricular Activities", which he has developed at the Institute for Biomedical Technology at the Karlsruhe Institute of Technology (KIT).

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We welcome Mr. Tobias Gerach

Sep/01/2017

We welcome Mr. Tobias Gerach as a new member at the Institute of Biomedical Engineering. Inside the framework of the Collaborative Research Centre 1173: Wave phenomena, Mr. Gerach is working with the cardiac modeling group at IBT on the dynamics of electro-cardiac depolarization waves.

Mr. Gerach received his bachelor and master degrees in geophysics from the Karlsruher Institute of Technology. His research topics at the Geophysical Institute were focused on the simulation of seismic wave fields and the full waveform inversion of seismic waves in maritime environments.

DGBMT 2017IBT strongly represented at the joint annual conference of the Society of Biomedical Engineering and of the Society of Medical Physics

The annual conference of the Society of Biomedical Engineering (DGBMT) 2017 took place in Dresden together with the Society of Medical Physics (DGMP).
Among 700 scientific contributions, the IBT was represented with 19 contributions and was one of the strongest groups at the annual conference. Furthermore, Areg Noshadi, Michael Stritt and Christian Marzi won the 1st, 2nd and 7th prize in the student competition of the DGBMT.

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Presentation of an in-vitro study at EMBC 2017 in Jeju Island

Hyperthermia during radiofrequency ablation causes reversible and irreversible changes of the electrophysiological properties of cardiac tissue. In a recent published study, we investigated changes of conduction velocity in rat myocardium under hyperthermic conditions from macroscopic to microscopic scale by using simultaneous optical mapping and a miniaturized electrode array. The findings of this study may be used to develop further computational models of acute ablation lesions.

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KIT Doktorandenpreis 2017KIT Doctoral Award

July/12/2017
Axel Loewe wins KIT Doctoral Award
KIT acknowledges outstanding doctoral researchers with the KIT Doctoral Award. One of the three prizes for the academic year 2015/16 was awarded to Axel Loewe  who is with the Institute of Biomedical Engineering for his PhD thesis  „Modeling human atrial patho-electrophysiology from ion channels to ECG: substrates, pharmacology, vulnerability, and P-waves“. The prize was awarded at the President’s honorable ceremony and presented by Vice President Kraft.

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Review article "Computerized modeling of the human heart“ published

July/01/2017

The next issue of the journal "Zeitschrift für Medizinische Physik“ features a review article on „Computerized modeling of the human heart“ by Olaf Dössel and Axel Loewe from IBT. The „Forum“ paper summarizes the state-of-the-art regarding modeling of cardiac electrophysiology, elasto-mechanics, fluid dynamics, and the circulatory system. Both the potential and challenges of this complementary research approach are discussed.

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A computational study about the additional benefit of an ablation catheter with integrated mini electrodes

Radiofrequency ablation has become a first-line approach for curative therapy of many cardiac arrhythmias. In a recent published study, the additional diagnostic benefit of an ablation catheter with integrated mini electrodes was investigated. The computational study showed that catheters with mini electrodes bring about additional benefit to differentiate ablated tissue from nonablated tissue in parallel position with high spatial resolution.

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Girls’ Day 2017Girls’ Day 2017 at the IBT

27th of April 2017. The Girls’ Day took place and the IBT is pleased to introduce the world of Medical Technologie to the visiting girls. 19 girls signed in for our workshop on „Technology in the Hospital - visualizing heart and lung activities“. Content was the electric-impedancetomography, photoplethysmography and the electrocardiography. The short introduction into the methods and the fellowing experiments resulted in a phenomenal feedback. The active participation in our build-in questions and experiments made it a great and funny event. We’d like to thank the organizers, supporters, participants and we are looking forward to the next Girls’ Day 2018!

News_2017-04-24IBT presents at ECAS in Rome

Phase mapping may provide important information about cardiac excitation dynamics during atrial fibrillation. Both computation and realistic visualisation of this novel parameter were addressed in two presentations by Tobias Oesterlein on the ECAS conference in Rome. By combined assessment of electrogram data and its spatial position, the presented methods allow an improved visualisation of cardiac excitation. This was a valuable addition to talks by the groups of Sanjiv Narayan and Vadim Fedorov, who established the link between electrogram information, optical mapping and resulting depolarisation patterns.

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Influence of filtering on the ST segment in the ECG

The so-called ST segment in the ECG plays an important role with the diagnosis of myocardial infarction. In a recent published study, the influence of different filtering methods on the ST segment in the ECG was analyzed. Realistic, simulated ECGs with a region of infarction und known noise were used for evaluation. It became apparent, that methods can influence the ST segment in such a manner that the diagnostic information can be falsified.

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2016
Valuable Information Regarding the Interpretation of the Atrial ECG Published

December/23/2016
IBT scientists in collaboration with cardiologists from Lund, Sweden identified mechanisms contributing to the ECG of the atria (P-wave). Results regarding the limited contribution of the left atrium and the influence of the site of earliest activation were published in the renowned journal "Europace“ of the European Society of Cardiology (ESC).

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KatheterPaper about the Mapping using Basket Catheters published

Basket-type catheters allow to acquired simultaneous electrograms from many distributed atrial positions. Correct interpretation of the mapping data, however, is complicated by the deformation of the catheter. We quantitatively analyzed both in-silico and clinical data from panoramic basket catheter mapping in our open-access publication „Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage“. Results emphasize that knowledge about the electrode positions during mapping is required for correct interpretation of panoramic mapping data.

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News 2016-10-06IBT strongly represented at the annual meeting of the German Society for Biomedical Engineering

October/06/2016
With 19 participants and 17 scientific contributions, the IBT was one of the strongest groups at the annual meeting of the German Society for Biomedical Engineering (DGBMT). This year’s meeting was held together with the Austrian and Swiss societies in Basel, CH (D-A-CH). Furthermore, Robin Andlauer and Joachim Greiner did win the first and second prize in the student competition.

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Prof. Dössel gives keynote lecture at IHU-LIRYC

September/28/2016
Prof. Olaf Dössel gives a keynote lecture "Simulated and measured atrial electrograms - what can we learn from a critical comparison?“ at the International Scientifc Workshop of the IHU-Liryc in Bordeaux. L’institut de rhytmologie et modélisation cardiaque is devoted to the study of cardiac electrical disorders and headed by Prof. Michel Haissaguerre.

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IBT contributions win prizes in Vancouver

September/14/2016
IBT’s studies presented at the „Computing in Cardiology“ conference in Vancouver were well received and awarded several prizes. Axel Loewe won the Rosanna Degani Young Investigator Award (YIA) with the paper "Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration“. Moreover, IBT contributions were awarded 2 poster prizes, one YIA semi final participation, and 2 Mortara Fellowships.
 [More] [Conference website]

IBT presents at Cardiac Physiome Workshop in Seoul, Korea

August/26/2016
Results of research conducted at IBT were presented at the workshop of the Cardiac Physiome Society in Seoul, Korea by Axel Loewe. The contribution "P-wave terminal force is affected by site of earliest right atrial activation“ was selected to be presented during one of the 22 oral scientific presentations. [More]

News 2016-04-14IBT awarded teaching prize

April/14/2016
The teaching prize of the faculty of electrical engineering and information technology was awarded to Gustavo Lenis (IBT) at the annual ceremony of the KIT for the creation of the video exercises for the class “Lineare Elektrische Netze”. [More]

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