A Reproducible Protocol to Assess Arrhythmia Vulnerability in silico: Pacing at the End of the Effective Refractory Period

Researchers at IBT showed the influence of the chosen protocol to induce arrhythmia on the assessment of atrial fibrillation vulnerability. They compared state-of-the-art protocols, such as phase singularity distribution and rapid pacing, with their proposed method - pacing at the end of the effective refractory period (PEERP), in a computational study. They concluded that the PEERP can foster standardization and reproducibility, since, in contrast to the other protocols, it is a parameter-free method.

The paper was published in Frontiers of Physiology and is freely available.

Darstellung des transmembranen Potential KIT-IBT
Tansmembrane potential