Engineering for Health

Welcome to the web page of the Institute of Biomedical Engineering (IBT) at Karlsruhe Institute of Technology (KIT). For more than 50 years we have been active in research and teaching in the field of biomedical engineering.

In interdisciplinary projects together with medical doctors and medical industry, we investigate new technical systems that help to diagnose diseases earlier and more accurately as well as systems that make therapies more successful.

The main focus of the research program of Prof. Dr. Werner Nahm's group is optical systems in medicine and life sciences. Current projects are focussing on surgical visualization and optical diagnosis [more].

The group of PD Dr. Axel Loewe develops computational models of the heart and applies them to cardiological problems. We focus on cardiac electrophysiology and elastomechanics to contribute to answer clinical questions such as the genesis of e.g. cardiac arrhythmias and appropriate treatment strategies [more].

The main focus of the research program of Prof. Dr. Olaf Dössel was the analysis of biosignals from the heart (ECG and electrograms) and the imaging of electrophysiological sources in the heart (ECG imaging) [more].

News

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What distinguishes different types of atrial fibrillation?

While good treatment options exist for paroxysmal atrial fibrillation, persistent atrial fibrillation still cannot be treated satisfactorily. Together with researchers from the University Heart Center Freiburg Bad Krozingen, anatomical and functional differences between these two types have now been identified, which may form the basis for future tailored therapeutic approaches.

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Commentary in the Journal of Cardiovascular Electrophysiology

In an invited editorial, Axel Loewe (IBT) and Amir Jadidi (University Heart Center Freiburg Bad Krozingen) discuss the recent article by Boyle et al. in the Journal of Cardiovascular Electrophysiology on predicting the success of pulmonary vein isolation using magnetic resonance imaging.

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Functional characterization of genetic mutations

Together with researchers from Marburg, Munich, Frankfurt, the effect of a new group of genetic mutations on cardiac electrophysiology was investigated. The study was published open access in the special isse "Molecular Effects of Mutations in Human Genetic Diseases" of the "International Journal of Molecular Sciences".

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Comparison of numerical methods to simulate the heart

How do different numerical splitting schemes for solving the monodomain equation of cardiac electrophysiology compare in terms of convergence, accuracy and efficiency? We answer this question collaboratively with mathematicians (CRC 1173 - Wave phenomena) in a study published in the "International Journal of Numerical Methods in Biomedical Engineering".

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Uncertainty quantification for ECG simulations

Together with researchers from the PTB in Berlin, we systematically studied the influence of uncertainty in the input parameters of multiscale heart simulations on the resulting ECG. The work is published open access in the journal "Metrology".

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How important is the reverse mode of the sodium-calcium exchanger?

Together with a team from the University of Szeged, IBT researchers have studied the reverse mode of the sodium-calcium exchanger for the function of the sinus node, the natural pacemaker of the heart. By combining biological experiments and computer simulations, evidence for a crucial role could be demonstrated.

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