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Head of Institute:
Prof. Dr. rer. nat. Olaf Dössel 
Prof. Dr. rer. nat. Werner Nahm


Postal address:
Kaiserstr. 12
76131 Karlsruhe

Visitor / Delivery address:
Building 30.33
Fritz-Haber-Weg 1
76131 Karlsruhe

Fon: +49 721 608-42650
Fax: +49 721 608-42789
E-Mail: infoNsf1∂ibt kit edu

Presentations

Mr B.Sc. Alexander Seer
„Parameterization of a Spatial Cerebral Temperature Model Using Thermal Image Information“
(Master thesis)

Date:  02.Jul.2020    14:00 h

Fs B. Sc. Jeanne Koch
"Enhancing Conduction Velocity Estimation by Atrial Electrogram Analysis“
(Master thesis)

Date:  09.Jul.2020   14:00 h

Mr Carlo Wenzel
"Analysis of stenosis and regurgitation as effects of valve defects on the fluid dynamics in the left heart“
(Bachelor thesis)

Date:   30.Jul.2020  14:00 h

Mr B. Sc. Jose Enaola Capa
"Co- Registrations of Multimodal Datasets in Patient-Specific Computational Models to Correlate Fibrotic Area and Electrograms Signals“
(Master thesis)

Date:  20.Aug.2020 14.00 h

Engineering for Health

Welcome to the web page of the Institute of Biomedical Engineering (IBT) at Karlsruhe Institute of Technology (KIT). For more than 50 years we have been active in research and teaching in the field of biomedical engineering.

In interdisciplinary projects together with medical doctors and medical industry, we investigate new technical systems that help to diagnose diseases earlier and more accurately as well as systems that make therapies more successful.

The main focus of the research program of Prof. Dr. Olaf Dössel is the analysis of biosignals from the heart (ECG and electrograms), the imaging of electrophysiological sources in the heart (ECG imaging). Moreover, we are working on impedance tomography for lung perfusion and hypothermia in stroke patients [more].

The area of research of Prof. Dr. Werner Nahm's group is optical systems in medicine and life sciences. Current projects are focussing on surgical visualization and optical diagnosis [more].

The group of Dr. Axel Loewe develops computational models of the heart and applies them to cardiological problems. We focus on cardiac electrophysiology and elastomechanics to contribute to answer clinical questions such as the genesis of e.g. cardiac arrhythmias and appropriate treatment strategies [more].

 

NEWS

15.Apr.2020: All lectures will take place online for the time being

All IBT lectures will initially take place online in the 2020 summer semester. An exception to this is the Praktikum Biomedizinische Messtechnik, which is postponed to the winter semester 20/21.
All students interested in our courses should join the relevant work areas in ILIAS (no password required). Detailed information on the teaching concept, dial-up options, communication channels, etc. is then communicated via ILIAS for each course. Direct links to the individual ILIAS work areas can be found on the respective lecture pages on the IBT homepage.

18.Mar.2020 Teaching and examinations at KIT temporarily suspended
The KIT will largely stop teaching and testing from March 17th. 2020 decided until April 19th. 2020 inclusive.
- Information on how the KIT Faculty ETIT deals with the changes in teaching and testing
- KIT NEWS: Questions and answers on how to deal with the corona virus
We ask you to write messages to the IBT secretary's office by email and not to appear in person.

 
News 2020-06-23
Identification of intraatrial arrhythmogenic sources

The university clinic of Freiburg and the scientist Mark Nothstein (IBT) have released a paper on the Identification of intraatrial arrhythmogenic sources using intracardiac electrogram characteristics. Several characteristics were explored in-situ and the underlying mechanisms were examined using computational models. Additionally, for one case an in-silico ablation procedure of the detected tissue zone was simulated resulting in the successfull termination of the atrial fibrillation. This work aims to aid clinicians to identify heterogeneous tissue and deepen the understanding of the underlying mechanisms of atrial fibrillation.

More
 
Effect of fibre orientation and bulk modulus on the electromechanical modelling of human ventricles

In collaboration with the group Modeling and Scientific Computing (MOX), at the Politecnico of Milan, the IBT researcher Luca Azzolin presented an electromechanical model of bi-ventricular human geometries and studied the influence of different fibre directions and incompressibility constraint and penalization on the compressibility of the material (bulk modulus) on the pressure-volume relation simulating a full heart beat. The paper showed how various fibre configurations and bulk modulus modified relevant clinical quantities such as stroke volume, ejection fraction and ventricle contractility.

More
 
IMG_2020-06-02_atrial flutter in ECG
New spatio-temporal methods to characterize atrial flutter mechanisms using the ECG

IBT researchers published two novel methods for a non-invasive atrial flutter characterization together with physicians from the University of Leicester, the ABC Federal University, and the clinicians form the Städtisches Klinikum Karlsruhe in the journal “IEEE Transactions on Biomedical Engineering”. Spatio-temporal recurrence quantification analysis methods were used to characterize and discriminate several atrial flutter mechanisms from the 12-lead ECG in a computational framework. Thanks to these methods, the duration of the invasive atrial mapping and ablation procedure might shorten significantly. The computational study was complemented and fortified by a clinical case used as a proof of concept.

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Hemmstoff A293
Potassium channel inhibitor A293 indicates therapeutic potential for the treatment of atrial fibrillation

In collaboration with the Institute of Biomedical Engineering at KIT and the University Heart Center Freiburg – Bad Krozingen, researchers from the Medical University Hospital Heidelberg published an article on the antiarrhythmic effects of A293 on cardioversion of atrial fibrillation. As a high-affinity potassium channel inhibitor, A293 mitigates the pathological shortening of the atrial action potential duration.  The study indicated the therapeutic potential of A293 for the treatment of atrial fibrillation with single cell experiments, a porcine model, as well as computer simulations in a three-dimensional atrium. The open access article was published in the Journal of the American Heart Association (JAHA).

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Natrium-Calcium-Austauschers
What's the role of the sodium calcium exchanger for the spontaneous beating of the heart?

Together with researchers from the University of Szeged, IBT researchers have published a review article on the role of the sodium calcium exchanger for the activity of natural pacemaker cells. These cells are located in the so-called sinus node of the heart and make for the rhythmic beating of our hearts. The review article integrates findings from experimental studies with computational modeling. It was published in the Frontiers in Pharmacology journal and is freely available (open access).

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