Engineering for Health

Welcome to the web page of the Institute of Biomedical Engineering (IBT) at Karlsruhe Institute of Technology (KIT). For more than 50 years we have been active in research and teaching in the field of biomedical engineering.

In interdisciplinary projects together with medical doctors and medical industry, we investigate new technical systems that help to diagnose diseases earlier and more accurately as well as systems that make therapies more successful.

The main focus of the research program of Prof. Dr. Werner Nahm's group is optical systems in medicine and life sciences. Current projects are focussing on surgical visualization and optical diagnosis [more].

The group of PD Dr. Axel Loewe develops computational models of the heart and applies them to cardiological problems. We focus on cardiac electrophysiology and elastomechanics to contribute to answer clinical questions such as the genesis of e.g. cardiac arrhythmias and appropriate treatment strategies [more].

The main focus of the research program of Prof. Dr. Olaf Dössel was the analysis of biosignals from the heart (ECG and electrograms) and the imaging of electrophysiological sources in the heart (ECG imaging) [more].

News

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Comparison of propagation models and forward calculation methods in atrial electrophysiology

IBT members and collaborators from the Medical University of Graz investigated if and to what extent simplified methods and models can yield physiologically accurate results in electrophysiological atrial simulations regarding activation times and electrocardiograms (ECG) while reducing computational cost markedly at the same time. These analyses form the basis for extensive ECG-based simulation studies to e.g., generate large-scale datasets for machine learning approaches.

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Which strategy for ablating atrial fibrillation works best?

IBT researchers, together with the University Hospital of Freiburg, have systematically compared different therapeutic approaches in a cohort of 29 digital twins of atrial fibrillation patients. They were able to show that precise identification of tissue changes is crucial. Personalized computer models can help to achieve the optimal therapeutic success with the smallest possible intervention.

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EMBC 22

44th International Engineering in Medicine and Biology Conference (EMBC) was held in Glasgow, Scotland,  from 11-15 July 2022.
Four representatives from the Institute of Biomedical Engineering (IBT) participated in EMBC 22, with 3 full paper and one absract presentations.

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Computational and Mathematical Biomedical Engineering Conference

This year’s Computational and Mathematical Biomedical Engineering Conference (CMBE22) was hosted by the Politecnico di Milano (Italy) from June 27th to 29th. Jochen Brenneisen presented the latest studies on the Immersed Boundary Method to simulate fluid dynamics in the heart.

It was a great conference with highly interesting presentations and fruitful discussions. Conference proceedings will follow soon on https://www.compbiomed.net/2021/

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IBT research featured in "AI in Healthcare Highlights & Milestones" report 3/22

The machine learning method to predict atrial fibrillation therapy success noninvasively from the ECG is one of the first approaches trained exclusively on data from computational models and benchmarked on real world clinical data.
[report] [paper]

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Is electromechanical tissue coupling a determinant for altered left ventricular rotation patterns?

In cooperation with physicians from the St. Anne’s University Hospital, Brno, researchers at IBT showed that a dyssynchronous activation of the left ventricle is insufficient to result in a breakdown of the typical torsional contraction pattern in patients diagnosed with heart failure.

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