|Comparison of propagation models and forward calculation methods in atrial electrophysiology|
IBT members and collaborators from the Medical University of Graz investigated if and to what extent simplified methods and models can yield physiologically accurate results in electrophysiological atrial simulations regarding activation times and electrocardiograms (ECG) while reducing computational cost markedly at the same time. These analyses form the basis for extensive ECG-based simulation studies to e.g., generate large-scale datasets for machine learning approaches.More
|Which strategy for ablating atrial fibrillation works best?|
IBT researchers, together with the University Hospital of Freiburg, have systematically compared different therapeutic approaches in a cohort of 29 digital twins of atrial fibrillation patients. They were able to show that precise identification of tissue changes is crucial. Personalized computer models can help to achieve the optimal therapeutic success with the smallest possible intervention.More
44th International Engineering in Medicine and Biology Conference (EMBC) was held in Glasgow, Scotland, from 11-15 July 2022.
|Computational and Mathematical Biomedical Engineering Conference|
This year’s Computational and Mathematical Biomedical Engineering Conference (CMBE22) was hosted by the Politecnico di Milano (Italy) from June 27th to 29th. Jochen Brenneisen presented the latest studies on the Immersed Boundary Method to simulate fluid dynamics in the heart.
It was a great conference with highly interesting presentations and fruitful discussions. Conference proceedings will follow soon on https://www.compbiomed.net/2021/Mehr
|IBT research featured in "AI in Healthcare Highlights & Milestones" report 3/22|
|Klee Prize for Giorgio Luongo|
The German Society for Biomedical Engineering (DGBMT) annually awards the Klee Prize to scientists for practical developments in the field of medical technology. Giorgio Luongo was awarded 3rd place for his dissertation "Non-Invasive Atrial Arrhythmia Diagnosis Using the 12-Lead ECG: Machine Learning Leveraging in-silico and Clinical Signals" at IBT.
|Prof. Olaf Dössel was honored for his outstanding scientific achievements in the faculty council|
The wish and application of the division and faculty management to appoint the recently retired Prof. Dössel as a Distinguished Senior Fellow was positively approved by the KIT. Prof. Dössel is involved, among other things, in 3 academies of science and in international professional societies as well as an expert in his field of medical technology.
|New research assistant at IBT|
As of June 2022, the IBT welcomes Joshua Steyer as a new research assistant within the „Computational Cardiac Modelling“ group. In the scope of the MICROCARD research project, he will investigate the effect of microscopic tissue structure on clinical electrograms using HPC simulations for an improved assessment of the vulnerability to arrhythmias and tailored ablation strategies. He studied physics and numerically analyzed spatiotemporally chaotic excitation dynamics of the heart during his Master’s thesis at the MPI for Dynamics and Self-Organization.More
|Is electromechanical tissue coupling a determinant for altered left ventricular rotation patterns?|
In cooperation with physicians from the St. Anne’s University Hospital, Brno, researchers at IBT showed that a dyssynchronous activation of the left ventricle is insufficient to result in a breakdown of the typical torsional contraction pattern in patients diagnosed with heart failure.More
|Graduation Tobias Gerach|
Tobias Gerach successfully defended his dissertation „ Personalized Electromechanical Modeling of the Human Heart - Challenges and Opportunities in Pathophysiological Scenarios “ on May 19th 2022 and passed the doctoral exam with distinction. Sincere congratulations to our new PhD from the team’s whole heart!
|Tribute for Prof. Em. Olaf Dössel|
Olaf Dössel was appointed Fellow of the International Union for Physical and Engineering Sciences in Medicine (IUPESM) in recognition of his outstanding contribution to the international development of physical and engineering sciences in medicine.
|DGK Annual Meeting|
The 88th Annual Meeting of the German Society of Cardiology, which was held for the first time since 2019 in the presence of the Congress Center Rosengarten in Mannheim, was very well attended.
|Deborah Nairn, PhD|
Deborah Nairn successfully defended her PhD thesis „Multi-Modality Correspondence to Enhance Arrhythmogenic Atrial Substrate Identification - Guiding Persistent Atrial Fibrillation Ablation Therapy“ on April 14th, 2022.
|Symposium and farewell party for Prof. Dr. Olaf Dössel|
After more than 25 years at the Faculty of Electrical Engineering and Information Technology, Prof. Dr. Olaf Dössel with a symposium on medical technology and with various subsequent celebrations in retirement. Specialist presentations by current and former representatives of the Institute for Biomedical Engineering (IBT) and the Städtisches Klinikum were followed by greetings from the KIT, Division III, professional associations, companions as well as the faculty and student council. At the celebration that followed, the IBT said goodbye to its head of institute with various musical personal contributions and with the traditional, self-made "doctoral hat".
|EHRA Congress 2022|
Carmen Martinez, scientist in the IBT, presented her research results in the EHRA Congress 2022 poster sessions under the title: “Impact of contact force on local impedance measurements in different atrial locations“. The conference took place in Copenhage between the 3rd and the 5th of April. The scientific program of this year was focused on “Getting back to the rhythm!”, referring also to the recovering of on-site conferences after the pandemic.More
|Development environment for sustainable research software|
How can the maintenance effort for research software be reduced by clever concepts and automation? The article published in the journal "Bausteine Forschungsdatenmanagement" presents ideas and solutions using the example of openCARP.More
|PhD Laura Unger|
Laura Unger successfully defended her PhD thesis „Multimodal Characterization of the Atrial Substrate – Risks and Rewards of Electrogram and Impedance Mapping“ on February 22nd, 2022 and passed the doctoral examination with distinction. Our heartfelt congratulations!
|Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment|
A recent research topic published in the renowned Frontiers in Physiology journal highlights the latest progress in technology for atrial fibrillation diagnosis, monitoring and treatment.
|Which atrial fibrillation patients are at increased risk for heart failure?|
Together with physicians at Freiburg University Hospital, IBT researchers present a method to non-invasively identify those atrial fibrillation patients at increased risk of heart failure. The method is based on machine learning on the electrocardiogram.More
|What ECG can tell us about the events on a molecular scale|
|Software Carpentry Workshop at KIT|
On April 11th and 12th 2022, the Institute of Biomedical Engineering is hosting a workshop which aims at teaching foundational coding to researchers, open to registration for all KIT members.More
|New research assistant at IBT|
The Institute of Biomedical Engineering welcomes Mr. Jonathan Krauß as a new research assistant. Since January 2022, he has been working in the "Computational Cardiac Modeling“ research group on electro-mechanically coupled human heart simulations. For this purpose, efficient and robust coupling schemes will be developed and evaluated.
|Let's to talk about research software|
In the days of Otto Hahn and Lise Meitner, scientific life was characterized solely by laboratory experiments, observations of nature and theoretical considerations, scientific essays and discourses. What has changed in the last 100 years? Nowadays, there is hardly a field in which research can be carried out without software.More
|Hybrid machine learning to localize atrial flutter substrates using the surface 12-lead ECG|
IBT former researcher Giorgio Luongo, PhD presented a hybrid machine learning-based classification of 12-lead ECG to discriminate between patients with three different kind of atrial flutter (cavotricuspidal-isthmus-dependent vs. peri-mitral vs. other left atrium atrial flutters). This novel algorithm may aid to identify non-invasively the best ablation procedure to terminate the arrhythmia prior to the invasive procedure in the EP labs. This work is the result of a successful collaboration between 5 engineering and clinical groups (Università degli Studi di Milano, University of Leicester, ABC Federal University, Städtisches Klinikum Karlsruhe and IBT). The paper is published in EP Europace journal and is freely available.More
|Blood flow shows minor effects on the deformation of the healthy heart|
Researchers of the IBT and the ISTM (Institute of Fluid Mechanics, KIT) have implemented a sequential coupling approach and found that the influence of the blood flow only slightly changes the deformation of the heart wall.More
|Progress - first technical, then clinical|
The international "Atrial Signals" congress took place for the fourth time in September 2021 under the patronage of the Karlsruhe Municipal Hospital (Prof. Dr. med. Claus Schmitt) and the Karlsruhe Institute of Technology (Prof. Dr. rer. nat. Olaf Dössel ) including synergy effects.More
|ECG Imaging improved|
The solution of the inverse problem for ECG imaging (ECGI) is prone to detection of artifacts. A team around IBT researcher Steffen Schuler presented a method to avoid line-of-block artifacts to improve ECGI as a noninvasive diagnostic tool.More
|Influence of cardiac motion on the ECG|
Using an electromechanical computational model, researchers at IEKM in Freiburg and IBT could quantify the effect that cardiac motion has on the ECG. This work is an important basis for faster ECG simulations in the future.More
|EP Europace cover story|
A joint study of the University Heart Center Freiburg-Bad Krozingen and the IBT is featured on the cover page of the December issue of the renowned scientific journal "EP Europace". The study uses the ECG and ECGI to diagnose pathological changes in the atria.More
|Axel Loewe completes habilitation|
With the colloquium "Machine Learning for Medicine and the Role of Simulated Data", Dr.-Ing. Axel Loewe qualified as a university lecturer for the field "Modeling and Simulation for Medicine".More
|PhD Mark Nothstein|
The graduations season continues at IBT. We are very proud to announce that Mark Nothstein has successfully defended his PhD thesis: "Characterizing Atrial Fibrillation Substrate by Electrogram and Restitution Analysis”. Look what a nice hat his colleagues have made for him!More
|PhD Steffen Schuler|
Last week, Steffen Schuler from our group successfully defended his thesis “Novel Methods to Incorporate Physiological Prior Knowledge into the Inverse Problem of Electrocardiography” Congratulations to our newest PhD! #phdlife #CardioTwitter.More
|Directed Graph Mapping for Atrial Flutter|
IBT researchers in the MY-ATRIA consortium have published a new method to better characterize atrial flutter. The approach makes use of graph-theoretical methods.More
|American Heart Association Meeting|
Claudia Nagel participated at the Cardiac Physiome Workshop and at the annual meeting of the American heart association. She presented her latest results regarding the influence of the ventricular shape on simulated QRS complexes in the ECG and showed that an estimation of the left atrial fibrotic volume fraction based on simulated P waves was possible with an average error of 8.7%.More
|IBT at BMT|
20 employees and students of IBT attended this year's annual meeting of the German society of biomedical engineering. 9 presentations and 3 posters from the three research groups were held and presented. Congratulations to Giorgio Luongo for winning the 2nd price for patient safety and to Hannes Welle for the 2nd place in the student competition.More
|Virtual Metrology Meeting (VirtMet)|
Olaf Dössel and Claudia Nagel participated in the first international workshop on metrology for virtual measuring instruments. Olaf Dössel held a keynote lecture about digital twins in medicine and Claudia Nagel talked about how fidelity of simulated ECGs can be assessed for a successful and meaningful application of simulated signals to clinical use cases.
|Workshop on Statistical Atlases and Computational Modeling of the Heart (STACOM)|
Claudia Nagel presented her work at the workshop for Statistical Atlases and Computational Modeling of the Heart (STACOM). In her presentation, she talked about an application of the bi-atrial statistical shape model developed at IBT for identifying left atrial enlargement with the 12-lead ECG.More
|Atrial Signals conference|
The biannual Atrial Signals conference convened at KIT in September. More than 200 experts from both engineering and clinical communities joined discussions and presented the latest research.More
|Award for Patient Safety in Biomedical Engineering 2021|
Let's congratulate our colleague Giorgio Luongo and the whole team for winning the second prize for the patient safety in biomedical engineering 2021 with the publication “Machine learning enables noninvasive prediction of atrial fibrillation driver location and acute pulmonary vein ablation success using the 12-lead ECG”. The award was handed in occasion of the BMT 21 conference in Hannover, and offered by the German Society of Biomedical Engineering (DGBMT).More
|New research scholarship holder at IBT|
We welcome Miriam Weiß as a new research scholarship holder in the group "Optical Technologies in Medicine".More
|Cobiveco: Consistent biventricular coordinates|
IBT researchers have published an improved ventricular coordinate system for localization, data mapping and regression on cardiac geometries. An open MATLAB implementation of the method for precise and intuitive description of position in the heart is available for the community.
|Software Carpentry Workshop at KIT|
On October 28th and 29th 2021, the Institute of Biomedical Engineering is hosting a workshop which aims at teaching foundational coding to researchers, open to registration for all KIT members.More
|Statistical Shape Model of the Atria|
Claudia Nagel, Steffen Schuler, Olaf Dössel and Axel Loewe published a paper on a bi-atrial statisical shape model. The model includes the anatomical shape variations of the atria in the study population and was analyzed with standard evaluation criteria. The shape model and 100 exemplary atrial geometries suitable for electrophysiological simulations are openly available online.More
|Research Software - Sustainable Development and Support|
IAMO Policy Brief 42 focuses on the needs and strategies for sustainable research software practices based on a position paper.More
|Review article on the calculation of the ECG with the help of computer models of the heart published|
Olaf Dössel, Giorgio Luongo, Claudia Nagel and Axel Loewe have written a review article that deals with the calculation of the ECG from computer models of the heart. Both the healthy heart and simulations of various heart diseases are considered. It becomes clear how computer modeling can contribute to a better interpretation of the EKG.More
|Mechanisms of hypertrophic cardiomyopathy|
Hypertrophic cardiomyopathy impairs cardiac mechanics but the differential effects of a thicker wall, reduced active force, fiber disarray and increased tissue stiffness are not clear. IBT researchers could elucidate their contribution to deformation, strain, strain rate and wall thickening using a computational model of the heart.More
|iHeart conference 2021|
|Promotion Ekaterina Kovacheva|
On the 8th of July Ekaterina Kovacheva completed her PhD with the title “Model Based Estimation of the Elastomechanical Properties of the Human Heart.” Congratulations from everyone at IBT.More
|Doctorate Jorge Sanchez|
Congratulations to Jorge Patricio Sanchez Arciniegas on the completion of his PhD and the beginning of his work at IBT as a postdoc.More
|Computer Model of a personalized heart|
In cooperation with the IANM (KIT) and the IEKM (University Heart Center Freiburg), researchers at IBT proposed an electro-mechanically coupled computer model of a personalized human heart. The manuscript was published in the Journal Mathematics.More
|Transit Time Measurement in Indicator Dilution Curves|
|Number of cameras for the 3D reconstruction|
|EHRA Congress 2021|
A scientist of the IBT presented and discussed their research titled: “Spatial and Quantitative Assessment of the Correlation between Sinus Rhythm and Atrial Fibrillation Voltage Mapping to Identify Low Voltage Substrate in Persistent Atrial Fibrillation“ at this years EHRA congress. The congress was held online from the 23-25th of April, with this years' scientific program emphasising “Making connections to overcome arrhythmia”.
|Estimation of Atrial Fibrosis with the ECG|
Researchers at IBT investigated whether the amount of diseased fibrotic tissue in the atria can be estimated non-invasively and quantitatively with features extracted from P waves of the 12-lead ECG.
|Girls’ Day 2021|
Der Workshop des IBT im Rahmen des Girls‘ Day 2021 traf auf großes Interesse des weiblichen Nachwuchses in den Bereichen Medizin und Technik.More
|Simon Hoffmann will be research assistant at IBT|
We welcome Mr. Simon Hoffmann as a research assistant. His work will focus on data processing in ophthalmology.More
|New research assistant at IBT|
Since April 1st, 2021 Dr. Marie Houillon is new research assistant in the computational cardiac modeling group at IBT.More
|Non invasive prediction of atrial fibrillation driver location|
IBT researcher Giorgio Luongo and colleagues presented a machine learning-based classification of 12-lead ECG to discriminate between patients with pulmonary vein drivers vs. those with extra-pulmonary vein drivers of atrial fibrillation.
|Protocol to Assess Arrhythmia Vulnerability|
Researchers at IBT showed the influence of the chosen protocol to induce arrhythmia on the assessment of atrial fibrillation vulnerability.More
|Computational hearts for success of therapy|
KIT's Institute of Biomedical Engineering develops, based on mathematical equations, a computational heart model to enable targeted therapy of cardiac arrhythmias. The model supports medical research and development in the fields of diagnostic and therapeutic approaches.More
|Estimating Cardiac Active Tension from Wall Motion - An Inverse Problem of Cardiac Biomechanics|
IBT researches have published a paper, which presents a model-based method for solving an inverse problem of the heart biomechanics.More
|Cycle Length Statistics during ongoing Atrial Fibrillation Yield Refractory Measure|
Researchers at IBT showed that the statistical analysis of cycle lengths during atrial fibrillation allows to estimate refractory periods of the underlying substrate. The study combines a broad set of simulations with clinical acquisitions and was published in Europace EP.More
|Graduation Nicolas Pilia|
Nicolas Pilia defended his dissertation „Electrocardiogram Signal Analysis and Simulations for Non-Invasive Diagnosis - Model-Based and Data-Driven Approaches for the Estimation of Ionic Concentrations and Localization of Excitation Origins“ on February 18th 2021 and graduated with distinction. Congratulations!
|Whitepaper on sustainable development of research software in Germany|
|Comparison of Unipolar and Bipolar Voltage Mapping|
Das IBT nimmt an der jährlichen VDE DGBMT Kongressveranstaltung teil.Mehr
|North Baltic Conference 2020|
A scientist of the IBT presented and discussed his results on the simulation of the propagation of photons in a blood vessel.More
|Computing in Cardiology 2020|
Eight delegates represented IBT at this year’s Computing in Cardiology conference in Rimini which brought together both onsite and remote participants during the COVID-19 pandemic.More
|Review article on the ECG-based potassium and calcium concentration estimation|
|A digital heart|
The current issue of the popular scientific journal „Spektrum der Wissenschaft“, the German branch of the Scientific American, features an article of the head of the Computational Cardiac Modeling group at IBT. Under the headline „A digital heart“, Axel Loewe describes the motivation for and the basics of computational heart models and illustrates first successful examples of translation to clinical practice and clinical research.More
|Geodesic Length Measurement in Medical Images|
Publication of the investigation of the discretization error and its reduction in the geodesic length measurement.More
|Artificial intelligence in medicine|
That is the topic of the Herrenhausen Forum on July 14, 2020. The discussion with experts from IT, medicine and law was about responsibility and trust.More
|Identification of intraatrial arrhythmogenic sources|
Contributions by the university medical center Freiburg and IBT resulted in a paper on the identification of intraatrial arrhythmogenic sources using intracardiac electrogram characteristics.More
|Effect of fibers and bulk modulus on the electromechanics of the ventricle|
In collaboration with the Politecnico of Milan, IBT presented an electromechanical model of bi-ventricular human geometries to study influences on the pressure-volume relation.More
|New spatio-temporal methods to characterize atrial flutter mechanisms using the ECG|
IBT researchers published two novel methods for a non-invasive atrial flutter characterization together with physicians from the University of Leicester, the ABC Federal University, and the clinicians form the Städtisches Klinikum Karlsruhe in the journal “IEEE Transactions on Biomedical Engineering”. Spatio-temporal recurrence quantification analysis methods were used to characterize and discriminate several atrial flutter mechanisms from the 12-lead ECG in a computational framework. Thanks to these methods, the duration of the invasive atrial mapping and ablation procedure might shorten significantly. The computational study was complemented and fortified by a clinical case used as a proof of concept.More
|Potassium channel inhibitor A293 indicates therapeutic potential for the treatment of atrial fibrillation|
In collaboration with the Institute of Biomedical Engineering at KIT and the University Heart Center Freiburg – Bad Krozingen, researchers from the Medical University Hospital Heidelberg published an article on the antiarrhythmic effects of A293 on cardioversion of atrial fibrillation. As a high-affinity potassium channel inhibitor, A293 mitigates the pathological shortening of the atrial action potential duration. The study indicated the therapeutic potential of A293 for the treatment of atrial fibrillation with single cell experiments, a porcine model, as well as computer simulations in a three-dimensional atrium. The open access article was published in the Journal of the American Heart Association (JAHA).More
|What's the role of the sodium calcium exchanger for the spontaneous beating of the heart?|
Together with researchers from the University of Szeged, IBT researchers have published a review article on the role of the sodium calcium exchanger for the activity of natural pacemaker cells. These cells are located in the so-called sinus node of the heart and make for the rhythmic beating of our hearts. The review article integrates findings from experimental studies with computational modeling. It was published in the Frontiers in Pharmacology journal and is freely available (open access).More
|Policy paper on Research Software Engineering in Germany|
The collaborative opinion article "An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action" was recently published as a preprint for open peer review in F1000Research. This paper is the outcome of a workshop at the first German conference on Research Engineering and a dedicated DFG-funded follow up workshop hosted by the Robert Koch Institute. KIT and IBT researchers played a leading role in bringing together the group and coordinating the writing process. With more than 40 authors and wide community review, this grass-roots initiative calls for action to make software a first class citizen in research.More
openCARP is an open cardiac electrophysiology simulator for in-silico experiments. Its source code is public and the software is freely available for academic purposes. openCARP is easy to use and offers single cell as well as multiscale simulations from ion channel to organ level. Additionally, openCARP includes a wide variety of functions for pre- and post-processing of data as well as visualization. The python-based CARPutils framework enables the user to develop and share simulation pipelines, i.e. automating in-silico experiments including all modeling/simulation steps.
|SPIE Photonics West|
Two members of the IBT attended, presented two talks and shared their results on novel segmentation methods and a 3D microscale test target at the SPIE Photonics West Conference in San Francisco on the 01st February to 06th February. The useful feedback will be incorporated in further research and contact to possible new collaborates was set.
|What makes the heart beat?|
The sinus node is the natural pacemaker of the heart initiating each heart beat. Its pacemaking function results from the interplay of to cooperating systems: the so-called membrane clock and the calcium clock. The precise role of these two mechanisms is incompletely understood. Together with a group of experimental researchers from Szeged (Hungrary), the Cardiac Modeling group could now further elucidate the role of the calcium clock. A novel pharmacological agent allows to specifically block the sodim-calcium exchanger. IBT researcher could reproduce and further investigate this effect mechanistically in a computational model. By combining experiment and computer simulation, the crucial role of the sodium-calcium exchanger and the interplay with the membrane clock could be consolidated. The study explains how the natural pacemaker of the heart becomes robust and reliable through the interplay of the two systems calcium clock and membrane clock.More
|Heart Simulator 1.0|
The issue 1/2020 of the "dotnetpro“ journal features an article about the research of the cardiac modeling group. dotnetpro delivers expert knowledge for software developers, who use Microsoft technologies to write programs for Microsoft and non-Microsoft platforms. The idea behind the article is to provide a broader view for the dotnetpro readers, who mostly are software developers. The article introduces and describes the implementation of the multiscale simulation approach (from ion channels via cells and tissue up to the organ) for electrophysiology, which is developed and used at IBT.More
|Towards the Digital Twin|
Axel Loewe from IBT was invited to present at the 10th "TRM Forum on the Computer Simulation of Cardiac Function“. The meeting brings together leading experts on computational modeling, experimental assessment, and clinical research in the field of cardiac arrhythmias. We contributed to this year’s theme „Towards the Digital Twin“ by presenting work that allows to build a biomechanical twin of an individual patient. In addition, the session "Atrial modeling & experimental data" was chaired by the IBT researcher.More