Together with researchers from the Medical University of Graz, PTB Berlin and King's College London, we have published a dataset of 16,900 synthetic ECGs. The ECGs have been generated by detailed computer simulations that allow each ECG signal to be traced back to unique model parameters with biological meaning.

The IBT and Prototera Association (Portugal) established an agreement for 4-year PhD fellowships funded by the Portuguese Government. Students who are interested in doctoral research projects in the field of Image Guidance in Proton Therapy can contact Prof. Francesca Spadea mf.spadea@kit.edu. The 4 year project will be conducted in joint collaboration with the University “Instituto Superior Técnico” of Lisbon.

Together with physicians from the University Heart Center Freiburg Bad Krozingen, we compared whether substrate underlying atrial fibrillation can be localized not only in sinus rhythm but also during atrial fibrillation. The moderate agreement suggests to perform the investigation in sinus rhythm.

At the SIAM Conference in Portland, Cristian Barrios Espinosa presented research on advancing machine learning methods in cardiology. Discover more about the diverse applications of dynamical systems in medicine.

From May 24-26, we could welcome around 60 international guests in Karlsruhe for the 5th openCARP user meeting. The fully booked workshop offered training and discussion formats for both new users and experts.

The Institute of Biomedical Engineering welcomes Mr. Moritz Linder as a new research associate. Moritz Linder completed a master's degree in mechatronics and information technology at the KIT.

Classic machine learning methods require the pre-processing of ECG signals. Together with researchers from the University of Oldenburg, PTB Berlin, Aalborg University and Charité Berlin, among others, IBT researchers have recently published annotations of more than 20,000 ECGs. For this, also signal processing algorithms developed at the IBT were used.

At the beginning of May, we had the pleasure to welcome about 30 researchers from all over Europe at KIT, who are working on the improvement of diagnosis and therapy of atrial fibrillation in the European PersonalizeAF project. After two days of "Career Opportunities Workshop" for the 15 PhD students, the focus of the last two days was on the exchange of latest research results.

The European Heart Rhythm Association (EHRA) conference took place in Barcelona on April 16-18, 2023 at its 20th anniversary. Our PhD student Patricia Martínez was nominated for a Young Investigator Award in Clinical and Translational Science.

In collaboration with University Magna Graecia (Italy), Politecnico di Milano (Italy) and our Clinical Partner at San Raffaele Hospital of Milan (Italy), we proved that the prognostic value of radiomics features extracted from MR images of PCNSL patients overcomes the current prediction model based on clinical features. These results pave the way for further investigations on the potential role of image features to drive treatment choice.

Last week the Gordon Research Conference (GRC) on Cardiac Arrhythmia Mechanisms was held in Galveston (Texas, USA). Patricia Martínez and Albert Dasí won first prize in the student poster competition.

On March 29th and 30th 2023, the Institute of Biomedical Engineering is hosting a workshop which aims to teach foundational coding to researchers, open to registration for all KIT members.

On January 1, 2023, Prof. Maria Francesca Spadea took over the professorship for modeling and simulation in medical technology at the Institute of Biomedical Engineering.

While good treatment options exist for paroxysmal atrial fibrillation, persistent atrial fibrillation still cannot be treated satisfactorily. Together with researchers from the University Heart Center Freiburg Bad Krozingen, anatomical and functional differences between these two types have now been identified, which may form the basis for future tailored therapeutic approaches.

Together with researchers from Marburg, Munich, Frankfurt, the effect of a new group of genetic mutations on cardiac electrophysiology was investigated. The study was published open access in the special isse "Molecular Effects of Mutations in Human Genetic Diseases" of the "International Journal of Molecular Sciences".

Together with researchers from the PTB in Berlin, we systematically studied the influence of uncertainty in the input parameters of multiscale heart simulations on the resulting ECG. The work is published open access in the journal "Metrology".

With contributions of IBT as coeditor and authors of two chapters on machine learning in cardiac electrophysiology and cardiac digital twin modeling, the book was published in the series Lecture Notes in Bioengineering of the Springer publishing house.

Claudia Nagel successfully defended her PhD thesis „Multiscale Cohort Modeling of Atrial Electrophysiology - Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms“ on November 17th, 2022. Our heartfelt congratulations!

From September 28 to September 30 the IBT took part at BMT2022 ("Joint Annual Conference of the Austrian, German and Swiss Societies for Biomedical Engineering") in Innsbruck. 3 students and 4 PhDs were responsible for 5 presentations and 2 posters in total. Jule Bender won second place in the student's competition for her paper "A Large-Scale Virtual Patient Cohort to Study ECG Features of Interatrial Conduction Block". Congratulations!
Additionally, two former PhDs were awarded retrospectively for their PhD theses. Congratulations to Giorgio Luongo for getting third place in the Klee Award as well as to Ady Naber for winning the first place award for patient security.

The 49th edition of Computing in Cardiology (CinC) took place in Tampere, Finland from 04-07 Sep, 2022. 5 current PhD students from the IBT as well as Albert Dasí who is visiting our lab presented their recent work. Carmen Martínez was recognized as a semi-finalist for the Young Investigators Award and former postdoc Jorge Sánchez took home the Poster Award for the work he did while still at the IBT. Congratulations, Carmen and Jorge!

IBT researchers, together with the University Hospital of Freiburg, have systematically compared different therapeutic approaches in a cohort of 29 digital twins of atrial fibrillation patients. They were able to show that precise identification of tissue changes is crucial. Personalized computer models can help to achieve the optimal therapeutic success with the smallest possible intervention.

This year’s Computational and Mathematical Biomedical Engineering Conference (CMBE22) was hosted by the Politecnico di Milano (Italy) from June 27th to 29th. Jochen Brenneisen presented the latest studies on the Immersed Boundary Method to simulate fluid dynamics in the heart.

It was a great conference with highly interesting presentations and fruitful discussions. Conference proceedings will follow soon on https://www.compbiomed.net/2021/

The German Society for Biomedical Engineering (DGBMT) annually awards the Klee Prize to scientists for practical developments in the field of medical technology. Giorgio Luongo was awarded 3rd place for his dissertation "Non-Invasive Atrial Arrhythmia Diagnosis Using the 12-Lead ECG: Machine Learning Leveraging in-silico and Clinical Signals" at IBT.
[DGMBT news] [thesis]

As of June 2022, the IBT welcomes Joshua Steyer as a new research assistant within the „Computational Cardiac Modelling“ group. In the scope of the MICROCARD research project, he will investigate the effect of microscopic tissue structure on clinical electrograms using HPC simulations for an improved assessment of the vulnerability to arrhythmias and tailored ablation strategies. He studied physics and numerically analyzed spatiotemporally chaotic excitation dynamics of the heart during his Master’s thesis at the MPI for Dynamics and Self-Organization.

Tobias Gerach successfully defended his dissertation „ Personalized Electromechanical Modeling of the Human Heart - Challenges and Opportunities in Pathophysiological Scenarios “ on May 19th 2022 and passed the doctoral exam with distinction. Sincere congratulations to our new PhD from the team’s whole heart!

The 88th Annual Meeting of the German Society of Cardiology, which was held for the first time since 2019 in the presence of the Congress Center Rosengarten in Mannheim, was very well attended. 
More than 7,100 audience members watched the sessions of the 88th Annual Meeting, the majority of them - more than 5,300 people - on site in Mannheim. The IBT was represented with several posters and an invited talk on "Computational Cardiac Modeling - Synergies with Machine Learning" (Axel Loewe).

After more than 25 years at the Faculty of Electrical Engineering and Information Technology, Prof. Dr. Olaf Dössel with a symposium on medical technology and with various subsequent celebrations in retirement. Specialist presentations by current and former representatives of the Institute for Biomedical Engineering (IBT) and the Städtisches Klinikum were followed by greetings from the KIT, Division III, professional associations, companions as well as the faculty and student council. At the celebration that followed, the IBT said goodbye to its head of institute with various musical personal contributions and with the traditional, self-made "doctoral hat".
Many thanks to Olaf Dössel and all the best for your retirement!

How can the maintenance effort for research software be reduced by clever concepts and automation? The article published in the journal "Bausteine Forschungsdatenmanagement" presents ideas and solutions using the example of openCARP.

A recent research topic published in the renowned Frontiers in Physiology journal highlights the latest progress in technology for atrial fibrillation diagnosis, monitoring and treatment.
The collection of 38 articles was co-edited by IBT researcher Axel Loewe and features 3 studies in which IBT was involved.

Our research is featured in the latest episode of Renal Research Institute's "Frontiers in Kidney Medicine and Biology" in an interview with Axel Loewe. Watch the video, listen to the podcast, or read the transcript.

The Institute of Biomedical Engineering welcomes Mr. Jonathan Krauß as a new research assistant. Since January 2022, he has been working in the "Computational Cardiac Modeling“ research group on electro-mechanically coupled human heart simulations. For this purpose, efficient and robust coupling schemes will be developed and evaluated. 
Jonathan Krauß completed his studies in mechanical engineering at KIT. His research topics were focused on continuum mechanics and medical robotics.

IBT former researcher Giorgio Luongo, PhD presented a hybrid machine learning-based classification of 12-lead ECG to discriminate between patients with three different kind of atrial flutter (cavotricuspidal-isthmus-dependent vs. peri-mitral vs. other left atrium atrial flutters). This novel algorithm may aid to identify non-invasively the best ablation procedure to terminate the arrhythmia prior to the invasive procedure in the EP labs. This work is the result of a successful collaboration between 5 engineering and clinical groups (Università degli Studi di Milano, University of Leicester, ABC Federal University, Städtisches Klinikum Karlsruhe and IBT). The paper is published in EP Europace journal and is freely available.

The international "Atrial Signals" congress took place for the fourth time in September 2021 under the patronage of the Karlsruhe Municipal Hospital (Prof. Dr. med. Claus Schmitt) and the Karlsruhe Institute of Technology (Prof. Dr. rer. nat. Olaf Dössel ) including synergy effects.

A joint study of the University Heart Center Freiburg-Bad Krozingen and the IBT is featured on the cover page of the December issue of the renowned scientific journal "EP Europace". The study uses the ECG and ECGI to diagnose pathological changes in the atria.

The graduations season continues at IBT. We are very proud to announce that Mark Nothstein has successfully defended his PhD thesis: "Characterizing Atrial Fibrillation Substrate by Electrogram and Restitution Analysis”. Look what a nice hat his colleagues have made for him!

IBT researchers in the MY-ATRIA consortium have published a new method to better characterize atrial flutter. The approach makes use of graph-theoretical methods.

20 employees and students of IBT attended this year's annual meeting of the German society of biomedical engineering. 9 presentations and 3 posters from the three research groups were held and presented. Congratulations to Giorgio Luongo for winning the 2nd price for patient safety and to Hannes Welle for the 2nd place in the student competition.

Claudia Nagel presented her work at the workshop for Statistical Atlases and Computational Modeling of the Heart (STACOM). In her presentation, she talked about an application of the bi-atrial statistical shape model developed at IBT for identifying left atrial enlargement with the 12-lead ECG.

Let's congratulate our colleague Giorgio Luongo and the whole team for winning the second prize for the patient safety in biomedical engineering 2021 with the publication “Machine learning enables noninvasive prediction of atrial fibrillation driver location and acute pulmonary vein ablation success using the 12-lead ECG”. The award was handed in occasion of the BMT 21 conference in Hannover, and offered by the German Society of Biomedical Engineering (DGBMT).

IBT researchers have published an improved ventricular coordinate system for localization, data mapping and regression on cardiac geometries. An open MATLAB implementation of the method for precise and intuitive description of position in the heart is available for the community.
To the article

Claudia Nagel, Steffen Schuler, Olaf Dössel and Axel Loewe published a paper on a bi-atrial statisical shape model. The model includes the anatomical shape variations of the atria in the study population and was analyzed with standard evaluation criteria. The shape model and 100 exemplary atrial geometries suitable for electrophysiological simulations are openly available online.

Olaf Dössel, Giorgio Luongo, Claudia Nagel and Axel Loewe have written a review article that deals with the calculation of the ECG from computer models of the heart. Both the healthy heart and simulations of various heart diseases are considered. It becomes clear how computer modeling can contribute to a better interpretation of the EKG.

During the iHeart conference from July 1-3, about 200 participants virtually presented and discussed their research. The IBT was successfully involved with two presentations.

Congratulations to Jorge Patricio Sanchez Arciniegas on the completion of his PhD and the beginning of his work at IBT as a postdoc.

Researchers at IBT investigated how accurate a transit time measurement of an indicator bolus can be and proposed methods to enhance the accuracy. The work was published in the  Frontiers in Physiology .

A scientist of the IBT presented and discussed their research titled: “Spatial and Quantitative Assessment of the Correlation between Sinus Rhythm and Atrial Fibrillation Voltage Mapping to Identify Low Voltage Substrate in Persistent Atrial Fibrillation“ at this years EHRA congress. The congress was held online from the 23-25th of April, with this years' scientific program emphasising “Making connections to overcome arrhythmia”.

Der Workshop des IBT im Rahmen des Girls‘ Day 2021 traf auf großes Interesse des weiblichen Nachwuchses in den Bereichen Medizin und Technik.

Since April 1st, 2021 Dr. Marie Houillon is new research assistant in the computational cardiac modeling group at IBT.

Researchers at IBT showed the influence of the chosen protocol to induce arrhythmia on the assessment of atrial fibrillation vulnerability.

The paper was published in Frontiers of Physiology and is freely available.

IBT researches have published a paper, which presents a model-based method for solving an inverse problem of the heart biomechanics.

Nicolas Pilia defended his dissertation „Electrocardiogram Signal Analysis and Simulations for Non-Invasive Diagnosis - Model-Based and Data-Driven Approaches for the Estimation of Ionic Concentrations and Localization of Excitation Origins“ on February 18th 2021 and graduated with distinction. Congratulations!

Das IBT nimmt an der jährlichen VDE DGBMT Kongressveranstaltung teil.

Eight delegates represented IBT at this year’s Computing in Cardiology conference in Rimini which brought together both onsite and remote participants during the COVID-19 pandemic.

The current issue of the popular scientific journal „Spektrum der Wissenschaft“, the German branch of the Scientific American, features an article of the head of the Computational Cardiac Modeling group at IBT. Under the headline „A digital heart“, Axel Loewe describes the motivation for and the basics of computational heart models and illustrates first successful examples of translation to clinical practice and clinical research.

That is the topic of the Herrenhausen Forum on July 14, 2020. The discussion with experts from IT, medicine and law was about responsibility and trust.

In collaboration with the Politecnico of Milan, IBT presented an electromechanical model of bi-ventricular human geometries to study influences on the pressure-volume relation.

In collaboration with the Institute of Biomedical Engineering at KIT and the University Heart Center Freiburg – Bad Krozingen, researchers from the Medical University Hospital Heidelberg published an article on the antiarrhythmic effects of A293 on cardioversion of atrial fibrillation. As a high-affinity potassium channel inhibitor, A293 mitigates the pathological shortening of the atrial action potential duration.  The study indicated the therapeutic potential of A293 for the treatment of atrial fibrillation with single cell experiments, a porcine model, as well as computer simulations in a three-dimensional atrium. The open access article was published in the Journal of the American Heart Association (JAHA).

The collaborative opinion article "An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action" was recently published as a preprint for open peer review in F1000Research. This paper is the outcome of a workshop at the first German conference on Research Engineering and a dedicated DFG-funded follow up workshop hosted by the Robert Koch Institute. KIT and IBT researchers played a leading role in bringing together the group and coordinating the writing process. With more than 40 authors and wide community review, this grass-roots initiative calls for action to make software a first class citizen in research.

Two members of the IBT attended, presented two talks and shared their results on novel segmentation methods and a 3D microscale test target at the SPIE Photonics West Conference in San Francisco on the 01st February to 06th February. The useful feedback will be incorporated in further research and contact to possible new collaborates was set.

The issue 1/2020 of the "dotnetpro“ journal features an article about the research of the cardiac modeling group. dotnetpro delivers expert knowledge for software developers, who use Microsoft technologies to write programs for Microsoft and non-Microsoft platforms. The idea behind the article is to provide a broader view for the dotnetpro readers, who mostly are software developers. The article introduces and describes the implementation of the multiscale simulation approach (from ion channels via cells and tissue up to the organ) for electrophysiology, which is developed and used at IBT.