Computational Cardiac Modeling
I am a research enthusiast leading an interdisciplinary team dedicated to develop computational models of the human heart using engineering methods of software engineering, algorithmics, numerics, signal processing, data analysis, and machine learning.
In my group, we apply the models in simulation studies and translate them into clinical application to generate benefit for patients and society by
- building individualized digital twin models of patients to personalize medicine and leverage the potential of digital tools,
- optimizing existing and exploring new diagnostic and therapeutic approaches including artificial intelligence based on a synergy of simulated data and clinical information,
- unraveling fundamental physiological and disease mechanisms with implications for clinical care.
Details regarding specific projects can be found on the page of my group. My research is rooted in a network of excellent local and international collaborations, is published in renowned scientific journals and recognized by funding agencies and outstanding awards. I enjoy outreach and dissemination to the interested public and advocate open science and the research software engineer profession.
- Alban Lefebvre, Axel Loewe, Mariappan S Nadar, Jun Liu, Zero Communication Block Partitioning, US Patent App. 2014/0037228 A1 (2012P18991 US01, 13/950,535, 2012P18991 US, 61/679,132)
- Jun Liu, Zhili Yang, Mariappan S Nadar, Nirmal Janardhanan, Qiu Wang, Axel Loewe, Multi-stage Magnetic Resonance Reconstruction for Parallel Imaging Applications, US Patent App. 2014/0133724 A1 (2012P26350 US01, 14/054,003, 2012P26350 US, 61/724,470)
2022: Senior Member of the Institute of Electrical and Electronics Engineers (IEEE)
Semi-Finalist at Rosanna Degani Young Investigators Award, Konferenz „Computing in Cardiology“ 2020 in Rimini (Italien)
Tobias Gerach, Steffen Schuler, Ekaterina Kovacheva, Olaf Dössel, Axel Loewe
Consequences of Using an Orthotropic Stress Tensor for Left Ventricular Systole
5th place in student competition, German Society for Biomedical Engineering (DGBMT) annual conference 2020, Online
Armin Müller, Ekaterina Kovacheva, Axel Löwe
„Validating a Numerical Simulation of Human Heart Motion Using Clinical Data”
Best Poster Award, Workshop Biosignalverarbeitung 2020, Kiel, Deutschland
N. Pilia, C. Corsi, S. Severi, O. Dössel, A. Loewe
Eingereichte Arbeit: Reconstruction of Potassium Concentrations with the ECG on Imbalanced Datasets
Biophysical Society Travel Award for the 63rd Annual Meeting 2019 in Baltimore, MD (USA).
Bill and Gary Sanders Poster Award, Conference "Computing in Cardiology" 2018 in Maastricht (The Netherlands)
Ekaterina Kovacheva, Lukas Baron, Olaf Dössel, Axel Loewe: "Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry"
Patient Safety Award 2018
Axel Loewe and Olaf Dössel won the Patient Safety Award (2nd place) together with clinical collaborators from University Heart Center Freiburg-Bad Krozingen.
The honored study introduces two novel ECG-based approaches for real-time assessment of success of catheter ablation to terminate perimitral flutter.
3rd place at Gips-Schüle junior scientist award 2018
Axel Loewe for his dissertation Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves
Semi-Finalist Rosanna Degani Young Investigator Award, Conference „Computing in Cardiology“ 2017 in Rennes (France)
Nicolas Pilia, Olaf Doessel, Gustavo Lenis, Axel Loewe, ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space
Bill and Gary Sanders Poster Award, Conference „Computing in Cardiology“ 2017 in Rennes (France)
Axel Loewe, Emanuel Poremba, Tobias G. Oesterlein, Nicolas Pilia, Micha Pfeiffer, Olaf Doessel, Stefanie Speidel:
An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning
KIT Doctoral Award, Karlsruhe, July/12/2017
KIT acknowledges outstanding doctoral researchers with the KIT Doctoral Award. One of the three prizes for the academic year 2015/16 was awarded to Axel Loewe who is with the Institute of Biomedical Engineering for his PhD thesis „Modeling human atrial patho-electrophysiology from ion channels to ECG: substrates, pharmacology, vulnerability, and P-waves“. [See Video]
Best Poster Presentation: Kentucky Academy of Science 2016, Student Research Competition, Computer and Information Sciences,
Eura Shin, Emanuel Poremba, Olaf Dössel, Axel Loewe: "Automated Initiation of Fibrillatory Excitation in Monodomain Simulations“
1st place in student competition at the "DGBMT Anniversary (DACH) 2016 in Basel: Axel Loewe, Robin Andlauer, Olaf Dössel, Gunnar Seemann: "Effect of Left Atrial Hypertrophy on P-Wave Morphology in a Computational Model“
Awards at the Conference „Computing in Cardiology“ 2016 at Vancouver (Kanada)
Rosanna Degani Young Investigator Award: Axel Loewe, Robin Andlauer, Olaf Dössel, Gunnar Seemann, Pyotr Platonov: „Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration“
Bill and Gary Sanders Poster Award: Axel Loewe, Bhawna Verma, Armin Luik, Claus Schmitt, Olaf Dössel: „Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries“
Mortara Fellowship: Gustavo Lenis, Axel Loewe
1st place in student competition, DGBMT annual conference 2014, Hannover,
Y. T. Lutz, A. Loewe, M. Wilhelms, O. Dössel, G. Seemann.
Submitted paper: Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
Preis für das beste Doktorandenposter im Rahmen des Cardiac Physiome Workshop in Bar Harbor, USA, 2013
Axel Loewe, Mathias Wilhelms, Jochen Schmid, Mathias J. Krause, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
"A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations"
2nd place in student competition, BMT, 2013 Graz, Axel Loewe, Mathias Wilhelms, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann,
submitted paper: "Impact of hERG Mutations on Simulated Human Atrial Action Potentials"
Best poster award on the conference Computers in Cardiology at Hangzhou: A. Loewe, W. H. W. Schulze, Yuan Jiang, M. Wilhelms, O. Dössel
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study; Computing in Cardiology, vol. 38, pp. 741 - 744, 2011
- Annals of Biomedical Engineering
- Biomechanics and Modeling in Mechanobiology
- Biomedizinische Technik Conference
- Biophysical Journal
- BMC Medical Research Methodology
- BMC Nephrology
- Cardiology Research and Practice
- Cardiovascular Engineering and Technology
- Cardiovascular Research
- Circulation: Arrhythmia and Electrophyisology
- Clinical Medicine Insights: Cardiology
- Computers in Biology and Medicine
- Computing in Cardiology Conference
- Engineering with Computers
- EP Europace
- European Heart Journal
- European Heart Journal - Digital Health
- Frontiers in Cardiovascular Medicine
- Frontiers in Physiology
- Heart Rhythm Journal
- Heart Rhythm Conference
- IEEE Journal of Biomedical and Health Informatics
- IEEE Transactions on Automation Science and Engineering
- IEEE Transactions on Biomedical Engineering
- IEEE Transactions on Medical Imaging
- International Journal of Clinical Cardiology
- JACC Clinical Electrophysiology
- Journal of Cardiovascular Electrophysiology
- Journal of Computational Physics
- Journal of Open Source Software
- Medical & Biological Engineering & Computing
- Medical Image Analysis
- Nature Cardiovascular Research
- Platform for Advanced Scientific Computing (PASC) Conference
- Philosophical Transactions of the Royal Society A
- Physiological Reports
- PLOS Computational Biology
- PLOS ONE
- Pflügers Archiv - European Journal of Physiology
- Simulation: Transactions of the Society for Modeling and Simulation International
- Wellcome Open Research
- Belgian Physical Society
- British Heart Foundation
- Czech Academy of Sciences: member of review panel "Engineering and Technology
- Deutsche Forschungsgemeinschaft / German Research Foundation
- Dutch Heart Foundation
- Dutch Research Council (NWO)
- Fondazione Leonardo, Lugano
- Medical Research Council, UK
- Swiss National Science Foundation
- Wellcome Trust
Politecnico di Milano
Karlsruhe Institute of Technology, Department of Electrical Engineering and Information Technology
Karlsruhe Institute of Technology, Department of Mathematics
Atrial Signals Workshop
- 2021 (Karlsruhe, Germany), Member local organization committee, Session Chair, invited talk "Predicting potential AFlut patterns using computational modeling"
- 2015 (Karlsruhe, Germany) - Poster "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology"
BMT: Annual Meeting of the German Society for Biomedical Engineering (DGBMT)
- 2020 (online)
- 2019 (Frankfurt, Germany) - Poster “Patient-Specific Identification of Atrial Flutter Vulnerability–A Computational Approach to Reveal Latent Reentry Pathways”
- 2018 (Aachen, Germany) - Presentation “Sudden cardiac death in hemodialysis patients: severe sinus bradycardia due to hypocalcaemia as a potential pathomechanism”
- 2017 (Dresden, Germany) - Presentation "Optimal ECG Lead Systems to Maximimze Left Atrial Information Content"
- 2016 (Basel, Switzerland) - Poster "P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activa-tion and its Proximity to Inter-Atrial Connections Independent from Atrial Size"
- 2015 (Lübeck, Germany) - Presentation "Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions"
- 2014 (Hanover, Germany) - Presentation "Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model"
- 2013 (Graz, Austria) - Presentation "Impact of hERG Mutations on Simulated Human Atrial Action Potentials" (2nd Prize Student Competition)
BPS: Biophysical Society
- 2019 (Baltimore, USA) 63rd Annual Meeting - Poster "Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients" (Early Career Travel Award Winner)
- 2018 (Berlin, Germany) Thematic Meeting "The heart by Numbers" - Poster "The Challenge of Transferring in vitro Calcium Concentrations to Models Reflecting in vivo Conditions"
CinC: Computing in Cardiology
- 2021 (Brno, Czech Republic) - Session Chair "Whole Heart Modeling", Poster judge, Member program committee
- 2020 (Rimini, Italy) - Session Chair "Cardiovascular Mechanics", Poster judge, Member program committee
- 2018 (Maastricht, The Netherlands) - Talk “A Heterogeneous Formulation of the Himeno et al. Human Ventricular Myocyte Model for Simulation of Body Surface ECGs", Session chair "Atrial Fibrillation Drivers & Targets"
- 2017 (Rennes, France) - Poster "An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning" & Poster "Left Atrial Information Through the Optimization of ECG Lead Systems", Session chair "Cardiac Mechanics and Heart Failure"
- 2016 (Vancouver, Canada) - Presentation "Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration" (Winner Young Investigator Award)
- 2014 (Boston, USA) - Presentation "Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology"
CMBE: Computational & Mathematical Biomedical Engineering
- 2019 (Sendai City, Japan) - inivited presentation "The Inverse Problem of Cardiac Mechanics - Estimation of Cardiac Active Stress from Endocardial Motion Tracking"
CPP: Cardiac Physiome Workshop
- 2016 (Seoul, Korea) - Presentation "P-wave terminal force is affected by site of earliest right atrial activation"
- 2015 (Auckland, New Zealand) - Presentation "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology"
- 2013 (Bar Harbor, USA) - Poster "A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data" (Best Graduate Student Poster)
DGK: Deutsche Gesellschaft für Kardiologie
- 2022 (Mannheim, Germany) - invited talk "Computational Cardiac Modeling - Synergies with Machine Learning"
deRSE: German Conference for Research Software Engineering
- 2019 (Potsdam, Germany) - Workshop "Herausforderungen für die nachhaltige Entwicklung, Bereitstellung und Pflege von Forschungssoftware in Deutschland" & Poster "The SuLMaSS Project: Development of a Sustainable Open Source Software Package for Cardiac Electrophysiology"
EHRA: European Hearty Rhythm Association
- 2020 (online) - Poster "Automatic classification of 20 different types of atrial tachycardia using 12-lead ECG signals"
EMBC: IEEE Engineering in Medicine and Biology Conference
- 2019 (Berlin, Germany) - Special Session Organizer "Computational Cardiac Modeling at the Interface of Engineering and Clinics"; Presentation "Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium"; Chair of 4 further sessions
FIMH: Functional Imaging and Modelling of the Heart
- 2015 (Maastricht, The Netherlands) - Presentation "Left and Right Atrial Contribution to the P-wave in Realistic Computational Models"
GRC/GRS: Gordon Research Conference / Gordon Research Seminar on Cardiac Arrhythmia Mechanisms
- 2019 (Lucca, Italy) - Chair of the Gordon Research Seminar on Cardiac Arrhythmia Mechanisms
- 2019 (Lucca, Italy) - Poster "The Challenge of Transferring in vitro Extracellular Calcium Concen-trations to Models Reflecting in vivo Conditions"
- 2017 (Ventura Beach, USA) - Presentation (GRS) / Poster (GRC) "Influence of Electrolyte Concentration Changes on Sinus Node Function - A New Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?"
GYSS: Global Young Scientists Summit
- 2019 (Singapur) inivited participant, Poster "Severe Sinus Bradycardia Due To Electrolyte Changes As A Pathomechanism Of Sudden Cardiac Death In Chronic Kidney Disease Patients Undergoing Hemodialysis"
HRS: Heart Rhythm Society Scientific Sessions
- 2018 (Boston, USA) - Poster "Severe Sinus Bradycardia Due To Electrolyte Changes As A Pathomechanism Of Sudden Cardiac Death In Chronic Kidney Disease Patients Undergoing Hemodialysis"
ICIAM: International Congress of Industrial and Applied Mathematics
- 2019 (Valencia, Spain) - Invited Presentation "The inverse problem of cardiac biomechanics: estimating active stress distribution through imaging-driven computational modeling"
MEC: Cardiac Mechano-Electric Coupling and Arrhythmias
- 2016 (Freiburg, Germany)
openCARP: openCARP User Meeting
- 2021 (Karlsruhe, Germany) - Organizer
- 2020 (Freiburg, Germany / online) - Co-Organizer
- 2018 (Bordeaux, France) - Talk "Open Source CARP"
TRM: Theo-Rossi-di-Montelera Forum on Computer Simulation and Experimental Assessment of Cardiac Function
- 2019 (Lugano, Switzerland) - Talk "Towards the digital biomechanical twin: the inverse problem of cardiac mechanics"
- 2017 (Lugano, Switzerland) - Talk "Validation upside down - in-silico models to sound the potential and limitations of diagnostic tools"
- 2015 (Lugano, Switzerland) - Poster "P-wave morphology is affected by site of earliest right atrial activation: a simulation study"
- 2013 (Lugano, Switzerland) - Poster "Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning"
- "Computational Cardiac Modeling - Synergies with Machine Learning and Clinical Translation", Oxford Symposium on the Future of Therapy Discovery and Development, 06 December 2022
- "Computational Cardiac Modeling - Synergies with Machine Learning", Annual Meeting of the German Cardiac Society (DGK), 22 April 2022
- "Computational Cardiac Modeling - Synergies with Machine Learning", Cardiac Electromechanics Research Group Seminar, King's College London, UK (online), 30 June 2021
- "Towards the digital biomechanical twin: the inverse problem of cardiac mechanics", TRM Forum on Computer Simulation and Experimental Assessment of Cardiac Function, Lugano, Switzerland, 10 December 2019
- "The Inverse Problem of Cardiac Mechanics - Estimation of Cardiac Active Stress from Endocardial Motion Tracking", International Conference on Industrial and Applied Mechanics, Valencia, Spain, 16 July 2019
- "The Inverse Problem of Cardiac Mechanics - Estimation of Cardiac Active Stress from Endocardial Motion Tracking", Computational and Mathematical Biomedical Engineering Conference, Sendai, Japan, 10 June 2019
- "Validation upside down - in-silico models to sound the potential and limitations of diagnostic tools", TRM Forum, Lugano, Switzerland, 04 December 2017
- „Multiscale modeling of cardiac electrophysiology”, School of Science and Engineering, Reykjavik University (RU) / Háskólann í Reykjavík (HR), Iceland, 30 August 2017
- "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology", Workshop "Emerging mathematical topic in biology and life sciences", Research Core Area "Modeling and Simulation", Karl-Franzens-Universität Graz, Austria, 07 May 2015
- "Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents", Simula Cardiac Modeling Workshop, Oslo, Norway, 06 November 2014
- "Multiscale in silico modeling of human atrial electrophysiology", Computational Cardiology Lab (Prof. Natalia Trayanova), Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA, 03 Sep 2014 via Contact scholarship of Karlsruhe House of Young Scientists (KHYS)
- "Multiscale computational cardiology", Computational Physiopathology Unit (Prof. Stefano Severi), Laboratory of Cellular and Molecular Engineering “Silvio Cavalcanti“, University of Bologna, Italy, 29 Jun 2016 via DAAD-MIUR joint mobility program
Details of current and completed projects can be found on the page of my research group.
Public Outreach and Dissemination
Renal Research Institute, Frontiers in Kidney Medicine and Biology, "What ECG can tell us about the events on a molecular scale", (recorded interview, podcast, transcript) Februrary 2022
KIT im Rathaus (public lecture in the city hall), “Mein digitaler Zwilling: Welche Möglichkeiten eröffnen mathematische Computermodelle des Herzens für die Diagnose und Therapie von Herzkrankheiten?” (recorded presentation, “My digital twin: Which opportunities do mathematical computational models of the heart provide for diagnosis and therapy of heart diseases?”), February 2022
Wissenschaftsmanagement, "Es ist Zeit über Forschungssoftware zu sprechen", issue 2021
Forschung & Lehre, "Forschungssoftware - Nachhaltige Entwicklung und Bereitstellung", issue May 2021
KIT “Neuland” magazine article “Mit Computerherz zum Therapieerfolg“ (“Computational models for successful therapy“), issue 2020
Spektrum der Wissenschaft, “Mathematische Modelle des Herzens” (“Mathematical models of the heart”), issue October 2020
dotnetpro (popular software engineering journal), issue January 2019, “Herzsimulator 1.0”
r2b-student Karlsruhe TechPitch, Nov 15, 2018
Radio Regenbogen Campus Report, Oct 2, 2018, “Herz aus Bits und Bytes“
Badische Neueste Nachrichten (regional newspaper), Aug 7, 2018, “Mit Vortests zur besten Therapie - KIT-Forscher simuliert am PC Behandlungsmethoden bei Vorhofflimmern”
Participation in “University for Beginners” info days at KIT, regularly
Participation in “Girls' Day” at KIT (information event for girls in STEM), regularly