Publications
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Selected Publications
Journal Articles (39)
Hypocalcemia-Induced Slowing of Human Sinus Node Pacemaking.
In Biophysical Journal, 2019
Patient-Specific Identification of Atrial Flutter Vulnerability–A Computational Approach to Reveal Latent Reentry Pathways.
In Frontiers in Physiology, vol. 9(Article 1910) , 2019
Cardiac ischemia-insights from computational models..
In Herzschrittmachertherapie & Elektrophysiologie, vol. 29(1) , pp. 48-56, 2018
Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
In Europace, vol. 18(suppl 4) , pp. iv35-iv43, 2016
Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology..
In Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 16(S4) , pp. iv30-iv38, 2014
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
In BioMed Research International Article, vol. 2015, pp. 530352, 2014
Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
In Europace, vol. 16(3) , pp. 435-443, 2014
Quantification and classification of potassium and calcium disorders with the electrocardiogram: What do clinical studies, modeling, and reconstruction tell us?.
In APL bioengineering, vol. 4(4) , pp. 041501, 2020
Specific Electrogram Characteristics Identify the Extra-Pulmonary Vein Arrhythmogenic Sources of Persistent Atrial Fibrillation - Characterization of the Arrhythmogenic Electrogram Patterns During Atrial Fibrillation and Sinus Rhythm..
In Scientific Reports, vol. 10(1) , pp. 9147, 2020
Non-Invasive Characterization of Atrial Flutter Mechanisms Using Recurrence Quantification Analysis on the ECG: a Computational Study..
In IEEE Transactions on Biomedical Engineering, 2020
An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action.
In F1000Research, vol. 9, pp. 295, 2020
Selective Brain Hypothermia for Ischemic MCA-M1 Stroke: Influence of Cerebral Arterial Circulation in a 3D Brain Temperature Model.
In IEEE Transactions on Biomedical Engineering, vol. accepted, pp. 1-1, 2020
Comparison of Unipolar and Bipolar Voltage Mapping for Localization of Left Atrial Arrhythmogenic Substrate in Patients With Atrial Fibrillation.
In Frontiers in Physiology, vol. 11, 2020
Monitoring the dynamics of acute radiofrequency ablation lesion formation in thin-walled atria – a simultaneous optical and electrical mapping study.
In Biomedical Engineering / Biomedizinische Technik, vol. 65(3) , pp. 327-341, 2020
Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model.
In Journal of the American Heart Association, 2020
Mapping and Removing the Ventricular Far Field Component in Unipolar Atrial Electrograms..
In IEEE Transactions on Biomedical Engineering, vol. 67(10) , pp. 2905-2915, 2020
Novel Na/Ca Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na/Ca Exchanger in Pacemaking of Rabbit Sinus Node Tissue..
In Frontiers in Pharmacology, vol. 10, pp. 1632, 2020
Modeling selective therapeutic hypothermia in case of acute ischemic stroke using a 1D hemodynamics model and a simplified brain geometry..
In Mathematical biosciences and engineering : MBE, vol. 17(2) , pp. 1147-1167, 2019
Wie wirken Arzt und digitale Technik im Jahr 2035 zusammen?.
In VDE DGBMT, 2019
A robust computational framework for estimating 3D Bi-Atrial chamber wall thickness.
In Computers in Biology and Medicine, vol. 114, pp. 103444, 2019
Influence of left atrial size on P-wave morphology: differential effects of dilation and hypertrophy.
In Europace, vol. 20(S3) , pp. iii36-iii44, 2018
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, vol. 102, pp. 267-277, 2018
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, vol. 65(10) , pp. 2334-2344, 2018
A Computational Framework to Benchmark Basket Catheter Guided Ablation in Atrial Fibrillation.
In Frontiers in Physiology, vol. 9, pp. 1251, 2018
Novel Electrocardiographic Criteria for Real-Time Assessment of Anterior Mitral Line Block.
In JACC: Clinical Electrophysiology, vol. 4(7) , pp. 920-932, 2018
Regional conduction velocity calculation from clinical multichannel electrograms in human atria.
In Computers in Biology and Medicine, vol. 92, pp. 188-196, 2018
Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information? Insights from a Computational Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
Books (1)
Book of Abstracts - Workshop on Cardiac Modeling. - Towards an integrated numerical heart model, Coupling the relevant physics the right way.
April 15-17 2019, Bad Herrenalb, Germany. 2019.
Conference Contributions (94)
Can Hypocalcaemia Cause Severe Sinus Bradycardia and Asystole in Dialysis Patients?.
In Clinical research in cardiology: Official journal of the German Cardiac Society, vol. 109(Suppl 1) , pp. 1, 2020
SuLMaSS - Sustainable Lifecycle Management for Scientific Software.
In E-Science-Tage 2019: Data to Knowledge, 2019
Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 1875-1878, 2019
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning.
In 2017 Computing in Cardiology Conference (CinC), vol. 44, 2017
Validation upside down - In-silico models to sound the potential and limitations of diagnostic tools.
In TRM Forum, 2017
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration.
In Computing in Cardiology, vol. 43, pp. 1-4, 2016
P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size.
In Biomedizinische Technik, vol. 61, pp. S223, 2016
P-wave terminal force is affected by site of earliest right atrial activation.
In Cardiac Physiome Project, 2016
P-wave terminal force is affected by the site of earliest right atrial activation independent from atrial size in silico.
In International Conference on Electrocardiology, 2016
P-wave morphology is affected by site of earliest right atrial activation: a simulation study.
In TRM Forum, 2015
Left and Right Atrial Contribution to the P-wave in Realistic Computational Models.
In Lecture Notes in Computer Science, vol. 9126, pp. 439–447, 2015
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Cardiac Physiome Workshop, 2015
Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 418-422, 2015
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Atrial Signals, 2015
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Emerging Mathematical Topics in Biology and Life Sciences, 2015
Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Computing in Cardiology, vol. 41, pp. 745-748, 2014
Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(S1) , pp. S929-S932, 2014
Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents.
In Simula Cardiac Modeling Workshop, 2014
Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning.
In TRM Forum, 2013
Impact of hERG Mutations on Simulated Human Atrial Action Potentials.
In Biomedizinische Technik/Biomedical Engineering, vol. 58(s1) , 2013
A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data.
In Cardiac Physiome Workshop, 2013
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study.
In Computing in Cardiology, vol. 38, pp. 741-744, 2011
Automatic classification of 20 different types of atrial tachycardia using 12-lead ECG signals.
In EP Europace, vol. 22(Supplement_1) , 2020
Influence of Gradient and Smoothness of Atrial Wall Thickness on Initiation and Maintenance of Atrial Fibrillation.
In Computing in Cardiology Conference (CinC), 2020
Consequences of Using an Orthotropic Stress Tensor for Left Ventricular Systole.
In Computing in Cardiology Conference (CinC), 2020
Optimization Framework to Identify Constitutive Law Parameters of the Human Heart.
In Current Directions in Biomedical Engineering, vol. 6(3) , pp. 95-98, 2020
Automatic ECG-based Discrimination of 20 Atrial Flutter Mechanisms: Influence of Atrial and Torso Geometries.
In Computing in Cardiology Conference (CinC), 2020
Non-invasive identification of atrial fibrillation driver location using the 12-lead ECG: pulmonary vein rotors vs. other locations.
In EMBC 20, 2020
Machine Learning to Find Areas of Rotors Sustaining Atrial Fibrillation From the ECG.
In Computing in Cardiology Conference (CinC), 2020
openCARP: An Open Sustainable Framework for in-silico Cardiac Electrophysiology Research.
In Computing in Cardiology Conference (CinC), vol. 47, 2020
The inverse problem of cardiac mechanics - estimation of cardiac active stress from endocardial motion tracking.
In Computational & Mathematical Biomedical Engineering Proceedings, vol. 1, pp. 91-95, 2019
Generation of a Simplified Brain Geometry for the Calculation of Local Cerebral Temperature using a 1D Hemodynamic Model.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 529-532, 2019
Influence of ECG Lead Reduction Techniques for Extracellular Potassium and Calcium Concentration Estimation.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 69-72, 2019
Modeling of the Human Cerebral Collateral Circulation: Evaluation of the Impact on the Cerebral Perfusion in Case of Ischemic Stroke.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 533-536, 2019
FP616 Low Serum Calcium is Correlated with Lower Heart Rate in Elderly Dialysis Patients.
In Nephrology Dialysis Transplantation, vol. 34(S1) , 2019
Recurrence Quantification Analysis for Investigating Atrial Fibrillation Dynamics in a Heterogeneous Simulation Setup*.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 2277-2280, 2019
Influence of the protocol used to induce arrhythmia on atrial fibrillation vulnerability.
In 41 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019
Initiation and maintenance of re-entrant cardiac propagation: a computational vulnerability study.
In Gordon Research Conference - Cardiac Arrhythmia Mechanisms, 2019
An In-Silico Study of the Effects of Conductance Variation on the Regionally Based Action Potential Morphology.
In Computing in Cardiology (CinC), vol. 46, 2019
A Method for Pressure-Volume-Based Parameter Identification for a Passive Constitutive Model of Myocardium.
In RISM Congress: iHEART - Modelling the Cardiac Function, 2019
Discrimination of Atrial Flutter on Simulated 12-Lead-ECG Signals by Applying Biosignal Processing.
In Gordon Research Conference - Cardiac Arrhythmia Mechanisms, 2019
12-Lead ECG Feature Identification to Discriminate Different Types of Atrial Flutter.
In 41 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019
Estimating Local Therapeutic Hypothermia in Case of Ischemic Stroke Using a 1D Hemodynamics Model and an Energetic Temperature Model.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 3983-3986, 2019
Hypocalcemia-Induced Bradycardia Is More Pronounced in Male Hemodialysis Patients.
In Kidney Week 2019, vol. 30(AS) , pp. 542-543, 2019
ECG-based Estimation of Potassium and Calcium Concentrations: Proof of Concept with Simulated Data.
In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 2610-2613, 2019
Noise quantification and noise reduction for unipolar and bipolar electrograms.
In Computing in Cardiology (CinC), vol. 46, 2019
Forcing Transmembrane Voltages to Decrease Slowly: A Temporal Regularization for ECG Imaging.
In Computing in Cardiology, vol. 45, 2018
Spatio-temporal Analysis of Multichannel Atrial Electrograms Based on a Concept of Active Areas.
In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2018, pp. 490-493, 2018
Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry.
In Computing in Cardiology Conference (CinC), vol. 45, 2018
Novel ECG-criteria For Real-time Assessment Of Anterior Mitral Line Block - “V1-jump” And “V1-delay”.
In Heart Rhythm, vol. 15(5S) , pp. S229, 2018
Haemodynamics in an elasto-mechanic model of the human heart.
In Annual Scientific Conference of the International Association of Applied Mathematics and Mechanics, 2018
Cycle Length Statistics During Atrial Fibrillation Reflect Refractory Properties of the Underlying Substrate.
In Annual Congress of the European Cardiac Arrhythmia Society, pp. 16-27 A15-61, 2018
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
Modelling of patient-specific Purkinje activation based on measured ECGs.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 171-174, 2017
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
Developing and coupling a lumped element model of the closed loop human vascular system to a model of cardiac mechanics.
In BMTMedPhys 2017, vol. 62(S1) , pp. S69, 2017
Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 317-320, 2017
A Computational Framework to Benchmark Basket Catheter Guided Ablation.
In Computing in Cardiology, vol. 44, 2017
Propagation of the primary pacemaker activity in the human heart: a computational approach.
In European Medical and Biological Engineering Conference (EMBEC), vol. 65, pp. 201, 2017
Pace-and-Drive of the Human Sinoatrial Node – A Preliminary Computational Investigation.
In Computing in Cardiology, vol. 44, 2017
Selective Inhibition of the Cardiac Na+/Ca2+ Exchanger by a Novel Compound ORM-10962 Modulates Spontaneous Automaticity.
In European Working Group on Cardiac Cellular Electrophysiology, 2017
Effects of Fibroblasts Coupling on the Electrophysiology of Cardiomyocytes from Different Regions of the Human Atrium: A Simulation Study.
In Computing in Cardiology, vol. 44, 2017
Computational Study on Regional Differences in Pro-Arrhythmic Effects of Fibroblasts Coupling to Human Atrial Myocytes.
In TRM Forum, 2017
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation.
In Computing in Cardiology Conference, vol. 44, 2017
A Computational Study on the Electrophysiological Effects of Fibroblasts Coupling to Human Atrial Myocytes from Different Regions.
In Cardiac Physiome Project, 2017
Effect of left atrial hypertrophy on P-wave morphology in a computational model.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 603-606, 2016
ECG imaging of focal atrial excitation: Evaluation in a realistic simulation setup.
In Computing in Cardiology, vol. 43, pp. 113-116, 2016
Automated Initiation of Fibrillatory Excitation in Monodomain Simulations.
In Kentucky Academy of Science , 2016
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
In 2015 Computing in Cardiology Conference (CinC), pp. 485-488, 2015
Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 405-408, 2015
Mesh structure-independent modeling of patient-specific atrial fiber orientation.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 409-412, 2015
Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s933-s936, 2014
Elora: Enforcing Low Rank for Parallel MR Reconstruction.
In International Society for Magnetic Resonance in Medicine, pp. 2652, 2013
Kalman Filter with Augmented Measurement Model: an ECG Imaging Simulation Study.
In FIMH, LNCS 7945, pp. 200-207, 2013
Simulating the Effects of Drugs and Genetic Defects on Atrial Electrophysiology.
In TRM Forum, 2013