BildComparison of Unipolar and Bipolar Voltage Mapping

IBT researches in collaboration with the University Heart Centre Freiburg have published a paper comparing unipolar and bipolar voltage mapping for localisation of atrial substrate.


Frontiers in Physiologie
Logo BMT 2020BMT 2020

Das IBT nimmt an der jährlichen VDE DGBMT Kongressveranstaltung teil.

Logo NBC 2020North Baltic Conference 2020

A scientist of the IBT presented and discussed his results on the simulation of the propagation of photons in a blood vessel.

GruppenbildComputing in Cardiology 2020

Eight delegates represented IBT at this year’s Computing in Cardiology conference in Rimini which brought together both onsite and remote participants during the COVID-19 pandemic.

FIG. 1. Each section of this work can be attributed to at least one of the topics in the green boxes. Although they are separated in this diagram, they are closely connected and depend on each other. That is why collaboration between the fields is of paraReview article on the ECG-based potassium and calcium concentration estimation
Spektrum der Wissenschaft 2020.10A digital heart

The current issue of the popular scientific journal „Spektrum der Wissenschaft“, the German branch of the Scientific American, features an article of the head of the Computational Cardiac Modeling group at IBT. Under the headline „A digital heart“, Axel Loewe describes the motivation for and the basics of computational heart models and illustrates first successful examples of translation to clinical practice and clinical research.

Geodätische Längenmessung in medizinischen Aufnahmen.Geodesic Length Measurement in Medical Images

Publication of the investigation of the discretization error and its reduction in the geodesic length measurement.

AI in medicineArtificial intelligence in medicine

That is the topic of the Herrenhausen Forum on July 14, 2020. The discussion with experts from IT, medicine and law was about responsibility and trust.

News 2020-06-23Identification of intraatrial arrhythmogenic sources

Contributions by the university medical center Freiburg and IBT resulted in a paper on the identification of intraatrial arrhythmogenic sources using intracardiac electrogram characteristics.

FasernEffect of fibers and bulk modulus on the electromechanics of the ventricle

In collaboration with the Politecnico of Milan, IBT presented an electromechanical model of bi-ventricular human geometries to study influences on the pressure-volume relation.

IMG_2020-06-02_atrial flutter in ECGNew spatio-temporal methods to characterize atrial flutter mechanisms using the ECG

IBT researchers published two novel methods for a non-invasive atrial flutter characterization together with physicians from the University of Leicester, the ABC Federal University, and the clinicians form the Städtisches Klinikum Karlsruhe in the journal “IEEE Transactions on Biomedical Engineering”. Spatio-temporal recurrence quantification analysis methods were used to characterize and discriminate several atrial flutter mechanisms from the 12-lead ECG in a computational framework. Thanks to these methods, the duration of the invasive atrial mapping and ablation procedure might shorten significantly. The computational study was complemented and fortified by a clinical case used as a proof of concept.

Hemmstoff A293Potassium channel inhibitor A293 indicates therapeutic potential for the treatment of atrial fibrillation

In collaboration with the Institute of Biomedical Engineering at KIT and the University Heart Center Freiburg – Bad Krozingen, researchers from the Medical University Hospital Heidelberg published an article on the antiarrhythmic effects of A293 on cardioversion of atrial fibrillation. As a high-affinity potassium channel inhibitor, A293 mitigates the pathological shortening of the atrial action potential duration.  The study indicated the therapeutic potential of A293 for the treatment of atrial fibrillation with single cell experiments, a porcine model, as well as computer simulations in a three-dimensional atrium. The open access article was published in the Journal of the American Heart Association (JAHA).

Natrium-Calcium-AustauschersWhat's the role of the sodium calcium exchanger for the spontaneous beating of the heart?

Together with researchers from the University of Szeged, IBT researchers have published a review article on the role of the sodium calcium exchanger for the activity of natural pacemaker cells. These cells are located in the so-called sinus node of the heart and make for the rhythmic beating of our hearts. The review article integrates findings from experimental studies with computational modeling. It was published in the Frontiers in Pharmacology journal and is freely available (open access).

F1000ResearchPolicy paper on Research Software Engineering in Germany

The collaborative opinion article "An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action" was recently published as a preprint for open peer review in F1000Research. This paper is the outcome of a workshop at the first German conference on Research Engineering and a dedicated DFG-funded follow up workshop hosted by the Robert Koch Institute. KIT and IBT researchers played a leading role in bringing together the group and coordinating the writing process. With more than 40 authors and wide community review, this grass-roots initiative calls for action to make software a first class citizen in research.

openCARPopenCARP released

openCARP is an open cardiac electrophysiology simulator for in-silico experiments. Its source code is public and the software is freely available for academic purposes. openCARP is easy to use and offers single cell as well as multiscale simulations from ion channel to organ level. Additionally, openCARP includes a wide variety of functions for pre- and post-processing of data as well as visualization. The python-based CARPutils framework enables the user to develop and share simulation pipelines, i.e. automating in-silico experiments including all modeling/simulation steps.
openCARP is a joint effort of the Medical University of Graz (Gernot Plank), LIRYC Bordeaux (Ed Vigmond), U Freiburg (Gunnar Seemann) and KIT (Axel Loewe).

Konferenz 2020-02-04SPIE Photonics West

Two members of the IBT attended, presented two talks and shared their results on novel segmentation methods and a 3D microscale test target at the SPIE Photonics West Conference in San Francisco on the 01st February to 06th February. The useful feedback will be incorporated in further research and contact to possible new collaborates was set.

News 2020-01-30What makes the heart beat?

The sinus node is the natural pacemaker of the heart initiating each heart beat. Its pacemaking function results from the interplay of to cooperating systems: the so-called membrane clock and the calcium clock. The precise role of these two mechanisms is incompletely understood. Together with a group of experimental researchers from Szeged (Hungrary), the Cardiac Modeling group could now further elucidate the role of the calcium clock. A novel pharmacological agent allows to specifically block the sodim-calcium exchanger. IBT researcher could reproduce and further investigate this effect mechanistically in a computational model. By combining experiment and computer simulation, the crucial role of the sodium-calcium exchanger and the interplay with the membrane clock could be consolidated. The study explains how the natural pacemaker of the heart becomes robust and reliable through the interplay of the two systems calcium clock and membrane clock.

dotnetpro 2020Heart Simulator 1.0

The issue 1/2020 of the "dotnetpro“ journal features an article about the research of the cardiac modeling group. dotnetpro delivers expert knowledge for software developers, who use Microsoft technologies to write programs for Microsoft and non-Microsoft platforms. The idea behind the article is to provide a broader view for the dotnetpro readers, who mostly are software developers. The article introduces and describes the implementation of the multiscale simulation approach (from ion channels via cells and tissue up to the organ) for electrophysiology, which is developed and used at IBT. 

TRM_2020Towards the Digital Twin

Axel Loewe from IBT was invited to present at the 10th "TRM Forum on the Computer Simulation of Cardiac Function“. The meeting brings together leading experts on computational modeling, experimental assessment, and clinical research in the field of cardiac arrhythmias. We contributed to this year’s theme „Towards the Digital Twin“ by presenting work that allows to build a biomechanical twin of an individual patient. In addition, the session "Atrial modeling & experimental data" was chaired by the IBT researcher.