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Gunnar Seemann

Dr.-Ing. Gunnar Seemann

Alumnus
room: 509
phone: +49 721 608 - 42790
fax: +49 721 608 - 42789
Gunnar SeemannQcu5∂kit edu


Lectures
title type semester place
Seminar
Lecture


Completed bachelor or master theses
title type sws tutor
Master thesis

Robin Moss

Bachelor thesis

Emanuel Poremba 

Diplomarbeit

Jan Wingerter 

Studienarbeit

Marieme Ly

Bachelor thesis

Silvio Bauer 

Bachelor thesis

Robin Moss 

Bachelor thesis

Yannick Lutz

Diplomarbeit

Alexander Kurz

Diplomarbeit

Bettina Schwab

Diplomarbeit

Maider Alvarez de Eulate

Studienarbeit

Alexander Kurz

Bachelorarbeit

Maren Arp

Studienarbeit

Stefan Ponto

Diplomarbeit

Christian Rombach

Diplomarbeit

Paola Carrillo

Diplomarbeit

Thomas Fritz 

Studienarbeit

Mathias Wilhelms

Studienarbeit

Paola Carrillo

Diplomarbeit

Meike Karl 

Diplomarbeit

Dipl. Ing.  Stephan Lurz

Studienarbeit

Martin Janich

Li Rong

Diplomarbeit Dipl.-Ing. David Keller
Diplomarbeit

Dipl.-Ing. Hao Chen

Diplomarbeit

Dipl.-Ing. Joachim Buchta

Studienarbeit

Hong Ying  

Diplomarbeit

Kraisorn Chaisaowong  

Reinhold Müller

Diplomarbeit

Christine Höper  

Diplomarbeit

Daniel Weiß

Diplomarbeit

Kerstin Glänzel  

Diplomarbeit

Johannes Häfner  

Studienarbeit

Daniel Weiß  

Diplomarbeit

Matthias Mohr

Diplomarbeit

Leonhard Blümcke  

Diplomarbeit

Markus Jösel



Research Projects
title contact


Supported Grants

Nov. 2006 – Oct. 2007

Funded member of the "Exzellenzakademie Medizintechnik 2006" of the DFG with the topic
"Multimodal Imaging in Medicine" with the project: "From channel protein to surface
ECG: Quantitative assessment of multi channel ECG variations in patients with Long QT syndrome
by computer models of the heart in conjunction with MRI"

Apr. 2009 – Mar. 2011

DFG Project SE 1758/2-1 research grant with the topic: "From channel protein to body surface ECG:
Investigating electrocardiographic effects of ion channel mutations using computational heart models"

Oct. 2009 – Mar. 2011 Research Seed Capital (RiSC) project of the Karlsruhe Institute of Technology (KIT) and the
Ministry of Science, Research and the Arts, Baden-Wuerttemberg with the topic:
"MEDICARI – Modeling Efficiently Drug Induced Cardiac Arrhythmia for Research and Industry"
Apr. 2011 – Sept. 2011 Startup Budget (STUB) project of the Karlsruhe Institute of Technology (KIT) with the topic:
"High-throughput-procedure to quantify the risk of drugs on the electrophysiology of the
 human heart: Measurement data integration and efficient simulation on GPU architectures"
Apr. 2011 – Mar. 2014 DFG Project SE 1758/3-1 research grant with the topic:"Computer-assisted investigation of
electrophysiological mechanisms of atrial fibrillation syndromes"

Supervised PhD work

2002 – 2005
                      

Iulia Graf
"Electrical Stimulation of the Human Left Ventricle"

2004 – 2007

Matthias Reumann
"Computer Assisted Optimisation of Non-Pharmacological Treatment of Congestive Heart Failure and Supraventricular Arrhythmia"

2004 – 2008

Daniel Weiss
"Anatomical and Electrophysiological Modeling of the Human Ventricles – from the Ion Channel to the Electrocardiogram"

2008 – 2011 Frank Weber
"Personalizing Simulations of the Human Atria: Intracardiac Measurements, Tissue Conductivities and Cellular Electrophysiology"
2006 – 2011 David Keller
"Multi-Scale Modeling of the Ventricles: From Cellular Electrophysiology to Body Surface Electrocardiograms"

2009 – 2013

Martin Krüger
"Personalized Multi-Scale Modeling of the Atria : Heterogeneities, Fiber Architecture, Hemodialysis and Ablation Therapy"
2009 – 2013 Mathias Wilhelms
"Multiscale Modeling of Cardiac Electrophysiology : Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment"
2010 – 2014 Matthias Keller
"Simultaneous fluorescence optical and electrical characterization of atrial tissue"
2010 – today

Thomas Fritz
Work about: Mechanical Modeling of the Heart

2013 – today Axel Loewe
Work about: In-silico Modeling of Atrial Fibrillation
2013 – today Markus Rottmann
Work about: Mulichannel Data Analysis of Simulated Atrial Pathologies
2013 – today Lukas Baron
Work about: Mechanical Modeling of the Heart

All Publications, sorted by years

          2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 [All]
[PubMed] [Google Scholar] ResearcherID

Journal Articles (73)

G. Seemann, D. U. J. Keller, M. W. Krueger, F. M. Weber, M. Wilhelms, and O. Dössel.
Electrophysiological modeling for cardiology: methods and potential applications.
In Information Technology, vol. 52(5) , pp. 242-249, 2010
  PDF    
  
  
G. Seemann, F. B. Sachse, M. Karl, D. L. Weiss, V. Heuveline, and O. Dössel.
Framework for modular, flexible and efficient solving the cardiac bidomain equation using PETSc.
In Mathematics in Industry, vol. 15(2) , pp. 363-369, 2010
  PDF    
  
  
G. Seemann, F. B. Sachse, D. L. Weiss, L. J. Ptacek, and M. Tristani-Firouzi.
Modeling of IK1 mutations in human left ventricular myocytes and tissue.
In Am J Physiol Heart Circ Physiol, vol. 292(1) , pp. H549-H559, 2007
  PDF    
G. Seemann, C. Höper, F. B. Sachse, O. Dössel, A. V. Holden, and H. Zhang.
Heterogeneous three-dimensional anatomical and electrophysiological model of human atria.
In Philos Trans A Math Phys Eng Sci., vol. 364(1843) , pp. 1465-1481, 2006
  PDF    
G. Seemann, F. B. Sachse, D. L. Weiß, and O. Dössel.
Investigating Heterogeneity in Human Heart with Simulated Transmural Electrocardiograms.
In Int. J. Bioelectromagnetism, 2003
  PDF  
G. Seemann, F. B. Sachse, D. L. Weiß, and O. Dössel.
Quantitative reconstruction of cardiac electromechanics in human myocardium: Regional heterogeneity.
In J. Cardiovasc. Electrophysiol., vol. 14(S10) , pp. S219-S228, 2003
  PDF  
A. Loewe, E. Poremba, T. Oesterlein, A. Luik, C. Schmitt, G. Seemann, and O. Dössel.
Patient-Specific Identification of Atrial Flutter Vulnerability–A Computational Approach to Reveal Latent Reentry Pathways.
In Frontiers in Physiology, vol. 9(Article 1910) , 2019
  PDF    
  
R. Andlauer, G. Seemann, L. Baron, O. Dössel, P. Kohl, P. Platonov, and A. Loewe.
Influence of left atrial size on P-wave morphology: differential effects of dilation and hypertrophy.
In Europace, vol. 20(S3) , pp. iii36-iii44, 2018
  PDF    
  
R. Moss, F. B. Sachse, E. G. Moreno-Galindo, R. A. Navarro-Polanco, M. Tristani-Firouzi, and G. Seemann.
Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function..
In PLoS computational biology, vol. 14(10) , pp. e1006438, 2018
  PDF    
  
  
A. Loewe, E. M. Wülfers, and G. Seemann.
Cardiac ischemia-insights from computational models..
In Herzschrittmachertherapie & Elektrophysiologie, vol. 29(1) , pp. 48-56, 2018
  PDF    
  
  
J. Greiner, A. C. Sankarankutty, G. Seemann, T. Seidel, and F. B. Sachse.
Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart.
In Frontiers in Physiology, vol. 9:239, 2018
  PDF    
  
O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
  PDF    
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dossel, G. Seemann, and P. G. Platonov.
Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
In Europace, vol. 18(suppl 4) , pp. iv35-iv43, 2016
  PDF    
  
  
A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, D. Thomas, E. P. Scholz, O. Dössel, and G. Seemann.
Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016
  PDF    
  
  
T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
  PDF    
  
  
S. R. Kharche, I. V. Biktasheva, G. Seemann, H. Zhang, and V. N. Biktashev.
A computer simulation study of anatomy induced drift of spiral waves in the human atrium.
In BioMed Research International, vol. 2015, pp. 731386, 2015
  PDF    
  
  
S. Land, V. Gurev, S. Arens, C. M. Augustin, L. Baron, R. Blake, C. Bradley, S. Castro, A. Crozier, M. Favino, T. E. Fastl, T. Fritz, H. Gao, A. Gizzi, B. E. Griffith, D. E. Hurtado, R. Krause, X. Luo, M. P. Nash, S. Pezzuto, G. Plank, S. Rossi, D. Ruprecht, G. Seemann, N. P. Smith, J. Sundnes, J. J. Rice, N. Trayanova, D. Wang, Z. Jenny Wang, and S. A. Niederer.
Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour.
In Proceedings. Mathematical, Physical, and Engineering Sciences / the Royal Society, vol. 471(2184) , pp. 2015.0641, 2015
  PDF    
  
  
C. Lenk, F. M. Weber, M. Bauer, M. Einax, P. Maass, and G. Seemann.
Initiation of atrial fibrillation by interaction of pacemakers with geometrical constraints.
In Journal of Theoretical Biology, vol. 366, pp. 13-23, 2015
  PDF    
  
  
A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology..
In Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 16(S4) , pp. iv30-iv38, 2014
  PDF    
  
  
T. Fritz, C. Wieners, G. Seemann, H. Steen, and O. Dössel.
Simulation of the contraction of the ventricles in a human heart model including atria and pericardium : Finite element analysis of a frictionless contact problem.
In Biomechanics and Modeling in Mechanobiology, vol. 13(3) , pp. 627-641, 2014
  PDF    
  
  
M. Keller, S. Schuler, M. Wilhelms, G. Lenis, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Characterization of radiofrequency ablation lesion development based on simulated and measured intracardiac electrograms.
In IEEE Transactions on Biomedical Engineering, vol. 61(9) , pp. 2467-2478, 2014
  PDF    
  
  
J. T. Koivumaki, G. Seemann, M. M. Maleckar, and P. Tavi.
In silico screening of the key cellular remodeling targets in chronic atrial fibrillation.
In PLoS Computational Biology, vol. 10(5) , pp. e1003620, 2014
  PDF    
  
  
M. W. Krueger, K. S. Rhode, M. D. O'Neill, C. A. Rinaldi, J. Gill, R. Razavi, G. Seemann, and O. Doessel.
Patient-specific modeling of atrial fibrosis increases the accuracy of sinus rhythm simulations and may explain maintenance of atrial fibrillation.
In Journal of Electrocardiology, vol. 47(3) , pp. 324-328, 2014
  PDF    
  
  
A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, A. Luik, O. Dössel, and G. Seemann.
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
In BioMed Research International Article, vol. 2015, pp. 530352, 2014
  PDF    
  
  
A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
In Europace, vol. 16(3) , pp. 435-443, 2014
  PDF    
  
  
A. Panas, A. Comouth, H. Saathoff, T. Leisner, M. Al-Rawi, M. Simon, G. Seemann, O. Dössel, S. Mulhopt, H.-R. Paur, S. Fritsch-Decker, C. Weiss, and S. Diabate.
Silica nanoparticles are less toxic to human lung cells when deposited at the air-liquid interface compared to conventional submerged exposure.
In Beilstein Journal of Nanotechnology, vol. 5, pp. 1590-1602, 2014
  PDF    
  
  
M. W. Krueger, A. Dorn, D. U. J. Keller, F. Holmqvist, J. Carlson, P. G. Platonov, K. S. Rhode, R. Razavi, G. Seemann, and O. Dössel.
In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state.
In Medical & Biological Engineering & Computing, vol. 51(10) , pp. 1105-1119, 2013
  PDF    
  
  
M. W. Krueger, W. H. W. Schulze, K. Rhode, R. Razavi, G. Seemann, and O. Dössel.
Towards personalized clinical in-silico modeling of atrial anatomy and electrophysiology.
In Medical & Biological Engineering & Computing, vol. 51(11) , pp. 1251-1260, 2013
  PDF    
M. W. Krueger, G. Seemann, K. Rhode, D. U. J. Keller, C. Schilling, A. Arujuna, J. Gill, M. D. O'Neill, R. Razavi, and O. Dössel.
Personalization of atrial anatomy and electrophysiology as a basis for clinical modeling of radio-frequency ablation of atrial fibrillation.
In IEEE Transactions on Medical Imaging, vol. 32(1) , pp. 73-84, 2013
  PDF    
  
  
E. P. Scholz, P. Carrillo-Bustamante, F. Fischer, M. Wilhelms, E. Zitron, O. Dössel, H. A. Katus, and G. Seemann.
Rotor termination is critically dependent on kinetic properties of I kur inhibitors in an in silico model of chronic atrial fibrillation.
In PloS one, vol. 8(12) , pp. e83179, 2013
  PDF    
  
  
B. C. Schwab, G. Seemann, R. A. Lasher, N. S. Torres, E. M. Wulfers, M. Arp, E. D. Carruth, J. H. B. Bridge, and F. B. Sachse.
Quantitative analysis of cardiac tissue including fibroblasts using three-dimensional confocal microscopy and image reconstruction: Towards a basis for electrophysiological modeling.
In IEEE Transactions on Medical Imaging, vol. 32(5) , pp. 862-872, 2013
  PDF    
  
  
M. Wilhelms, H. Hettmann, M. M. C. Maleckar, J. T. Koivumäki, O. Dössel, and G. Seemann.
Benchmarking electrophysiological models of human atrial myocytes.
In Frontiers in Physiology, vol. 3(487) , pp. 1-16, 2013
  PDF    
  
  
D. U. J. Keller, D. L. Weiss, O. Dossel, and G. Seemann.
Influence of I(Ks) heterogeneities on the genesis of the T-wave: a computational evaluation..
In IEEE Transactions on Bio-Medical Engineering, vol. 59(2) , pp. 311-22, 2012
  PDF    
  
  
M. Burdumy, A. Luik, P. Neher, R. Hanna, M. W. Krueger, C. Schilling, H. Barschdorf, C. Lorenz, G. Seemann, C. Schmitt, O. Dössel, and F. M. Weber.
Comparing measured and simulated wave directions in the left atrium - a workflow for model personalization and validation.
In Biomed Tech (Berl), vol. 57(2) , pp. 79-87, 2012
  PDF    
  
  
F. O. Campos, A. J. Prassl, G. Seemann, R. Weber Dos Santos, G. Plank, and E. Hofer.
Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study.
In Medical & Biological Engineering & Computing, 2012
  PDF    
  
  
O. Dössel, M. W. Krueger, F. M. Weber, M. Wilhelms, and G. Seemann.
Computational modeling of the human atrial anatomy and electrophysiology.
In Medical & Biological Engineering & Computing, vol. 50(8) , pp. 773-799, 2012
  PDF    
  
  
M. Wilhelms, L. P. Holl, O. Dössel, and G. Seemann.
Impact of antiarrhythmic drugs on a virtual model of atrial fibrillation.
In Biomedizinische Technik / Biomedical Engineering, vol. 57 Suppl 1, 2012
  PDF    
  
  
M. Wilhelms, C. Rombach, E. P. Scholz, O. Doessel, and G. Seemann.
Impact of amiodarone and cisapride on simulated human ventricular electrophysiology and electrocardiograms.
In Europace, vol. 14, pp. v90-v96, 2012
  PDF    
  
  
R. H. Clayton, O. Bernus, E. M. Cherry, H. Dierckx, F. H. Fenton, L. Mirabella, A. V. Panfilov, F. B. Sachse, G. Seemann, and H. Zhang.
Models of cardiac tissue electrophysiology: progress, challenges and open questions..
In Progress in Biophysics and Molecular Biology, vol. 104(1-3) , pp. 22-48, 2011
  PDF    
  
M. Fink, S. A. Niederer, E. M. Cherry, F. H. Fenton, J. T. Koivumäki, G. Seemann, R. Thul, H. Zhang, F. B. Sachse, D. Beard, E. J. Crampin, and N. P. Smith.
Cardiac cell modelling: observations from the heart of the cardiac physiome project.
In Progress in Biophysics and Molecular Biology, vol. 104(1-3) , pp. 2-21, 2011
  PDF    
  
D. U. J. Keller, O. Jarrousse, T. Fritz, S. Ley, O. Dössel, and G. Seemann.
Impact of physiological ventricular deformation on the morphology of the T-wave: a hybrid, static-dynamic approach.
In IEEE Trans Biomed Eng., vol. 58(7) , pp. 2109-2119, 2011
  PDF    
  
M. W. Krueger, S. Severi, K. Rhode, S. Genovesi, F. M. Weber, A. Vincenti, P. Fabbrini, G. Seemann, R. Razavi, and O. Dössel.
Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model.
In Journal of Electrocardiology, vol. 44(2) , pp. 176-183, 2011
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S. A. Niederer, E. Kerfoot, A. P. Benson, M. O. Bernabeu, O. Bernus, C. Bradley, E. M. Cherry, R. Clayton, F. H. Fenton, A. Garny, E. Heidenreich, S. Land, M. Maleckar, P. Pathmanathan, G. Plank, J. F. Rodriguez, I. Roy, F. B. Sachse, G. Seemann, O. Skavhaug, and N. P. Smith.
Verification of cardiac tissue electrophysiology simulators using an N-version benchmark.
In Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 369(1954) , pp. 4331-4351, 2011
  PDF    
  
  
F. M. Weber, D. U. J. Keller, S. Bauer, G. Seemann, C. Lorenz, and O. Dössel.
Predicting tissue conductivity influences on body surface potentials-an efficient approach based on principal component analysis.
In IEEE Transactions on Biomedical Engineering, vol. 58(2) , pp. 265-273, 2011
  PDF    
F. M. Weber, A. Luik, C. Schilling, G. Seemann, M. W. Krueger, C. Lorenz, C. Schmitt, and O. Dössel.
Conduction velocity restitution of the human atrium--an efficient measurement protocol for clinical electrophysiological studies.
In IEEE Transactions on Biomedical Engineering, vol. 58(9) , pp. 2648-2655, 2011
  PDF    
  
  
M. Wilhelms, O. Dössel, and G. Seemann.
In silico investigation of electrically silent acute cardiac ischemia in the human ventricles.
In IEEE Transactions on Biomedical Engineering, vol. 58(10) , pp. 2961-2964, 2011
  PDF    
  
  
D. U. J. Keller, F. M. Weber, G. Seemann, and O. Dössel.
Ranking the influence of tissue conductivities on forward-calculated ECGs.
In IEEE Transactions on Biomedical Engineering, vol. 57(7) , pp. 1568-1576, 2010
  PDF    
F. M. Weber, C. Schilling, G. Seemann, A. Luik, C. Schmitt, C. Lorenz, and O. Dössel.
Wave-direction and conduction-velocity analysis from intracardiac electrograms--a single-shot technique.
In IEEE Transactions on Biomedical Engineering, vol. 57(10) , pp. 2394-2401, 2010
  PDF    
  
  
K. Wendel, J. Vaisanen, G. Seemann, J. A. K. Hyttinen, and J. Malmivuo.
The influence of age and skull conductivity on surface and subdermal bipolar EEG leads.
In Computational Intelligence and Neuroscience, vol. 2010, 2010
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F. B. Sachse, A. P. Moreno, G. Seemann, and J. A. Abildskov.
A model of electrical conduction in cardiac tissue including fibroblasts.
In Annals of Biomedical Engineering, vol. 37(5) , pp. 874-889, 2009
  PDF    
  
  
F. B. Sachse, and G. Seemann.
Special issue: Functional imaging and modelling of the heart.
2009
  PDF    
  
D. Scherer, D. Hassel, R. Bloehs, E. Zitron, K. von Lowenstern, C. Seyler, D. Thomas, F. Konrad, H. F. Burgers, G. Seemann, W. Rottbauer, H. A. Katus, C. A. Karle, and E. P. Scholz.
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents.
In British Journal of Pharmacology, vol. 156(2) , pp. 226-236, 2009
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D. L. Weiss, M. Ifland, F. B. Sachse, G. Seemann, and O. Dössel.
Modeling of cardiac ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations / Modellierung kardialer Ischämie in menschlichen Myozyten und Gewebe.
In Biomedizinische Technik/Biomedical Engineering, vol. 54(3) , pp. 107-125, 2009
  PDF    
  
D. Hassel, E. P. Scholz, N. Trano, O. Friedrich, S. Just, B. Meder, D. L. Weiss, E. Zitron, S. Marquardt, C. A. Karle, G. Seemann, M. C. Fishman, H. A. Katus, and W. Rottbauer.
Deficient zebrafish ether-a-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
In Circulation, vol. 117(7) , pp. 866--875, 2008
  PDF    
S. Kharche, G. Seemann, L. Margetts, J. Leng, A. V. Holden, and H. Zhang.
Simulation of clinical electrophysiology in 3D human atria: a high-performance computing and high-performance visualization application.
In Concurrency and Computation: Practice and Experience, vol. 20(11) , pp. 1317-1328, 2008
  PDF    
  
  
M. Reumann, J. Bohnert, G. Seemann, B. Osswald, and O. Dössel.
Preventive ablation strategies in a biophysical model of atrial fibrillation based on realistic anatomical data.
In IEEE Transactions on Biomedical Engineering, vol. 55(2) , pp. 399-406, 2008
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E. P. Scholz, F. M. Konrad, D. L. Weiss, E. Zitron, C. Kiesecker, R. Bloehs, M. Kulzer, D. Thomas, S. Kathöfer, A. Bauer, M. H. Maurer, G. Seemann, H. A. Katus, and C. A. Karle.
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
In Naunyn-Schmiedebergís Arch. Pharmacol., vol. 376(4) , pp. 275-284, 2007
  PDF    
D. L. Weiss, D. U. J. Keller, G. Seemann, and O. Dössel.
The influence of fibre orientation, extracted from different segments of the human left ventricle, on the activation and repolarization sequence: a simulation study.
In Europace, vol. 9(suppl 6) , pp. vi96-vi104, 2007
  PDF    
O. Dössel, M. Reumann, G. Seemann, and D. Weiss.
The missing link between cardiovascular rhythm control and myocardial cell modeling.
In Biomed Tech. (Berl), vol. 51(4) , pp. 205-209, 2006
  PDF    
I. M. Graf, G. Seemann, D. L. Weiss, and O. Dössel.
Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts.
In Medical & Biological Engineering & Computing, vol. 43(6) , pp. 783-792, 2005
  PDF    
D. L. Weiss, G. Seemann, F. B. Sachse, and O. Dössel.
Modelling of the short QT syndrome in a heterogeneous model of the human ventricular wall.
In Europace, vol. 7s2, pp. 105-117, 2005
  PDF  
I. M. Popp, G. Seemann, and O. Dössel.
A Simulation Study of Biphasic Defibrillation Shocks.
In BMC Cardiovascular Disorders, vol. 4(1) , pp. 9, 2004
  PDF  
L. M. Popp, G. Seemann, and O. Dössel.
A simulation study of the reaction of human heart to biphasic electrical shocks.
In BMC Cardiovascular Disorders, vol. 4, pp. 9, 2004
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G. Reinerth, T. M. Schmidt, G. Seemann, J. Albers, O. Dössel, S. Hagl, and C. F. Vahl.
Simulation of biventricular activity in ventricular pacing on 3D-echocardiographic images using the cellular automaton in a porcine model.
In The Thoracic and Cardiovascular Surgeon, vol. 52(S1) , pp. 22, 2004
  PDF  
O. Dössel, and G. Seemann.
Modeling cardiac electric fields.
In Int. J. Bioelectromagnetism, vol. 5(1) , pp. 9-13, 2003
  PDF    
G. Reinerth, G. Seemann, O. Dössel, C. F. Vahl, and S. Hagl.
Elektrophysiologische Modellierung des Herzens zur Planung von herzchirurgischen und kardiologischen Eingriffen.
In Herzschrittmachertherapie und Elektrophysiologie, vol. 14(1) , pp. 742-746, 2003
  PDF  
G. Reinerth, G. Seemann, S. Kewitz, O. Dössel, T. Schmidt, J. Albers, C. F. Vahl, and S. Hagl.
Simulation of cardiac electrophysiology using mathematical models and computer based processing of digital image data.
In Europ. Heart J., vol. 24, pp. 285, 2003
F. B. Sachse, K. Glänzel, and G. Seemann.
Modeling of protein interactions involved in cardiac tension development.
In Int. J. Bifurcation and Chaos, vol. 13(12) , pp. 3561-3578, 2003
  PDF  
F. B. Sachse, G. Seemann, K. Chaisaowong, and D. Weiß.
Quantitative reconstruction of cardiac electromechanics in human myocardium: Assembly of electrophysiological and tension generation models.
In J. Cardiovasc. Electrophysiol., vol. 14(S10) , pp. S210-S218, 2003
  PDF  
F. B. Sachse, G. Seemann, M. B. Mohr, and A. V. Holden.
Mathematical modeling of cardiac electro-mechanics: From protein to organ.
In Int. J. Bifurc. Chaos, vol. 13(12) , pp. 3747-3755, 2003
  PDF    
O. Dössel, F. B. Sachse, G. Seemann, and C. D. Werner.
Computermodelle der elektrophysiologischen Eigenschaften des Herzens - Computer models of the electrophysiological properties of the heart.
In Biomedizinische Technik, vol. 47(9-10) , pp. 250-257, 2002
  PDF    
F. B. Sachse, G. Seemann, and C. D. Werner.
Combining the Electrical and Mechanical Functions of the Heart.
In Int. J. Bioelectromagnetism, vol. 3(2) , 2001
  PDF    
F. B. Sachse, G. Seemann, C. Riedel, C. D. Werner, and O. Dössel.
Modeling of the cardiac mechano-electrical feedback.
In Int J Bioelectromagnetism, vol. 2(2) , 2000
  PDF    

Book Chapters (6)

G. Seemann, M. W. Krueger, and M. Wilhelms.
Elektrophysiologische Modellierung und Virtualisierung für die Kardiologie - Methoden und potenzielle Anwendungen.
In Der virtuelle Patient, W. Niederlag, H. Lemke, H. Lehrach (eds), Health Academy, pp. 98-116, 2012
  
O. Dössel, M. W. Krueger, and G. Seemann.
Personalized Electrophysiological Modeling of the Human Atrium.
In Cardiac Mapping, M. Shenesa, G. Hindricks, M. Borggrefe, G. Breithardt, M. E. Josephson (eds), Wiley-Blackwell, pp. 150-158, 2013
  
O. Dössel, D. Farina, D. Keller, R. Miri, M. Reumann, G. Seemann, F. Weber, and D. Weiss.
Modellbasierte Fusion von Herz-Bildgebung und Elektrokardiographie.
In Modellgestützte Therapie, H. U. L. (. W. Niederlag (Dresden) (eds), Health Academy, Dresden, pp. 225-236, 2008
  PDF    
O. Dössel, and G. Seemann.
Computer model of the electrical excitation of the heart.
In Modelling and Control in Biomedical Systems. A Proceedings Volume from the 5th IFAC Symposium Hilton on the Park, Melbourne, Australia, 21-23 August, D. D. Feng, E. R. Carson (eds), Oxford: Pergamon, pp. 179-184, 2003
  PDF  
F. B. Sachse, G. Seemann, and R. Mayer.
Modelling of Electro-Mechanics in the Heart: Mathematical and Numerical Aspects.
In High Performance Scientific Computing, W. Juling (eds), Scientific Supercomputing Center Karlsruhe, pp. 36-37, 2003
  PDF  
F. B. Sachse, C. D. Werner, and G. Seemann.
Simulation of Cardiac Electrophysiology and Electrocardiography.
In Computer Simulation and Experimental Assessment of Cardiac Electrophysiology, N. Virag, O. Blanc, L. Kappenberger (eds), Futura Publishing, Armonk, New York, pp. 97-104, 2001

Conference Contributions (221)

G. Seemann, A. Loewe, and E. M. Wülfers.
Effects of Fibroblasts Coupling on the Electrophysiology of Cardiomyocytes from Different Regions of the Human Atrium: A Simulation Study.
In Computing in Cardiology, vol. 44, 2017
  PDF    
  
G. Seemann, A. Loewe, and E. M. Wülfers.
Computational Study on Regional Differences in Pro-Arrhythmic Effects of Fibroblasts Coupling to Human Atrial Myocytes.
In TRM Forum, 2017
G. Seemann.
Simulating the effects of drugs and genetic defects on atrial electrophysiology.
In 7th TRM Forum on Computer Simulation and Experimental Assessment of Cardiac Function, 2013
G. Seemann, M. Alvarez de Eulate, O. Dössel, and D. U. J. Keller.
Variation of human ventricular Iks heterogeneities to reconstruct measured multi-channel ECG data.
In Biomedizinische Technik. Biomedical Engineering, vol. 58(s1) , 2013
  PDF    
  
  
G. Seemann, M. Alvarez de Eulate, N. Konrad, J. Maier, M. Wilhelms, D. Keller, O. Dössel, and E. Scholz.
Evaluating body surface ECG differences of simulated long-QT syndromes.
2013
  PDF    
G. Seemann, A. Loewe, Y. Lutz, M. Wilhelms, and O. Dössel.
Simulating the Effects of Drugs and Genetic Defects on Atrial Electrophysiology.
In TRM Forum, 2013
G. Seemann, R. Moss, A. K. E. Kurz, O. Dössel, M. Tristani-Firouzi, and F. B. Sachse.
A 2-state markov model of IKACh based on a membrane voltage dependent muscarinic M2 receptor approach.
In Proc. Computing in Cardiology, pp. 241-244, 2012
  PDF    
G. Seemann, P. Carrillo Bustamante, S. Ponto, M. Wilhelms, E. P. Scholz, and O. Dössel.
Atrial fibrillation-based electrical remodeling in a computer model of the human atrium.
In Proc. Computing in Cardiology, vol. 37, pp. 417-420, 2010
  PDF    
  
G. Seemann.
Modeling of cardiac Ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations.
In VPH Events - 4th Cardiac Physiome Workshop, 2009
  
  
G. Seemann, P. Carillo, D. L. Weiss, M. W. Krueger, O. Dössel, and E. P. Scholz.
Investigating Arrhythmogenic Effects of the hERG Mutation N588K in Virtual Human Atria.
In Lecture Notes in Computer Science, vol. 5528, pp. 144-153, 2009
  PDF    
  
  
G. Seemann, C. Rombach, D. U. J. Keller, and O. Dössel.
Effect of the drug cisapride on human ventricular cardiomyocytes: A simulation study.
In FMBE Proceedings World Congress on Medical Physics and Biomedical Engineering, vol. 25/4, 2009
  
G. Seemann, S. Lurz, D. U. J. Keller, D. L. Weiss, E. P. Scholz, and O. Dössel.
Adaption of Mathematical Ion Channel Models to measured data using the Particle Swarm Optimization.
In IFMBE Proceedings, vol. 22, pp. 2507–-2510, 2008
  PDF    
G. Seemann, E. Scholz, D. L. Weiss, and O. Dössel.
Effects of the reggae mutation on sinus node function: A simulation study.
In Proc. CinC, 2008
  PDF    
G. Seemann, D. L. Weiss, E. P. Scholz, F. B. Sachse, and O. Dössel.
Effects of a KCNA5 Mutation in a Human Atrial Myocyte: A Computational Study.
In Biophys. J (Annual Meeting Abstracts), 2008
  PDF  
G. Seemann, D. L. Weiss, E. P. Scholz, and O. Dössel.
Simulating the characteristics and effects of an IKur mutation in a human atrial cardiomyocyte.
In 41. Jahrestagung der DGBMT im VDE. Proceedings BMT 2007, vol. 52, 2007
  PDF  
G. Seemann, J. Buchta, D. L. Weiss, F. B. Sachse, and O. Dössel.
Simulating electrophysiological consequences of HERG S4-S5 linker mutations E544A and E544K in cardiomyocytes.
In Biophys. J (Annual Meeting Abstracts), 2006
  PDF  
G. Seemann, D. U. J. Keller, D. L. Weiss, and O. Dössel.
Modeling Human Ventricular Geometry and Fiber Orientation Based on Diffusion Tensor MRI.
In Proc. Computers in Cardiology, vol. 33, pp. 801-804, 2006
  PDF  
G. Seemann, R. Nir, D. L. Weiss, and O. Doessel.
Reaction of Electrophysiological in-Silico Models on IK1 Blocking in the Human Ventricle.
In IFMBE Proc., vol. 14, pp. 4112, 2006
  PDF  
G. Seemann, D. L. Weiss, F. B. Sachse, and O. Dössel.
Interaction of the Human Sinoatrial Node with Surrounding Atrial Tissue: A Simulation Study.
In Biomedizinische Technik(50) , pp. 560-561, 2005
  PDF  
G. Seemann, D. L. Weiß, F. B. Sachse, and O. Dössel.
Electrophysiology and Tension Development in a Transmural Heterogeneous Model of the Visible Female Left Ventricle.
In Lecture Notes in Computer Science, vol. 3504, pp. 172-182, 2005
  PDF  
G. Seemann, H. Ying, D. L. Weiss, F. B. Sachse, and O. Dössel.
Effects of Electrophysiological Remodeling in Human Right Atrium: A Simulation Study.
In Proc. Computers in Cardiology, vol. 32, pp. 69-72, 2005
  PDF  
G. Seemann, C. Höper, F. B. Sachse, H. Zhang, and O. Dössel.
A Detailed Model of Human Atrium towards Simulation of Electromechanics in the Heart.
In Proc. MEDICON, 2004
  PDF  
G. Seemann, F. B. Sachse, O. Dössel, A. V. Holden, M. R. Boyett, and H. Zhang.
3D anatomical and electrophysiological model of human sinoatrial node and atria.
In J Physiol, pp. 26, 2004
  PDF  
G. Seemann, D. L. Weiß, F. B. Sachse, and O. Dössel.
Familial atrial fibrillation: simulation of the mechanisms and effects of a slow rectifier potassium channel mutation in human atrial tissue.
In Proc. Computers in Cardiology, vol. 31, pp. 125-128, 2004
  PDF    
G. Seemann.
Elektromechanische Modellierung des menschlichen Herzens.
In I. Kongress junge Naturwissenschaft und Technik, pp. 178-179, 2003
G. Seemann, G. Reinerth, T. Schmidt, M. Reumann, O. Dössel, C. F. Vahl, and S. Hagl.
Simulation of ventricular activity in ventricular pacing using mathematical models in a porcine model based on 3D-echocardiographic images.
In Proc. CURAC03, 2003
  PDF  
G. Seemann, F. B. Sachse, D. L. Weiß, and O. Dössel.
Investigation of Fibrillation in Human Left Ventricle with a Reaction-Diffusion Model.
In Biomedizinische Technik, vol. 48-1, pp. 226-227, 2003
  PDF  
G. Seemann, D. L. Weiß, F. B. Sachse, and O. Dössel.
Simulation of the Long-QT Syndrome in a Model of Human Myocardium.
In Proc. Computers in Cardiology, vol. 30, pp. 287-290, 2003
  PDF  
G. Seemann, G. Reinerth, O. Dössel, and C. F. Vahl.
Elektrophysiologische Modellierung des Herzens als Grundlage therapeutischer Interventionen.
In Biomedizinische Technik, vol. 47-1/2, pp. 927-929, 2002
  PDF  
G. Seemann, F. B. Sachse, and O. Dössel.
Excitation Propagation and Force Development in the Left Ventricle of the Visible Female Data Set.
In Biomedizinische Technik, vol. 47-1/1, pp. 221-224, 2002
  PDF  
G. Seemann, F. B. Sachse, C. D. Werner, and O. Dössel.
Simulation of surgical interventions: Atrial radio frequency ablation with a haptic interface.
In Proc. CARS 2002, pp. 49-54, 2002
  PDF  
G. Seemann, F. B. Sachse, C. Riedel, C. D. Werner, and O. Dössel.
Regional And Frequency Dependencies Of Force Development In The Myocardium: A Simulation Study.
In Proc. Computers in Cardiology, vol. 28, pp. 345-348, 2001
  PDF  
G. Seemann, F. B. Sachse, C. D. Werner, and O. Dössel.
Simulation der Kraftentwicklung im Myokard bei physiologischer und pathologischer Erregungsausbreitung.
In Biomedizinische Technik, vol. 46-1, pp. 192-193, 2001
  PDF  
G. Seemann, F. B. Sachse, C. D. Werner, and O. Dössel.
Parametrisierung Zellulärer Automaten der Erregungsausbreitung im Herzen ausgehend von elektrophysiologischen Zellmodellen.
In Biomedizinische Technik, vol. 45-1, pp. 481-482, 2000
  PDF  
G. Seemann, and O. Dössel.
Simulation of the cardial electrical activity: interactive control of the simulation process and modelling in pathologies.
In Proceedings of European Medical and Biological Engineering Conference, pp. 1210-1211, 1999
G. Seemann, C. D. Werner, F. B. Sachse, and O. Dössel.
Simulation of Cardiac Electrical Activity: Interactive User Interface to Control the Simulation Process.
In Proc. EMBEC 99, pp. 1210-1211, 1999
  PDF  


Awards

2013: Best PhD Poster Award

during the Cardiac Physiome Workshop in Bar Harbor, USA
Axel Loewe, Mathias Wilhelms, Jochen Schmid, Mathias J. Krause, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations

2013: 2nd price at students competition

2nd price at student competition, BMT, 2013 Graz
Axel Loewe, Mathias Wilhelms, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
Impact of hERG Mutations on Simulated Human Atrial Action Potentials

2012: 3rd price at students competition

3rd price at student competition, BMT, 2012 Jena
A. Dorn, M. W. Krueger, G. Seemann, and O. Dössel,
Modelling of heterogeneous human atrial electrophysiology

2006: Best Poster Award

During the conference Computers in Cardiologie in Valencia the following presentation received the best poster award:
G. Seemann, D. U. J. Keller, D. L. Weiss, and O. Dössel.
Modeling Human Ventricular Geometry and Fiber Orientation based on Diffusion Tensor MRI. In Proc. Computers in Cardiology, volume 33, Sep. 2006.

DGBMT-Award 2006 of the Foundation-Family-Klee for the advancement of scientific procreation

Submitted PhD thesis:
G. Seemann: Modeling of Electrophysiology and Tension Development in the Human Heart. Universitätsverlag Karlsruhe, ISBN 3-937300-66-X, 2005.

2005:

Students competition at the 14th International Conference of Medical Physics und der 39th Annual Conference of the German Society for Biomedical Engineering 14-17 September 2005 in Nürnberg

3. Price
H. Chen, D. L. Weiß, G. Seemann, O. Dössel.
Simulated Electromechanical Heterogeneity in Human Left Ventricle. In Proc. Biomedizinische Technik, volume 50-1, pages 564-565, Sep. 2005.

2004: Best Poster Award

During the workshops for the retirement of Prof. Dennis Noble in Oxford Oct. 2004 the following presentation received the best poster award:
G. Seemann, F. B. Sachse, O. Dössel, A. V. Holden, M. R. Boyett, and H. Zhang.
3D Anatomical and Electrophysiological Model of Human Sinoatrial Node and Atria. In J. Physiol, PC26, 2004

2003: Students competition at the Joint Congress of the Austrian, German, and Swiss Society of Biomedical Engineering 25-27 September 2003 in Salzburg

1. Price in the category "Modeling - Fibrillation/Defibrillation"
D. L. Weiß, G. Seemann, F. B. Sachse and O. Dössel.
Investigation of electrophysiological heterogeneity and anisotropy across the human ventricular wall. In Biomedizinische Technik, volume 48-1, pages 228-229, Sep. 2003.

2. Price in the category "Modeling-Simulation I"
C. Höper, G. Seemann, F. B. Sachse, H. Zhang and O. Dössel.
3D Computer Model of Human Atrial Anatomy and Electrophysiology. In Biomedizinische Technik, volume 48-1, pages 2-3, Sep. 2003.(PDF)

2001: Best Poster Award

During the conference Computers in Cardiologie in Rotterdam the following presentation received the best poster award:
G. Seemann, F. B.  Sachse, C. Riedel, C. D. Werner, and O. Dössel.
Regional and Frequency Dependencies of Force Development in the Myocardium: A Simulation Study. In Proc. Computers in Cardiology, volume 28, Sep. 2001.

2001: Siemens Technology Award

Award of the faculty for Electrical Engineering and Information Technology for the best diploma thesis in the area of Information Technology:
G. Seemann, Elektrische Erregungsausbreitung im Herzen ausgehend von  elektrophysiologischen Zellmodellen: Erregungsausbreitung im Zellverband,  Parametrisierung Zellulärer Automaten. Diploma Thesis, Institut für Biomedizinische Technik, Universität  Karlsruhe (TH), Aug. 2000.

2001: Students competition at the 35th Annual Congress of the German Society of Biomedical Engineering 19-21 September in Bochum

1. Price in the category "Simulation / Software I"
L.G. Blümcke, F. B. Sachse, G. Seemann, C. D. Werner, and O. Dössel.
Entwicklung eines schnellen Verfahrens zur Deformation im Herzen ausgehend von makroskopischen Modellen der Kraftentwicklung. In Biomedizinische Technik, volume 46-1, pages 516-517 Sep. 2001. (PDF)

2. Price in the category "Simulation / Software I"
D.L. Weiß, F. B. Sachse, C. D. Werner, G. Seemann, and O. Dössel.
Vergleich elektrophysiologischer Modelle bei simulierten atrialen Fibrillationen. In Biomedizinische Technik, volume 46-1, pages 514-515, Sep. 2001. (PDF)

2. Price in the category "Simulation / Software II"
M. Jösel, F. B. Sachse, G. Seemann, C. D. Werner, and O. Dössel.
Simulation der Katheterisierung und Radio-Frequenz-Ablation in der Kardiologie mit einem haptischen Interface. In Biomedizinische Technik, volume 46-1, pages 528-529, Sep. 2001. (PDF)

2000: Students competition at the 34th Annual Congress of the German Society of Biomedical Engineering

1. Price
G. Seemann, F. B. Sachse,  C. D. Werner, and O. Dössel.
Parametrisierung Zellulärer Automaten der Erregungsausbreitung im Herzen  ausgehend von elektrophysiologischen Zellmodellen. In Biomedizinische Technik, volume 45-1, pages 481-482, Sep.  2000.

Curriculum Vitae

1973 Born in Hamburg, Germany, on October 28th.
Oct. 1994 – Sep. 2000 Studies included Electrical Engineering and Information Technology at the Universität Karlsruhe (TH),
Karlsruhe, Germany
Industrial practical work experience at Philips Medical Systems in Hamburg, Germany, in summer 1998.
Specialization of the studies: Biomedical Engineering
Final degree: Diplom-Ingenieur
Diploma thesis: “Elektrische Erregungsausbreitung im Herzen ausgehend von elektrophysiologischen
Zellmodellen: Erregungsausbreitung im Zellverband, Parametrisierung Zellulärer Automaten” at the
Institute of Biomedical Engineering at the Universität Karlsruhe (TH), Karlsruhe, Germany
Nov. 2000 – Sep. 2005 Postgraduate at the Institute of Biomedical Engineering at the Universität Karlsruhe (TH),
Karlsruhe, Germany
Final degree: Doktor-Ingenieur (summa cum laude)
Dissertation: “Modeling of Electrophysiology and Tension Development in the Human Heart”
Sep. 2005 – current Asisstant and accociate professor and research group leader at the Institute of Biomedical Engineering
at the Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany

Additional tasks

  • Group leader cardiac modeling
  • System administrator (MacOSX workstation + cluster; user management; web page; software etc.)                                                                                          
  • Class advisor for the biomedical engineering class
  • Administration of the IBT developed software
  • IT delegate of the Institute

Memberships

  • German Society of Biomedical Engineering (DGBMT) in the VDE
  • Biophysical Society
  • European Society of Cardiology

Miscellaneous

  • Coordinator und researcher in the project H4 of the SFB 414 "Rechner und sensorgestützte Chirurgie" of the German Research Foundation DFG (Nov. 2000 – Dec. 2003)
  • Co-organizer of the conference "Biomedizinische Technik 2002" in Karlsruhe with approximately 330 presentations and 600 participants
  • Funded member of the "Exzellenzakademie Medizintechnik 2005" of the DFG (Project phase: Nov. 2006 – Oct. 2007)
  • Conference chair of "Functional Imaging and Modeling of the Heart 2007" in Salt Lake City, USA
  • Reviewer for the Journal of Electrocardiology, Journal of Theoretical Biology, and Annals of Biomedical Engineering