In-silico Assessment of Arrhythmogenic Potential of Atrial Ablation Patterns

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Atrial fibrillation (AF) and Atrial flutter (AFlut) are the most common cardiac arrhythmias affecting more than 1% of the population. Even though they are not immediately life threatening, they are associated with severe complications such as cerebral stroke. Radio frequency or cryo-ablation are the only curative therapies for these diseases. However, many patients who underwent AF ablation develop AFlut subsequently. The aim of this work is to predict the changes in vulnerability to AFlut induced by certain ablation scar patterns in-silico.
Towards this end, personalized models are built based on patient-specific cardiac imaging data and enhanced with rule-based fiber orientation and tissue labels. Further individualization can include the patient’s AF history (degree of AF-induced remodeling), medication, and genetic information.
The arrhythmogenic potential of certain ablation patterns can then be assessed by dedicated algorithms using the patient-specific model.
IMG PRJ Ablation 2014-09-16


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