M.Sc. Miriam Weiß

Jesco Malz

Speckle variance optical coherence tomography (SV-OCT) is a widely used technique to visualize microvascular flow in vivo. While numerous studies have demonstrated its ability to qualitatively detect the presence of flow, a quantitative relationship between SV signal strength and flow velocity has not been fully established. A key parameter in this context is the interscan time—the time interval between two sequential scans that are compared to generate the SV signal. In our case, the interscan time is directly determined by the A-scan rate, which therefore critically affects the velocity range in which the SV signal is sensitive to flow. A systematic investigation of this relationship is crucial for optimizing SV-OCT acquisition settings and enabling more robust flow characterization.