M.Sc. Miriam Weiß

Jesco Malz

Speckle variance optical coherence tomography (SV-OCT) is a widely used technique for visualizing microvascular flow in vivo. While numerous studies have demonstrated its ability to qualitatively detect the presence of flow, a quantitative relationship between SV signal strength and flow velocity has not yet been fully established.
In particular, the SV signal exhibits a characteristic dependence on flow velocity, often described as a velocity response curve. This relationship is influenced by multiple factors, including acquisition parameters such as interscan time, as well as system- and sample-related properties. A systematic investigation of the SV–velocity response and its influencing parameters is essential for optimizing SV-OCT acquisition strategies and enabling more robust and quantitative flow characterization.