In silico characterization of pace-and-drive capacity of the human sinus node effects of cellular variability and tissue structure Projekttitel
Computational models of cardiac electrophysiology have significantly advanced in the last years and nowadays contribute to understanding fundamental physiological and disease mechanisms, optimization of diagnostic tools, and tailored therapeutic approaches. Most computational models of cardiac electrophysiology use external impulses to initiate excitation waves. Under healthy conditions, this approach is valid if only the spread of excitation waves within the working myocardium is of interest. However, the heart possesses the sinus node as its primary intrinsic pacemaker composed of cells that rhythmically generate impulses themselves. Understanding the fundamental mechanisms by which cardiac depolarization waves are initiated in the sinus node and excite the surrounding atrial tissue is of paramount importance under many pathological conditions (e.g., the frequent case of change of ion concentrations in kidney disease patients).