M.Sc. Christian Götz

Motivation
More than 50 million individuals worldwide are affected by atrial fibrillation (AF), which is the most common sustained arrhythmia and leads to an increased risk of stroke and heart failure. Current treatment strategies largely follow a one-size-fits-all approach and achieve only limited success rates, underscoring the need for personalized treatment options. To enable localized analyses of diseased tissue, as well as to support the planning and comparison of treatment strategies across patients, imaging modalities and clinical centers, a common reference system is required.
The clinical consensus statement on a standardized bi-atrial regionalization by the European Heart Rhythm Association (EHRA) and the European Association of Cardiovascular Imaging (EACVI) marks an important step into this direction [1]. Building on this, we developed an algorithm that automatically applies this standardized regionalization to any bi-atrial geometry, thereby reducing inter-operator variability and enabling consistent, regional quantitative comparisons [2].
While these advances rely on a discrete regionalization of the atria, a continuous parametrization – such as the universal atrial coordinates framework presented in [3] – aligned with the EHRA/EACVI consensus statement would offer additional advantages. It ensures consistent alignment of coordinates with anatomical regions across geometries, provides a clear coordinate-based language for spatial description, and enables the mapping of data between geometries. With a new standard for atrial regionalization now established, but no aligned continuous parametrization available, this thesis offers you the opportunity to contribute a coordinate system with the potential for broad use in future research.
 

Projekt
In dieser Arbeit entwickelst du ein Koordinatensystem für beide Vorhöfe, das explizit an die veröffentlichte standardisierte atriale Regionalisierung angepasst ist. Zunächst definierst du die Anforderungen und wesentlichen Eigenschaften von Koordinatensystemen, gefolgt von einer Analyse der Stärken und Schwächen der bestehenden Implementierung eines universellen atrialen Koordinatensystems. Anschließend führst du eine Literaturrecherche zu Methoden zur Herleitung von Koordinaten auf 3D-Oberflächen durch. Abschließend implementierst du die ausgewählte(n) Methode(n) in Python und validierst das resultierende Koordinatensystem anhand biatrialer Geometrien aus der Computertomographie (CT), der Magnetresonanztomographie (MRT) und dem elektroanatomischen Mapping (EAM).

[1] Althoff, T.F., Anderson, R.H., Goetz, C. et al. 2025. Europace 27. doi.org/10.1093/europace/euaf134
[2] Goetz, C. et al. 2024. Computing in Cardiology Conference 2024. doi.org/10.22489/CinC.2024.316
[3] Roney, C. et al. 2019. Medical Image Analysis 55. doi.org/10.1016/j.media.2019.04.004