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Axel Loewe

Dr.-Ing. Axel Loewe

Akademischer Rat, KIT Associate Fellow
Gruppenleiter Computational Cardiac Modeling
Gruppe: 

KIT-Nachwuchsgruppenleiter, Mitglied im Young Investigator Network (YIN)


Raum: 509
Tel.: +49 721 608 - 42790
Fax: +49 721 608 - 42789
Axel LoeweYwv5∂kit edu

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Veröffentlichungen

  Alle Veröffentlichungen, sortiert nach Jahren

    2019 2018 2017 2016 2015 2014 2013 2011 2010 [Alle]



Ausgewählte Veröffentlichungen

Journal Articles (24)

Y. Lutz, A. Loewe, S. Meckel, O. Dössel, and G. Cattaneo.
Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model..
In Journal of Thermal Biology, vol. 84, pp. 316-322, 2019
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A. Loewe, Y. Lutz, D. Nairn, A. Fabbri, N. Nagy, N. Toth, X. Ye, D. H. Fuertinger, S. Genovesi, P. Kotanko, J. G. Raimann, and S. Severi.
Hypocalcemia-Induced Slowing of Human Sinus Node Pacemaking..
In Biophysical journal, 2019
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A. Loewe, Y. Lutz, N. Nagy, A. Fabbri, C. Schweda, A. Varró, and S. Severi.
Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium.
In bioRxiv - the preprint server for biology, 2019
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A. Loewe, E. Poremba, T. Oesterlein, A. Luik, C. Schmitt, G. Seemann, and O. Dössel.
Patient-Specific Identification of Atrial Flutter Vulnerability–A Computational Approach to Reveal Latent Reentry Pathways.
In Frontiers in Physiology, vol. 9(Article 1910) , 2019
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S. Hallensleben, and A. Loewe.
Wie wirken Arzt und digitale Technik im Jahr 2035 zusammen?.
In VDE DGBMT, 2019
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Y. Wang, Z. Xiong, A. Nalar, B. J. Hansen, S. Kharche, G. Seemann, A. Loewe, V. V. Fedorov, and J. Zhao.
A robust computational framework for estimating 3D Bi-Atrial chamber wall thickness.
In Computers in Biology and Medicine, vol. 114, pp. 103444, 2019
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R. Andlauer, G. Seemann, L. Baron, O. Dössel, P. Kohl, P. Platonov, and A. Loewe.
Influence of left atrial size on P-wave morphology: differential effects of dilation and hypertrophy.
In Europace, vol. 20(S3) , pp. iii36-iii44, 2018
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S. Pollnow, N. Pilia, G. Schwaderlapp, A. Loewe, O. Dössel, and G. Lenis.
An adaptive spatio-temporal Gaussian filter for processing cardiac optical mapping data.
In Computers in Biology and Medicine, vol. 102, pp. 267-277, 2018
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A. Loewe, E. M. Wülfers, and G. Seemann.
Cardiac ischemia-insights from computational models..
In Herzschrittmachertherapie & Elektrophysiologie, vol. 29(1) , pp. 48-56, 2018
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T. G. Oesterlein, A. Loewe, G. Lenis, A. Luik, C. Schmitt, and O. Doessel.
Automatic Identification of Reentry Mechanisms and Critical Sites during Atrial Tachycardia by Analyzing Areas of Activity..
In IEEE Transactions on Bio-Medical Engineering, vol. 65(10) , pp. 2334-2344, 2018
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M. Alessandrini, M. Valinoti, L. Unger, T. Oesterlein, O. Dössel, C. Corsi, A. Loewe, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation in Atrial Fibrillation.
In Frontiers in Physiology, vol. 9, pp. 1251, 2018
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H. Lehrmann, A. S. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel Electrocardiographic Criteria for Real-Time Assessment of Anterior Mitral Line Block.
In JACC: Clinical Electrophysiology, vol. 4(7) , pp. 920-932, 2018
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B. Verma, T. Oesterlein, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional conduction velocity calculation from clinical multichannel electrograms in human atria.
In Computers in Biology and Medicine, vol. 92, pp. 188-196, 2018
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O. Dössel, and A. Loewe.
Computerized modeling of the human heart.
In Zeitschrift für Medizinische Physik, vol. 27(3) , pp. 167-169, 2017
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G. Lenis, N. Pilia, A. Loewe, W. H. W. Schulze, and O. Dössel.
Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 9295029) , pp. 13, 2017
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A. Loewe, and O. Dössel.
Commentary: Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study.
In Frontiers in Physiology, vol. 8, pp. 1113, 2017
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S. Pollnow, J. Greiner, T. Oesterlein, E. M. Wülfers, A. Loewe, and O. Dössel.
Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information? Insights from a Computational Study.
In Computational and Mathematical Methods in Medicine, vol. 2017(Article ID 168629) , pp. 13, 2017
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O. Dössel, G. Lenis, A. Loewe, M. Rottmann, G. Seemann, and T. Oesterlein.
Model Assisted Biosignal Analysis of Atrial Electrograms.
In Technisches Messen, vol. 83(2) , pp. 102-111, 2016
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A. Loewe, M. W. Krueger, F. Holmqvist, O. Dossel, G. Seemann, and P. G. Platonov.
Influence of the earliest right atrial activation site and its proximity to interatrial connections on P-wave morphology.
In Europace, vol. 18(suppl 4) , pp. iv35-iv43, 2016
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A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, D. Thomas, E. P. Scholz, O. Dössel, and G. Seemann.
Parameter estimation of ion current formulations requires hybrid optimization approach to be both accurate and reliable.
In Frontiers in Bioengineering and Biotechnology, vol. 3, pp. 209, 2016
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T. Oesterlein, D. Frisch, A. Loewe, G. Seemann, C. Schmitt, O. Dössel, and A. Luik.
Basket-Type Catheters: Diagnostic Pitfalls caused by Deformation and Limited Coverage.
In BioMed Research International, vol. Article ID 5340574, pp. 1-13, 2016
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology..
In Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 16(S4) , pp. iv30-iv38, 2014
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A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, A. Luik, O. Dössel, and G. Seemann.
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
In BioMed Research International Article, vol. 2015, pp. 530352, 2014
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A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
In Europace, vol. 16(3) , pp. 435-443, 2014
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Books (1)

C. Wieners, O. Dössel, A. Loewe, B. Frohnapfel, and V. Heuveline.
Book of Abstracts - Workshop on Cardiac Modeling. - Towards an integrated numerical heart model, Coupling the relevant physics the right way.
April 15-17 2019, Bad Herrenalb, Germany. 2019.
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Conference Contributions (69)

A. Loewe, G. Seemann, E. M. Wülfers, Y.-L. Huang, J. Sanchez, F. Bach, R. Ulrich, and M. Selber.
SuLMaSS - Sustainable Lifecycle Management for Scientific Software.
In E-Science-Tage 2019: Data to Knowledge, 2019
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T. Fritz, E. Kovacheva, G. Seemann, O. Dössel, and A. Loewe.
The inverse problem of cardiac mechanics - estimation of cardiac active stress from endocardial motion tracking.
In Computational & Mathematical Biomedical Engineering Proceedings, vol. 1, pp. 91-95, 2019
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R. Daschner, L. Krames, Y. Lutz, A. Loewe, O. Dössel, and G. Cattaneo.
Generation of a Simplified Brain Geometry for the Calculation of Local Cerebral Temperature using a 1D Hemodynamic Model.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 529-532, 2019
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M. Hernández Mesa, N. Pilia, O. Dössel, and A. Loewe.
Influence of ECG Lead Reduction Techniques for Extracellular Potassium and Calcium Concentration Estimation.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 69-72, 2019
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L. Krames, R. Daschner, Y. Lutz, A. Loewe, O. Dössel, and G. Cattaneo.
Modeling of the Human Cerebral Collateral Circulation: Evaluation of the Impact on the Cerebral Perfusion in Case of Ischemic Stroke.
In Current Directions in Biomedical Engineering, vol. 5(1) , pp. 533-536, 2019
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A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients.
In Biophysical Journal, vol. 116(3 suppl1) , pp. 231A, 2019
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D. Nairn, X. Ye, D. H. Fuertinger, P. Kotanko, A. Loewe, and J. Raimann.
FP616 Low Serum Calcium is Correlated with Lower Heart Rate in Elderly Dialysis Patients.
In Nephrology Dialysis Transplantation, vol. 34(S1) , 2019
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S. Schuler, A. Loewe, and O. Dössel.
Forcing Transmembrane Voltages to Decrease Slowly: A Temporal Regularization for ECG Imaging.
In Computing in Cardiology, vol. 45, 2018
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O. Dössel, T. Oesterlein, L. Unger, A. Loewe, C. Schmitt, and A. Luik.
Spatio-temporal Analysis of Multichannel Atrial Electrograms Based on a Concept of Active Areas.
In Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2018, pp. 490-493, 2018
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M. Hernández Mesa, N. Pilia, O. Dössel, S. Severi, and A. Loewe.
Effects of Serum Calcium Changes on the Cardiac Action Potential and the ECG in a Computational Model.
In Current Directions in Biomedical Engineering, vol. 4(1) , pp. 251-254, 2018
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E. Kovacheva, L. Baron, O. Dössel, and A. Loewe.
Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry.
In Computing in Cardiology Conference (CinC), vol. 45, 2018
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H. Lehrmann, A. Jadidi, J. Minners, J. Chen, B. Müller-Edenborn, R. Weber, O. Dössel, T. Arentz, and A. Loewe.
Novel ECG-criteria For Real-time Assessment Of Anterior Mitral Line Block - “V1-jump” And “V1-delay”.
In Heart Rhythm, vol. 15(5S) , pp. S229, 2018
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A. Loewe, Y. Lutz, A. Fabbri, and S. Severi.
Severe sinus bradycardia due to electrolyte changes as a pathomechanism of sudden cardiac death in chronic kidney disease patients undergoing hemodialysis.
In Heart Rhythm, vol. 15(5S) , pp. S354-S355, 2018
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A. Daub, A. Loewe, and B. Frohnapfel.
Haemodynamics in an elasto-mechanic model of the human heart.
In Annual Scientific Conference of the International Association of Applied Mathematics and Mechanics, 2018
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A. Loewe, M. Hernandez Mesa, N. Pilia, S. Severi, and O. Dössel.
A Heterogeneous Formulation of the Himeno et al. Human Ventricular Myocyte Model for Simulation of Body Surface ECGs .
In Computing in Cardiology, vol. 45, 2018
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S. Severi, A. Fabbri, M. Paci, R. Wilders, Y. Lutz, and A. Loewe.
Computational Modeling of the Cardiac Pacemaking in Humans.
In INdAM Workshop on Mathematical and Numerical Modeling of the Cardiovascular System, 2018
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L. A. Unger, T. G. Oesterlein, P. Spector, A. Luik, C. Schmitt, A. Loewe, and O. Dössel.
Cycle Length Statistics During Atrial Fibrillation Reflect Refractory Properties of the Underlying Substrate.
In Annual Congress of the European Cardiac Arrhythmia Society, pp. 16-27 A15-61, 2018
L. Baron, A. Loewe, and O. Dössel.
From clinics to the virtual beating heart a general modeling workflow for patient-specific electromechanical heart simulations.
In BMTMedPhys 2017, vol. 62(S1) , pp. S70, 2017
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O. Dössel, G. Lenis, A. Loewe, S. Pollnow, M. Rottmann, B. Verma, C. Schmitt, A. Luik, and T. Oesterlein.
Atrial Signals Modeling Meets Biosignal Analysis.
In IFMBE Proceedings, vol. 65, pp. 723-726, 2017
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W. Kahlmann, E. Poremba, D. Potyagaylo, O. Dössel, and A. Loewe.
Modelling of patient-specific Purkinje activation based on measured ECGs.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 171-174, 2017
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A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Optimal ECG lead systems to maximimze left atrial information content.
In BMTMedPhys 2017, vol. 62(s1 - V73) , pp. 68, 2017
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Y. Lutz, . Fabbri A., S. Severi, O. Dössel, and A. Loewe.
Plasma electrolyte concentrations in patients with chronic kidney disease influence cardiac pacemaking in a computational model.
In BMTMedPhys 2017, vol. 62(s1 - V71) , pp. 67, 2017
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T. Oesterlein, A. Loewe, G. Lenis, and O. Dössel.
Statistical assessment of cardiac excitation by morphology-based clustering of local activation waves.
In BMTMedPhys 2017, vol. 62(S1) , pp. S120, 2017
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S. Schuler, L. Baron, A. Loewe, and O. Dössel.
Developing and coupling a lumped element model of the closed loop human vascular system to a model of cardiac mechanics.
In BMTMedPhys 2017, vol. 62(S1) , pp. S69, 2017
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L. Unger, T. Oesterlein, G. Seemann, O. Dössel, P. Spector, and A. Loewe.
Estimating refractory periods during atrial fibrillation based on electrogram cycle lengths in a heterogeneous simulation setup.
In Current Directions in Biomedical Engineering, vol. 3(2) , pp. 317-320, 2017
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M. Alessandrini, M. Valinoti, A. Loewe, T. Oesterlein, O. Dössel, C. Corsi, and S. Severi.
A Computational Framework to Benchmark Basket Catheter Guided Ablation.
In Computing in Cardiology, vol. 44, 2017
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O. Dössel, and A. Loewe.
V 10 Computer Modelling pharmakologischer Effekte.
In Frühjahrstagung der Deutschen Gesellschaft für Kardiologie, 2017
A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Propagation of the primary pacemaker activity in the human heart: a computational approach.
In European Medical and Biological Engineering Conference (EMBEC), vol. 65, pp. 201, 2017
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A. Fabbri, A. Loewe, R. Wilders, and S. Severi.
Pace-and-Drive of the Human Sinoatrial Node – A Preliminary Computational Investigation.
In Computing in Cardiology, vol. 44, 2017
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A. Loewe, R. Andlauer, S. Pollnow, J. Greiner, T. G. Oesterlein, G. Seemann, and O. Dössel.
Validation upside down - In-silico models to sound the potential and limitations of diagnostic tools.
In TRM Forum, 2017
A. Loewe, Y. Lutz, A. Fabbri, S. Severi, G. Seemann, and D. Dössel.
Influence of Electrolyte Concentration Changes on Sinus Node Function - A new Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?.
In Gordon Research Conference on Cardiac Arrhythmia Mechanisms, 2017
A. Loewe, S. Debatin, G. Lenis, and O. Dössel.
Maximization of left atrial information through the optimization of ECG lead systems.
In Computing in Cardiology, vol. 44, 2017
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A. Loewe, E. Poremba, T. G. Oesterlein, N. Pilia, M. Pfeiffer, O. Dössel, and S. Speidel.
An interactive virtual reality environment for analysis of clinical atrial arrhythmias and ablation planning.
In Computing in Cardiology, vol. 44, 2017
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N. Nagy, A. Loewe, Z. Kohaida, K. Halász, N. Tóth, J. Levijoki, P. Pollesello, T. Koskelainen, L. Otsomaa, A. Tóth, J. Gy, and A. Varró.
Selective Inhibition of the Cardiac Na+/Ca2+ Exchanger by a Novel Compound ORM-10962 Modulates Spontaneous Automaticity.
In European Working Group on Cardiac Cellular Electrophysiology, 2017
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N. Pilia, O. Dössel, G. Lenis, and A. Loewe.
ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space.
In Computing in Cardiology, vol. 44, 2017
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G. Seemann, A. Loewe, and E. M. Wülfers.
Effects of Fibroblasts Coupling on the Electrophysiology of Cardiomyocytes from Different Regions of the Human Atrium: A Simulation Study.
In Computing in Cardiology, vol. 44, 2017
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G. Seemann, A. Loewe, and E. M. Wülfers.
Computational Study on Regional Differences in Pro-Arrhythmic Effects of Fibroblasts Coupling to Human Atrial Myocytes.
In TRM Forum, 2017
M. Valinoti, F. Bertoni, M. Alessandrini, R. Mantovan, A. Loewe, O. Dössel, S. Severi, and C. Corsi.
Phase Analysis of Endoatrial Electrograms for 3D Rotor Detection in Atrial Fibrillation.
In Computing in Cardiology Conference, vol. 44, 2017
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E. M. Wülfers, A. Loewe, and G. Seemann.
A Computational Study on the Electrophysiological Effects of Fibroblasts Coupling to Human Atrial Myocytes from Different Regions.
In Cardiac Physiome Project, 2017
R. Andlauer, A. Loewe, O. Dössel, and G. Seemann.
Effect of left atrial hypertrophy on P-wave morphology in a computational model.
In Current Directions in Biomedical Engineering, vol. 2(1) , pp. 603-606, 2016
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A. Loewe, R. Andlauer, P. G. Platonov, O. Dössel, and G. Seemann.
Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration.
In Computing in Cardiology, vol. 43, pp. 1-4, 2016
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A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size.
In Biomedizinische Technik, vol. 61, pp. S223, 2016
  
  
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by site of earliest right atrial activation.
In Cardiac Physiome Project, 2016
A. Loewe, M. W. Krueger, F. Holmqvist, O. Dössel, G. Seemann, and P. G. Platonov.
P-wave terminal force is affected by the site of earliest right atrial activation independent from atrial size in silico.
In International Conference on Electrocardiology, 2016
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B. Verma, A. Loewe, A. Luik, C. Schmitt, and O. Dössel.
Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries.
In Computing in Cardiology, vol. 43, pp. 985-988, 2016
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D. Potyagaylo, A. Loewe, P. van Dam, and O. Dössel.
ECG imaging of focal atrial excitation: Evaluation in a realistic simulation setup.
In Computing in Cardiology, vol. 43, pp. 113-116, 2016
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E. Shin, E. Poremba, O. Dössel, and A. Loewe.
Automated Initiation of Fibrillatory Excitation in Monodomain Simulations.
In Kentucky Academy of Science , 2016
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
P-wave morphology is affected by site of earliest right atrial activation: a simulation study.
In TRM Forum, 2015
A. Loewe, M. W. Krueger, P. G. Platonov, F. Holmqvist, O. Dössel, and G. Seemann.
Left and Right Atrial Contribution to the P-wave in Realistic Computational Models.
In Lecture Notes in Computer Science, vol. 9126, pp. 439–447, 2015
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Cardiac Physiome Workshop, 2015
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A. Loewe, Y. Xu, E. P. Scholz, O. Dössel, and G. Seemann.
Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 418–-422, 2015
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N. A. Pilia, G. Lenis, A. Loewe, W. H. W. Schulze, and . O. Dössel.
The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECG.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 96-99, 2015
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M. Rottmann, L. A. Unger, W. Kaltenbacher, . Seemann G., A. Loewe, M. W. Krueger, A. S. Jadidi, T. Arentz, and O. Dössel.
Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
In Computing in Cardiology, vol. 42, pp. 485-488, 2015
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J. Trächtler, . Oesterlein T., A. Loewe, E. Poremba, A. Luik, C. Schmitt, and O. Dössel.
Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 405-408, 2015
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A. Wachter, A. Loewe, M. W. Krueger, O. Dössel, and G. Seemann.
Mesh structure-independent modeling of patient-specific atrial fiber orientation.
In Current Directions in Biomedical Engineering, vol. 1(1) , pp. 409-412, 2015
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A. Loewe, Y. Lutz, M. Wilhelms, D. Sinnecker, P. Barthel, E. P. Scholz, O. Dössel, G. Schmidt, and G. Seeman.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Atrial Signals, 2015
A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology.
In Emerging Mathematical Topics in Biology and Life Sciences, 2015
M. Rottmann, L. A. Unger, W. Kaltenbacher, A. Loewe, M. W. Krueger, G. Seemann, T. Arentz, A. Jadidi, and O. Dössel.
Methods for analyzing signal characteristics of stable and unstable rotors in a realistic heart model.
In Computing in Cardiology Conference (CinC), 2015
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A. Loewe, Y. Lutz, M. Wilhelms, E. P. Scholz, O. Dössel, and G. Seemann.
Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Computing in Cardiology, vol. 41, pp. 745-748, 2014
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A. Loewe, M. Wilhelms, O. Dössel, and G. Seemann.
Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(S1) , pp. S929-S932, 2014
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Y. Lutz, A. Loewe, O. Dössel, and G. Seemann.
Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.
In Biomedizinische Technik / Biomedical Engineering, vol. 59(s1) , pp. s933-s936, 2014
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A. Loewe, M. Wilhelms, Y. Lutz, O. Dössel, and G. Seemann.
Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents.
In Simula Cardiac Modeling Workshop, 2014
J. Liu, A. Loewe, M. Zenge, A. Lefebvre, E. Mueller, and M. S. Nadar.
Elora: Enforcing Low Rank for Parallel MR Reconstruction.
In International Society for Magnetic Resonance in Medicine, pp. 2652, 2013
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A. Loewe, E. Poremba, M. W. Krueger, O. Dössel, and G. Seemann.
Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning.
In TRM Forum, 2013
A. Loewe, M. Wilhelms, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
Impact of hERG Mutations on Simulated Human Atrial Action Potentials.
In Biomedizinische Technik/Biomedical Engineering, vol. 58(s1) , 2013
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A. Loewe, M. Wilhelms, J. Schmid, M. J. Krause, F. Fischer, E. P. Scholz, O. Dössel, and G. Seemann.
A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data.
In Cardiac Physiome Workshop, 2013
W. H. W. Schulze, F. Elies Henar, D. Potyagaylo, A. Loewe, M. Stenroos, and O. Dössel.
Kalman Filter with Augmented Measurement Model: an ECG Imaging Simulation Study.
In FIMH, LNCS 7945, pp. 200-207, 2013
  PDF    
G. Seemann, A. Loewe, Y. Lutz, M. Wilhelms, and O. Dössel.
Simulating the Effects of Drugs and Genetic Defects on Atrial Electrophysiology.
In TRM Forum, 2013
A. Loewe, W. H. W. Schulze, Y. Jiang, M. Wilhelms, and O. Dössel.
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study.
In Computing in Cardiology, vol. 38, pp. 741-744, 2011
  PDF    
  

Patents (3)



Patente

  • Alban Lefebvre, Axel Loewe, Mariappan S Nadar, Jun Liu, Zero Communication Block Partitioning, US Patent App. 2014/0037228 A1 (2012P18991 US01, 13/950,535, 2012P18991 US, 61/679,132)
  • Jun Liu, Zhili Yang, Mariappan S Nadar, Nirmal Janardhanan, Qiu Wang, Axel Loewe, Multi-stage Magnetic Resonance Reconstruction for Parallel Imaging Applications, US Patent App. 2014/0133724 A1 (2012P26350 US01, 14/054,003, 2012P26350 US, 61/724,470)

 

Vorlesungen
Titel Typ Ort Zeit Beginn Dozent
Seminar 15.10.2019
Vorlesung 23.04.2019


Zu vergebende Arbeiten
Titel Typ Betreuer
Bachelor oder Masterarbeit


Laufende Arbeiten
Titel Typ Bearbeiter Betreuer


Abgeschlossene Arbeiten
Titel Typ Bearbeiter Betreuer
Bachelorarbeit

Emanuel Poremba 

Masterarbeit

Axel Loewe 

Bachelorarbeit

Yan Xu

Bachelorarbeit

Amine Khalef

Studentische Forschungsarbeit

Robin Andlauer

Bachelorarbeit

Robin Andlauer

Bachelorarbeit

Sebastian Debatin

Bachelorarbeit

Maria Hernandez Mesa

Masterarbeit

Willi Kahlmann

Bachelorarbeit

Yannick Lutz

Masterarbeit

Yannick Lutz

Studentische Forschungsarbeit

Yannick Lutz

Bachelorarbeit

Huy Nguyen Cong

Forschungsarbeit

Dr. Tiago Paggi de Almeida

Masterarbeit

Nicolas Pilia

Studentische Forschungsarbeit

Eura Shin

Studentische Forschungsarbeit

Maximilian Stabel

Masterarbeit

Laura Unger

Bachelorarbeit

Axel Loewe

Diplomarbeit

Andreas Wachter



Preise

Biophysical Society Travel Award für die 63. Jahrestagung 2019 in Baltimore, MD (USA).

Bill and Gary Sanders Poster Award, Konferenz „Computing in Cardiology“ 2018 in Maastricht (Niederlande)
Ekaterina Kovacheva, Lukas Baron, Olaf Dössel, Axel Loewe: "Electro-Mechanical Delay in the Human Heart: A Study on a Simple Geometry"

Preis für Patientensicherheit 2018
Axel Loewe und Olaf Dössel haben gemeinsam mit klinischen Partnern des Universitäts-Herzzentrums Freiburg-Bad Krozingen den Preis für Patientensicherheit (2. Platz) gewonnen.
Die prämierte Arbeit führt zwei neue EKG-basierte Verfahren zur unmittelbaren Beurteilung des Erfolgs der Katheterablation zur Beendigung von Perimitralflattern ein.

Den 3. Platz beim Gips-Schüle-Nachwuchspreis 2018 belegt
Axel Loewe für seine Dissertation Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Semi-Finalist Rosanna Degani Young Investigator Award, Konferenz „Computing in Cardiology“ 2017 in Rennes (Frankreich)
Nicolas Pilia, Olaf Doessel, Gustavo Lenis, Axel Loewe, ECG as a Tool to Estimate Potassium and Calcium Concentrations in the Extracellular Space

Bill and Gary Sanders Poster Award, Konferenz „Computing in Cardiology“ 2017 in Rennes (Frankreich)
Axel Loewe, Emanuel Poremba, Tobias G. Oesterlein, Nicolas Pilia, Micha Pfeiffer, Olaf Doessel, Stefanie Speidel:
An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning

Doktorandenpreis des KIT, Karlsruhe, 12.07.2017
Mit dem dem KIT-Doktorandenpreis würdigt das KIT herausragende Promovierte. Eine der drei Auszeichnungen für das akademische Jahr 2015/16 geht an Axel Loewe vom Institut für Biomedizinische Technik, dessen Dissertation „Modeling human atrial patho-electrophysiology from ion channels to ECG: substrates, pharmacology, vulnerability, and P-waves“ prämiert wurde. [Video ansehen]

Beste Poster Präsentation: Kentucky Academy of Science 2016, Student Research Competition, Computer and Information Sciences,
Eura Shin, Emanuel Poremba, Olaf Dössel, Axel Loewe: "Automated Initiation of Fibrillatory Excitation in Monodomain Simulations“

1. Preis im Studentenwettbewerb bei der DGBMT Jahrestagung (DACH) 2016 in Basel: Robin Andlauer, Axel Loewe, Olaf Dössel, Gunnar Seemann: "Effect of Left Atrial Hypertrophy on P-Wave Morphology in a Computational Model“

Preise bei der Konferenz „Computing in Cardiology“ 2016 in Vancouver (Kanada)
Rosanna Degani Young Investigator Award: Axel Loewe, Robin Andlauer, Olaf Dössel, Gunnar Seemann, Pyotr Platonov: „Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration“
Bill and Gary Sanders Poster Award: Axel Loewe, Bhawna Verma, Armin Luik, Claus Schmitt, Olaf Dössel: „Regional Conduction Velocity Calculation based on Local Activation Times: A Simulation Study on Clinical Geometries“
Mortara Fellowship: Gustavo Lenis, Axel Loewe

1. Preis im Studentenwettbewerb, DGBMT Jahrestagung 2014, Hannover,
Y. T. LutzA. LoeweM. Wilhelms, O. Dössel, G. Seemann.
Eingereichte Arbeit: Specific antiarrhythmic therapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology.

Preis für das beste Doktorandenposter im Rahmen des Cardiac Physiome Workshop in Bar Harbor, USA, 2013
Axel Loewe, Mathias Wilhelms, Jochen Schmid, Mathias J. Krause, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
"A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations"

2. Preis im Studentenwettbewerb, BMT, 2013 Graz, Axel Loewe, Mathias Wilhelms, Fathima Fischer, Eberhard P. Scholz, Olaf Dössel, Gunnar Seemann
Eingereichte Arbeit: "Impact of hERG Mutations on Simulated Human Atrial Action Potentials"

Preis für bestes Poster im Rahmen der Tagung Computers in Cardiology in Hangzhou: A. LoeweW. H. W. SchulzeYuan JiangM. WilhelmsO. Dössel
Determination of optimal electrode positions of a wearable ECG monitoring system for detection of myocardial ischemia: a simulation study; Computing in Cardiology, vol. 38, pp. 741 - 744, 2011

Gutachtertätigkeit

Publons Profil

 

Konferenzen

BMT: Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (DGBMT)

  • 2018 (Aachen, Deutschland) - Vortrag “Sudden cardiac death in hemodialysis patients: severe sinus bradycardia due to hypocalcaemia as a potential pathomechanism”
  • 2017 (Dresden, Deutschland) - Vortrag "Optimal ECG Lead Systems to Maximimze Left Atrial Information Content"
  • 2016 (Basel, Schweiz) - Poster "P-Wave Terminal Force Is Affected by the Site of Earliest Right Atrial Activation and its Proximity to Inter-Atrial Connections Independent from Atrial Size"
  • 2015 (Lübeck, Deutschland) - Vortrag "Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions"
  • 2014 (Hannover, Deutschland) - Vortrag "Influence of chronic atrial fibrillation induced remodeling in a computational electrophysiological model"
  • 2013 (Graz, Österreich) - Vortrag "Impact of hERG Mutations on Simulated Human Atrial Action Potentials" (2. Preis im Studentenwettbewerb)

BPS: Biophysical Society

  • 2019 (Baltimore, USA) 63rd Annual Meeting - Poster "Sinus Bradycardia Due to Electrolyte Changes as a Potential Pathomechanism of Sudden Cardiac Death in Hemodialysis Patients" (Early Career Travel Award Winner)
  • 2018 (Berlin, Germany) Thematic Meeting "The heart by Numbers" - Poster "The Challenge of Transferring in vitro Calcium Concentrations to Models Reflecting in vivo Conditions"

CARP: CARP User Workshop

  • 2018 (Bordeaux, Frankreich) Vortrag "Open Source CARP"

CinC: Computing in Cardiology

  • 2018 (Maastricht, Niederlande) - Talk “A Heterogeneous Formulation of the Himeno et al. Human Ventricular Myocyte Model for Simulation of Body Surface ECGs"
  • 2017 (Rennes, Frankreich) - Poster "An Interactive Virtual Reality Environment for Analysis of Clinical Atrial Arrhythmias and Ablation Planning" & Poster "Left Atrial Information Through the Optimization of ECG Lead Systems"
  • 2016 (Vancouver, Kanada) - Vortrag "Left Atrial Hypertrophy Increases P-Wave Terminal Force Through Amplitude but not Duration" (1. Preis im Young Investigator Award)
  • 2014 (Boston, USA) - Vortrag "Optimization of pharmacotherapy for familial atrial fibrillation in a numerical model of human atrial electrophysiology"

CMBE: Computational & Mathematical Biomedical Engineering

  • 2019 (Sendai City, Japan) - eingeladener Vortrag "The Inverse Problem of Cardiac Mechanics -
    Estimation of Cardiac Active Stress from
Endocardial Motion Tracking"

CPP: Cardiac Physiome Workshop

  • 2016 (Seoul, Korea) - Vortrag "P-wave terminal force is affected by site of earliest right atrial activation"
  • 2015 (Auckland, Neuseeland) - Vortrag "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology"
  • 2013 (Bar Harbor, USA) - Poster "A Hybrid Optimization Approach for the Adaptation of Cardiac Ion Current Formulations to Voltage and Patch Clamp Data" (Bestes Doktorandenposter)

deRSE: German Conference for Research Software Engineering

  • 2019 (Potsdam, Deutschland) - Workshop "Herausforderungen für die nachhaltige Entwicklung, Bereitstellung und Pflege von Forschungssoftware in Deutschland" & Poster "The SuLMaSS Project: Development of a Sustainable Open Source Software Package for Cardiac Electrophysiology"

EMBC: IEEE Engineering in Medicine and Biology Conference 

  • 2019 (Berlin, Deutschland) - Special Session Organisator "Computational Cardiac Modeling at the Interface of Engineering and Clinics"; Vortrag "Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium"; Chair 4 weiterer Sessions

FIMH: Functional Imaging and Modelling of the Heart

  • 2015 (Maastricht, Niederlande) - Vortrag "Left and Right Atrial Contribution to the P-wave in Realistic Computational Models"

GYSS: Global Young Scientists Summit

  • 2019 (Singapur), eingeladener Teilnehmer - Poster "Severe Sinus Bradycardia Due To Electrolyte Changes As A Pathomechanism Of Sudden Cardiac Death In Chronic Kidney Disease Patients Undergoing Hemodialysis"

GRC/GRS: Gordon Research Conference / Gordon Research Seminar on Cardiac Arrhythmia Mechanisms

  • 2019 (Lucca, Italien) - Chair des Gordon Research Seminars "Cardiac Arrhythmia Mechanisms"
  • 2019 (Lucca, Italien) - Poster "The Challenge of Transferring in vitro Extracellular Calcium Concen-trations to Models Reflecting in vivo Conditions"
  • 2017 (Ventura Beach, USA) - Vortrag (GRS) / Poster (GRC) "Influence of Electrolyte Concentration Changes on Sinus Node Function - A New Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?"

HRS: Heart Rhythm Society Scientific Sessions

  • 2018 (Boston, USA) - Poster "Severe Sinus Bradycardia Due To Electrolyte Changes As A Pathomechanism Of Sudden Cardiac Death In Chronic Kidney Disease Patients Undergoing Hemodialysis"

ICIAM: International Congress of Industrial and Applied Mathematics

  • 2019 (Valencia, Spanien) - eingeladener Vortrag "The inverse problem of cardiac biomechanics: estimating active stress distribution through imaging-driven computational modeling"

MEC: Cardiac Mechano-Electric Coupling and Arrhythmias

  • 2016 (Freiburg, Deutschland)

TRM: Theo-Rossi-di-Montelera Forum on Computer Simulation and Experimental Assessment of Cardiac Function

  • 2017 (Lugano, Schweiz) - Vortrag "Validation upside down - in-silico models to sound the potential and limitations of diagnostic tools"
  • 2015 (Lugano, Schweiz) - Poster "P-wave morphology is affected by site of earliest right atrial activation: a simulation study"
  • 2013 (Lugano, Schweiz) - Poster "Fast Marching Simulation of Atrial Excitation: Towards Personalized Ablation Planning"

Sitzungsleitung:

  • Session chair "Cardiac Mechanics and Heart Failure", Computing in Cardiology Konferenz 2017

  • Session chair "Atrial Fibrillation Drivers & Targets", Computing in Cardiology Konferenz 2018

  • Co-Chair des Gordon Research Seminars "Cardiac Arrhythmia Mechanisms" 2019

  • Organisator & Chair der Invited Session "Computational Cardiac Modeling at the Interface of Engineering and Clinics", IEEE Engineering in Medicine and Biology Conference 2019

Eingeladene Vorträge:

  • "The Inverse Problem of Cardiac Mechanics - Estimation of Cardiac Active Stress from Endocardial Motion Tracking", International Conference on Industrial and Applied Mechanics, Valencia, Spanien, 16. Juli 2019
  • "The Inverse Problem of Cardiac Mechanics - Estimation of Cardiac Active Stress from Endocardial Motion Tracking", Computational and Mathematical Biomedical Engineering Conference, Sendai, Japan, 10. Juni 2019
  • "Validation upside down - in-silico models to sound the potential and limitations of diagnostic tools", TRM Forum, Lugano, Schweiz, 04. Dezember 2017
  • „Multiscale modeling of cardiac electrophysiology”, School of Science and Engineering, Reykjavik University (RU) / Háskólann í Reykjavík (HR), Island, 30. August 2017
  • "In-silico Assessment of the Dynamic Effects of Amiodarone and Dronedarone on Human Atrial Patho-Electrophysiology", Workshop "Emerging mathematical topic in biology and life sciences", Research Core Area "Modeling and Simulation", Karl-Franzens-Universität Graz, Österreich, 07. Mai 2015
  • "Modeling human atrial patho-electrophysiology: genetic defects and pharmacological agents", Simula Cardiac Modeling Workshop, Oslo, Norwegen, 06. November 2014

Andere Vorträge

  • "Multiscale in silico modeling of human atrial electrophysiology", Computational Cardiology Lab (Prof. Natalia Trayanova), Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA, 02. September 2014 über Kontaktstipendium des Karlsruhe House of Young Scientists (KHYS)
  • "Multiscale computational cardiology", Computational Physiopathology Unit (Prof. Stefano Severi), Laboratory of Cellular and Molecular Engineering “Silvio Cavalcanti“, Universität Bologna, Italien, 29. Juni 2016 via DAAD-MIUR joint mobility program

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